• Next, we designed and constructed a cell microarray to perform immunohistochemistry studies for the evaluation of palmitoyl-protein thioesterase 1 (PPT1), Ki67, cleaved-poly (ADP-ribose) polymerase (cleaved-PARP), multidrug resistance-associated protein 2 (MRP2), P-glycoprotein (P-gp), and nuclear factor-kappa-B (NF-kB) p65 expression. (bvsalud.org)
  • More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)
  • Intracellular heme chaperone. (swisspalm.org)
  • During growth, genes associated with protein ubiquitination/deubiquitination, cell cycle progression, and proteasomal degradation were affected, while genes linked to protein and carbohydrate catabolism were affected during early development. (frontiersin.org)
  • Component of a progesterone-binding protein complex. (swisspalm.org)
  • protein_coding" "Cz09g17180.t1","No alias","Chromochloris zofingiensis","Inosine/uridine-preferring nucleoside hydrolase domain [Interproscan]. (ntu.edu.sg)
  • EH domain binding protein 1 like 1. (gsea-msigdb.org)
  • DnaJ heat shock protein family (Hs. (gsea-msigdb.org)
  • Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2). (swisspalm.org)
  • Protein palmitoylation is catalyzed by members of the DHHC family of eukaryotic integral membrane enzymes so called because of the catalytic Asp-His-His-Cys motif in a cysteine rich domain (CRD) that resides in an intracellular loop. (nih.gov)
  • Three members of the membrane bound O-acyltransferase (MBOAT) family, a distinct family of integral membrane enzymes, also catalyze protein lipidation. (nih.gov)
  • Of the multiple proteins that transiently interact with AMPARs and that determine their trafficking, synaptic targeting and recycling in neurons, some special attention must be given to transmembrane proteins that form integral part of the functional receptor. (frontiersin.org)
  • What sets these three apart is that each of these three enzymes, Goat, Hhat and Porcupine, has a unique substrate, all secreted signaling proteins and each uses a distinct fatty acyl substrate. (nih.gov)
  • These components are then inserted into enzymes and other proteins for use in a wide range of crucial cellular activities like electron transport in respiratory chain complexes, regulatory sensing, photosynthesis, and DNA repair. (nih.gov)
  • The quantity of m6A in RNA is orchestrated by enzymes that write and erase it, while its effects are mediated by proteins that bind to read this modification. (bvsalud.org)
  • Although the initial focus has been on pharmacological targeting of the writer and eraser enzymes, interest in the reader proteins has been challenged by a lack of clear understanding of their functional roles and molecular mechanisms of action. (bvsalud.org)
  • This is known as protein S-acylation or more commonly, protein palmitoylation, owing to the prevalence of the attachment of the 16 carbon palmitoyl moiety through this kind of modification. (nih.gov)
  • Our integrated results strengthen the evidence for disease-specific defects related to bioenergetics and protein quality control systems and reinforce the role of dysregulated cytoskeletal organization in the pathogenesis of ARSACS. (bvsalud.org)
  • Despite the abundance of AMPAR partners, recent proteomic studies have revealed even more interacting proteins that could potentially be involved in AMPAR regulation. (frontiersin.org)
  • Log2 (ZT12/ZT0) is the base 2 logarithm of the protein abundance ratio between ZT12 and ZT0. (nih.gov)
  • P-value is from t-statistic of log2(protein abundance) values from the 6 samples. (nih.gov)
  • Covalent attachment of lipids is one of the most prevalent forms of post translational protein modification. (nih.gov)
  • Although physico-chemically it amounts to attachment of a mere "hydrophobic stick", protein lipidation can modulate protein function by altering structure, folding, interaction with other proteins, degradation and importantly, attachment to membranes. (nih.gov)
  • Of the different forms of protein lipidation, the most pervasive form is attachment of a fatty acid to internal cysteines through a thioester. (nih.gov)
  • Our understanding of ARSACS (genetic basis, protein function, and disease mechanisms) remains partial. (bvsalud.org)
  • Interacts with the chaperone complex consisting of HSC70 and SGTA (By similarity). (swisspalm.org)
  • In the cellular milieu, thioesters can be cleaved by thioesterases and thus protein S-acylation is unique in being the only reversible form of protein lipidation. (nih.gov)
  • In our previous study, we studied the metabolome changes caused by chronic heat stress and found that it caused a negative energy balance in broilers and rendering them unable to effectively oxidize fat for energy production, and instead resorting to protein decomposition [ 6 ]. (biomedcentral.com)