Previous work has shown that the Shal potassium channel subfamily underlies the predominant fast transient outward current in Drosophilaneurons (Tsunoda, S., and Salkoff, L. (1995) J. Neurosci. (wikigenes.org)
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. (nih.gov)
Rectifier potassium2
This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. (nih.gov)
Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
A delayed rectifier subtype of shaker potassium channels that is commonly mutated in human episodic ATAXIA and MYOKYMIA. (ucdenver.edu)
Voltage-gated5
Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene. (wikipedia.org)
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (nih.gov)
The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. (nih.gov)
L-type voltage-gated calcium channels play a key role in the regulation of arterial vascular smooth muscle tone and blood pressure levels and L-type calcium channel blockers (CCBs) are widely used antihypertensive drugs. (bvsalud.org)
Protein1
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. (ucsc.edu)
SIMILARITY2
channel properties depend on the type of alpha subunits that are part of the channel (By similarity). (nih.gov)
Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). (nih.gov)
Regulate1
Additionally, T-type channels regulate vascular tone in small-resistance vessels and renin and aldosterone secretion, and N-type channels, expressed in sympathetic nerve terminals, regulate the release of neurotransmitters. (bvsalud.org)
Proteins1
This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. (wikipedia.org)
Functional2
Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable). (ucsc.edu)
This narrative review summarizes some studies showing functional data on regulation of the main human atrial and ventricular Na + , Ca 2+ , and K + channels by cardiac TFs such as Pitx2c, Tbx20, Tbx5, Zfhx3, among others. (bvsalud.org)
Cardiac ion channels2
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
Besides its critical role in cardiac development, recent data demonstrated that they control cardiac electrical activity through the direct regulation of the expression and function of cardiac ion channels in adult hearts. (bvsalud.org)
Molecular1
Probing molecular identity of native single potassium channels by overexpression of dominant negative subunits. (ucdenver.edu)
SHL-1 channels are apparently important in fine-tuning complex behaviors, such as mating, that play a crucial role in the survival and propagation of the species. (wikigenes.org)
Forms heteromultimeric complex with alpha subunits. (ucsc.edu)
Forms1
Forms tetrameric potassium-selective channels through which potassiumions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). (nih.gov)
Shown1
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
Homogeneous development of electrical excitability via heterogeneous ion channel expression. (ucdenver.edu)
Acquired or inherited abnormalities in the expression and/or function of ion channels usually result in electrophysiological changes that can cause cardiac arrhythmias. (bvsalud.org)
Alters1
Gating is thought to involve conformational changes of the ion channel which alters selective permeability. (lookformedical.com)
Shaker3
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
A delayed rectifier subtype of shaker potassium channels that is commonly mutated in human episodic ATAXIA and MYOKYMIA . (nih.gov)
Subtipo rectificador tardío de los canales de potasio de la familia shaker que suele estar mutado en la ATAXIA episódica y en la MIOCIMIA humana. (bvsalud.org)
Potassium channels where the flow of K+ ions into the cell is greater than the outward flow. (lookformedical.com)
Antagonists1
The alpha-1 subunit is the binding site for calcium-based antagonists. (lookformedical.com)
Neurons2
The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of IA channels in mature cortical pyramidal (CP) neurons and that Kv4.2-, Kv4.3- and Kv1.4-encoded IA channels play distinct roles in regulating the intrinsic excitability and the firing properties of mature CP neurons. (nih.gov)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)