Characteristics fetal dermal cells fetal tissue research. Medical search. Frequent questions

Conditioned medium from adipose derived stem cells (ADSC-CM) stimulates both collagen synthesis and migration of fibroblasts, and accelerates wound healing in vivo. (indexindex.com)
After ADSC-CM addition, collagen type I, type III, HAS and hyaluronic acid (HA) expressions on human dermal fibroblasts (HDFs) were evaluated. (indexindex.com)
SALPs inhibited LP-induced phosphorylation of NF-κB p65 and p38 MAPK and reduced cytokine release and gene expression in primary human keratinocytes and dermal fibroblasts. (nature.com)
iPS were generated via a platelet lysate or fetal bovine serum-based culturing protocol from matched dermal, buccal and gingival human fibroblasts, isolated from healthy donors ( n = 2) after informed consent, via episomal plasmid transfection. (biomedcentral.com)
Furthermore, oral fibroblasts generally required more attempts for successful iPS generation as opposed to dermal fibroblasts. (biomedcentral.com)
The oral fibroblasts generally proved to be more difficult to reprogram than dermal fibroblasts. (biomedcentral.com)
Xeno-free dermal, buccal and gingival fibroblasts can successfully generate iPS with a comparable genotype/phenotype to their xenogenic counterparts. (biomedcentral.com)
Applying MPTR to dermal fibroblasts from middle-aged donors, we found that cells temporarily lose and then reacquire their fibroblast identity, possibly as a result of epigenetic memory at enhancers and/or persistent expression of some fibroblast genes. (elifesciences.org)
Subsequently, the scaffold was bioconjugated with apelin-13 using the EDC-NHS linker and acellular scaffolds were recellularized using fibroblasts, endothelial cells, and smooth muscle cells. (biomedcentral.com)
We examined THS taken out from different materials on mouse sensory come cells (mNSC) from the neonatal cerebellum and on adult human being skin fibroblasts (hDFs). (immune-source.com)
Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. (thermofisher.com)
Herein, we introduce a cardiac-mimetic cell-culture system that resembles the microenvironment in the heart and provides interactions with cardiomyocytes and electrical cues to the cultured fibroblasts for direct cardiac reprogramming. (thno.org)
The human neonatal dermal fibroblasts containing cardiac transcription factors were plated on the membrane and cultured with the murine cardiomyocyte in the presence of the electric stimulus. (thno.org)

Radiography in focal dermal hypoplasia (FDH) may reveal osteopathia striata. (medscape.com)
A careful clinical history taking and dermatologic examination may lead to the diagnosis of focal dermal hypoplasia. (medscape.com)
Parents and siblings of patients with new, apparently sporadic cases of focal dermal hypoplasia (FDH) should be closely examined for subtle skin findings or other abnormalities. (medscape.com)
Diseases associated with defects in adipocyte homeostasis, such as lipodystrophy and focal dermal hypoplasia, lead to alopecia. (jcadonline.com)

By the fourth day, phagocytosis of contaminated tissues is well underway, and the processes of epithelization, collagen deposition, and maturation are occurring. (medscape.com)
48,49 In addition, cyclic mechanical strain enhances the function and development of engineered tissues by improving the production of collagen and elastin. (researchgate.net)
Y-27632 eye drops (or vehicle only) were administered to eyes after a superficial keratectomy, and the tissue was examined by immunohistochemistry for α-SMA, collagen types I, II, and III, and keratan sulfate. (molvis.org)
Interestingly, bundles of aligned and uniformly spaced collagen fibrils were more prevalent in keratocytes in Y-27632-treated corneas, which is reminiscent of fibripositor-like structures that have been proposed as a mechanism of matrix deposition in embryonic connective tissues. (molvis.org)
The atrophic reticulated patches of skin reveal attenuation of dermal collagen fibers with partial-to-complete loss of dermal collagen. (medscape.com)
The image depicts the characteristic absence of dermal collagen and the accompanying appearance of adipose tissue in the dermis. (medscape.com)
Systemic transplantation of an enriched CXCR2 population of mouse adipose-derived stem cells (mADSC) into DEB-affected mice demonstrated effective recruitment of cells to the blistering skin under the influence of blister-derived ligands and deposition of therapeutic type VII collagen. (biomedcentral.com)

6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
Fracture Healing in Diabetes Fracture repair entails recruitment of mesenchymal stem cells after which differentiation to chondrocytes that type cartilage (see Chapter 12). (dnahelix.com)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)

Extracellular matrix scaffolds derived from porcine small intestinal submucosa (SIS-ECM) have been shown to promote the formation of site-specific tissue in a number of preclinical animal studies. (researchgate.net)
However, efficient harvest and handling of cell sheets remain challenging, including insufficient extracellular matrix content and poor mechanical strength. (researchgate.net)
Mechanical loading has been widely used to enhance extracellular matrix production in a variety of cell types. (researchgate.net)
We found that the extracellular matrix content and thickness of cell sheet were markedly elevated upon appropriate mechanical conditioning. (researchgate.net)
These studies provided proof-of-concept data suggesting that adult stem cell-derived connective tissue proteins can participate directly in restoration of defective extracellular matrix and demonstrating the feasibility of systemic cellular therapy for DEB. (biomedcentral.com)
The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
Our results proposed 16-h perfusion of 0.25% sodium dodecyl sulfate (SDS) + 0.5% Triton X-100 combination to the vessel as an optimal decellularization protocol in terms of cell elimination as well as extracellular matrix preservation. (biomedcentral.com)
Kit consists of 500mL Cell Systems Medium, 5mL CultureBoost™ (containing animal derived growth factors) and 10mL Attachment Factor™ (extracellular matrix reagent for coating flasks). (cell-systems.com)
For best results, use Cell Systems Medium in conjunction with cell culture vessels coated with Attachment Factor™ extracellular matrix reagent. (cell-systems.com)

If the accumulation of adipose tissue is pronounced, it may cause the apparent herniation of subcutaneous tissue through the thinned skin. (medscape.com)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
In this review, we discuss the potential influence of stromal vascular fraction from adipose tissue in the management of alopecia as well as its involvement in preclinical and clinical trials. (jcadonline.com)
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
11 However, the greater the abundance of adipose tissue in the human body, the significantly higher the yield of MSCs is compared to other tissues. (jcadonline.com)

Embryonic stem cells (ESC) can be expanded indefinitely without undergoing replicative senescence or aging due to their high telomerase expression. (biomedcentral.com)
Embryonic stem cell lines derived from human blastocysts. (springer.com)
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. (springer.com)
Evans MD, Kelley J. US attitudes toward human embryonic stem cell research. (springer.com)
An immunologically identical cardiac tissue can be produced by direct reprogramming from the patients' tissue without the potential risk of tumorigenesis that occurs with induced pluripotent stem cells [ 2 ] and the ethical issue using embryonic stem cells. (thno.org)

The lentigolike, pigmented-macule lesions indicate increased amounts of melanin deposition in the basal epidermal keratinocytes, with an underlying mild dermal infiltrate of lymphocytes with numerous dermal melanophages. (medscape.com)
Specific Treg then provide active tolerance to the harmless food proteins at all mucosal surfaces, either via cell contact or via their secretion of immunosuppressive factors that both prevent the induction of adaptive T helper (Th) lymphocytes in response to antigenic re-exposure ( 7 ). (frontiersin.org)
Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)

2014). THS exposure can occur through inhalation, dermal contact, or ingestion. (immune-source.com)

Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
26,27 Dermal adipocytes are organized in small clusters under the reticular dermis and interact with the hair follicular cells regulating the hair cycle. (jcadonline.com)

These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. (jcadonline.com)
22 The underlying mechanism is believed to be a higher concentration of dihydrotestosterone (DHT) to androgen-sensitive hair follicles, causing thinning of the dermal papillae and shortening of the anagen phase. (jcadonline.com)
Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)

however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)

Therefore, we aimed to compare the efficiency of using humanized culture conditions, specifically human platelet lysate to fetal bovine serum, for iPS generation from different sources, and to evaluate their stemness. (biomedcentral.com)

MCF7 breast cancer cell lines were exposed to TCF extract, and cell viability and apoptosis assays were performed to evaluate the antiproliferative and apoptogenic effects. (bvsalud.org)
The TCF extract exhibited significant antiproliferative effects on MCF7 breast cancer cells and induced apoptosis in a dose-dependent manner. (bvsalud.org)
"Long noncoding RNA MALAT1 inhibits apoptosis induced by oxygen-glucose deprivation and reoxygenation in human brain microvascular endothelial cells" Yin et al. (cell-systems.com)
Although most cells have vitamin D receptors, several key genes that encode proteins and peptides are modulated in part by vitamin D and thus affect musculoskeletal functions, mitochondrial respiration, cell growth, proliferation, differentiation, and apoptosis [13]. (vitamindwiki.com)
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)

Six parasites ont montré une résistance in vitro au stibogluconate de sodium en utilisant le test de détection des amastigotes dans les macrophages J774 murins. (who.int)
Here, we developed CellAgeClock, a new epigenetic clock that measures subtle ageing changes in primary human cells in vitro . (biorxiv.org)
Our method expands the scope of CpG methylation profiling from measuring human chronological and biological age from human samples in years, to accurately and rapidly detecting anti-ageing potential of drugs using human cells in vitro , providing a novel accelerated discovery platform to test sought after geroprotectors. (biorxiv.org)
In vitro studies show that Leishmania infection decreases the adhesion of inflammatory phagocytes to connective tissue by a mechanism dependent on the modulation of integrin function. (biomedcentral.com)
In the present research, we looked into the cytotoxicity and genotoxicity of THS using in vitro cell versions and managed lab circumstances for the era and collection of THS. (immune-source.com)
Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses " Jiang et al. (cell-systems.com)
The stem cell field witnessed a genuine breakthrough when a combination of solely four transcription factors ( Oct3 / 4 , Sox2 , Klf4 and c-Myc, OSKM ) proved enough to revert, in vitro, the differentiated status of a variety of cell types back to pluripotency, giving rise to so-called induced pluripotent stem (iPS) cells. (springer.com)
Therefore, the implantation of human cells reprogrammed in vitro represents an alternative strategy [ 16 - 19 ]. (thno.org)

To gain pluripotency, the reprogramming process typically involves transfecting adult somatic cells with certain pluripotency markers. (biomedcentral.com)
The molecular mechanisms that govern directional migration of the adult stem cells, allowing their efficient and controlled homing to the skin affected with DEB, are poorly understood. (biomedcentral.com)
In recent years, adult stem cell-based therapy was suggested as a potential approach to attenuate DEB progression. (biomedcentral.com)
The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. (springer.com)
Viable offspring derived from fetal and adult mammalian cells. (springer.com)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)

The synthesis can occur either intracellularly, within the microbial cells, or extracellularly, using proteins, enzymes, and other biomolecules secreted by the microbes. (bvsalud.org)

These cells include dermal resident dendritic cells (DC), epidermal Langerhans cells, neutrophils and monocytes, which are released from the blood when the dermal capillary is disrupted and a reputed blood lake is formed [ 3 - 6 ]. (biomedcentral.com)

Successful application of ASC for the correction of genodermatoses, including DEB, and treatment of chronic wounds which often accompany these disorders, mainly depends on the efficacy of stem cell homing to the damaged skin and is considered a major issue in stem cell-based therapy. (biomedcentral.com)
Mora MV, Ibán MAR, Heredia JD, Laakso RB, Cuéllar R, Arranz MG. Stem cell therapy in the management of shoulder rotator cuff disorders. (wjgnet.com)
Cell Stem Cell. (springer.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)

Appropriate methodology does not exist to develop MRLs for dermal exposure. (cdc.gov)
Exposure to a potential fetal health hazard can be estimated through ecological assessment (e.g., testing the community water supply), questionnaires (e.g., classifying residents accord- ing to whether they drink bottled or tap water), or biological markers (e.g., testing for exposures to chemicals or solvents found in tap water). (cdc.gov)
Nevertheless, over exposure to sunlight, does not cause hypervitaminosis D but can cause damage to skin cells. (vitamindwiki.com)

In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)

Foreign materials are walled off by macrophages that may metamorphose into epithelioid cells, which are encircled by mononuclear leukocytes, forming granulomas. (medscape.com)
At the inoculation site, amastigotes are maintained in the interior of the mononuclear phagocytes, and the immunoreactions elicited by these cells are associated with different types of nodular lesions or ulcers. (biomedcentral.com)

Stem cells and regenerative medicine - future perspectives. (springer.com)
Stem cells in regenerative medicine: introduction. (springer.com)
Banking Progenitor Cells for Hippiatric Regenerative Medicine: Optimized Establishment of Safe and Consistent Cell Sources for Standardized Veterinary Therapeutic Protocols Abstract Acute musculoskeletal injuries in large animals such as horses or camels often result in productivity losses and euthanasia in racing, esthetic or stock animal industries. (blogspot.com)

Such changes in dendritic cell migration may be associated with immunological events that maintain inflammation at the sites of infection. (biomedcentral.com)

The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. (springer.com)

This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)

This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)

These findings provide a foundation for future research aimed at isolating saccharopine and conducting in vivo studies to evaluate its potential as a targeted therapy for breast cancer. (bvsalud.org)
Coincubation with Leishmania changes the migratory pattern of dendritic cells in vivo . (biomedcentral.com)
In this Chapter, we dissect the proof-of-principle studies that demonstrated that cellular reprogramming to pluripotency can be induced in vivo, in spite of unfavorable pro-differentiation signals present within the tissues. (springer.com)
The links of in vivo reprogramming to pluripotency with tumorigenesis and teratoma formation, and the cross-talk with cellular senesce and tissue injury are also discussed. (springer.com)

Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. (thermofisher.com)

A layered effect sometimes occurs, with attenuated collagenous connective tissue lying both above and beneath an adipose layer. (medscape.com)
Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue dysfunction and disease. (elifesciences.org)

Recent work has demonstrated that the epigenome is already rejuvenated by the maturation phase of somatic cell reprogramming, which suggests full reprogramming is not required to reverse ageing of somatic cells. (elifesciences.org)
Pluripotent teratocarcinoma-thymus somatic cell hybrids. (springer.com)

Sex differences in human physiology are distinctions of physiological characteristics associated with either male or female humans. (wikipedia.org)
Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)
The CellAgeClock outperforms other epigenetic clocks in measuring subtle ageing changes in primary human cells in culture. (biorxiv.org)
THS components from terry towel had been also examined with human being palatal mesenchyme cells (hPM). (immune-source.com)
"MnTBAP or catalase Is more protective against oxidative stress in human retinal endothelial cells exposed to Intermittent hypoxia than their co-administration " Quan et al. (cell-systems.com)
Biomed Grid and Research is to publish scientific and technical research papers, to bring attention to the importance of technology in the field of human sciences. (blogspot.com)
Know more about the iMM, a Biomedical research institute of excellence, conducting basic and clinical research with the mission of improving human life. (ulisboa.pt)

Upon maturation, the cell sheets were harvested by lowering the temperature. (researchgate.net)
This study describes a novel "maturation phase transient reprogramming" (MPTR) method to restore the epigenome of cells to a more youthful state. (elifesciences.org)

Although various categories of wound healing have been described, the ultimate outcome of any healing process is repair of a tissue defect. (medscape.com)

We also developed a novel strategy to eliminate the remnant detergents from the scaffold and increase cell viability by incubating acellular scaffolds with Bio-Beads SM-2 resin. (biomedcentral.com)
The immunohistochemical (IHC) staining of CD31, α-SMA, and vimentin markers suggested placement of seeded cells in the suitable sites and considerable elevation of cell attachment within the scaffolds bioconjugated with apelin-13 compared to the non-bioconjugated, and decellularized groups. (biomedcentral.com)

Induced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell types of the body. (biomedcentral.com)
The main property that sets ESC apart from other cells is their pluripotent nature, meaning they can give rise/differentiate to cells of the three primary germ layers (mesoderm, endoderm and ectoderm) [ 13 ]. (biomedcentral.com)
Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. (springer.com)
At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)

The establishment of oral tolerance is dependent on the controlled uptake of food proteins through the intestinal epithelial barrier and its delivery to local dendritic cells (DC) that matured in the intestinal pro-tolerogenic environment. (frontiersin.org)
Cells of axes and cotyledons of seeds under investigation contained extremely low quantity of globulins, and high level of non-compartmentalized heat-stable proteins. (blogspot.com)
Heat-stable proteins comprised about 30% of soluble cytosolic proteins in cells of seed axes and more than 80% in cotyledons [ 8 , 9 ]. (blogspot.com)
The histochemical analysis (protein staining in the cells of axes and cotyledons) did not detect considerable depositions of proteins or formed protein bodies in the cells of axes and in the storage parenchyma of cotyledons of dormant horse chestnut seeds before and during stratification. (blogspot.com)
We found similar cell structure and fraction composition of proteins in another species growing in Central Russia and producing recalcitrant seeds - English oak (Quercus robur) [ 11 ]. (blogspot.com)

To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoart. (biomedcentral.com)

A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)

Recently, the production and secretion of growth factors has been identified as an essential function of adipose-derived stem cells (ADSCs). (indexindex.com)
However, despite encouraging results, these trials revealed that the majority of curative effects resulted from the secretion of various paracrine factors elicited by transplanted cells rather than from donation of the therapeutic protein to the affected cutaneous tissue [ 11 ]. (biomedcentral.com)

Total viable cells, as determined by Fixable Viability Dye eFluor® 450, were used for analysis. (thermofisher.com)

and altering cell and tissue characteristics for biomedical research and manufacturing. (nationalacademies.org)

"MicroRNA‐containing extracellular vesicles released from endothelial colony‐forming cells modulate angiogenesis during ischaemic retinopathy" Dellett et al. (cell-systems.com)
"Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells" Wang et al. (cell-systems.com)

The papillomatous lesions typically consist of a fibrovascular stalk composed of loose connective tissue with dilated vessels and a variable perivascular admixture of inflammatory cells. (medscape.com)
Tissue engineering of native vessels is an alternative approach for patients with vascular disease who lack sufficient saphenous vein or other suitable conduits for autologous vascular graft. (biomedcentral.com)
Moreover, the harvest of vessels prolongs the surgical procedure and it may lead to the morbidity of donor site in elder patients: therefore, it seems that the use of tissue-engineered vessels would be an attractive and less invasive substitute for autologous vascular grafts. (biomedcentral.com)
Testometric tensile testing machine was also used for the assessment of mechanical properties and uniaxial tensile strength of decellularized and recellularized vessels compared to that of native tissues. (biomedcentral.com)
In conclusion, our results provide a platform in which xenograft vessels are decellularized properly in a short time, and the recellularization process is significantly improved after the bioconjugation of the acellular scaffold with apelin-13 in terms of cell adhesion and viability within the scaffold. (biomedcentral.com)

The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)

While much study has been devoted to genetic "triggers" of CNS neurodegeneration-notably mutant Htt in Huntington's disease (HD)-such inherited triggers are typically expressed from early fetal development and are fundamentally inaccessible to timely clinical intervention. (hdsa.org)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)

The "pro-tolerogenic" antigen-loaded DC will migrate to draining mesenteric lymph nodes, where they will present the food protein-derived peptides to naive T cells and favour the induction of a subpopulation of T cells, namely regulatory T cells (Treg). (frontiersin.org)
Findings Secreted, retained cytoplasmically, and endocytosed forms of AFP use exclusive subscriber base and digesting paths, ensuing in different immunologic reactions from the caused antigen-specific Compact disc4+ and Compact disc8+ Capital t cells and between healthful contributor and HCC individuals. (immune-source.com)
CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. (thermofisher.com)
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. (thermofisher.com)

Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)
The skin comprises various cell types providing the potential to react to bacterial pathogenicity factors and can thus initiate inflammatory responses if exposed to these factors 5 . (nature.com)
Phenol red in cell culture medium binds to receptors on cell surfaces and causes the cell to respond as though pharmacologic levels of estrogen and/or inflammatory mediators (such as prostaglandin or thromboxane A2) are present in the medium. (cell-systems.com)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)

CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. (thermofisher.com)

Background Dendritic cells (DC) are uniquely outfitted to catch, procedure, and present antigens from their environment. (immune-source.com)

Wound healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers. (medscape.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)

We aimed to assess the antiproliferative effects of TCF extract on breast cancer cells and explore the potential role of saccharopine, a phytochemical found in TCF, as an anticancer agent. (bvsalud.org)
43 Therefore, cell sheets with enhanced thickness and mechanical properties obtained through appropriate cyclic mechanical stimulation possess great potential for bone tissue engineering applications. (researchgate.net)
Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
Collectively, these studies demonstrate that recruitment of mADSC into DEB skin is tightly controlled by disease-site chemotactic activities and suggest a potential mechanism for effective application of therapeutic stem cells for DEB. (biomedcentral.com)
Introduction The research of Hatch (1) has greatly increased our understand- ing of the use and potential limitations of biological markers for adverse reproductive effects. (cdc.gov)
Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)

Squamous cell carcinoma and less often basal cell carcinoma can develop in long-standing lesions and/or scars. (medscape.com)

The present invention meets the unique nutrient needs of the acute or chronic patient that are generated due to tissue repair and healing requirements of wounds. (everypatent.com)

Anatomy29

Organisms7

Diseases15

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology7

Phenomena and Processes28

Disciplines and Occupations25

Anthropology, Education, Sociology and Social Phenomena14

Humanities12

Information Science15

Named Groups3

Health Care37

Geographicals2

Fibroblasts13

Focal dermal hypoplasia4

Collagen7

Mesenchymal stem4

Extracellular matrix9

Adipose tissue5

Embryonic5

Lymphocytes3

Inhalation1

Adipocytes2

Hair follicles3

Stromal1

Platelet1

Apoptosis5

Vitro8

Adult6

Synthesis1

Epidermal1

Stem-cell5

Exposure3

Monocyte-derived1

Mononuclear2

Regenerative medicine3

Dendritic cell migration1

Hematopoietic stem1

Fibroblast1

Inflammation1

MSCs1

Vivo4

Differentiation1

Occurs2

Somatic cell2

Human7

Maturation2

Defect1

Scaffolds2

Pluripotent4

Proteins5

Cartilage1

Bone marrow1

Secretion2

Viable1

Biomedical1

Endothelial2

Vessels5

Intracellular1

Clinical4

Antigen4

Inflammatory4

Adhesion1

Antigens1

Cellular2

Potential6

Basal1

Wounds1