• IL-1α transgenic mice ( 11 ) and gene targeting of an IL-1 receptor antagonist ( 12 ) indicated that the increased activity of a proinflammatory cytokine (IL-1) results in arthritis. (rupress.org)
  • Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. (nih.gov)
  • Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. (cancerindex.org)
  • In the present study, to clarify the factor characterizing Stx1a gene expression via the protein kinase A (PKA) pathway inducing the Stx1a mRNA, we investigated whether the epigenetic process is involved in the Stx1a gene transcription induced by PKA signaling. (medworm.com)
  • The FMS-like tyrosine (FLT3) gene encodes a class III receptor tyrosine kinase, sharing structural and sequence homologies with family members, including c-kit, c-FMS, FLT1, and PDGF- β R. FLT3 plays a key role in the control of hematopoiesis. (hindawi.com)
  • Ligands for rhodopsin like GPCR's release an alpha unit (Gaq11) which activates phospholipase C, which cleaves PIP2, releasing IP3 which opens calcium channels, and DAG, which attracts PKC to the cell membrane. (brainscape.com)
  • The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. (cancerindex.org)
  • This receptor was cloned in 1991 by two separate groups and it was reported its expression in undifferentiated stem/progenitor cells and its absent expression on the majority of differentiated hemopoietic cells. (hindawi.com)
  • Subsequently, it was shown that these FLT3-ITD mutations resulted in an uncontrolled receptor activation, characterized by ligand-independent receptor dimerization, constitutive FLT3 signaling with consequent activation of STAT5 and of the RAS/MAPK and PI3 K pathways. (hindawi.com)
  • The receptor for this group is the CGMPR family secretin like which uses various G proteins (Gas) to activate/deactivate adenylate cyclase as well as cause calcium release. (brainscape.com)
  • At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. (ubc.ca)
  • In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells. (ubc.ca)
  • High levels of WT FLT3-expression have been observed in various hematological malignancies including the majority of acute myelogenous leukemias (AMLs) and B-cell acute lymphoblastic leukemias (ALLs). (hindawi.com)
  • These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. (kegg.jp)
  • Early studies of this complex suggested only pro-oncogenic role, which triggered massive interest in both academia and industry in developing drugs targeting this transcription factor complex. (springer.com)
  • IL-6, which was originally identified as a B cell differentiation factor ( 13 , 14 ), is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation ( 4 , 15 ). (rupress.org)
  • In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. (kegg.jp)
  • The development of the genetic studies on acute myeloid leukemias (AMLs) has led to the identification of some recurrent genetic abnormalities. (hindawi.com)
  • IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. (miltenyibiotec.com)
  • This study highlights the importance of post-translational modifications of host cellular factors in HIV-1 replication and pathogenesis. (medworm.com)