LipidTyrosine kinase activityEnzymeCyclin-dependPhosphorylationProtein kinaseSerinePhosphatePhosphatasesPhosphatidylinositolPhorbol estersPhospholipasesAcyltransferaseGenePD98059InhibitorYeastCloningCellularActivationRecombinantSpindleCalciumActivateProteinsRolesGenesDependentCellsCellRegulationFunctionRoleDomainResponseMajorPotentialCancer
Lipid7
- Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases. (ox.ac.uk)
- Thus although the bioinformatics analysis and structure of YegS indicate that many of the ligand recognition determinants for lipid kinase activity are present, the absence of such activity may be due to specificity for a different lipid substrate or the requirement for activation by an, as yet, undetermined mechanism. (ox.ac.uk)
- Using tobacco pollen tubes as a model, we addressed the signaling effects of PA by probing the functions of three most relevant enzymes that regulate the production and degradation of PA, namely, phospholipases D (PLD), diacylglycerol kinases (DGKs), and lipid phosphate phosphatases (LPPs). (frontiersin.org)
- Once dolichol is generated, it must be phosphorylated by the enzyme dolichol kinase (DOLK), generating dolichol-phosphate (Dol-P) before it can be used as a lipid carrier or monosaccharide donor 8,12 . (cdghub.com)
- NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions. (embl-heidelberg.de)
- Athenstaedt K, Zweytick D, Jandrositz A, Kohlwein SD, Daum G: Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. (smpdb.ca)
- Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Tyrosine kinase activity1
- v-Src, an oncogene first identified in the Rous sarcoma virus, is an oncogenic version of c-Src and has constitutively active tyrosine kinase activity. (bvsalud.org)
Enzyme6
- Diacylglycerol kinase (CTP dependent) (EC 2.7.1.174, DAG kinase, CTP-dependent diacylglycerol kinase, diglyceride kinase) is an enzyme with systematic name CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase. (wikipedia.org)
- He co-authored a paper that describes the NMR structure determination of an integral membrane protein enzyme, diacylglycerol kinase, a 100-kDa protein-detergent complex, which was published in Science . (vckd.org)
- The DOLK gene encodes the enzyme dolichol kinase (DOLK), which is also called DK1. (cdghub.com)
- Classical protein kinase C (PKC) family members are activated by the binding of various ligands to one of several cysteine-rich domains of the enzyme. (embl-heidelberg.de)
- The natural agonist, diacylglycerol (DAG), and the natural product superagonist, phorbol dibutyrate (PDB), activate the enzyme to produce wide-ranging physiological effects. (embl-heidelberg.de)
- The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
Cyclin-depend2
- upon further inhibition of cyclin-dependent kinase (CDK1) by RO-3306, cells underwent monopolar cytokinesis with bleb-like protrusions. (bvsalud.org)
- 42. The phosphoinositide 3-kinase/Akt pathway regulates cellcycle progression of HL60 human leukaemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inibitor p27Kip1 and control of cyclin D1 expression. (units.it)
Phosphorylation2
- It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. (thermofisher.com)
- Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. (antibodies-online.cn)
Protein kinase12
- The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling. (biologists.com)
- Phosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. (drugbank.com)
- Protein kinase C facilitation of acetylcholine release has been reported in rats. (drugbank.com)
- Phosphatidylserine was found to restore protein kinase C activity in aging rats. (drugbank.com)
- Stimulation of calcium uptake by brain synaptosomes and activation of protein kinase C are yet other speculative mechanisms of phosphatidylserine's putative cognition-enhancing action. (drugbank.com)
- Taxonomy and function of C1 protein kinase C homology domains. (embl-heidelberg.de)
- These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl-heidelberg.de)
- The α 1 adrenergic receptor stimulates phosphatidylinositol turnover and increased diacylglycerol activates protein kinase C, while increased inositoltrisphosphate mobilize Ca 2+ to cause smooth muscle contraction. (scirp.org)
- The muscarinic receptor-mediated contraction of smooth muscle is induced by activation of protein kinase C and by increased intracellular Ca 2+ . (scirp.org)
- An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
- SnRK1: a versatile plant protein kinase that limits geminivirus infection. (ncsu.edu)
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. (antibodies-online.cn)
Serine3
- A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
- Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
- A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
Phosphate1
- Phosphatidic acid reacts with water through a phosphatidic acid phosphohydrolase 1 resulting in the release of a phosphate and a diacylglycerol. (smpdb.ca)
Phosphatases1
- Phosphoinositides (PPIs) together with various kinases and phosphatases were described as specific lipids and enzymes with signaling functions earlier ( Martin, 1998 ). (frontiersin.org)
Phosphatidylinositol4
- We report here that Sac1p has a specific role in secretion and acts as an antagonist of the phosphatidylinositol 4-kinase Pik1p in Golgi trafficking. (embl.de)
- Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)
- The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. (embl.de)
- To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. (embl.de)
Phorbol esters1
- Some bind phorbol esters and diacylglycerol. (embl-heidelberg.de)
Phospholipases1
- ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
Acyltransferase1
- The diacylglycerol reacts in the endoplasmic reticulum with an acyl-CoA through a diacylglycerol O-acyltransferase resulting in the release of coenzyme A and a triacylglycerol. (smpdb.ca)
Gene5
- Here we report the characterization of a new gene on the long arm of the X-chromosome (position Xq12) and the identification in unrelated individuals of different mutations that are predicted to cause a loss of function. (embl-heidelberg.de)
- The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. (bio.net)
- Molecular characterization and gene expression of lhcb5 gene encoding CP26 in the light-harvesting complex II of Chlamydomonas reinhardtii. (bio.net)
- The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
- Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. (ucdenver.edu)
PD980592
- Consistently, LTD by dopamine + 1 S ,3 R -ACPD coapplication, as well as the two other forms of LTD (LTD by dopamine + tetani and LTD by 1S,3R-ACPD + tetani), was blocked by bath application of MAP-K kinase inhibitor PD98059. (jneurosci.org)
- Inhibition of the Ras-MAPK pathway by expression of the dominant-negative Ras mutant HRasN17 or by addition of the MAPK kinase (MEK) inhibitor PD98059 reduced several of these parameters but failed to block transformation. (embl.de)
Inhibitor1
- Importantly, it appears that orexigenic neuropeptide Y agouti connected protein neurons come to be lively inside a low ROS situation, which can be the opposite of anorexigenic VEGFR tyrosine kinase inhibitor pro opiomelanocortin cocaine and amphetamine regulated transcript cells, which appear to rely a lot more on glucose and are much more lively at increased ROS levels. (wnt-signaling.com)
Yeast1
- Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)
Cloning2
- Cloning and characterization of an active fragment of luciferase from a luminescent marine alga, Pyrocystis lunula. (bio.net)
- Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus. (ucdenver.edu)
Cellular2
- In addition, since much of the cellular diacylglycerol (DG) derives from breakdown of PI, and since free Ca2+ levels appear to affect this breakdown, it seems likely that PIP2 breakdown is both directly and indirectly affecting the diacylglycerol level in cells. (grantome.com)
- Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol- 1,4,5-trisphosphate. (antibodies-online.cn)
Activation2
- Immunoblot analyses with anti-active mitogen-activated protein kinases (MAP-Ks) revealed that D1 receptors, D2 receptors, group I mGluRs, and group II mGluRs all contribute to MAP-K activation in prefrontal cortex, and that combined activation of dopamine receptors and mGluRs synergistically or additively activate MAP-Ks. (jneurosci.org)
- Therefore, the orexigenic circuit may well rely far more on fatty acids, whereas the anorexic one relies additional on carbohydrate, In another examine, via activation of PKC, ghrelin was discovered to activate diacylglycerol lipase, which increases 2 arachidonoylglycerol, so activating the CB 1 receptor. (wnt-signaling.com)
Recombinant2
- However, biochemical assays showed that recombinant YegS is endogenously neither an active diacylglycerol nor sphingosine kinase. (ox.ac.uk)
- Recombinant expression, purification, and characterization of Toxoplasma gondii adenosine kinase. (ucdenver.edu)
Spindle2
- An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
- Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. (lookformedical.com)
Calcium1
- The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. (lookformedical.com)
Activate1
- They also activate other kinase cascades. (embl-heidelberg.de)
Proteins1
- Proteins containing typical C1 domains are predicted to be regulated by diacylglycerol, whereas those containing only atypical domains are not. (embl-heidelberg.de)
Roles1
- c-Src tyrosine kinase plays roles in a wide range of signaling events and its increased activity is frequently observed in a variety of epithelial and non-epithelial cancers. (bvsalud.org)
Genes1
- Potential characterization of other PD interact ing cytological areas will most likely bring about the identification of more PD interacting genes. (wnt-signaling.com)
Dependent1
- This reaction can be reversed through a CTP-dependent diacylglycerol kinase. (smpdb.ca)
Cells1
- Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)
Cell2
- Analysis of biological specimens treated for SPM (scanning probe microscopy) and SEM microscopies: can different techniques influence imaging and morphological high-resolution characterization of cell surface and substratum? (units.it)
- Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. (lookformedical.com)
Regulation2
- Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
- An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
Function2
- Although the function of YegS is not definitively known, it has been annotated as a potential diacylglycerol or sphingosine kinase based on sequence similarity with eukaryotic enzymes of known function. (ox.ac.uk)
- Aurora kinases are found in all organisms in which their function has been conserved throughout evolution, namely the control of chromosome segregation. (lookformedical.com)
Role1
- Role of sulfoquinovosyl diacylglycerol for the maintenance of photosystem II in Chlamydomonas reinhardtii. (bio.net)
Domain1
- The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)
Response2
- Here, we show that formation of mitochondrial diacylglycerol (DAG) and its binding to PKD1 is the means by which PKD1 is localized to the mitochondria in response to ROS. (biologists.com)
- SnRK2 Protein Kinases and mRNA Decapping Machinery Control Root Development and Response to Salt. (uva.nl)
Major1
- This graph shows the total number of publications written about "Adenosine Kinase" by people in this website by year, and whether "Adenosine Kinase" was a major or minor topic of these publications. (ucdenver.edu)
Potential1
- The N-terminal and C-terminal domains of YegS are however counter-rotated, relative to the polyphosphate/ATP NAD kinase archetype, such that the potential nucleotide binding site is blocked. (ox.ac.uk)
Cancer1
- Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer. (gu.se)