• We found that glial cell D2 activity resulted in increased T3 production, which acted in a paracrine fashion to induce T3-responsive genes, including ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), in the cocultured neurons. (jci.org)
  • Expression of Cln8 in the developing and mature brain suggests roles for Cln8 in maturation, differentiation and supporting the survival of different neuronal populations. (biomedcentral.com)
  • Neural Progenitor Cells Derived from XCL-1 DCXp-GFP are a neuronal lineage reporter cell line that can be used in neuronal differentiation and drug screening. (atcc.org)
  • Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation. (stowers.org)
  • Together, these results suggest that the transcriptome of cultured primary neuronal cells, in comparison to whole brain tissue, more robustly demonstrated the difference between Fmr1KO and WT mice and might reveal a molecular phenotype, which is typically hidden by compensatory mechanisms present in vivo. (harvard.edu)
  • In the present study we have mapped the expression of molecular markers in relationship to primary neuronal clusters and their PABs. (unibas.ch)
  • Recent genome-wide molecular genetic studies have identified several protein-coding genes and microRNAs (miRNAs) significantly associated with BD. (en-journal.org)
  • By identifying differences in neuronal gene expression profiles between healthy elderly persons and individuals diagnosed with AD, we may be able to better understand the molecular mechanisms that drive AD pathogenesis, including the formation of amyloid plaques and neurofibrillary tangles. (elsevierpure.com)
  • The molecular basis of human diseases, including but not limited to the most common single-gene cause of intellectual disability and autism, Fragile X Syndrome, and the development of therapeutics. (rochester.edu)
  • Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. (elifesciences.org)
  • 1985-1990 Degree in Pharmaceutical Chemistry and Technology cum laude (thesis work in molecular biology on oestrogen regulation of prodynorphin gene expression in rat hypothalamus and hypophysis, with prof S. Ferri), School of Pharmacy, University of Bologna, Italy. (unibo.it)
  • It has been found that various genes that encode the G1/S transition, such as D1, Cdk4, Rb proteins, E2Fs, and CKIs, can be detected in different areas of a normal human brain (Frade and Ovejero-Benito, 2015). (wikipedia.org)
  • Notably, some of the proteins expressed from BD-associated genes function in neuronal synapses, suggesting that abnormalities in synaptic function could be one of the key pathogenic mechanisms of BD. (en-journal.org)
  • Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
  • The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. (nih.gov)
  • Translation of these hexanucleotide repeat sequences gives rise to dipeptide-repeat proteins, which form intracellular protein aggregates in neuronal and non-neuronal cells of affected patients. (europa.eu)
  • Genes encoding proteins that affect neurotransmitter release, receptor function and inactivation have been implicated in autism. (sfari.org)
  • Each individual cell expresses a specific subset of genes, which in turn make a specific set of proteins. (stanford.edu)
  • Those with schizophrenia and bipolar depression express different isoforms, or end products of gene expression, which markedly changes what proteins are made 15 . (autismsciencefoundation.org)
  • Kollmann K, Uusi-Rauva K, Scifo E, Tyynela J, Jalanko A, Braulke T. Cell biology and function of neuronal ceroid lipofuscinosis-related proteins. (medlineplus.gov)
  • In addition to regulation of cytoplasmic cytoskeletal dynamics, a little appreciated property of actin signaling is modulation of gene expression so far only reported for non-neuronal cells. (jneurosci.org)
  • These mice provide a useful tool for investigating activity-dependent regulation of GABA(A) receptor expression under physiological and pathological conditions. (psu.edu)
  • Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage. (figshare.com)
  • Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism. (rochester.edu)
  • These defects are mediated by increased expression of a protein called Xrp1, which is involved in gene expression regulation. (europa.eu)
  • Xrp1 is a DNA-binding protein that is involved in gene expression regulation. (europa.eu)
  • Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
  • 1989-1990: research assistant, Department of Pharmacology, University of Bologna, studying the regulation of opioid gene expression in cell lines using the antisense technology. (unibo.it)
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. (neurotree.org)
  • The up-regulation of several genes that are known to be responsible for song learning and singing in songbirds suggest a shared evolutionary background of sound perception between vocalizing birds and humans," says Dr. Irma Järvelä, the leader of the study. (sciencedaily.com)
  • Conclusions: The transcriptional profile in brain tissues primarily centered on immunological mechanisms, whereas the profiles from cell cultures showed defects in neuronal activity. (harvard.edu)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • We characterized the transcriptional profile of cortical neurons from CdLS patients and found deregulation of hundreds of genes enriched for neuronal functions related to synaptic transmission, signalling processes, learning and behaviour. (biorxiv.org)
  • Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)
  • Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
  • The presence of these core cell cycle factors can be explained through their role in neuronal migration, maturation, and synaptic plasticity (Christopher L. Frank1 and Li-Huei Tsai1, 2009). (wikipedia.org)
  • Genes that regulate activity-dependent synaptic plasticity, including ARC, have been implicated in autism. (sfari.org)
  • Variants of the UBE3A gene are associated with reduced activity-dependent synaptic plasticity. (sfari.org)
  • The course also includes detailed studies of the mechanisms that underlie neuronal signaling and cell function, and how these are activated during development and neuronal plasticity. (lu.se)
  • CONCLUSIONS: We conclude that the olfactory neuronal pathway is efficient for translocating in the brain. (cdc.gov)
  • Mutations in the CLN8 gene, encoding an endoplasmic reticulum (ER) transmembrane protein of unknown function, underlie NCL phenotypes in humans and mice. (biomedcentral.com)
  • In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
  • This paper reports that loss of function of the Drosophila gene cabeza (the Drosophila equivalent of the human FUS gene, mutations in which can cause a familial form of the motor neurodegenerative disease amyotrophic lateral sclerosis or ALS) induces muscle developmental defects. (europa.eu)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Increased frequencies and amplitudes of excitatory synaptic potentials have been observed in mouse models bearing human mutations in genes such as NLGN3, SHANK3, TSC1 and TSC2. (sfari.org)
  • Mutations in the MFSD8 gene cause CLN7 disease. (medlineplus.gov)
  • MFSD8 gene mutations likely lead to the production of a protein with altered structure or function. (medlineplus.gov)
  • which means both copies of the gene in each cell have mutations. (medlineplus.gov)
  • Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis. (medlineplus.gov)
  • Methods: We used genome-wide mRNA expression profiling as a robust characterization tool for studying differentially expressed pathways in fragile X mental retardation 1 (Fmr1) knockout (KO) and wild-type (WT) murine primary neuronal cultures and in embryonic hippocampal and cortical murine tissue. (harvard.edu)
  • 2000). The downregulation of p130/E2F4 (a complex which has been shown to maintain the post mitotic nature of neurons) induces neuronal apoptosis by upregulating B-myb and C-myb (Liu et al. (wikipedia.org)
  • To address this significant question, we utilized the innovative CaM/Tet-DT(A) mouse model that selectively induces neuronal ablation. (nih.gov)
  • In addition, we provide novel evidence of angiogenic and vasculature changes following hippocampal neuronal loss in CaM/Tet-DTA mice. (nih.gov)
  • We posit that angiogenesis may be an important factor that promotes neurogenic upregulation following hippocampal neuronal loss, and both factors, angiogenesis and neurogenesis, can contribute to the adaptive response of the brain for behavioral recovery. (nih.gov)
  • The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues, especially in neurons. (biomedcentral.com)
  • The neuronal ceroid lipofuscinoses (NCLs) comprise a group of human neurodegenerative disorders (CLN1-CLN8) characterized by epilepsy, visual failure, psychomotor deterioration and accumulation of autofluorescent lipopigment in many tissues, especially in neurons [ 1 ]. (biomedcentral.com)
  • CLN7 disease is one of a group of disorders known as neuronal ceroid lipofuscinoses (NCLs), which may also be collectively referred to as Batten disease. (medlineplus.gov)
  • Moreover, cultures might be useful for investigating the perturbed pathways in early human brain development and genes previously implicated in autism. (harvard.edu)
  • We then conducted a comprehensive transcriptome analysis in mouse embryos to identify genes and pathways whose expression correlates with the amount of ELP1. (figshare.com)
  • A 6.4-kb genomic fragment faithfully directed neuron-specific transcription of a lacZ reporter gene in the central nervous system. (psu.edu)
  • Using a transgenic mouse model in which an ALS-like mutation was introduced in the mouse Fus gene, we could show that ALS pathology starts at the neuromuscular juction (the transition between motor nerves and skeletal muscle cells), long before motor neuron cell bodies in the spinal cord degenerate. (europa.eu)
  • Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. (elifesciences.org)
  • 2001. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. (cdc.gov)
  • In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
  • Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
  • Hypoxia decreases astrocyte-mediated thyroid hormone signaling in neuronal SK-N-AS cells. (jci.org)
  • The promoter of the GABA(A) receptor δ subunit gene was analyzed in transgenic mice and in cultured cells to study sequences involved in neuronal subtype-specific gene expression. (psu.edu)
  • Transfection studies using primary cortical neurons and astroglial cells revealed that the δ subunit gene promoter was selectively active in neurons even when truncated to a 267-bp core fragment. (psu.edu)
  • In cerebellar granule cells and cortical neurons, E2F1 can trigger neuronal apoptosis through activation of Bax/caspase-3 and the induction of the Cdk1/FOXO1/Bad pathway (Giovanni et al. (wikipedia.org)
  • In our preliminary experiments, the expression of miR-1908-5p was increased after chronic treatment with valproate but not lithium in control human neural progenitor cells. (en-journal.org)
  • In the cerebral isocortex the pyramidal cells of the deeper parts of lamina III are severely ballooned, and hippocampal region CA2 shows neuronal loss and neuronophagy [ 16 ]. (biomedcentral.com)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)
  • [ 2 ] The tumor cells are mitotically active and are the precursor cells that develop into sustentacular and neuronal cells. (medscape.com)
  • To see the entire repertoire of genes expressed in these cells, the Stanford team used a method pioneered by Quake that enables researchers to sequence all the messenger RNA in a cell. (stanford.edu)
  • This is particularly challenging because although cells can be defined by function, physiology, anatomy and gene expression, researchers have had a hard time unifying these properties. (stanford.edu)
  • We also observed that expression of Cp protein in mouse muscle resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
  • The localization pattern of capsid expression was analyzed by immunofluorescent assay in HeLa, 293-T, RD, or SH-SY5Y cells by using anti-His tag antibody as described ( 6 ). (cdc.gov)
  • We are currently generating neurons by iPS and iN cell technology aiming to produce cortical neurons and after intracerebral transplantation or direct in vivo reprogramming of non-neuonal cells restore damaged neuronal network. (lu.se)
  • Listening to music represents a complex cognitive function of the human brain, which is known to induce several neuronal and physiological changes. (sciencedaily.com)
  • Here we characterized the spatial and temporal expression of Cln8 mRNA in mice. (biomedcentral.com)
  • Furthermore, we could show that expression of the acetylcholine receptor in skeletal muscles of these mice is affected. (europa.eu)
  • The notion of sleep as a local, activity-dependent process suggests that activity history must be integrated to determine the dynamics of global Process S. Here, we developed novel mathematical models of Process S based on cortical activity recorded in freely behaving mice, describing local Process S as a function of the deviation of neuronal firing rates from a locally defined set-point, independent of global sleep-wake state. (elifesciences.org)
  • The results confirmed a causative role for Glo1 copy number variants, as mice with more copies of the Glo1 gene exhibited higher anxiety-like behavior in their experiments. (sciencedaily.com)
  • Homozygous null mice display defects in apoptotic signaling affecting hair cycling and neuronal physiology. (jax.org)
  • Regarding animal models in ASD, many studies focus on gene expression, cortical neuronal migration and cell maturation, and neural network deficits. (bvsalud.org)
  • Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)
  • These data suggest a direct link between a specific genetic background and a biological mechanism leading to the development of dyslexia: the risk haplotype on chromosome 6p22.2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex. (ox.ac.uk)
  • Exposure to titanium dioxide (TiO2) nanoparticle s up-regulates neurotrophin expression in rodent airways. (cdc.gov)
  • Our analysis represents an important step along the way to identify neuronal lineages of the mature brain with genes expressed in the early embryo in discrete neuroblasts. (unibas.ch)
  • Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
  • These experiments show that cohesin is continuously required for neuronal gene expression and provide a tractable approach for addressing mechanisms of neuronal dysfunction in CdLS. (biorxiv.org)
  • We found that Xrp1 expression is increased in cabeza mutant fruit flies, leading to neuronal dysfunction. (europa.eu)
  • Accumulation of abnormal protein leads to progressive neuronal dysfunction and loss. (medscape.com)
  • To study the developmental trajectory and to relate mouse model data to human data, we used an expression map of human development to plot murine differentially expressed genes in KO/WT cultures and brain. (harvard.edu)
  • Genes whose expression was up-regulated in Fmr1KO murine cultures tended to peak early in human development, whereas differentially expressed genes in embryonic cortical and hippocampal tissues clustered with genes expressed later in human development. (harvard.edu)
  • Further, gene length analysis of the differentially expressed genes showed that the loss of Elp1 mainly impacts the expression of long genes and that by gradually restoring Elongator their expression is progressively rescued. (figshare.com)
  • We identified significant regional differential expression in AD brains compared with control brains including expression changes of genes previously implicated in AD pathogenesis, particularly with regard to tangle and plaque formation. (elsevierpure.com)
  • We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. (nature.com)
  • We identified and validated its novel target genes including DLGAP4 , GRIN1 , STX1A , CLSTN1 and GRM4 , which all function in neuronal glutamatergic synapses. (en-journal.org)
  • Our results show a successful conversion in 25 days with upregulation of neuronal gene and protein expression levels. (lu.se)
  • Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
  • By testing the controversial role of a gene called Glo1 in anxiety, scientists uncovered a new inhibitory factor in the brain: The metabolic by-product methylglyoxal. (sciencedaily.com)
  • It's a completely different system that is tying neuronal inhibitory tone into metabolic activity," Palmer said. (sciencedaily.com)
  • The study, published in the Journal of Clinical Investigation , found that animals with multiple copies of the Glo1 gene were more likely to exhibit anxiety-like behavior in laboratory tests. (sciencedaily.com)
  • It's the first study to show that it's the copy number variant that has the potential to change Glo1 expression and behavior," said Distler, an MD/PhD student in the Pritzker School of Medicine's Medical Scientist Training Program. (sciencedaily.com)
  • We invite investigators to contribute original research articles as well as review articles that highlight the multifaceted impact of stress and glucocorticoids on synaptic transmission, neuroplasticity, gene expression, cognition, and behavior. (hindawi.com)
  • The object of our study aimed to review and to correlate genes involved in ASD and those related to ultrasonic communication in animal model studies of language-based social behavior at the PubMed database. (bvsalud.org)
  • Listening to music enhanced the activity of genes involved in dopamine secretion and transport, synaptic function, learning and memory. (sciencedaily.com)
  • The transgene expression pattern in the cerebral cortex, hippocampal formation, thalamus, and brainstem was consistent with the regional and neuronal subtype-specific expression of the endogenous δ subunit protein in both developing and mature brain. (psu.edu)
  • In conclusion, the δ subunit gene promoter/upstream region contains the information for neuronal subtype-specific expression in the entire brain except in the cerebellum and is selectively active in primary cortical neurons in vitro. (psu.edu)
  • The markers we analyzed include many of the genes involved in patterning of the brain along the anteroposterior axis (cephalic gap genes, segment polarity genes) and dorso-ventral axis (columnar patterning genes), as well as genes expressed in the dorsal protocerebrum and visual system (early eye genes). (unibas.ch)
  • Neuronal loss is a common component of a variety of neurodegenerative disorders (including Alzheimer's, Parkinson's, and Huntington's disease) and brain traumas (stroke, epilepsy, and traumatic brain injury). (nih.gov)
  • One brain region that commonly exhibits neuronal loss in several neurodegenerative disorders is the hippocampus, an area of the brain critical for the formation and retrieval of memories. (nih.gov)
  • Can these deficits be recovered, and if so, is the brain capable of regeneration following neuronal loss? (nih.gov)
  • In this study, we expression profiled histopathologically normal cortical neurons collected with laser capture microdissection (LCM) from six anatomically and functionally discrete postmortem brain regions in 34 AD-afflicted individuals, using Affymetrix Human Genome U133 Plus 2.0 microarrays. (elsevierpure.com)
  • We provide this carefully phenotyped, laser capture microdissected intraindividual brain region expression data set to the community as a public resource. (elsevierpure.com)
  • In postnatal brain the highest expression is in the cortex and hippocampus. (biomedcentral.com)
  • For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
  • Their gene expression during brain development and within cell types highlights how they relate to ASD. (springer.com)
  • Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
  • The basic idea behind the research is to understand the neuronal cell types of the relatively simple fly brain, and to identify the molecules that direct the precise wiring of different types of neurons in the fly brain. (stanford.edu)
  • First, looking at the genetic profile of brain tissue obtained from the cortex of individuals affected by ASD, schizophrenia, bipolar depression and major depressive disorder, scientists revealed overlap in genetic expression. (autismsciencefoundation.org)
  • Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
  • More importantly, direct in vivo expression of WNV-Cp protein in mouse brain resulted in an induction of apoptosis similar to what is observed in natural infection. (cdc.gov)
  • A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
  • They express markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity. (nih.gov)
  • The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. (wikipedia.org)
  • Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
  • Aye votes move the voltage potential across the neuronal membrane in a positive direction by allowing positive ions to flow into the cell. (gnxp.com)
  • Now, researchers at Stanford led by professor of biology Liqun Luo and professor of bioengineering and of applied physics Stephen Quake have taken a significant step forward in that direction by making a detailed cell-by-cell gene blueprint of the fruit fly's olfactory neurons. (stanford.edu)
  • Luo, a senior author on the paper who has been studying the fruit fly for two decades, explained: "We know every gene, so we can tell whether a particular gene is expressed in a particular cell or tissue. (stanford.edu)
  • By combining Quake's single-cell RNA sequencing with Luo's detailed knowledge of the fruit fly's olfactory circuit, the team was able to create the first blueprint showing how specific gene/protein activity correlates with the biological wiring of at least one component of an organism's nervous system. (stanford.edu)
  • Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. (lu.se)
  • Nevertheless, the generation of neurons from adult human fibroblasts, an easily accessible cell source to obtain patient-derived neurons, has proved to be challenging due to the intrinsic blockade of neuronal commitment. (lu.se)
  • Whole-exome sequencing studies have been useful for identifying genes that, when mutated, affect risk for autism spectrum disorder (ASD). (springer.com)
  • Several autism-risk genes affect the function of chemical synapses. (sfari.org)
  • Genes encoding voltage-gated calcium, sodium and potassium channels that likely contribute to E/I balance have been implicated in autism. (sfari.org)
  • Another hypothesis, not entirely independent of the first, suggests that autism-related changes in synaptic transmission depend on neuronal activity, or experience. (sfari.org)
  • What is the influence of neuronal activity on the expression of autism-risk genes? (sfari.org)
  • 14 Also, critical research from brains of people with autism compared to schizophrenia and bipolar disorder show that while gene are expressed similarly, the tiniest differences lead to different outcomes. (autismsciencefoundation.org)
  • Together, our results provide new insights into the potential role of miR-1908-5p in the pathogenesis of BD and also propose a hypothesis that neuronal synapses could be a key converging pathway of some BD-associated protein-coding genes and miRNAs. (en-journal.org)
  • These loci include several protein-coding genes (e.g. (en-journal.org)
  • Finally, through evaluation of co-expression modules, we identified gene sets with unique expression patterns that depended on ELP1 expression. (figshare.com)
  • Gene Expression Patterns, Vol. 7, H. 5. (unibas.ch)
  • However, the expression of these markers was not followed into later embryonic or larval stages, mainly due to the fact that anatomical landmarks to which expression patterns could be related had not been defined. (unibas.ch)
  • We show that dysregulation of appropriate expression of components of the fibroblast growth factor (FGF) pathway contributes to muscle developmental defects in cabeza mutant Drosophila. (europa.eu)
  • We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
  • A central part of the course is application of technologies that push the research forward, including optogenetic manipulation and gene editing to manipulate neural circuits and identify neural functions. (lu.se)
  • In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)
  • The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. (ox.ac.uk)
  • Widespread transcription at neuronal activity-regulated enhancers. (neurotree.org)
  • Together, our work revealed how PARIS drives adverse effects on modulation of PPAR-γ associated gene clusters in DA neurons. (nature.com)
  • SRF controls gene transcription of various actin isoforms (e.g. (jneurosci.org)
  • Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
  • Transcription factors help control gene expression. (labroots.com)
  • We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S + neurons of the suprachiasmatic nucleus. (nature.com)
  • Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
  • According to a new study, listening to classical music enhanced the activity of genes involved in dopamine secretion and transport, synaptic neurotransmission, learning and memory, and down-regulated the genes mediating neurodegeneration. (sciencedaily.com)
  • The recognition of these two subtypes, one maintaining a cone-differentiated state, and the other, more aggressive, associated with cone dedifferentiation and expression of neuronal markers, opens up important biological and clinical perspectives for retinoblastomas. (nih.gov)
  • Most of these genes can be markers of communication deficits. (bvsalud.org)
  • Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
  • A 2009 study from Palmer's laboratory suggested that differences in Glo1 expression between mouse strains were due to copy number variants, where the segment of the genome containing the gene is repeated multiple times. (sciencedaily.com)
  • Do reported variants in genes that regulate autophagy, or cellular self-ingestion, play a role in synapse elimination? (sfari.org)
  • Our study was a physiological representation of what it means to increase Glo1 expression for anxiety. (sciencedaily.com)
  • Overall, our catalog of neuronal subclasses provides new understanding of hypothalamic organization and function. (nature.com)
  • Interestingly, gene expression was largely rescued by subsequent reconstitution of cohesin function. (biorxiv.org)
  • HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. (neurotree.org)
  • Turning to analyses of gene function across these overlapping genes, these three disorders also showed similar impact of synaptic genes and those affecting the central nervous immune system 13 . (autismsciencefoundation.org)
  • The MFSD8 gene provides instructions for making a protein whose function is unknown. (medlineplus.gov)
  • We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
  • To test this hypothesis, lead author Margaret Distler inserted two, eight or ten copies of the Glo1 gene into mouse lines. (sciencedaily.com)
  • Here we analyzed neuronal actin signaling by a novel approach using actin mutant isoforms known to favor or preclude actin polymerization. (jneurosci.org)
  • One of the most up-regulated genes, synuclein-alpha (SNCA) is a known risk gene for Parkinson's disease that is located in the strongest linkage region of musical aptitude. (sciencedaily.com)
  • We show that neuronal motility evoked by these actin mutants requires SRF activity. (jneurosci.org)
  • We conclude that local Process S dynamics reflects neuronal activity integrated over time, and global Process S reflects local processes integrated over space. (elifesciences.org)
  • The short time course suggested that MG might have a direct effect on neuronal activity. (sciencedaily.com)
  • Emerging themes in neuronal activity-dependent gene expression. (neurotree.org)
  • Our work to generate a phenotypic mouse model for FD headed to the discovery that homozygous deletion of the mouse Elp1 gene leads to embryonic lethality prior to mid-gestation. (figshare.com)
  • Given that FD is caused by a reduction, not loss, of ELP1, we generated two new mouse models by introducing different copy numbers of the human FD ELP1 transgene into the Elp1 knockout mouse (Elp1-/-) and observed that human ELP1 expression rescues embryonic development in a dose dependent manner. (figshare.com)
  • Pinpointing the expression of factors that may play a role in AD pathogenesis provides a foundation for future identification of new targets for improved AD therapeutics. (elsevierpure.com)