• Given the paucity of effective therapies for CMML, delineating the molecular mechanisms of ASXL1 -mutant CMML (ASXL1 MT ) is of particular interest from a therapeutic standpoint. (nature.com)
  • Using recent techniques such as targeted genome editing, whole-brain activity imaging, brain atlas registration, and behavioral profiling, Thyme wants to analyze how these genes contribute to psychiatric disorders through disruption of molecular, cellular, developmental and behavioral processes. (harvard.edu)
  • BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
  • We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)
  • Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
  • Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
  • Therefore, to understand the interplay between SWR1-C and NuA4-C in flowering time, we studied in detail the Arabidopsis SWC4 and YAF9 genes using a combination of molecular genetics, chromatin biology and biochemical approaches. (europa.eu)
  • Molecular characterization and histone modifications analyses defined a novel regulatory mechanism of plant gene expression by H2AZ deposition. (europa.eu)
  • Furthermore, molecular profiling disclosed that neurodegenerative-related gene pathways altered in PD can be reversed using gene-editing approaches. (nih.gov)
  • Phenotypic and molecular characterisation of these mutants involves Drosophila genetic approaches, behavioural analysis, immunohistochemistry, fluorescent in situ hybridisation (FISH), in vivo non-canonical amino acid tagging (NCAT), confocal and super-resolution imaging, molecular biology, biochemistry, and next-generation sequencing. (academictransfer.com)
  • The molecular characterization was based on the RAPD markers, telomeric fingerprinting and ITS sequencing. (scielo.br)
  • Molecular defects of the ACTH receptor gene, consisting of point mutations, are described in approximately 25-40% of patients with FGD. (medscape.com)
  • Molecular characterization of 11 Italian patients with Darier disease. (medscape.com)
  • The cpr 5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1 -independent resistance. (springer.com)
  • Genes encoding for these two proteins are conserved in most eukaryotes, and Arabidopsis thaliana genome presents one gene encoding for SWC4 and the two YAF9 homologs, YAF9A and YAF9B. (europa.eu)
  • Here, we evaluated Arabidopsis thaliana mutants with defects in different parts of the immune system for an altered bacterial community assembly using a gnotobiotic system. (nature.com)
  • We revealed that Arabidopsis mutant lacking FtsH2 had increased levels of oxidative Trp residues in D1, among which an N-terminal Trp-14 was distinctively localized in the stromal side. (elifesciences.org)
  • Focks N, Sagasser M, Weisshaar B, Benning C. Characterization of tt15, a novel transparent testa mutant of Arabidopsis thaliana (L.) Heynh. (uni-bielefeld.de)
  • Update on transparent testa mutants from Arabidopsis thaliana: characterisation of new alleles from an isogenic collection. (uni-bielefeld.de)
  • In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
  • Further characterization showed that susa2-2 only suppresses the autoimmunity mediated by either CHS1-SOC3 or TN2-SOC3 paired NLR proteins, indicating that SUSA2 is specifically involved in NLR protein SOC3-mediated immunity. (ubc.ca)
  • Further work on purification and characterization of these proteins is needed, along with characterization of mutant strains deficient in the respective genes. (vt.edu)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • Additionally, it can knock out genes, facilitating efforts to elucidate gene functions through the analysis of mutant phenotypes. (mdpi.com)
  • Initial characterization of EMVs derived from idiopathic patients (AHNPs) and mutant LRRK2 patients showed differences between both phenotypes and when compared with a sibling control in EMV size and release based on Nanosight analysis. (nih.gov)
  • Together, these phenotypes contribute to the loss of flight behavior observed in itpr mutants. (jneurosci.org)
  • Mutant strains deficient in each of these genes will be constructed, and phenotypes will be assessed. (vt.edu)
  • This paper describes the construction of 10 mutant HSV-1 viruses with deletion and insertion mutations in Vmw110. (microbiologyresearch.org)
  • At low multiplicity, mutations in Vmw110 reduced viral gene expression in the least permissive cell type. (microbiologyresearch.org)
  • Familial juvenile hyperuricemic nephropathy is caused by mutations in the UMOD gene encoding uromodulin. (elsevierpure.com)
  • Several TSHR gene mutations have been identified in people with congenital hypothyroidism, a condition characterized by abnormally low levels of thyroid hormones starting from birth. (medlineplus.gov)
  • TSHR gene mutations change one of the protein building blocks (amino acids) used to make the thyroid stimulating hormone receptor. (medlineplus.gov)
  • Cases of congenital hypothyroidism caused by TSHR gene mutations are sometimes classified as thyroid dysgenesis because development of the thyroid gland is impaired. (medlineplus.gov)
  • TSHR gene mutations can cause disorders associated with hyperthyroidism. (medlineplus.gov)
  • TSHR gene mutations can lead to an enlarged thyroid gland (goiter) and symptoms of hyperthyroidism, such as a rapid heartbeat. (medlineplus.gov)
  • Sometimes gene mutations are acquired during a person's lifetime and are present only in certain cells. (medlineplus.gov)
  • Somatic mutations in the TSHR gene have been identified in thyroid tumors. (medlineplus.gov)
  • Somatic TSHR gene mutations have been reported in many cases of noncancerous (benign) thyroid tumors, called nodules or adenomas, which are associated with an overactive thyroid (hyperthyroidism). (medlineplus.gov)
  • Mutations in the gene ATP2A2 cause keratosis follicularis (Darier disease). (medscape.com)
  • Family members with confirmed identical ATP2A2 mutations can exhibit differences in the clinical severity of disease, suggesting that other genes or environmental factors affect the expression of keratosis follicularis (Darier disease). (medscape.com)
  • In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)
  • Because the disease-causing mutations in ATP2A2 affect functional domains of the gene, the mechanism of autosomal dominant transmission is believed to be haploinsufficiency, in which a single wild-type functioning ATP2A2 is insufficient to prevent disease. (medscape.com)
  • Normal C1 inhibitor mRNA expression level in type I hereditary angioedema patients: newly found C1 inhibitor gene mutations. (lu.se)
  • Five novel mutations in the C1 inhibitor gene (C1NH) leading to a premature stop codon in patients with type I hereditary angioedema. (lu.se)
  • A review of the reported defects in the human C1 esterase inhibitor gene producing hereditary angioedema including four new mutations. (lu.se)
  • Frequent de novo mutations and exon deletions in the C1inhibitor gene of patients with angioedema. (lu.se)
  • Seven novel mutations in the ATP2A2 gene of Austrian patients with Darier's disease. (medscape.com)
  • Echinocandin-resistant clinical isolates of Candida albicans have been reported, and key-hot spot mutations in the FKS1 gene, which encodes a major glucan synthase subunit, have been identified in these (caspofungin-resistant [CAS-R]) strains. (who.int)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • Finally, we used gene knockout strains to validate the potential target genes related to ethanol tolerance. (biomedcentral.com)
  • The International Mouse Strain Resource (IMSR) is a searchable online database of mouse strains and stocks available worldwide, including inbred, mutant, and genetically engineered mice. (tigm.org)
  • Exon 12 of the ATP2A2 gene in patients with Darier disease: one novel mutation and one previously described. (medscape.com)
  • We describe the development of a two-step nested polymerase chain reaction (PCR) protocol to amplify the triosephosphate isomerase (TPI) gene of G. duodenalis and G. microti and nucleotide sequence characterization of amplified TPI fragment. (cdc.gov)
  • The nucleotide sequence of a fragment of the T. brucei GPI8 gene has also been obtained. (gla.ac.uk)
  • A mutation in the CASQ1 gene causes a vacuolar myopathy with accumulation of sarcoplasmic reticulum protein aggregates. (nih.gov)
  • Using PCR/single-strand conformation polymorphism analysis of the gene encoding GDH in 12 Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI), we found a mutation (Y266C) in one PHHI patient. (diabetesjournals.org)
  • The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
  • Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
  • A novel RNA splice site mutation in the C1 inhibitor gene of a patient with type I hereditary angioedema. (lu.se)
  • Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedema. (lu.se)
  • Hereditary angioedema with a de novo mutation of exon 8 in the C1 inhibitor gene showing recurrent edema of the hands around the peripheral joints: importance for the differential diagnosis of joint swelling. (lu.se)
  • A point mutation in exon 7 of the C1-inhibitor gene causing type I hereditary angioedema. (lu.se)
  • Huo J, Liu Y, Ma J, Xiao S. A novel splice-site mutation of ATP2A2 gene in a Chinese family with Darier disease. (medscape.com)
  • The ATP2A2 gene in patients with Darier's disease: one novel splicing mutation. (medscape.com)
  • Ueo D, Hamada T, Hashimoto T, Hatano Y, Okamoto O, Fujiwara S. Late-onset Darier's disease due to a novel missense mutation in the ATP2A2 gene: a different missense mutation affecting the same codon has been previously reported in acrokeratosis verruciformis. (medscape.com)
  • Pengjun Z, Jianwen R, Biao Y. A novel missense mutation of ATP2A2 gene in a Chinese family with Darier disease. (medscape.com)
  • Miyabe C, Mitsuhashi Y, Saito M, Tsuboi R. Novel mutation in the ATP2A2 gene in a Japanese Darier's disease patient with extremely hyperkeratotic lesions. (medscape.com)
  • This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)
  • The wood phenotype resembles that of brown midrib (bm) mutants and some transgenic plants in which xylem is red-brown due to a reduction in CAD activity. (ox.ac.uk)
  • Recently, we reported that functional wheat inositol penta kis phosphate kinase ( TaIPK1 ) is involved in PA biosynthesis, however, the functional roles of the IPK1 gene in wheat remains elusive. (frontiersin.org)
  • Although there is ample evidence that the inhibition of bud outgrowth by auxin from the shoot apex is linked to stem elongation and highly branched auxin biosynthesis or signaling mutants are dwarf, the third theory proposed in the 1930s, the indirect theory, that explains apical dominance as auxin-induced stem growth indirectly inhibits bud outgrowth has been overlooked. (frontiersin.org)
  • Mutants of A. thaliana with defects in pigment biosynthesis often produce seeds that are olive brown or even yellow in appearance, and the responsible genetic loci are referred to as TRANSPARENT TESTA (TT). (uni-bielefeld.de)
  • Analysis of pigment accumulation and the study of expression patterns of genes involved in flavonoid biosynthesis in tt15 plants and seeds indicated a seed-specific phenotype. (uni-bielefeld.de)
  • Subsequent comparative transcriptomics identified a set of differentially expressed genes (DEGs) associated with the biosynthesis and regulation of flavonoids and BIAs in lotus. (bvsalud.org)
  • The recessive cad-n1 allele, which causes this phenotype, was discovered in a tree heterozygous for this mutant allele. (ox.ac.uk)
  • Fig. 3: The plant mutant rbohD shows a dysbiosis phenotype and assembles a microbiota enriched in Gammaproteobacteria. (nature.com)
  • The phenotype of the GPI8 null mutants was analysed with the following findings: (1) Mutant promastigotes grow well in culture. (gla.ac.uk)
  • We found that deletion of NUP2 delayed pairing and synapsis during meiosis, and led to decreased spore viability, similar to the ndj1Δ mutant phenotype. (biorxiv.org)
  • A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier's disease. (medscape.com)
  • Effects of Deletion of Mutant Huntingtin in Steroidogenic Factor 1 Neurons on the Psychiatric and Metabolic Phenotype in the BACHD Mouse Model of Huntington Disease. (lu.se)
  • Results of the study have validated previous observations on the genetic diversity of Giardia parasites on the basis of characterization of the glutamate dehydrogenase (GDH), small subunit ribosomal RNA (SSU rRNA), and TPI genes ( 12 , 15 - 17 ). (cdc.gov)
  • This gene encodes the skeletal muscle specific member of the calsequestrin protein family. (nih.gov)
  • The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. (rupress.org)
  • Phenotypic characterization and genetic analyses of loss-of function mutant lines revealed that AtSWC4 and AtYAF9 regulate flowering altering the expression of floral master genes. (europa.eu)
  • Distribution, structure and biosynthetic gene families of (1,3;1,4)-β-glucan in Sorghum bicolor [J]. J Integr Plant Biol. (jipb.net)
  • These methods emphasize combinations of classical and modern genetic approaches, including isolation and characterization of mutants, two-hybrid analysis, tetrad analysis, complementation, and recombination. (cshlpress.com)
  • We previously described the isolation of mutants of the methylotrophic yeast Hansenula polymorpha that are defective in peroxisome biogenesis. (rupress.org)
  • Mutants in the gene encoding the InsP 3 R ( itpr ) in Drosophila exhibit a range of defects including altered wing posture, increased spontaneous firing, and loss of rhythmic flight patterns in response to an air puff stimulus. (jneurosci.org)
  • The investigators found that the resultant transfected cells showed defects in ATP2A2 protein expression (15 mutants), ATP hydrolysis (29 mutants), calcium transport (4 mutants), and calcium binding and kinetics (3 mutants). (medscape.com)
  • Characterization of a functional thrombin receptor. (jci.org)
  • The fp2 gene was mapped on chromosome 10. (jipb.net)
  • By map-based cloning,casual gene was limited into a 100 Kb region between Indel markers 1-9.23 and 1-9.333 on chromosome 1 of foxtail millet. (refine.bio)
  • The locus at chromosome 1q21 was identified by linkage mapping in 1998, but the gene has only recently been discovered due to difficulty with sequencing this highly repetitive region and was previously missed using next-generation sequencing. (medscape.com)
  • TPI and small subunit ribosomal RNA (SSU rRNA) gene sequences of G. microti from muskrats were also generated and analyzed. (cdc.gov)
  • Exon 8 of the mouse α 6 subunit gene was disrupted by homologous recombination. (jneurosci.org)
  • The δ subunit mRNA was present at wild-type levels in the mutant granule cells, indicating a post-translational loss of the δ subunit. (jneurosci.org)
  • For example, cerebellar granule cells express six subunit genes abundantly (α 1 , α 6 , β 2 , β 3 , γ 2 , and δ), and so they probably have several distinct GABA A receptor subtypes of unknown subunit stoichiometry. (jneurosci.org)
  • Tests have been developed that detect mutant, fragmented, and/or methylated deoxyribonucleic acid (DNA) from exfoliated colon tumor cells in stool. (medscape.com)
  • Inheritance, gene expression, and lignin characterization in a mutant pine deficient in cinnamyl alcohol dehydrogenase. (ox.ac.uk)
  • Here, we have addressed these questions by altering intracellular Ca 2+ signals in flight-deficient itpr mutants through genetic means. (jneurosci.org)
  • Complementation of the Myc11 mutant with MSMEG1604 resulted in loss of L1334 from the cell envelope. (suny.edu)
  • Large-scale screening for mutants affected in seed development and complementation analysis of a candidate mutant line with all published A. thaliana tt mutants identified a new tt locus designated tt15. (uni-bielefeld.de)
  • Elucidation of the deficiency in two yeast coenzyme Q mutants. (wikipedia.org)
  • Structural analyses revealed that the fks1 mutant biofilms were generally less dense and had a clear predominance of yeast and pseudohyphae, with unusual "pit"-like cell surface structures. (who.int)
  • Combined transcriptome sequencing and gene function analysis, we identified two candidate genes that are highly expressed in panicle, and reported to participate in plant floral development and stress responses. (refine.bio)
  • Characterization and Mapping of a Salt-Sensitive Mutant in Rice ( Oryza sativa L.) [J]. J Integr Plant Biol. (jipb.net)
  • Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes. (medscape.com)
  • Genetic analysis indicated that the brittle of fp2 was controlled by a recessive gene. (jipb.net)
  • A foxtail millet panicle apical abortion mutant sipaa1, induced from Yugu1 by EMS treatment, was genetically identified.Genetic analysis showed that segregating ratio of wild type to mutant plants were 3:1 in sipaa1 × SSR41 F2 generation, suggesting that the panicle apical abortion trait of sipaa1 was controlled by a single recessive nuclear gene. (refine.bio)
  • We found that a transcription factor gene (Bmacj6) was defective in the mutants. (nii.ac.jp)
  • 5) GPI8 null mutants are capable of forming lesions in mice. (gla.ac.uk)
  • A transgenic mouse model was developed by introducing a human mutant UMOD (C148W) cDNA under control of the mouse umod promoter. (elsevierpure.com)
  • RT "Cloning and characterization of cDNA for adenosine kinase from RT mammalian (Chinese hamster, mouse, human and rat) species. (linuxfocus.org)
  • Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)
  • UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)
  • Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene. (microbiologyresearch.org)
  • RNA-seq based identification and mutant validation of gene targets related to ethanol resistance in cyanobacterial Synechocystis sp. (biomedcentral.com)
  • This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
  • Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)
  • Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay. (lu.se)
  • Surprisingly, the nup2Δ ndj1Δ double mutant failed to segregate chromosomes, even though the meiotic program continued. (biorxiv.org)
  • The mutant viruses were then studied in single-step growth curve experiments, by assaying for plaques in a variety of cell types and by analysis of viral polypeptide synthesis during productive infection at high and low multiplicities. (microbiologyresearch.org)
  • Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
  • Analysis of embryonic XY gonads suggests that sex reversal is caused by delayed and reduced expression of the sex-determining gene SRY . (plos.org)
  • The analysis provided a list of gene targets for engineering ethanol tolerance in cyanobacterium Synechocystis . (biomedcentral.com)
  • Onozuka T, Sawamura D, Yokota K, Shimizu H. Mutational analysis of the ATP2A2 gene in two Darier disease families with intrafamilial variability. (medscape.com)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
  • Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among overexpressed genes. (nature.com)
  • The patterns and amounts of viral polypeptide synthesis during high multiplicity infections with mutant and wild-type viruses were similar in all cell types. (microbiologyresearch.org)
  • To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
  • and (b) leucine-rich repeat kinase 2 (LRRK2) gene identified patient induced pluripotent stem cells (iPSCs), which were used to isolate EMVs and begin to characterize their cargoes. (nih.gov)
  • While higher-order mutants in receptors that recognize microbial features and in defence hormone signalling showed substantial microbial community alterations, the absence of the plant NADPH oxidase RBOHD caused the most pronounced change in the composition of the leaf microbiota. (nature.com)
  • The expression of the genes encoding olfactory receptors and so on was over- or mis-expressed in sensory organs of the mutants. (nii.ac.jp)
  • Promoter sequence and cell type can dramatically affect the efficiency of transcriptional activation induced by herpes simplex virus type 1 and its immediate-early gene products Vmw175 and Vmw110. (microbiologyresearch.org)
  • In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
  • These mutants display adult-onset progressive degeneration of peripheral motor and/or sensory neurons. (academictransfer.com)
  • Modificaci n gen tica de leguminosas y rhizobium para su uso en biorremediaci n. (us.es)
  • Accordingly, the epistatic relationship between cell death and SA accumulation, analyzed in crosses between lesion-mimic mutants (spontaneous lesion formation) and the transgenic nahG line (depleted in SA) places the SA activity in a feedback loop downstream and upstream of cell death. (springer.com)
  • The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
  • The effect of sequence variations within the coding region of the C1 inhibitor gene on disease expression and protein function in families with hereditary angio-oedema. (lu.se)
  • Loss of one of these genes, an uncharacterized transcription factor, resulted in a reduction of GABAergic inhibitory neurons in the forebrain and increased brain activity. (harvard.edu)
  • The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium . (tigm.org)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
  • The members of the International Knockout Mouse Consortium are working together to mutate all protein-coding genes in the mouse using a combination of gene trapping and gene targeting in C57BL/6 mouse embryonic stem (ES) cells. (tigm.org)
  • Lignin composition in this mutant shows dramatic modifications, including increased incorporation of the substrate of CAD (coniferaldehyde), indicating that CAD may modulate lignin composition in pine. (ox.ac.uk)
  • The activity of the p53 gene product is regulated by a plethora of posttranslational modifications. (rupress.org)
  • We first sought to assess biofilm formation and structure in these fks1 mutants and found that the biofilm mass and metabolic activities were reduced in most of the fks1 mutants as compared with reference strain SC5314. (who.int)
  • Your main project will involve the characterisation of mutant lines identified in a forward genetic screen for genes required for axonal maintenance (unpublished). (academictransfer.com)
  • High RT frequency mutants of Chinese hamster ovary cells involve structural RT alterations in the gene. (linuxfocus.org)
  • This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
  • The International Gene Trap Consortium (IGTC) represents all publicly available gene trap cell lines, which are available on a non-collaborative basis for nominal handling fees. (tigm.org)