• Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. (wikipedia.org)
  • This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
  • Kv1.1 belongs to the Kv1 subfamily, consisting of eight members (Kv1.1 to Kv1.8). (biomedcentral.com)
  • 10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)
  • 11. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, and Pongs O (1994) Inactivation properties of voltage-gated K + channels altered by presence of β-subunit. (aspetjournals.org)
  • 13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)
  • 8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)
  • TITLE Voltage-gated low threshold potassium current from Kv1 subunits COMMENT NEURON implementation of a potassium channel from Kv1.1 subunits Kinetical scheme: Hodgkin-Huxley m^4, no inactivation Experimental data taken from: Human Kv1.1 expressed in xenopus oocytes: Zerr et al. (yale.edu)
  • Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph mice. (biomedcentral.com)
  • Interactions between MCEPH and other Kv1 subunits were studied in cell culture, Xenopus oocytes and the brain. (biomedcentral.com)
  • The channels are hetero- or homotetramers, formed by a great variety of subunits, classified in 12 subfamilies [ 5 ]. (biomedcentral.com)
  • Kv1.1, Kv1.2 and Kv1.4 are the most abundant Kv1 subunits expressed in the brain [ 6 ]. (biomedcentral.com)
  • brush resides in a cluster of redundant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. (elifesciences.org)
  • The results reveal a mechanism by which quantitative competition between channel subunits for tetramer assembly can impact the phenotype of the mutation carrier. (elifesciences.org)
  • MicrocircuitDB: Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. (yale.edu)
  • Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. (yale.edu)
  • In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. (yale.edu)
  • K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. (modeldb.science)
  • Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. (modeldb.science)
  • Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neurons. (epfl.ch)
  • By heterologous overexpression, p.G230V was significantly more active than wild-type ELOVL5 in triggering the unfolded protein response and in decreasing viability in mouse cortical neurons. (bvsalud.org)
  • Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
  • 2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
  • 5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)
  • 12. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M (1995) Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases. (aspetjournals.org)
  • Treatment with potassium channel blockers have been shown to block apoptosis in various cell types [ 11 ]. (biomedcentral.com)
  • In this work, we developed an efficient system for the production of three potent Kv1.3 channel blockers from different scorpion venoms: Vm24, AnTx, and Ts6. (mdpi.com)
  • Cell Biosci (2017) 7:Web page 4 ofis reasonable to assume that KTX-Sp4 adopts the wellknown cysteine-stabilized / scaffold, which can be related towards the scorpion classical K+-channel blockers. (adenylate-cyclase.com)
  • The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. (biomedcentral.com)
  • 9. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, and Chandy KG (1990) Expression and chromosomal localization of a lymphocyte K + channel gene. (aspetjournals.org)
  • A direct link between potassium channel dysfunction and apoptosis is that reduced intracellular potassium levels appear to promote critical events early in the suicide program. (biomedcentral.com)
  • TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)
  • A sustained increase in the intracellular Ca²⁺ concentration induces proteolytic cleavage of EAG2 channel. (epfl.ch)
  • Roles of surface residues of intracellular domains of heag potassium channels. (epfl.ch)
  • Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
  • Neural differentiation of human mesenchymal stem cells: Evidence for expression of neural markers and eag K+ channel types. (epfl.ch)
  • The enlargement is in part due to that the numbers of both neurons and glia cells are dramatically increased in the hippocampus which is caused by increased proliferation and/or reduced apoptosis (Almgren et al, unpublished). (biomedcentral.com)
  • Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. (epfl.ch)
  • 2017 ( Nature Communications ), we combined super-resolution with opto- and thermogenetic neuronal stimulation in living neurons in the fruit fly. (edu.au)
  • 3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
  • The molecular weight of KTX-Sp4 was determined by matrix assisted-laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF S). Benefits showed that the measured value of KTX-Sp4was 4545.3 Da (Fig. 2c), which confirmed the theoretical molecular weight of 4547.three Da.Modulation of KTXSp4 on endogenous voltagegated potassium channelsexamined no matter if KTX-Sp4 could block endogenous Kv1.three expressed by human Jurkat T cells. (adenylate-cyclase.com)
  • Molecular basis of potassium channels in pancreatic duct epithelial cells. (epfl.ch)
  • Three-dimensional structure of human Kv10.2 ion channel studied by single particle electron microscopy and molecular modeling]. (epfl.ch)
  • Molecular regions responsible for differences in activation between heag channels. (epfl.ch)
  • 4 The new class of antibodies is directed against the neuropil-in particular against synaptic surface antigens such as N-methyl-D-aspartic acid (NMDA), gamma-aminobutyric acid (GABA), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). (touchneurology.com)
  • The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. (yale.edu)
  • 1 . Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. (yale.edu)
  • To better understand how mild demyelination gives rise to the early symptoms of demyelinating diseases, one approach is to build mathematical models of the axon and study the link between demyelination patterns and axonal conduction properties [ 2 , 3 , 4 , 5 ]. (springeropen.com)
  • A paranodal membrane barrier has long been described as the boundary separating nodal and juxtaparanodal ion channels. (rupress.org)
  • We have identified a critical role of the phospholipid phosphatidylinositol (4,5) bisphosphate in coordinating the actin-mediated recruitment of secretory vesicles to the plasma membrane. (edu.au)
  • Following exocytosis, the process of endocytosis is required for neurons to replenish their pools of synaptic vesicles by pinching off vesicles from the plasma membrane. (edu.au)
  • We demonstrated that Munc18-1 and syntaxin-1A and are organised in nanodomains on the plasma membrane of neurons and neurosecretory cells that control SNARE-dependent neuroexocytosis through lateral trapping in these nanoclusters. (edu.au)
  • In addition, we model sodium channel remodeling as a homeostatic control of nodal excitability. (springeropen.com)
  • Further experiments found that the channel formed by the mutated CNGC protein is leaky and allows calcium ions to enter the cell in the absence of any cue from the environment. (elifesciences.org)
  • These findings provide important insights into the function of CNGCs and reveal how a small change in a channel protein can have far reaching effects on an organism. (elifesciences.org)
  • 2,3,5,4′-Tetrahydroxystilbene 2-O-��-D-glucoside COA Expression, purification and characterization of KTXSp4 peptideThe expressed GST-KTX-Sp4 fusion protein was purified on GSH affinity column and then desalted using centrifugal filter devices. (adenylate-cyclase.com)
  • This multicenter, randomized phase 3 study evaluated the efficacy and safety of 0.3 mg/kg intravenous mogamulizumab, a monoclonal antibody targeting-CC chemokine receptor 4, every 12 weeks in HAM/TSP patients. (bvsalud.org)
  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
  • 4. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, and Numa S (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: primary structure and functional expression from cDNAs. (aspetjournals.org)
  • This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)
  • Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory. (epfl.ch)
  • These proteins act as channels and allow ions to move across cell membranes. (elifesciences.org)
  • Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. (epfl.ch)
  • Differential expression of potassium ion channels in human renal cell carcinoma. (epfl.ch)
  • 7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)
  • Multistate structural modeling and voltage-clamp analysis of epilepsy/autism mutation Kv10.2-R327H demonstrate the role of this residue in stabilizing the channel closed state. (epfl.ch)
  • External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor. (epfl.ch)
  • Tubulin as a binding partner of the heag2 voltage-gated potassium channel. (epfl.ch)
  • The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region. (epfl.ch)
  • Differential localization of rat Eag1 and Eag2 potassium channels in the retina. (epfl.ch)
  • Head wear is an severe disease that quickly progresses to loss of life within six months (4), whereas Head wear has a even more chronic program with the average length of three years (5). (healthanddietblog.info)
  • Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
  • This has allowed us to probe the nanoscopic environment of neurons and neurosecretory cells undergoing communication. (edu.au)
  • 2007). Here, we report the unusual genetic behavior of a quantitative gain-of-function CNGC mutation ( brush ) in Lotus japonicus resulting in a leaky tetrameric channel. (elifesciences.org)
  • The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. (mdpi.com)
  • The classic syndromes are antigen-target-oriented syndromes such as myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and ion channel-mediated diseases. (touchneurology.com)
  • The cells were incubated at 37°C for 24h in media containing different concentrations of ab120017 (CNQX) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. (abcam.com)
  • Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. (abcam.com)
  • An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cells. (epfl.ch)
  • Adaptation was predicted by parameter optimization in detailed computational models based on available knowledge on GrC ionic channels. (yale.edu)
  • Divalent cations slow activation of EAG family K+ channels through direct binding to S4. (epfl.ch)
  • Simulations showed that fine-tuning of pre- and post-synaptic parameters generated effective MF-GrC transmission channels, which could enrich the processing of input spike patterns and enhance spatio-temporal recoding at the cerebellar input stage. (yale.edu)
  • KTX-Sp4 could have related function with blocking Kv1.three channels, however it is essential to investigate the biological impact of KTX-Sp4 peptide by electrophysiological experiments for identifying its distinct target. (adenylate-cyclase.com)
  • EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. (epfl.ch)
  • Cyclic nucleotide-gated channel (CNGC) family members mediate Ca 2+ influx from cellular stores in plants (Charpentier et al. (elifesciences.org)
  • Whether through touch, smell or vision, all the information we have about the external world is channeled through bundles of axons. (springeropen.com)