Change the conformation. Medical search. Frequent questions

Changes in emission spectra of tryptophan are due to the protein conformational transitions, subunit association, ligand binding or denaturation, which affect the local environment surrounding the indole ring. (cgiar.org)
The serpin structures illustrate detailed control of conformation within a single protein. (psu.edu)
Many protein conformational changes involve relative motions of large rigid subunits. (psu.edu)
The overall objective of EuroNeut-41 was to design a vaccine that raises antibodies able to prevent HIV cell fusion by blocking the virus fusion protein gp41 in its pre-fusogenic conformation. (europa.eu)
The protein is in the inward-facing conformation with Cavity 1 open to the cytosol for substrate recruitment, the Leucine Plug intact, and Cavity 2 completely occluded. (proteopedia.org)
which is occluded when the protein in is the inward-facing conformation, is now open to the extracellular space and able to release the substrate. (proteopedia.org)
Companies have been developing cereblon-binding protein-degradation drugs that they can see are better degraders, but they didn't know this was because the drugs are better at driving this closed conformation," Watson says. (ddw-online.com)
In particular, we are interested in understanding how fluid shear and surface immobilization alters the three-dimensional structure of VWF thus promoting both protein conformation change and VWF self-association. (buffalo.edu)
He is also an author on the Nature paper that describes a three-dimensional structure of one of the shapes, or conformations of the HIV protein. (sciencedaily.com)
The only difference between the normal and 'scrapie' forms is one of protein conformation. (bio.net)
6, 7, 8] Alteration in protein conformation with temperature changes also leads to decreased solubility and subsequent vasculitic damage. (medscape.com)
In this process, hydration plays a key role in determining the protein dynamics and structural change. (lu.se)

Cereblon, the researchers determined, has a default 'open' conformation, but must be switched to a particular 'closed' conformation for the ubiquitin-tagging of target proteins. (ddw-online.com)
The contributors describe strategies for identifying and evaluating the biochemical and morphological changes that occur during apoptosis, autophagy, necrosis, and other forms of cell death, as well as for pinpointing the genes and proteins that may be involved. (cshlpress.com)
With two of these special beacons in place, smFRET imaging can be used to visualize how the molecules move over time, when the virus proteins change conformation. (sciencedaily.com)
They saw that the gp120 proteins' virus particles changed shape constantly and that the timing and nature of their movements were both similar and distinct. (sciencedaily.com)
The development of real-time rapid techniques for the characterization of DNA intrinsic curvature as well as DNA conformational changes upon interaction with proteins is of significance to analytical biotechnology due to the large number of DNA sequences and potential DNA bending proteins involved in genome analysis and drug screening. (unboundmedicine.com)
Here we will discuss in more detail about the denaturation mechanism and demonstrate a strong correlation between the hydration levels of the native proteins, thus its native conformation and their resulted denatured state. (lu.se)

To obtain a better understanding of the adhesion on a molecular scale, we herein examined the conformational change of polystyrene (PS) chains at the film surface after contacting with hydrophobic or hydrophilic surfaces using sum-frequency generation (SFG) spectroscopy. (elsevierpure.com)
The inhibitory mechanism involves a large conformational change known as the S → R (stressed → relaxed) transition. (psu.edu)
Knowing that the conformational change is initiated by cleavage at the reactive centre, we describe a mechanism of the S → R transition as a logical sequence of mechanical effects, even though the transition likely proceeds in a concerted manner. (psu.edu)
Some of the mAbs tested enhanced the in vitro light chain activity of BoNT/B, suggesting that BoNT/B may undergo conformational change upon binding some mAbs. (cdc.gov)

Isotope-edited FTIR in H2O: Determination of the conformation of specific residues in. (mtsu.edu)

RNase interaction with RNA requires a match of structural conformation," says Guo. (scienceblog.com)
The structural data revealed that CELMoDs must bind to cereblon in a way that changes its shape, or conformation. (ddw-online.com)

Precise control of the temperature during the experiment allows us to measure the activities of enzymes at different temperatures as well to study conformation changes and denaturation. (tufts.edu)
The most dramatic change during heating is denaturation, which is a transition from native state to denatured state. (lu.se)

Chains altered their local conformations with a quartz surface more quickly than a hydrophobic alkyl-functionalized one. (elsevierpure.com)
under illumination with blue light, the chromophores assume a closed ring conformation and are hydrophobic. (aps.org)

Experiments such as X-ray and electron diffraction analyses, nuclear magnetic resonance, microwave spectroscopies, and more have allowed researchers to determine which cycloalkane structures are the most stable based on the different possible conformations. (wikipedia.org)
The AtAgo10-guide-target complex adopts slicing-competent and slicing-incompetent conformations that are unlike known prokaryotic AGO structures. (nature.com)
Conformation, according to Ted Stashak, DVM, who wrote The Horseowner's Guide to Lameness , is the outline of a horse as dictated primarily by his bone and muscle structures. (thehorse.com)
The change in the structures of 1e - g versus those of 1a - c is called Y-dependence in 1 . (hindawi.com)

This collapse of the gels is caused by the decrease in hydration due to conformational changes and not by a light-induced heating of the polymer network. (aps.org)

Predicting the conformation of DNA from its primary sequence, although desirable, is a challenging problem owing to the polymorphic nature of DNA. (lu.se)
While it would be easier to fill the entire magazine with descriptions of desirable conformation for each breed or type of horse, instead we will concentrate on undesirable conformation, which practicaly is the same for all breeds. (thehorse.com)

The most promising Ags were submitted to a more in-depth biophysical investigation of their structure and conformation stability, and for their capacity to interact with neutralising antibodies (Abs) and peptides. (europa.eu)

We determine the rigid subunits of α 1 -antitrypsin and analyse the changes in their relative position and orientation. (psu.edu)
Although the substrate binding pockets of both proteasome types are lined with almost identical amino acids, subtle changes in the immunoproteasome cause one particular methionine to adopt a different orientation than in the constitutive proteasome. (mytum.de)

The vapor-phase-generated GSH-TDI conjugates were capable of transcarbamoylating human albumin in a pH-dependent manner, resulting in changes in the self-protein's conformation/charge, on the basis of electrophoretic mobility under native conditions. (cdc.gov)

CVR-L-Arg has been compared to flow-mediated dilatation as a gold standard for systemic endothelial function and intima-media thickness as a marker for morphological changes. (hindawi.com)
Intraluminal ultrasound techniques enable imaging of morphological changes. (hindawi.com)

Many scientists believe that the particles remain in one conformation until they come across a CD4-positive cell. (sciencedaily.com)
The lock and key particles exhibit temperature-dependent changes in size and conformation that allowed the researchers to reversibly tune the 'valence' of the colloidal molecules (see illustration). (lu.se)

In the study, reported in Science, researchers discovered that these drugs, in order to work, need to cause a critical shape-change in cereblon when they bind to it. (ddw-online.com)

Conformation is discussed so frequently because it often is what makes horses better able to perform their job, or at least can help them have longevity in regard to performance. (thehorse.com)
Horses with good conformation are prized and usually more valuable than a counterpart with poor conformation. (thehorse.com)
In this article, we will discuss the good, the bad, and the just plain ugly aspects of conformation in horses. (thehorse.com)

The ethane molecule in the eclipsed conformation is said to suffer from torsional strain, and by a rotation around the carbon carbon bond to the staggered conformation around 12.5 kJ/mol of torsional energy is released. (wikipedia.org)
If the front is rotated 60° clockwise, the butane molecule is now in a staggered conformation (right). (wikipedia.org)
Fundamental Studies of Enzymes: From Single Molecule Kinetics to Conformation Studies. (tufts.edu)
By changing one section of the ribose ring, Guo and his team altered the structure of the molecule, making it unable to bind with RNase and able to resist degradation. (scienceblog.com)
One molecule of ATP is hydrolyzed to transport substrates across the cell membrane while the second molecule of ATP is hydrolyzed to reset the transporter to its inward-facing conformation. (proteopedia.org)
Inheritance of some variant alleles causes a change in conformation of the alpha-1 antitrypsin molecule, leading to polymerization and retention within hepatocytes. (msdmanuals.com)

In 1973, the organization changed to a membership association. (hobbyfarms.com)

the altered potassium metabolism is a result of the PP. In primary and thyrotoxic PP, flaccid paralysis occurs with relatively small changes in the serum potassium level, whereas in secondary PP, serum potassium levels are markedly abnormal. (medscape.com)

Such a conformation can exist in any open chain, single chemical bond connecting two sp3-hybridised atoms, and it is normally a conformational energy maximum. (wikipedia.org)

In order to gain a deeper understanding of eclipsed conformations in organic chemistry, it is first important to understand how organic molecules are arranged around bonds, as well as how they move and rotate. (wikipedia.org)

Conformations can be described by dihedral angles, which are used to determine the placements of atoms and their distance from one another and can be visualized by Newman projections. (wikipedia.org)
Another 60° rotation gives us a second eclipsed conformation where both methyl groups are aligned with hydrogen atoms. (wikipedia.org)
1) and change the names of the HB3 atoms (command 3). (lu.se)

You found an all-breed club that offered classes for conformation dogs. (akc.org)

A new inhibited conformation of the KD is observed in a DFG-out conformation and with the glycine-rich loop adopting a structure that blocks ATP binding to the active site. (rcsb.org)
Biophysical, cryo-EM, and crosslinking data validate the crystal structure and reveal that a minor change in ionic environment shifts the conformational landscape to a more compact, twisted form. (nih.gov)
the A -type structure of 1b changes dramatically to B of 2b by G = Cl at the 8-position, which is called G-dependence. (hindawi.com)

We were able to apply this platform to study activities and conformational changes of individual enzymes. (tufts.edu)
If study limitations were not adequately addressed, please suggest appropriate changes. (cdc.gov)
Shear Acoustic Wave Biosensor for Detecting DNA Intrinsic Viscosity and Conformation: a Study With QCM-D." Biosensors & Bioelectronics, vol. 24, no. 4, 2008, pp. 842-7. (unboundmedicine.com)
fMRI is at least an order of magnitude too insensitive to timing to record this level of change, which is why it is worthless in the neuroscientific study of free will. (uncommondescent.com)

Fifty-one vaccine candidates were designed mainly to mimic fusion intermediate conformations of gp41 and in some instance to increase exposure of the 2F5/4E10 epitopes. (europa.eu)

Here we compare the conformations of α 1 -antitrypsin in native and cleaved states. (psu.edu)

Scaling down the size and increasing the throughput of glycosyltransferase assays: activity changes on stem cell differentiation. (buffalo.edu)
The latter is quantitatively related to the DNA conformation and specifically the molecule's shape and size, in a manner that is independent of the amount of bound DNA mass. (unboundmedicine.com)

This conformation is more specifically referred to as the gauche conformation of butane. (wikipedia.org)

Wow, that horse has great conformation! (thehorse.com)

Those include cardiofaciocutaneous syndrome, whose symptoms include heart problems, mental retardation, and changes to facial features. (news-medical.net)

This leads to multiple possible three-dimensional arrangements, known as conformations, conformational isomers (conformers), or sometimes rotational isomers (rotamers). (wikipedia.org)

return a copy of the set of positions within the newly modified region that has a defined conformation. (rosettacommons.org)

It was found that the most stable conformations had lower energies based on values of energy due to bond distances and bond angles. (wikipedia.org)
We performed the heating pulse experiment and we have found that the activities of individual enzymes change after heating pulse, where the average activity stays constant. (tufts.edu)

Ils ont été soumis au test de détection des virus de la grippe A et B via la méthode d'analyse RT-PCR simplex en temps réel. (who.int)

Anatomy6

Organisms6

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes93

Disciplines and Occupations9

Technology, Industry, Agriculture5

Information Science9

Health Care3

Protein12

Proteins6

Conformational change4

Residues1

Structural2

Denaturation2

Hydrophobic2

Structures4

Hydration1

Desirable2

Stability1

Orientation2

Electrophoretic1

Morphological changes2

Particles2

Researchers1

Horses3

Molecule6

Organization1

Occurs1

Open1

Molecules1

Atoms3

Dogs1

Structure3

Study4

Vaccine1

Native1

Size2

Specifically1

Great1

Include1

Leads1

Region1

Found2

Virus1