• The physical characteristics, or phenotypes, of the mutants are recorded, and a gene of interest is then isolated based on a particular phenotype. (databasefootball.com)
  • Additionally, it can knock out genes, facilitating efforts to elucidate gene functions through the analysis of mutant phenotypes. (mdpi.com)
  • It was recognized as a spontaneous mouse mutant with phenotypes characteristic of cerebellar lesions such as ataxic gait and hypotonia. (nature.com)
  • Chromosomal inactivation Many factors can affect gene expression (and thus phenotypes). (msdmanuals.com)
  • This work generated a comprehensive atlas of both co-occurring and mutually exclusive mutations among RAS and other genes at an unprecedented resolution. (news-medical.net)
  • When treating patients who have RAS-mutant tumors, clinicians must consider clinical outcomes and the tumor's aggressiveness as well as co-mutations and patient characteristics such as gender, racial background and age, Anagnostou says. (news-medical.net)
  • Our study shows that you need to consider who the host is and what the genetic makeup is of the tumor, because RAS-mutant tumors with different co-mutations have completely different profiles and clinical behavior. (news-medical.net)
  • They first looked at the distribution and heterogeneity, or variations, of mutant RAS across cancer types and co-occurring mutations. (news-medical.net)
  • Insertion mutations in mauJ, mauM, and mauN did not impair the ability of the mutants to utilize primary n-alkylamines as carbon sources. (caltech.edu)
  • Meanwhile, Schreiber and his colleagues particularly examined which molecules CTNNB1 mutant lines were sensitive to, as mutations in CTNNB1, the transcription factor b-catenin gene, are found in a number of cancers, though a targeted treatment aimed at them has yet to be found. (genomeweb.com)
  • They also tested the sensitivity of CTNNB1 mutant lines harboring mutations in their degradation boxes and saw that they had sensitivity levels similar to the other mutant lines. (genomeweb.com)
  • This paper describes the construction of 10 mutant HSV-1 viruses with deletion and insertion mutations in Vmw110. (microbiologyresearch.org)
  • At low multiplicity, mutations in Vmw110 reduced viral gene expression in the least permissive cell type. (microbiologyresearch.org)
  • Repeated experiments suggested the presence of cheaters inevitably gives rise to cheater-resistant mutations and that such spontaneous mutations were in fact the most robust (more so than when researchers inserted resistant genes into "wild" strains of Dictyostelium). (scienceblog.com)
  • Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
  • As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
  • You can find over 440 noted mutations within the calpain 3 gene up to now, included in this 212 (50%) are missense mutations, a lot of which alter its catalytic activity (22). (exposed-skin-care.net)
  • Mutations in the genes encoding the CNGA3 and CNGB3 subunits of the cyclic nucleotide-gated (CNG) channel of cone photoreceptors have been associated with autosomal recessive achromatopsia. (jneurosci.org)
  • Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
  • The concept of mutation was coined by Hugo De Vries in 1901, whom worked with plants species of the genus Oenothera where he discovered some phenotypic hereditary characteristics that he coined as "mutations" and "mutants" to those individuals that have these phenotypic alterations. (intechopen.com)
  • Additionally, we conducted feature importance analysis to identify top potential novel drug resistance mutations in the integrase gene. (h3africa.org)
  • The structural implications of these mutations were explored through modelling of mutant structures of integrase using i-TASSER and visualized with PyMOL. (h3africa.org)
  • Feature importance analysis identified top potential novel drug resistance mutations, including G134N, I135V, and K136Q in the integrase gene. (h3africa.org)
  • Bioinformatics analyses have identified unique, molecular biomarkers and clinical characteristics of TCF7L2 mutant colorectal cancers that include microsatellite instability, exclusivity of BRAFV600E mutations, better prognosis and differential gene expression. (cam.ac.uk)
  • I further showed the outcome of TCF7L2 mutations and the altered ratio of long and short versions of the TCF7L2 protein - alteration of the Wnt pathway gene expression program with specific consequences on cell proliferation, clonogenic growth, cell cycle progression and survival. (cam.ac.uk)
  • Lattice corneal dystrophy type II is caused by mutations in the GSN gene. (medlineplus.gov)
  • Although a mutation in one copy of the gene can cause the disorder, people with mutations in both copies of the gene have more severe signs and symptoms. (medlineplus.gov)
  • This syndrome is a result of mutations in the gene that codes for fatty aldehyde dehydrogenase. (medscape.com)
  • Beyond mutations, the neurologic and other phenotypic characteristics may result from unidentified epigenetic/environmental factors, gene modifiers, or other mechanisms. (medscape.com)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • UNC13D is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis. (lu.se)
  • Mutations in the perforin gene in children with hemophagocytic lymphohistiocytosis. (lu.se)
  • Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis. (lu.se)
  • Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma. (lu.se)
  • Perforin gene mutations in patients with acquired aplastic anemia. (lu.se)
  • A proportion of patients with lymphoma may harbor mutations of the perforin gene. (lu.se)
  • Foreign gene sequences could be inserted into deletion mutants, which may alter the infectious characteristics of the virus. (i-sis.org.uk)
  • The psbH deletion mutants gave a PSII minus phenotype and were unable to grow photoautotrophically. (ucl.ac.uk)
  • This leads into the creation of deletion mutants for the conserved gene ycf9, introduced into both C. reinhardtii and Synechocystis sp PCC 6803. (ucl.ac.uk)
  • Analysis with C-terminal deletion mutants of AML1-MTG8 indicated that the region of 51 residues (488 to 538), which contains NHR2, is essential for the induction of G-CSF-dependent cell proliferation. (embl-heidelberg.de)
  • Their four-year study of the RAS family - including the KRAS , NRAS and HRAS genes that are mutated in approximately one-third of all human cancers - found that the frequency of mutant RAS genes differs among various tumor types, age, sex and racial groups, and co-mutation patterns among RAS genes and other genes potentially can result in different clinical outcomes or identify new areas for therapeutic intervention. (news-medical.net)
  • Led by Robert Scharpf, Ph.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center, the team developed novel analytical frameworks to assess the prevalence and co-mutation patterns of RAS genes in the AACR Project GENIE registry. (news-medical.net)
  • This observation correlates with the experimental determination that when cells lack the ability to repair certain types of oxidative damage as a result of gene knockout, we see an increase in replicative mutation rates and adaptive mutation frequencies when compared to the wild type cell line. (plu.edu)
  • Drosophila sechellia females, which lay their eggs on these fruits, carry a mutation in a gene that inhibits egg production. (medizin-aspekte.de)
  • The same gene mutation also contributes to the resistance that these flies have to the toxic acids produced in the fruits and killing all other fruit fly species. (medizin-aspekte.de)
  • A genetic comparison with other Drosophila species showed that Drosophila sechellia carries a mutation in a gene called Catsup. (medizin-aspekte.de)
  • Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation. (nih.gov)
  • Alanyl-tRNA synthetase 1 (AARS1) gene mutation in a family with intermediate Charcot-Marie-Tooth neuropathy. (nih.gov)
  • Thirty-four years later, the mutation underlying staggerer was reported: a 6.4-kb deletion that removes an exon of the retinoic acid-related orphan receptor alpha ( ROR α) gene and causes a frameshift and premature stop codon. (nature.com)
  • However, in some of them, the disorder develops because of a germ cell mutation in their parents (eg, an autosomal dominant gene in a phenotypically normal parent). (msdmanuals.com)
  • Severe course of community-acquired pneumonia in an adult patient who is heterozygous for Q481P in the perforin gene: are carriers of the mutation free of risk? (lu.se)
  • The proteins which form this centre are encoded for by both nuclear and chloroplast genes and while the function of some has been determined, many play an unknown role. (ucl.ac.uk)
  • Subsequently, a corticosterone binding proteins was determined in synapses of amphibian mind, with characteristics just like G-protein combined receptors (6C9). (fabretp.org)
  • The lifestyle of such a receptor was also reported inside a mouse pituitary cell range (22), suggesting a second gene can be mixed up in manifestation of the GC-binding proteins at least in the central anxious system. (fabretp.org)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • Entitled 'A gene network for navigating the literature', the correspondence by Robert Hoffmann and Alfonso Valencia described a new database called iHOP (Information Hyperlinked over Proteins) that uses genes and proteins as hyperlinks to convert the abstracts in the published literature into a navigable network of information. (nature.com)
  • Preliminary structural modeling revealed slight conformational changes in the mutant integrase proteins, suggesting potential impacts on drug binding. (h3africa.org)
  • This new version of the database (R20, July 2019) includes a major update of data on germline variations and on the functional assessment of mutant proteins. (who.int)
  • They studied the cancer type-specific prevalence of KRAS , NRAS and HRAS mutant alleles (alternative forms of a gene) at codons (units of genetic code) 12, 13 and 61 in the overall population and stratified their results by patient age, race and gender. (news-medical.net)
  • Both siblings carry two mutant CNGA3 alleles that give rise to channel subunits with different single-amino acid substitutions. (jneurosci.org)
  • Because those patients retain some cone function, we reasoned that mutant alleles encode functional channel subunits that alter the human cone visual pathway in characteristic ways. (jneurosci.org)
  • In the mauG and mauL mutants, the MADH large and small subunit polypeptides were present at wild-type levels, although the MADHs in these strains were not functional. (caltech.edu)
  • The researchers found that cheater cells inserted into a population of mutants would "select" Dictyostelium strains that contained a particular resistor gene. (scienceblog.com)
  • In this study the prevalence of pcaA gene was determined in M. tuberculosis strains typed by spoligotyping. (scielo.br)
  • The pcaA gene was detected in M. tuberculosis clinical isolates but not in saprophyte strains such as M. kansasi. (scielo.br)
  • To perform directed evolution on these enzymes and yield mutant strains of the enzymes capable of faster botryococcene production requires a selective screen. (plu.edu)
  • Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during 2015. (cdc.gov)
  • More than 15 years ago, Cheng and his lab discovered a key gene in the evolution of light skin color in humans by studying a particular mutant zebrafish line, golden, that has lighter stripes. (sciencedaily.com)
  • They predict that scientists will be able to, for example, count the number of tumor cells of different characteristics and more definitively study invasion, a central characteristic of cancer, helping doctors with prognostic and treatment decisions. (sciencedaily.com)
  • In addition, NRAS mutant and KRAS mutant lines have increased sensitivity to the MEK1/2 inhibitor selumetinib, which has shown some activity in clinical trials, the researchers noted. (genomeweb.com)
  • Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers. (news-medical.net)
  • Results of genetic analysis and mapping indicated that these characteristics were controlled by the OsCOP1 gene. (isaaa.org)
  • NEW YORK (GenomeWeb News) - In Cell this week, researchers led by the Broad Institute's Stuart Schreiber presented a resource that correlates the genetic characteristics of a few hundred cancer cell lines to their sensitivity to a number of small molecules. (genomeweb.com)
  • Dictyostelium fascinate researchers because so many of them willingly give up their lives to save others of their colony - a characteristic seen at all rungs on the ladder of life, but only recently studied at the genetic level. (scienceblog.com)
  • By using genetic screening on the common fungal model species Aspergillus nidulans , Dr. Oakley and his team targeted a gene that fit their screening criteria: one that seemed to interact with beta-tubulin. (databasefootball.com)
  • The new microbial community editing approach leverages CRISPR technology and enables the genetic modification of a specific gene within a specific bacterium," said Deutschbauer. (eurekalert.org)
  • Finally, based on analysis of the phenotype, genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2Î"27/Î"27 iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed. (ibecbarcelona.eu)
  • In the present work, a genome-wide haploid genetic screen was performed to identify host cell genes crucial for S. aureus intracellular cytotoxicity. (uni-wuerzburg.de)
  • In most gram-positive bacteria, this operon consists of five genes dltXABCD but the involvement of the first ORF ( dltX ) encoding a small protein of unknown function, has never been investigated. (frontiersin.org)
  • We, therefore constructed an in frame deletion mutant of dltX , without affecting the expression of the other genes of the operon. (frontiersin.org)
  • The first chapter discusses the creation of a series of mutants in genes of the psbB operon. (ucl.ac.uk)
  • The mouse Pitx2 gene encodes three distinct protein isoforms (Pitx2a, b, c), and Pitx2c plays a determinant role in left-right atrium signaling from early somitogenesis onward 5 . (nature.com)
  • Analysis of these mutants does not lead to a simple hypothesis of the role of this protein as the characteristics from the two organisms are not identical. (ucl.ac.uk)
  • The final chapter discusses the nuclear encoded subunit of the PSII core, PSII-W. We report the isolation and partial sequencing of the gene for this protein in C. reinhardtii. (ucl.ac.uk)
  • Here, we show that among 45 transcription factors up-regulated in mycorrhizal roots of the legume Lotus japonicus, expression of a unique GRAS protein particularly increases in arbuscule-containing cells under low phosphate conditions and displays a phylogenetic pattern characteristic of symbiotic genes. (uni-koeln.de)
  • The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. (embl-heidelberg.de)
  • Unravelling the recircuitry imposed by mutant TCF7L2 protein will reveal therapeutic vulnerabilities and pave the way for developing treatment options. (cam.ac.uk)
  • This gene provides instructions for making a protein called gelsolin. (medlineplus.gov)
  • Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
  • The mauB, mauA, and mauC genes encode the periplasmic methylamine dehydrogenase (MADH) large and small subunit polypeptides and amicyanin, respectively. (caltech.edu)
  • The PITX gene encode the paired-like homeodomain transcription factor family. (nature.com)
  • All three genes encode key components of the phototransduction cascade in cone photoreceptors. (jneurosci.org)
  • PCR arrays looking into target genes from the main signaling pathways indicated how the mGR will not exert its results through the transcriptional activity of the most common kinases in these leukemic cells, but RhoA signaling surfaced from our pathway evaluation. (fabretp.org)
  • RORα is a transcription factor whose target genes are thought to have many roles in the developing cerebellum, such as protecting Purkinje cells from oxidative stress and regulating proliferation signals. (nature.com)
  • Two MYB transcription factor genes, GRMZM2G325907 and GRMZM2G108892, which might regulate plant cell wall metabolism are the candidate genes for qPH10 . (biomedcentral.com)
  • Research on patients with premature ovarian failure has implicated candidate genes (e.g. (frontiersin.org)
  • Transcription from the early and late classes of the herpes simplex virus type 1 (HSV-1) promoters requires prior immediate early (IE) gene expression. (microbiologyresearch.org)
  • The regulation of transcription of viral and cellular genes by herpesvirus immediate-early gene products. (microbiologyresearch.org)
  • The TCF7L2 transcription factor is a critical regulator of Wnt pathway-dependent gene expression in the intestinal epithelia. (cam.ac.uk)
  • Comparison of amino acid sequences of polypeptides encoded by mau genes from M. extorquens AM1, P. denitrificans, and Thiobacillus versutus shows that they have considerable similarity. (caltech.edu)
  • There were two different mismatches in the probe target sites of the HA gene sequences of all isolates ( n = 23) with additional mismatches only at position 7 (template binding site) identified for all eight negative real-time RT-PCR isolates. (who.int)
  • We genotyped SNP rs6817105 and examined the relationships among rs6817105 genotype, clinical characteristics, echocardiographic parameters, and electrophysiological parameters in 574 AF patients and 1,554 non-AF controls. (nature.com)
  • Within this context, we constructed a prognostic model of ERS-related genes, combining the risk scores in the model with clinical characteristics (age, sex, staging, etc.) to establish a nomogram, and found its performance in estimating patient survival was excellent. (biomedcentral.com)
  • Molecular epidemiology and clinical characteristics of norovirus gastroenteritis with seizures in children in Taiwan, 2006-2015. (cdc.gov)
  • Certain situations represent aberrant inheritance, often because genes or chromosomes are altered. (msdmanuals.com)
  • Twelve genes were identified, which were significantly enriched when compared to an infection with a non-cytotoxic S. aureus strain. (uni-wuerzburg.de)
  • Additionally, characteristics of regulated cell death pathways and the role of Ca2+ signaling in S. aureus-infected cells were investigated. (uni-wuerzburg.de)
  • In order to identify bacterial virulence factors implicated in S. aureus-induced host cell killing, the cytotoxicity of selected mutants was investigated. (uni-wuerzburg.de)
  • The primer and probe sets in the HA gene were checked for mismatches, and phylogenetic analyses were performed to determine the molecular epidemiology of these viruses. (who.int)
  • Our results are consistent with previous studies proposing that HDR is critical for cell reprogramming and demonstrate that reprogramming defects characteristic of Brca2 mutant cells can be efficiently overcome by gene complementation. (ibecbarcelona.eu)
  • This study confirmed the widespread existenceof pcaA gene in almost all the clinical isolates. (scielo.br)
  • Analysis of Plasmodium falciparum Pfcrt and Pfmdr1 genes in parasite isolates from asymptomatic individuals in Southeast Nigeria 11 years after withdrawal of chloroquine. (cdc.gov)
  • Using CRISPR-Cas9 , OsCOP1 was knocked out, and the transgenic seeds showed yel mutant characteristics. (isaaa.org)
  • Concerns have been raised over the spread of transgenic DNA by horizontal gene transfer. (i-sis.org.uk)
  • In the course of our studies concerning the evolution of Hox gene regulation, we produced a transgenic mouse model expressing fish Hox genes, which displayed a reduced number of thoraco-lumbar vertebrae and concurrent sacral homeotic transformations. (nih.gov)
  • Development and Characterization of an Ethyl Methane Sulfonate (EMS) Induced Mutant Population in Capsicum annuum L. (mdpi.com)
  • Conditional lethal mutants of the small filamentous coliphage M13: II. (wikipedia.org)
  • To elucidate more about this process, researchers from Seoul National University and partners generated three yellowish-pericarp embryo lethal ( yel ) rice mutants. (isaaa.org)
  • The nucleotide sequence of the methylamine utilization (mau) gene region from Methylobacterium extorquens AM1 was determined. (caltech.edu)
  • The CaMV promoter is a sequence of about 350 basepairs upstream of the 35S transcript (-343 to +8, with Cap site at +1), about 250 basepairs of which overlap with the 3' end of gene Vl, the last of the six large open reading frames. (i-sis.org.uk)
  • Promoter sequence and cell type can dramatically affect the efficiency of transcriptional activation induced by herpes simplex virus type 1 and its immediate-early gene products Vmw175 and Vmw110. (microbiologyresearch.org)
  • PCR was used for detection of pcaA gene and its nucleotide sequence was also determined. (scielo.br)
  • This highly shows that the mGR as well as the cGR possess a higher sequence homology & most probably result from the same gene. (fabretp.org)
  • Plasmid-less derivatives of these moderately resistant mutants were phenotypically similar to the cmlB mutants described by Reeve (1966 , 1968) , and also mapped in the same region. (microbiologyresearch.org)
  • Surprisingly, coexpression of this mutant subunit with CNGB3 rescues the channel phenotype, except for the Ca 2+ interaction. (jneurosci.org)
  • Gene complementation facilitated the generation of Brca2Î"27/Î"27 induced pluripotent stem cells (iPSCs) with a disease-free FA phenotype. (ibecbarcelona.eu)
  • This thesis will discuss mutants created in the subunits PSII-H and PSII-N, the isolation and sequencing of the psbW gene in C.reinhardtii and the characterisation of the conserved gene ycf9. (ucl.ac.uk)
  • Scanning electron microscopy experiments showed morphological alterations of these mutant bacteria, suggesting that depletion of D -alanine from TAs affects cell wall structure. (frontiersin.org)
  • These mutants exhibited slower bacterial growth, smaller size, loss of flagellar motility and lack of an extracellular matrix. (nature.com)
  • Twenty genes form the basis of a bacterial CCM. (elifesciences.org)
  • Although the product of IE gene 1, Vmw110, is not absolutely essential for virus growth in tissue culture, transfection experiments have demonstrated that Vmw110 can activate gene expression both by itself and in a synergistic manner with the product of IE gene 3, Vmw175. (microbiologyresearch.org)
  • The next chapter begins with the screening of a series of nuclear PSII mutants, with the aim of discovering new nuclear factors controlling the expression of chloroplast PSII genes. (ucl.ac.uk)
  • Heterologous expression revealed that only one mutant forms functional channels, albeit with grossly altered properties, including changes in Ca 2+ blockage and permeation. (jneurosci.org)
  • Analysis of the human thyroid cancer database of The Cancer Genome Atlas (TCGA) showed that THRA gene expression is lost in highly dedifferentiated anaplastic thyroid cancer (ATC). (bvsalud.org)
  • Transcriptome analysis revealed that Lla-Met treatment up-regulated the expression of superoxide dismutase SodB and MdaB genes, both anti-oxidation-related genes. (bvsalud.org)
  • Differently expressed genes were screened and verification was performed thereon with knockout expression. (bvsalud.org)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
  • High-throughput RNA sequencing (RNA-seq) has revolutionized our understanding of gene expression. (cdc.gov)
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • Diazinon immunotoxicity in mice: Modulation of cytokines level and their gene expression. (cdc.gov)
  • An inframe perforin gene deletion in familial hemophagocytic lymphohistiocytosis is associated with perforin expression. (lu.se)
  • However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
  • Mutants generated by insertions in mauF, mauB, mauE, mauD, mauA, mauG, and mauL were not able to grow on methylamine or any other primary amine as carbon sources, while a mutant generated from an insertion in mauC was not able to utilize methylamine as a source of carbon but utilized C_2 to C_4 n-alkylamines as carbon sources. (caltech.edu)
  • 72), including amino acid substitutions, small and large contiguous gene deletions, insertions, and splicing errors in this gene. (medscape.com)
  • By the sixth cycle of spore production and germination, the resistant mutants had increased their numbers 100-fold, to the detriment of the cheaters. (scienceblog.com)
  • We will combine plant molecular genetics, cell biology with transcriptomics and metabolomics to unravel cells, genes and metabolic networks that contribute to the checkpoint system ensuring nodule integrity. (europa.eu)
  • The IARC TP53 Database is a molecular epidemiology resource that compiles TP53 gene variations identified in human populations and tumour samples, with associated data on tumour pathology and patient characteristics. (who.int)
  • Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. (lu.se)
  • The performance of the machine learning algorithms was evaluated using three metrics which include: sensitivity, specificity, and the area under the receiver operating characteristic curve (AUROC). (h3africa.org)
  • This really opens the door to investigating the roles of specific bacteria and their genes in mediating interactions with each other and with plants, including for microbes that we cannot currently cultivate in isolation in the laboratory," said Deutschbauer. (eurekalert.org)
  • Studies in evolutionary mutant models have the potential to identify presently unknown genes and gene/environment interactions that affect human health and underlie human disease. (phys.org)
  • Within patients harboring mutant EGFR , HMGB1 rs1360485 C (TC + CC) allele carriers were at higher risk of developing poorly differentiated cancer types (odds ratio=5.493, 95% confidence interval: 1.130~26.696, p =0.019), compared to patients with TT homozygotes. (jcancer.org)
  • Furthermore, we found that HMGB1 rs1360485 polymorphisms seemed to be related to susceptibility to developing poorly differentiated cancer linked to tobacco consumption in EGFR mutant patients. (jcancer.org)
  • Cox regression analysis identifies independent prognostic factors for these patients, and enrichment analysis of prognosis-related genes was also performed. (biomedcentral.com)
  • We constructed a 13-gene prognostic model for LUAD patients. (biomedcentral.com)
  • For the clinical variables, calibrated on the samples, either using all the clinical param- eters or the Nottingham Prognostic Index (NPI) parameters, the areas under the receiver operating characteristics (ROC) curve were 0.78 and 0.79, respectively. (lu.se)
  • However, the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients is still unknown and needs to be further explored. (biomedcentral.com)
  • We found that after adjusting for other covariates, NSCLC patients who smoked and who respectively had CG, CT, and TC heterozygotes of HMGB1 rs2249825, rs1045411, and rs1360485, were at lower risk of developing mutant EGFR , compared to those patients with wild-type homozygotes. (jcancer.org)
  • Variations of the perforin gene in patients with type 1 diabetes. (lu.se)
  • During the study, researchers examined several characteristics of the RAS genes. (news-medical.net)
  • Those mutant lines, the researchers found, are among the most sensitive to navitoclax, which inhibits anti-apoptotic Bcl-2 family members. (genomeweb.com)
  • The mauJ product is the only polypeptide encoded by the mau gene cluster which is predicted to be cytoplasmic. (caltech.edu)
  • The mauD, mauE, and mauF mutants were found to lack the MADH small subunit polypeptide and have a decreased amount of the MADH large subunit polypeptide. (caltech.edu)
  • The mutant viruses were then studied in single-step growth curve experiments, by assaying for plaques in a variety of cell types and by analysis of viral polypeptide synthesis during productive infection at high and low multiplicities. (microbiologyresearch.org)
  • The patterns and amounts of viral polypeptide synthesis during high multiplicity infections with mutant and wild-type viruses were similar in all cell types. (microbiologyresearch.org)
  • Trends in Genetics features a new study co-authored by Dr. William Detrich, professor of biochemistry and marine biology in the Department of Biology at Northeastern University, which argues that these "evolutionary mutant models" are likely to hold important clues for understanding, and eventually treating, human diseases. (phys.org)
  • A cmlB mutant accumulated tetracycline at a threefold] lower rate than the wild-type strain, and it is proposed that the mutants have an altered permeability to the drugs and that this acts syner-gistically with the products of the R factor chloramphenicol and tetracycline resistance genes. (microbiologyresearch.org)
  • This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
  • One main factor determining the success of horizontal gene transfer is its tendency to recombine. (i-sis.org.uk)
  • On account of the persistence of DNA in all environments, and the ability of practically all cells to take up 'naked' or free DNA, the success of horizontal gene transfer may depend largely on the nature of the DNA itself. (i-sis.org.uk)
  • This suggests that CaMV evolved subsequent to the horizontal transfer of a retrotransposon to the cruciferae, either as the result of capture of RTgene by a pre-existing virus or by the transposable element acquiring additional genes to become a virus. (i-sis.org.uk)
  • The mauA, mauD, and mauE genes from Paracoccus denitrificans and the mauD and mauG genes from Methylophilus methylotrophus W3A1 were able to complement corresponding mutants of M. extorquens AM1, confirming their functional equivalence. (caltech.edu)
  • The growth characteristics of the dltX mutant and those of the wild type strain were similar under standard in vitro conditions. (frontiersin.org)
  • Such tracking becomes necessary as scientists talk about genetically altering microbial populations: inserting genes into microbes in the gut to fix digestive problems, for example, or altering the microbial environment of crops to make them more resilient to pests or drought. (eurekalert.org)
  • For example, they found that BRAF mutant lines had increased sensitivity to vemurafenib, the BRAF-V600E inhibitor approved by FDA. (genomeweb.com)
  • Sensitivity and specificity are key characteristics for diagnostic tools, and a high sensitivity is important Ribonucleic acid (RNA) extraction was conducted on a when the test is used to identify emerging infectious 140l aliquot of each sample using the QIAamp Viral diseases. (who.int)
  • In work appearing today in Nature , Rice evolutionary biologists Joan Strassmann and David Queller join forces with BCM geneticist Gad Shaulsky to determine how altruistic mutants help preserve cooperative behavior by single-celled amoebas. (scienceblog.com)
  • Familial hemophagocytic lymphohistiocytosis in an adult patient homozygous for A91V in the perforin gene, with tuberculosis infection. (lu.se)
  • Surprisingly, animal species in the wild have sometimes acquired the characteristics of a human disease through evolution. (phys.org)
  • A subset of Antarctic fishes, the icefishes, too, have acquired the characteristics of human disease. (phys.org)
  • In human beings, calpains are encoded by 15 genes with examined associates from the grouped family members getting the ubiquitously portrayed associates, calpains 1 and 2, referred to as - and m-calpain also, respectively. (exposed-skin-care.net)
  • CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. (embl-heidelberg.de)
  • We characterize two human MTG8-related genes, MTGR1 and MTGR2 (HGMW-approved symbols CBFA2T2 and CBFA2T3). (embl-heidelberg.de)
  • Allelic rad1 mutants display a strongly reduced number of arbuscules, which undergo accelerated degeneration. (uni-koeln.de)
  • We show here that the resultant AML1-MTG8 gene product specifically and strongly interacts with an 85-kDa phosphoprotein. (embl-heidelberg.de)
  • Now, a team led by Jennifer Doudna and Jillian Banfield - the UC Berkeley scientists who invented the CRISPR-Cas9 genome editing technology and pioneered metagenomics , respectively - has found a way to add or modify specific genes within a microbial community of many different species simultaneously, opening the door to what could be called "community editing. (eurekalert.org)
  • Herein, a total of nine RsCDF genes were identified from the radish genome. (bvsalud.org)
  • This study represents a proof-of-principle for how whole-body, 3D computational analysis of organisms and tissues can be achieved using micro-CT that may allow a far more complete understanding of gene function. (sciencedaily.com)
  • The resulting data from the analysis of this mutant did not explain the reason for this characteristic. (ucl.ac.uk)
  • Further analysis showed this to be a single copy gene containing two introns, which is expressed as a 1kb transcript. (ucl.ac.uk)
  • To date, CRISPR enzymes have been used to edit the genomes of one type of cell at a time: They cut, delete, or add genes to a specific kind of cell within a tissue or organ, for example, or to one kind of microbe growing in isolation in a test tube. (eurekalert.org)