• This gene encodes the integrin beta 4 subunit, a receptor for the laminins. (wikipedia.org)
  • This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. (wikipedia.org)
  • The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. (wikipedia.org)
  • Molecular cloning of the human alpha 6 integrin subunit. (wikipedia.org)
  • Different epithelial membrane zone components have been recognized by antibodies in patients with mucous membrane pemphigoid, including BP antigens 1 and 2 (BP230 and BP180), laminin-332, laminin-311, type VII collagen, b4 integrin subunit, and antigens with unknown identities (a 45-kd protein, uncein, a 168-kd epithelial protein, and a 120-kd epithelial protein). (medscape.com)
  • Laminin-332 contains disulfide-linked alpha, beta, and gamma chains, of which the alpha subunit is the major site of mucous membrane pemphigoid reactivity. (medscape.com)
  • Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
  • Integrins are nondisulfide-linked transmembrane (TM) heterodimers that contain an alpha- and beta-subunit (1). (bio-techne.com)
  • It only associates with the beta1 integrin subunit. (bio-techne.com)
  • Unlike the alpha-subunit, it does not undergo proteolytic cleavage. (bio-techne.com)
  • β1 integrin is the major β integrin subunit in pancreatic beta-cells and forms heterodimers with 12 α integrin subunits, which interact with components of the extracellular matrix (ECM) to control intracellular signaling via the focal adhesion kinase (FAK) and extracellular signal related kinase 1 and 2 (ERK1/2) pathways [ 4 ]. (oncotarget.com)
  • The Integrin alpha 6 subunit, also known as CD49f and VLA-6 alpha subunit, forms a heterodimer with Integrin beta 1 (CD29) or beta 4 (CD104) subunits. (rndsystems.com)
  • ELAV - like1 , methyltransferase like 7A , dolichyl-phosphate mannosyltransferase , laminin subunit beta-1 , gremlin 1 , BCL6 corepressor-like 1 , and three genes of unknown identity. (biomedcentral.com)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
  • Specifically, these extracellular matrix (ECM) components critically modulate the tumor cell "motile phenotype" affecting their adhesive/migratory abilities which are directly correlated to the metastatic cascade [ 5 , 6 ]. (hindawi.com)
  • Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
  • Flow-induced NF-κB activation is downstream of conformational activation of integrins, resulting in new integrin binding to the subendothelial extracellular matrix and signaling. (rupress.org)
  • Although the mechanisms mediating the effects of the extracellular matrix (ECM) on breast carcinoma development in vivo are largely unknown, contributing factors may be adhesion mediated signaling and mechanical signals imparted on mammary epithelial cells from surrounding type-I collagen-rich stroma, either directly or across basement membrane proteins. (biomedcentral.com)
  • Integrin alpha 6 beta 1 is a receptor for laminin. (rndsystems.com)
  • Integrin alpha 6 beta 4 is also a receptor for laminin and is a structural component of hemidesmosomes in stratified epithelia. (rndsystems.com)
  • providing a ligand for the α6β1 integrin receptor expressed by OLs. (jneurosci.org)
  • A specific inhibitor of PKCd, rottlerin, completely abrogated Go¨6976-dependent increase in PC12 cell adhesion to laminin as well as the activation of small GTPases, Rac1 and Cdc42, that are downstream of PKCd in adhesion receptor signaling. (mirnamimic.com)
  • In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)
  • adhesion G protein-coupled receptor E5. (gsea-msigdb.org)
  • This model was used to determine genes associated with cell adhesion and communication such as E-cadherin, the desmocollin 3, the gap junction protein alpha 1, the Integrin alpha 6, the Integrin beta 6, the Keratin 14, Keratin 16, Keratin 17, Keratin 6B, and the laminin beta 3. (bvsalud.org)
  • Integrin alpha 3, also known as CD49c and VLA-3 alpha, is a type I membrane protein that heterodimerizes with Integrin beta 1. (rndsystems.com)
  • In early culture, PSCs are polygonal in shape with abundant lipid droplets in the cytoplasm ( Figure 1B ) and express stellate cell selective markers such as desmin, glial fibrillary acidic protein (GFAP), nestin, neural cell adhesion molecule, nerve growth factor, and synemin (34, 167). (pancreapedia.org)
  • Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
  • ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)
  • Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. (academicinfluence.com)
  • Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
  • Results indicated that most genes had greater expression in the tumorigenic cell line Tumor2 derived from the athymic animal than the Alpha3, a non-tumorigenic cell line exposed only to radiation, indicating that altered expression levels of adhesion molecules depended on estrogen. (bvsalud.org)
  • VLA-3 (Very Late Antigen 3) is a member of the integrin family, beta1 subfamily, of cell membrane adhesion molecules (1-3). (bio-techne.com)
  • Significant reductions in the phosphorylation of signaling molecules focal adhesion kinase, extracellular signal-regulated kinases 1 and 2, and v-Akt murine thymoma viral oncogene were observed in male MIPβ1KO islets when compared to controls. (oncotarget.com)
  • He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
  • Cell adhesion molecules. (academicinfluence.com)
  • Cell adhesion molecules: implications for a molecular histology. (academicinfluence.com)
  • Cell adhesion molecules in the regulation of animal form and tissue pattern. (academicinfluence.com)
  • Cell adhesion molecules in early chicken embryogenesis. (academicinfluence.com)
  • Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. (wikipedia.org)
  • Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Beta 4 (ITGb4) in tissue homogenates, cell lysates and other biological fluids. (hudsen.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Beta 4 (ITGb4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hudsen.org)
  • Description: Quantitativesandwich ELISA kit for measuring Rat Integrin beta-4 (ITGB4) in samples from serum, plasma, tissue homogenates, cell lysates. (hudsen.org)
  • Synthetic peptides or recombinant fragments containing bio- logically active motifs have been shown to partially mimic the effects of native laminin in various cellular functions, such as cell adhesion, spreading, migration, neurite outgrowth, and tumor metastasis [6-10], suggesting that laminin-derived-short peptide- modified biomaterials may have therapeutic potential in tissue regeneration applications. (mirnamimic.com)
  • In experiments probing for a role of PKCa in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and stress fiber formation to 1 mM Go¨6976 with concomitant increase in membrane translocation of PKCd and autophosphorylation of focal adhesion kinase (FAK). (mirnamimic.com)
  • Pharmacologic blockade of PKC inhibits cell adhesion and spreading as well as focal adhesion formation and focal adhesion kinase (FAK) phosphorylation [13,14]. (mirnamimic.com)
  • To date, more than 25 have been identified and are categorized into 6 groups according to their substrate specificity. (medscape.com)
  • The two major antigens associated with mucous membrane pemphigoid are BP180 and laminin-332. (medscape.com)
  • A subset of patients with mucous membrane pemphigoid reacts with laminin-332. (medscape.com)
  • Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid. (fmu.ac.jp)
  • Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
  • Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
  • The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
  • This applies a tensile signal to the actin-binding domain (ABD) of α-catenin, which provides a clutch to promote lateral adhesion growth and inhibit the lamellipodial activity necessary for migration. (ibecbarcelona.eu)
  • It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)
  • IL-6, interestingly, does not seem to stimulate the production of collagenase, but is a potent inducer of TIMP-1. (biomedcentral.com)
  • Upon vascular injury, platelets are exposed to the subendothelium, and several agonists, including adenosine diphosphate (ADP) and thrombin, are generated at the injury site, which can stimulate platelet adhesion, activation and aggregation. (spandidos-publications.com)
  • Be the first to review Human Integrin alpha 6/CD49f Alexa Fluor® 405-conjugated Antibody and earn rewards! (rndsystems.com)
  • Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
  • The retinal distortion and continuous distraction caused by its contraction transforms RRD into traction retinal detachment [ 6 ]. (ijbs.com)
  • It is synthesized as a 1051 amino acid (aa) precursor that undergoes proteolytic cleavage to generate a disulfide-linked 110 kDa, 843 aa extracellular heavy chain and a 30 kDa, 176 aa TM/cytoplasmic light chain (1, 4, 5, 6). (bio-techne.com)
  • Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. (lookformedical.com)
  • Description: A sandwich ELISA kit for detection of Integrin Beta 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hudsen.org)
  • β4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex. (fmu.ac.jp)
  • In addition to IL-4, `biologicals' such as humanized anti-TGF-β antibodies and recombinant human interferons are, accordingly, being tested as a treatment for fibrotic diseases. (biomedcentral.com)
  • These processes are facilitated by a phenotypic change among quiescent keratocytes to become active myofibroblasts, a task mediated by transforming growth factor-beta (of presumptive epithelial origin). (medscape.com)
  • Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. (wikipedia.org)
  • The alpha 2 extracellular domain (ECD) contains an I (inserted) domain which includes the ligand binding site (2, 3). (novusbio.com)
  • This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
  • The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)
  • One particular type of phenotypic plasticity is that displayed as an inducible defense, which is stimulated directly by cues associated with a predation threat [ 6 - 12 ]. (biomedcentral.com)
  • In light of these findings, precisely how β1 integrin transduces ECM cues via signaling intermediates, and the mechanism by which this translates to cellular responses, need to be addressed. (jneurosci.org)
  • Detects human Integrin alpha 2/CD49b. (novusbio.com)
  • The 1102 amino acid (aa) human alpha 2 extracellular domain (ECD) shares 83‑89% aa sequence identity with mouse, rat, canine, bovine and equine alpha 2. (novusbio.com)
  • Fibroblasts produce TIMPs (1-4), which were previously called human fibroblast collagenase inhibitors. (biomedcentral.com)
  • Detects human Integrin alpha 6/CD49f. (rndsystems.com)
  • Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus. (fmu.ac.jp)
  • Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C. (lookformedical.com)
  • Integrins are important regulators of cellular differentiation, migration, maturation, and survival [ 1 - 3 ]. (oncotarget.com)
  • Static assays such as transwell migration in Boyden chambers 4 are hindered by effects of gravity, lack of physiological flow, and difficulty in visualizing and analysing the neutrophils at each stage of transmigration. (nature.com)
  • PKC activation by phorbol myristate acetate has been shown to induce the adhesion, spreading, and migration of cells [12]. (mirnamimic.com)