Characterization 20 alpha hydroxysteroid dehydrogenase. Medical search. Frequent questions

3α-Hydroxysteroid dehydrogenase (3α-HSD or aldo-keto reductase family 1 member C4) is an enzyme that in humans is encoded by the AKR1C4 gene. (wikipedia.org)

PCR using primers specific for 20beta-hydroxysteroid dehydrogenase (20beta-HSD) which is involved in DHP production, follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), the two forms of membrane progestin receptor: mPR-alpha and mPR-beta, as well as GAPDH (control), were performed. (biomedcentral.com)

On the other hand, TGF-beta1 had no effect on mPR-alpha mRNA expression and increased FSHR mRNA levels. (biomedcentral.com)

The dominant follicle of the cycle appears to be selected from a cohort of class five follicles, and it requires about 20 days to develop to the ovulatory stage. (glowm.com)
In a recent study, a cohort of 55 patients with 5-alpha-reductase type 2 deficiency displayed varied phenotypes in the neonatal period. (medscape.com)
Cirrhosis developed in 5% of patients with NASH in a community-based cohort and 20% of NASH patients in a referral population[ 7 8 ]. (wjgnet.com)

Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. (lookformedical.com)
The beta-defensin genes mapped closely on rat chromosome 16 and were closely linked to the alpha-defensins genes, suggesting that they are part of a gene cluster, similar to the organization reported for humans. (lookformedical.com)

AKRs are tissue-specific hydroxysteroid dehydrogenases that interconvert weak steroid hormones to their more potent counterparts and regulate processes involved in development, homeostasis and reproduction. (biomedcentral.com)

The SRD5A2 gene provides instructions for making an enzyme called steroid 5-alpha reductase 2. (medlineplus.gov)
Specifically, the steroid 5-alpha reductase 2 enzyme is responsible for a chemical reaction that converts the hormone testosterone to DHT. (medlineplus.gov)

Diagnosis of 5-alpha-reductase type 2 deficiency (5-ARD) is usually made in the newborn period when the infant presents with ambiguous genitalia. (medscape.com)
If 5-alpha-reductase deficiency is considered in a newborn, a broad approach to ambiguous genitalia should be taken. (medscape.com)

Lou H, Hammond L, Sharma V, Sparkes RS, Lusis AJ, Stolz A: Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding. (drugbank.com)

5-alpha reductase deficiency is a condition that affects sexual development before birth and during puberty. (medlineplus.gov)
Many people with 5-alpha reductase deficiency are assigned female at birth based on their external genitalia. (medlineplus.gov)
People with 5-alpha reductase deficiency do not develop much facial or body hair. (medlineplus.gov)
Variants (also called mutations) in the SRD5A2 gene cause 5-alpha reductase deficiency. (medlineplus.gov)
These hormonal factors underlie the changes in sexual development seen in infants with 5-alpha reductase deficiency. (medlineplus.gov)
Researchers believe that people with 5-alpha reductase deficiency develop secondary male sex characteristics in response to higher levels of this hormone. (medlineplus.gov)
in each cell) will have the characteristic signs of 5-alpha reductase deficiency. (medlineplus.gov)
Parental consanguinity increases the child's risk for autosomal recessive disorders including 5-alpha reductase type 2 deficiency. (medscape.com)
however, in some individuals with 5-alpha-reductase type 2 deficiency, the testes can be found in the labioscrotal folds or retained in the abdomen. (medscape.com)
Females homozygous for 5-alpha-reductase type 2 deficiency have very subtle manifestations, such as delayed menarche, minimal acne, and minimal body hair. (medscape.com)

Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20-30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses for the industry. (biomedcentral.com)
In seabass aquaculture, the high incidence (20 to 30%) of precocious sexual maturation in males during the first year of life places a critical restraint to production parameters. (biomedcentral.com)

Khanna M, Qin KN, Cheng KC: Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. (drugbank.com)

Some affected people also retain a small amount of 5-alpha reductase 2 activity, which may produce DHT and contribute to the development of secondary sex characteristics during puberty. (medlineplus.gov)
The development of female sex characteristics does not require DHT, so a lack of steroid 5-alpha reductase 2 activity does not cause physical changes in these individuals. (medlineplus.gov)
Gastroparesis Patients and Healthy Controls ages 20-49 will be asked to participate in an observational study measuring vagal activity following food ingestion in order to establish parameters of autonomic nerve/vagal function in healthy human subjects compared to those with gastroparesis. (stanford.edu)

METHODS: Twenty patients (46 XY) who underwent genitoplasty in infancy or early childhood were retrospectively identified. (bvsalud.org)

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease that typically presents before the age of 20 with weakness of the facial muscles and the scapular stabilizer muscles. (arkansasbluecross.com)

Ciaccio PJ, Jaiswal AK, Tew KD: Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. (drugbank.com)

Alternative splicing of the primary transcript gives rise to the 2 mRNA and protein isoforms, hGR-alpha and hGR-beta. (medscape.com)

When a major progress issue Procedure group response is obtained, the characterization is carried random Technique additional by the same general procedure to subgroups and 1. (ehd.org)

Variants in the SRD5A2 gene prevent steroid 5-alpha reductase 2 from effectively converting testosterone to DHT in the developing reproductive tissues. (medlineplus.gov)

3 beta-Hydroxysteroid dehydrogenase in cell extracts of C. innocuum was oxygen sensitive and required NADH for activity. (nih.gov)
An Mr of 80 000 was estimated for 3 beta-hydroxysteroid dehydrogenase. (nih.gov)
However, 5 beta-reductase and 3 beta-hydroxysteroid dehydrogenase activities were separated using an HPLC-DEAE chromatography technique. (nih.gov)
Partial purification and characterization of an NAD-dependent 3 beta-hydroxysteroid dehydrogenase from Clostridium innocuum. (nih.gov)
Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S: Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. (drugbank.com)
Labrie Y, Durocher F, Lachance Y, Turgeon C, Simard J, Labrie C, Labrie F: The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species. (drugbank.com)
10. The identification of 11 beta-hydroxysteroid dehydrogenase as carbonyl reductase of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (nih.gov)
3-Beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare form of congenital adrenal hyperplasia that results in decreased production of all 3 groups of adrenal steroids: mineralocorticoids, glucocorticoids, and sex steroids. (medscape.com)
This condition is due to defects in type II 3-beta-hydroxysteroid dehydrogenase, an enzyme that occurs almost exclusively in the gonads and adrenal glands. (medscape.com)
A variety of mutations in the HSD3B2 gene affect the activity of this enzyme, resulting in the extremely variable, phenotypic presentations of 3-beta-hydroxysteroid dehydrogenase deficiency. (medscape.com)
Older patients with mild defects in 3-beta-hydroxysteroid dehydrogenase activity (late-onset or nonclassic variant) may present with premature pubic hair development, hirsutism, irregular menstrual cycles or primary amenorrhea. (medscape.com)
Patients with classic salt-losing 3-beta-hydroxysteroid dehydrogenase require initial replacement of glucocorticoids and mineralocorticoid, plus the addition of sex steroids at appropriate, pubertal age. (medscape.com)
The need for replacement therapy varies in late-onset (nonclassic) 3-beta-hydroxysteroid dehydrogenase deficiency and depends on the severity of the defect. (medscape.com)
Although first described in male infants with ambiguous genitalia and severe salt wasting, 3-beta-hydroxysteroid dehydrogenase deficiency also occurs in 46,XX female infants (who may have mild clitoromegaly), as well as in older patients who present with a milder or so-called late-onset variant. (medscape.com)

In addition, there has been interest in the cytochrome p450c17alpha (CYP17) gene, which encodes the enzyme involved in testosterone biosynthesis, and the 3beta-hydroxysteroid dehydrogenase type II (HSD3beta2) gene which encodes enzymes involved in metabolism of dihydrotestosterone. (nih.gov)

16. Heterogeneity of 11beta-hydroxysteroid dehydrogenase type 1/microsomal carbonyl reductase (11beta-HSD/CR) in guinea pig tissues. (nih.gov)

5-alpha reductase deficiency is a condition that affects sexual development before birth and during puberty. (medlineplus.gov)
Many people with 5-alpha reductase deficiency are assigned female at birth based on their external genitalia. (medlineplus.gov)
People with 5-alpha reductase deficiency do not develop much facial or body hair. (medlineplus.gov)
Variants (also called mutations) in the SRD5A2 gene cause 5-alpha reductase deficiency. (medlineplus.gov)
Variants in the SRD5A2 gene prevent steroid 5-alpha reductase 2 from effectively converting testosterone to DHT in the developing reproductive tissues. (medlineplus.gov)
These hormonal factors underlie the changes in sexual development seen in infants with 5-alpha reductase deficiency. (medlineplus.gov)
Researchers believe that people with 5-alpha reductase deficiency develop secondary male sex characteristics in response to higher levels of this hormone. (medlineplus.gov)
Some affected people also retain a small amount of 5-alpha reductase 2 activity, which may produce DHT and contribute to the development of secondary sex characteristics during puberty. (medlineplus.gov)
The development of female sex characteristics does not require DHT, so a lack of steroid 5-alpha reductase 2 activity does not cause physical changes in these individuals. (medlineplus.gov)
in each cell) will have the characteristic signs of 5-alpha reductase deficiency. (medlineplus.gov)
1. Interindividual variability in the expression and NNK carbonyl reductase activity of 11beta-hydroxysteroid dehydrogenase 1 in human lung. (nih.gov)
3. Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung. (nih.gov)
12. Human 11beta-hydroxysteroid dehydrogenase 1/carbonyl reductase: recombinant expression in the yeast Pichia pastoris and Escherichia coli. (nih.gov)
Recent investigations have suggested that prostate cancer risk is related to certain polymorphic genes that regulate androgen metabolism, particularly the androgen receptor (AR) gene, and the steroid 5-alpha-reductase type II (SRD5A2) gene. (nih.gov)

17. Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro. (nih.gov)

2020. Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish. (nih.gov)

The substrate concentration at half-maximal reaction velocity was 4.2 microM, and a specific activity of 17 nmol product formed/h per mg protein was determined using 4-pregnen-3,20-dione (progesterone) as a substrate. (nih.gov)
Photoreceptor retinol dehydrogenase (prRDH) is a membrane-associated cytosolic protein that localizes to the outer segments (OS) of rods and cones. (jneurosci.org)

6. Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. (nih.gov)

Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases? (scholaris.sk)

9. Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol. (nih.gov)

15. Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1. (nih.gov)
19. Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes. (nih.gov)
Description: A competitive ELISA for quantitative measurement of Human 17 Î² hydroxysteroid dehydrogenase type 6(HSD17B6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (lotuskringpoeldijk.nl)

Isolation and characterization of an expressible cDNA encoding human IL-3. (wikidoc.org)
Virus isolation and accurate characterization plays a crucial role in the rapid identification of the causative agents of infectious disease outbreaks especially if the causative viruses are novel where no pre-existing diagnostic reagents would be available. (afpm.org.my)

13. 11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck. (nih.gov)

Our study provides valuable structural details for facilitating the design of crystalline suspension formulation of Keytruda and demonstrates the high potential of MAS NMR as an advanced tool for biophysical characterization of biological therapeutics. (tuberculosistest.net)

The patients younger than 20?years of age were excluded (n? (researchensemble.com)
Twenty patients (4.6%) died later after an average of 1.1 +/- 1.1 years. (plk-signaling.com)

Cell extracts prepared anaerobically from Clostridium innocuum and Clostridium paraputrificum reduced delta 4-3-ketosteroids to 3 beta 5 beta and 3 alpha 5 beta derivatives, respectively. (nih.gov)
He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3. (wikidoc.org)

METHODS: Data of 6277 men and nonpregnant women 20 years or older from the Third National Health and Nutrition Examination Survey (1988-1994) were analyzed. (cdc.gov)

2. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes. (nih.gov)

It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. (cancerindex.org)

One main challenge in drug development is the lack of high-resolution characterization of the crystallinity and stability of mAb microcrystals in the native formulations. (tuberculosistest.net)

Anatomy3

Diseases1

Chemicals and Drugs64

Phenomena and Processes7

Information Science3

Aldo-keto reductase1

Follicle stimulat1

FSHR1

Cohort3

Genes2

Tissue-specific1

Enzyme2

Ambiguous genitalia2

Localization1

Deficiency10

Incidence2

Molecular1

Activity3

Patients1

Facial1

Human1

MRNA1

Issue1

Gene1

Beta-hydroxysteroid dehydrogenase14

3beta-hydroxysteroi1

Microsomal1

Reductase14

Aldo-keto1

20201

Protein2

Enzymes1

Glucocorticoids1

Purification1

Type3

Isolation2

Expression1

Biological1

Patients2

Cell2

Years1

Responsible1

Domain1

Lack1