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  • heterotrimer
  • In all six JEB patients, the laminin-5 assembly intermediates we observed were as predicted by our previous work indicating that the α3β3γ2 heterotrimer assembles intracellularly via a β3γ2 heterodimer intermediate. (rupress.org)
  • pathology
  • The dy 3K /dy 3K mouse is completely deficient for laminin α2 and displays very severe muscle pathology whereas the dy 2J /dy 2J mouse, which expresses reduced levels of a truncated laminin α2, displays a milder muscular phenotype. (frontiersin.org)
  • defects
  • Junctional epidermolysis bullosa (JEB) is an autosomal recessive skin blistering disease with both lethal and nonlethal forms, with most patients shown to have defects in laminin-5. (rupress.org)
  • TISSUES
  • The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. (wikipedia.org)
  • antibodies
  • Mouse monoclonal antibodies (mAbs) that bind to specific chains of laminin-511 (LM-511) have been developed. (edu.au)
  • In combination, the antibodies recognize all three chains of LM-511 and combinations of the antibodies can be used to quantitate levels of LM-511 in physiological fluids. (edu.au)
  • Due to these encouraging cell culture data, we decided to select single chain antibodies (scFv) encompassing a suitable format for therapy. (uni-muenchen.de)
  • In this context, an approach based on the expression of single chain antibodies as secretory molecules in the brain via an adeno-associated virus (AAV) vector was initiated. (uni-muenchen.de)
  • molecules
  • The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo . (wikipedia.org)
  • Antibody
  • Our findings suggest that laminin-5 determined by a monoclonal antibody facilitates the identification of invasive lesions that are difficult or impossible to identify on routinely stained histologic sections. (ovid.com)
  • Antibody 2F12 binds to the LMα5 chain, 3G10 binds to the LMβ1 chain and 3C12 binds to the LMγ1 chain. (edu.au)
  • migration
  • Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration. (semanticscholar.org)
  • Laminin-mediated interactions play a key role in forming cellular architecture through processes such as cell adhesion , spreading and migration (1-3). (dict.md)
  • tumor
  • Type VII collagen appears to play a key role in tumor invasion, and appears to operate through association with laminin-5. (stanford.edu)
  • tissue
  • 7 - 13 We recently showed that the extraocular muscles (EOMs) of terminal ALS donors show signs of disease involvement, with the presence of hypertrophic and atrophic muscle fibers, increased connective tissue, as well as changes in myosin heavy chain composition. (arvojournals.org)
  • synthesis
  • Identification is based on: ability to direct the synthesis in Escherichia coli of polypeptides carrying laminin antigen determinants, in vitro translation of hybrid selected mRNA, and hybridization to high mol. (duke.edu)