AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Chagas DiseaseTrypanosoma cruziChagas CardiomyopathyTriatomaTriatominaeInsect ControlBoliviaTrypanocidal AgentsRhodniusInsect VectorsNitroimidazolesNifurtimoxLatin AmericaXenodiagnosisMegacolonDisease VectorsArgentinaAntibodies, ProtozoanVenezuelaSouth AmericaGuatemalaHousingParaguayCentral AmericaPanstrongylusMummiesEndemic DiseasesBrazilPan American Health OrganizationMexicoSeroepidemiologic StudiesPanamaChronic DiseaseHondurasNymphDNA, KinetoplastDNA, ProtozoanAntiprotozoal AgentsChileFood ParasitologyPaleopathologyNeglected DiseasesPyrethrinsPeruAmericasInsecticidesPregnancy Complications, ParasiticIndians, South AmericanHost-Parasite InteractionsParasitemiaRadioimmunoprecipitation AssayEctoparasitic InfestationsTrypanosomiasisProtozoan VaccinesEl SalvadorDidelphisInfectious Disease Transmission, VerticalEnzyme-Linked Immunosorbent AssayEuglenozoa InfectionsAntigens, ProtozoanTrypanosomaEmigrants and ImmigrantsColombiaAcute DiseaseImmunochromatographyEcuadorSerologic TestsInsect Bites and StingsParasitic Sensitivity TestsProtozoan ProteinsReduviidaeTopography, MedicalBlood DonorsDisease ReservoirsEmigration and ImmigrationRural PopulationCytochromes b14-alpha Demethylase InhibitorsGordonia BacteriumGenome, ProtozoanAnimals, WildMite InfestationsSterol 14-DemethylaseTropical MedicineChromosomes, InsectPolymerase Chain ReactionHemagglutination TestsDefecationPrevalenceArecaceaePopulation DensityAgelasAnimals, DomesticPiperFeeding BehaviorMyocarditisLife Cycle StagesEntomologyRodentiaAntiparasitic Agents
TrypanosomaLatin AmericaDilated cardiomyopathyEnfermedad de ChagasCauses Chagas diseaseAmerican TrypanosomiasisCases of Chagas diseaseTreatment For Chagas DiseaseCruziAcuteTreat Chagas diseaseLeishmaniasisDiagnosis of congenital Chagas diseaseWorld Health OrganVectorsCarlos ChagasInfectionBenznidazoleCentral AmericaTriatomine bugsBurden of Chagas diseasePositive for Chagas diseaseDNDiInclude Chagas diseaseEradicate Chagas diseasePLoS Neglected TropicalSouth AmericaSymptomsEndemicPrevalenceMalariaAffectsCentersPatientsBrazilianComplicationsPreventionAlthough ChagasPotentiallyInfectious diseaseCardiac300,000Blood DonorsParasiticSymptomaticRoadmapOccurs2016Left untreatedInfections2018GastrointestinalFlow CytometryIllnessHealthcare ProvidersChronic diseaseInsectTransmissionVector borne
Trypanosoma29
Latin America16
  • In the United States, Chagas disease is primarily a disease of immigrants from endemic areas of Latin America. (cdc.gov)
  • Chagas disease is common in Latin America, especially in poor, rural areas. (medlineplus.gov)
  • In areas of Latin America where human Chagas disease is an important public health problem, the bugs nest in cracks and holes of substandard housing. (cdc.gov)
  • First discovered more than 100 years ago, the disease continues to affect more than seven million people worldwide and is one of the most prevalent public health problems in Latin America. (world-heart-federation.org)
  • Most cases of Chagas disease occur in Latin America. (poison.org)
  • Chagas disease (named after Dr. Carlos Ribeiro Justiniano Chagas, the Brazilian physician who first described it in 1909) is most common in Latin America, where approximately 8-10 million people are infected and where the disease is a major public health problem. (poison.org)
  • According to the authors, molecules capable of modulating the cellular signaling pathway mediated by this enzyme may in future be tested as a treatment for Chagas disease, which affects some 7 million people in Latin America - 2 million-3 million in Brazil alone. (technologynetworks.com)
  • Chagas disease remains a profound public health issue in Latin America and increasingly on a global scale," said WHF President Karen Sliwa, MD, PhD, FACC . (acc.org)
  • Although Chagas disease occurs principally in the continental part of Latin America, in the past decades it has been increasingly detected in the U.S., Canada, many countries in Europe and some countries in the Western Pacific. (acc.org)
  • In parts of Latin America, Chagas disease is the most common cause of heart failure in the absence of coronary artery disease. (mainstreetdailynews.com)
  • Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy. (medscape.com)
  • Chagas disease is mostly present in Latin America, where it is endemic, but it tends to spread in North America and Europe with the increasing migratory flux and climate changes. (ldbiodiagnostics.com)
  • Webinar in commemoration of World Chagas Disease Day, organized by the Center for Research for Health in Latin America (CISeAL), in collaboration with the Vice Presidency of the Republic of Ecuador, the Pontificia Universidad Católica del Ecuador (PUCE), the Infectious and Tropical Disease Institute at Ohio University (ITDIOU), and also with our coordinator in the Chagas Global Coalition. (coalicionchagas.org)
  • This is critical for the control and elimination of the disease that affects about 6 million people worldwide, mostly in poor households of Latin America. (healthpolicy-watch.org)
  • The disease is predominately found in Latin America and mostly spreads by insects called triatomine bugs. (meridianbioscience.com)
  • Universal screening of blood banks for Chagas is carried out in most Western and European countries and the screening of women of child-bearing age is essential in Latin America. (meridianbioscience.com)
Dilated cardiomyopathy2
  • Cardiac disease usually begins with conduction abnormalities such as right bundle branch block and/or left anterior fascicular block, which may be followed years later by dilated cardiomyopathy. (cdc.gov)
  • As the disease progresses, the heart's ventricles become enlarged (dilated cardiomyopathy), which reduces its ability to pump blood. (wikipedia.org)
Enfermedad de Chagas1
  • Enfermedad de Chagas : aportes del Programa Nacional de Investigaci'on en Enfermedades Endémicas, 1979-1983. (who.int)
Causes Chagas disease1
American Trypanosomiasis5
Cases of Chagas disease2
  • In the US, there are an estimated 300,000 cases of Chagas disease but access to care is limited, according to one recent study . (genomeweb.com)
  • What we want to do is unearth undiagnosed cases of Chagas disease," Beatty said. (mainstreetdailynews.com)
Treatment For Chagas Disease1
  • Researchers from the University of Georgia, US have discovered a potential treatment for Chagas disease, marking the first medication with promise to successfully and safely target the parasitic infection in more than 50 years. (drugtargetreview.com)
Cruzi9
  • Chronic disease is diagnosed by finding antibodies for T. cruzi in the blood. (wikipedia.org)
  • There is a general consensus in favor of antiparasitic treatment for all cases of acute or reactivated Chagas disease, for chronic T cruzi infection of children up to age 18 years, and for all women of child‑bearing age. (medscape.com)
  • The protozoa T. cruzi can be classed into six "discrete typing units," or DTUs, based on three nuclear loci, and DTUs are differentially distributed in endemic areas, Alejandro Schijman, a researcher at El Instituto de Investigaciones en Ingeniería Genética y Biología Molecular inBuenos Aires, told GenomeWeb in an email. (genomeweb.com)
  • The organism T cruzi and infection in humans were first described in 1909 by the Brazilian physician Carlos RJ Chagas. (medscape.com)
  • A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)
  • Transmitted by insects known as triatomine or kissing bugs (mainly Triatoma infestans in South America), as well as by transfusions of blood from donors with Chagas disease and by the ingestion of contaminated food, T. cruzi stays with the patient for life. (technologynetworks.com)
  • Florida, home to both the kissing bug and T. cruzi , is thought to have the third-highest number of people living with chronic Chagas, behind California and Texas. (mainstreetdailynews.com)
  • As part of a three-year investigation, Beatty and UF/IFAS collaborators Samantha Wisely, Nathan Burkett-Cadena and John Diaz, as well as Colin Forsyth from the Drugs for Neglected Diseases initiative and Eva Novakova from the University of South Bohemia, have been working with urgency to track and diagnose the disease in Florida and investigate the ways in which T. cruzi spreads. (mainstreetdailynews.com)
  • Transmission of T. cruzi infection via liver transplantation to a nonreactive recipient for Chagas' disease. (medscape.com)
Acute11
  • Chagas disease occurs in two stages: an acute stage, which develops one to two weeks after the insect bite, and a chronic stage, which develops over many years. (wikipedia.org)
  • In rare cases (less than 1-5%), infected individuals develop severe acute disease, which can involve inflammation of the heart muscle, fluid accumulation around the heart, and inflammation of the brain and surrounding tissues, and may be life-threatening. (wikipedia.org)
  • In the study, the new typing protocol characterized all DTUs from patients with acute Chagas infection in total agreement with conventional PCR techniques. (genomeweb.com)
  • Chagas Disease is most common in children and starts in an acute stage. (novusbio.com)
  • When in the acute stage, Chagas Disease can be treated with medications that focus on killing the parasite. (novusbio.com)
  • After the acute phase, the disease goes into remission. (mountsinai.org)
  • The acute phase of reactivated Chagas disease should be treated. (mountsinai.org)
  • Drawing on the expertise of Chagas expert clinicians, researchers, implementation science experts and patients, it sets out recommendations for screening, diagnosis and treatment of both acute and chronic Chagas cases, while also recommending appropriate health system interventions to tackle the disease. (acc.org)
  • Chagas disease usually has two clinical phases, acute and chronic. (ldbiodiagnostics.com)
  • Benznidazole is highly effective at treating the disease in its acute stages, but its side effects, ranging from skin rashes to peripheral neuropathy, discourage patients from agreeing to the treatment. (healthpolicy-watch.org)
  • Detection during the acute phase is by microscopy or PCR, however, as Chagas does not typically present any symptoms until the later stages of the disease, the most common tests are serological assays which detect the presence of IgM or IgG antibodies to the parasite. (meridianbioscience.com)
Treat Chagas disease2
  • The 2 drugs used to treat Chagas disease are benznidazole and nifurtimox. (cdc.gov)
  • This webinar will highlight current efforts across the US to diagnose and treat Chagas disease in at-risk populations. (uth.edu)
Leishmaniasis1
  • It has also been shown to control sandflies and T. infestans which are known to transmit leishmaniasis and Chagas disease respectively. (who.int)
Diagnosis of congenital Chagas disease1
  • At present we are working on a kit prototype for molecular diagnosis of congenital Chagas disease using a similar PCR approach in the context of a private-public consortium financed by the [Argentina] National Ministry of Science, Technology and Innovation, but have not initiated actions towards the development of a kit for DTU typing," said Shijman. (genomeweb.com)
World Health Organ1
  • World Health Organization claims, in this second anniversary, for equitable health access and services to those affected by the disease. (tghn.org)
Vectors4
  • Samples from Chagas patients, animal reservoirs, and insect vectors came from about a dozen of the 21 endemic countries in the Americas as well as a number of European research labs. (genomeweb.com)
  • Like ticks , mosquitoes , and fleas , kissing bugs are important vectors of disease. (poison.org)
  • Lent H, Wygodzinsky P. Revision of the Triatominae (Hemiptera, Reduviidae), and their significance as vectors of Chagas' disease. (medscape.com)
  • Despite their charming sobriquet, kissing bugs are the vectors of Chagas disease, one of many NTDs re-emerging in Venezuela due to its ongoing healthcare crisis. (biomedcentral.com)
Carlos Chagas4
  • The disease was first described in 1909 by Brazilian physician Carlos Chagas, after whom it is named. (wikipedia.org)
  • According to the Casa de Oswaldo Cruz Researcher and Carlos Chagas expert, Simone Kropf, the recognition of this day is important for two important reasons: the rigorous Brazilian scientific work and a reminder for neglected diseases. (tghn.org)
  • This story started back in 1907 when the young Md Carlos Chagas arrived at a small city called Lassance, in the state of Minas Gerais. (tghn.org)
  • Carlos Chagas could name and describe it. (tghn.org)
Infection8
  • The study reports on a family case of transmissions from mother to unborn children, raising questions over prevention and diagnosis of Chagas disease in Canada, where thousands of individuals live with potentially undetected infection. (medindia.net)
  • Without access to resources, patients will continue to manifest the chronic disease state and may die from this infection without ever knowing they had this disease. (mainstreetdailynews.com)
  • People with a chronic infection should be under the care of a physician to help manage this disease before it becomes potentially fatal. (mainstreetdailynews.com)
  • Signs and symptoms of the disease may show up years after the initial infection, and include severe damage to the heart or gastrointestinal system . (biomedcentral.com)
  • Fortunately, measures to control the spread of infection are reducing the number of Chagas cases. (msdmanuals.com)
  • We've actually had a long history of Chagas in the state of Texas and in the United States," said Garcia, adding that the first case of locally acquired infection dates back to 1955. (medscape.com)
  • The disease is curable if treatment is initiated soon after infection, however, chronic disease can cause long-term cardiac, digestive, or neurological complications. (meridianbioscience.com)
  • Toxocariasis is a human disease caused by infection with the larval stages of the dog or cat roundworm. (cdc.gov)
Benznidazole3
  • Early infections are treatable with the medications benznidazole or nifurtimox, which usually cure the disease if given shortly after the person is infected, but become less effective the longer a person has had Chagas disease. (wikipedia.org)
  • But the CDC provided only 422 courses of benznidazole or nifurtimox used to treat Chagas during this period. (medscape.com)
  • Direct evidence gap on fixed versus adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: Systematic review and individual patient data meta-analysis. (bvsalud.org)
Central America2
Triatomine bugs3
  • Chagas disease is usually spread by triatomine bugs but can also be spread by an infected mother to her unborn baby. (cdc.gov)
  • The method also gave positive results in a high percentage of direct samples and culture isolates from the most common Chagas insect vector, triatomine bugs, as well as samples from mammalian reservoirs like raccoons, opossums, and dogs. (genomeweb.com)
  • While it's unclear how many triatomine bugs in the United States may carry the Chagas parasite, a pilot study conducted by the Baylor team may shed some light on the issue. (medscape.com)
Burden of Chagas disease2
  • The burden of Chagas disease in Southern Texas is 23 times higher than previously estimated, revealed a new study. (medindia.net)
  • The World Heart Federation (WHF) has released a new roadmap aimed at reducing the global burden of Chagas disease, a Neglected Tropical Disease that can cause irreversible damage to the heart and other vital organs. (acc.org)
Positive for Chagas disease2
  • Soon after the mother received a positive diagnosis, three of her four adult children - two sisters and one brother, born in Canada but with family in South America - also tested positive for Chagas disease. (medindia.net)
  • A separate study reported at the conference shows that most people who test positive for Chagas disease go untreated. (medscape.com)
DNDi6
  • This event, co-organized by the Brazilian Embassy, San Diego State University, the University of California-San Diego, and DNDi, aims to highlight advances and remaining challenges for Chagas disease and the many people it impacts throughout the world. (dndi.org)
  • This event, co-organized by the Brazilian Embassy, San Diego State University, the University of California-San Diego, and the Drugs for Neglected Diseases initiative ( DNDi ) , will highlight advances and remaining challenges for Chagas disease and the many people it impacts throughout the world. (coalicionchagas.org)
  • The trials, carried out at three Bolivian health centers and led by the Drugs for Neglected Diseases Initiative (DNDi), found that a two-week treatment was just as effective in treating the disease as the conventional eight-week course of treatment for Chagas, with treatment succeeding for about 80 percent of patients, according to a DNDi press release issued yesterday. (healthpolicy-watch.org)
  • DNDi partnered in the study with the Fundacion Ciencia y Estudios Aplicados para el Desarrollo en Salud y Medio Ambiente (CEADES Foundation) in Bolivia, the Barcelona Institute for Global Health (ISGlobal), as well as other pharmaceutical industry and local partners. (healthpolicy-watch.org)
  • This major step forward for Chagas disease treatment is part of a DNDi effort to make the disease much less debilitating for future patients. (healthpolicy-watch.org)
  • DNDi will now continue to work with national programmes, partners and ministries of health of endemic countries to confirm these results and encourage necessary steps to register the new regimen and turn this breakthrough discovery into a reality for people affected by the disease," Sergio Sosa Estani, head of the Chagas Clinical Programme at DNDi, said in the press release. (healthpolicy-watch.org)
Include Chagas disease1
Eradicate Chagas disease2
  • It represents a call to action to decision-makers and health care professionals to step up efforts to eradicate Chagas disease. (dndi.org)
  • Dedicating a day to find ways to cooperate internationally in order to eradicate Chagas disease is another important step ahead. (tghn.org)
PLoS Neglected Tropical2
  • In the study published last week in PLoS Neglected Tropical Diseases , Shijman and his collaborators described a multiplex, TaqMan probe-based, real-time PCR assay for the six DTUs. (genomeweb.com)
  • PLOS Neglected Tropical Diseases is the top Open Access tropical medicine journal, featuring an International Editorial Board and increased support for developing country authors. (plos.org)
South America2
Symptoms10
  • What are the symptoms of Chagas disease? (medlineplus.gov)
  • After four to eight weeks, untreated individuals enter the chronic phase of disease, which in most cases does not result in further symptoms. (wikipedia.org)
  • When used in chronic disease, medication may delay or prevent the development of end-stage symptoms. (wikipedia.org)
  • When present, the symptoms are typically minor and not specific to any particular disease. (wikipedia.org)
  • The symptoms of chronic Chagas Disease are irregular heartbeat, congestive heart failure, and difficulty swallowing. (novusbio.com)
  • During the chronic stage, it cannot be treated with medications, but the symptoms of Chagas disease can be treated by targeting that specific problem. (novusbio.com)
  • We want to collect blood tests and heart scans to understand the disease better, because we will never find a cure, if we don't know the symptoms, Mads Høi Rasmussen points out. (sdu.dk)
  • Chagas disease can be a silent killer: Symptoms may take decades to appear and are often irreversible once they are recognized. (mainstreetdailynews.com)
  • Chagas disease symptoms usually start 1 to 2 weeks after the protozoa enter the body, usually through the bite wound or tissues around an eye. (msdmanuals.com)
  • Symptoms of Chagas disease in cats and dogs can vary, but may include fever, lethargy, loss of appetite, and weight loss. (michelleatyourservice.com)
Endemic4
  • Anyone who lived in or visited those countries for an extended period of time and was bitten by a kissing bug, who received a blood transfusion in Chagas-endemic countries, or who was born to a mother diagnosed with Chagas disease should ask their healthcare providers to be tested for the disease," states Dr. Ndao who has been an infectious disease researcher for more than 20 years. (medindia.net)
  • We found at our hospital, Boston Medical Center (BMC), that among 3057 patients from Chagas-endemic countries with cardiac complications potentially due to Chagas, only 42 (1.4%) had been tested for Chagas over 5 years (Wheelock A et al. (bu.edu)
  • Finally, at-risk populations themselves are generally not aware of Chagas, even when coming from endemic areas. (bu.edu)
  • In Texas, where my business is located Chagas disease is considered endemic, meaning it is regularly found in the local population of wildlife, including rodents, armadillos, and opossums, which can serve as reservoirs for the parasite. (michelleatyourservice.com)
Prevalence2
  • Little is known about the prevalence of Chagas in Florida. (mainstreetdailynews.com)
  • We will also discuss current screening and diagnostic protocols that are needed to help us better understand the real prevalence of this underdiagnosed disease. (uth.edu)
Malaria1
  • Infectious diseases like malaria or Zika may have dominated recent headlines but Chagas - the "Kissing Bug" disease is in the spotlight following the publication of a new case study in the Canadian Medical Association Journal . (medindia.net)
Affects8
  • The disease affects more than 150 types of animals. (wikipedia.org)
  • However, over decades with the disease, approximately 30-40% of people develop organ dysfunction (determinate chronic Chagas disease), which most often affects the heart or digestive system. (wikipedia.org)
  • Also common in chronic Chagas disease is damage to the digestive system, which affects 10-21% of people. (wikipedia.org)
  • Chagas disease affects an estimated 300,000 individuals in the United States. (nih.gov)
  • Chagas disease affects approximately one in four people who have contracted it at some point in their lifetime," adds Dr. Plourde. (medindia.net)
  • Due to immigration, the disease also affects people in the United States. (mountsinai.org)
  • The disease is hard to detect, because it only affects the patient shortly, before it hibernates for 20-30 years. (sdu.dk)
  • On 2019, with the Fiocruz support, during the World Health Assembly, World Chagas Disease Day was established reversing one century of silence regarding this illness that affects around 7 million people worldwide. (tghn.org)
Centers10
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Image courtesy of the Centers for Disease Control and Prevention. (mountsinai.org)
  • The study was conducted at the Center for Research on Inflammatory Diseases (CRID), one of the Research, Innovation and Dissemination Centers (RIDCs) supported by FAPESP. (technologynetworks.com)
  • Centers for Disease Control and Prevention (U.S.) (2014). (cdc.gov)
  • See Centers for Disease Control and Prevention: Epidemiology & Risk Factors . (msdmanuals.com)
  • That rate is consistent with other studies in the southern U.S., she noted, but is 50 times higher than the national rate of one in 300,000 put forth by the Centers for Disease Control and Prevention (CDC). (medscape.com)
  • These illnesses will "continue to tax our public health and medical care systems for years to come," experts from the Centers for Disease Control and Prevention, or CDC, wrote in a 2016 analysis . (grist.org)
  • Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)
  • I'm Dana Woodhall, a Medical Officer at the Centers for Disease Control and Prevention. (cdc.gov)
Patients15
  • Reactivation disease can occur in immunocompromised patients. (cdc.gov)
  • Less frequently, patients with Chagas disease experience gastrointestinal disease (megasyndromes). (cdc.gov)
  • The test was less successful on samples from patients with chronic disease, for example. (genomeweb.com)
  • Drawing on the expertise of Chagas expert clinicians, researchers, implementation science experts and patients, the WHF-IASC Roadmap on Chagas disease outlines a vision of an ideal pathway of care, identifies potential roadblocks along this pathway, and offers evidence-informed solutions for healthcare professionals, health authorities and governments. (world-heart-federation.org)
  • The authors propose strategies and evidence-based solutions for healthcare professionals, health authorities and governments to help overcome the barriers to comprehensive care for Chagas disease patients. (dndi.org)
  • We concluded that the microorganism H. pylori should be considered a possible factor connected with the etiopathogenesis of chronic superficial and atrophic gastritis frequently observed in patients with the digestive form of Chagas' disease. (scielo.br)
  • Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients. (preprints.org)
  • A key research question is determining which patients are most likely to develop the chronic form of the disease. (mainstreetdailynews.com)
  • Chagas' disease in patients with kidney transplants: 7 years of experience 1989-1996. (medscape.com)
  • The high rate of infectious bugs, combined with the high rate of feeding on humans, should be a cause of concern and should prompt physicians to consider the possibility of Chagas disease in U.S. patients with heart rhythm abnormalities and no obvious underlying conditions," Dr. Kristy Murray, associate professor of tropical medicine at Baylor, said in a statement. (medscape.com)
  • This podcast is designed to inform health care providers about Chagas disease, diagnosis, and treatment and to assist in identifying infected patients. (holidayinsuranceover70.com)
  • Free session on the topic: Voices of Chagas Disease: Patients and Physicians Discuss the Barriers to Care in the U.S. Join this UT Health San Antonio & ECHO (extension for community healthcare outomes) learning event. (coalicionchagas.org)
  • Background: We investigated the mortality rates of patients with Chagas disease (CD) during the coronavirus disease 2019 (COVID-19) pandemic and assessed the association between this mortality and CD clinical presentation and comorbidities. (fiocruz.br)
  • Severe side effects make the current course of prolonged drug treatment difficult for many patients with Chagas disease, but a Phase II clinical trial in Bolivia may have found an alternative treatment that is both quicker and significantly safer. (healthpolicy-watch.org)
  • Despite the significant difference in length, both treatments eliminated the parasite's presence in 80 percent of patients from each group, who remained disease-free 12 months after the treatment course was finished. (healthpolicy-watch.org)
Brazilian2
  • Bibliografia brasileira sobre doenðca de Chagas (1909-1979 = Brazilian bibliography on Chagas' disease (1909-1979 / Aluizio Prata, Eurydice Pires de Santâanna. (who.int)
  • Brazilian bibliography on Chagas' disease (1909-1979). (who.int)
Complications4
  • The most pressing issues from a public health perspective are congenital transmission, chronic disease leading to cardiac and other complications (e.g. gastrointestinal), and a lack of awareness about Chagas among both healthcare providers (HCPs) and at-risk populations. (bu.edu)
  • The worst health outcomes for individuals with Chagas occur in the estimated 30% who develop potentially fatal cardiac complications. (bu.edu)
  • In severe cases, Chagas disease can lead to heart failure or other complications. (michelleatyourservice.com)
  • We believe treatment can spare people with Chagas the risk of a lifetime of debilitating complications associated with the disease. (healthpolicy-watch.org)
Prevention4
  • The WHF IASC Roadmap on Chagas disease offers a comprehensive summary of current knowledge on prevention, diagnosis and management of the disease. (dndi.org)
  • The Chagas Disease Roadmap, developed by WHF in partnership with the Inter-American Society of Cardiology (IASC), aims to both help raise awareness of Chagas disease and present a framework for prevention and control efforts at the national, regional and global level. (acc.org)
  • Prevention of Chagas disease in pets involves controlling the kissing bug population by eliminating their habitat and using insecticides. (michelleatyourservice.com)
  • It presents travel information about Chagas disease and it description, occurrence, risk of travelers, clinical presentation, prevention and treatment. (bvs.br)
Although Chagas1
  • Although Chagas was internationally recognized by his findings concerning the disease, there is a long path to acknowledge the situation of Chagas Disease worldwide as a global health emergency. (tghn.org)
Potentially3
  • Kissing bugs can transmit a parasite that leads to a potentially serious illness called Chagas disease. (poison.org)
  • And yet, some residents of remote areas in the U.S., including parts of Florida, use the nets in their homes each night - not to protect against mosquitoes, but kissing bugs, blood-sucking insects that can spread a potentially lethal disease known as Chagas. (mainstreetdailynews.com)
  • These results could change the way Chagas disease is treated, potentially preventing millions more people from living with the toll it takes on the body. (healthpolicy-watch.org)
Infectious disease3
  • Even among infectious disease (ID) specialists, knowledge about screening and testing is relatively low. (bu.edu)
  • In the United States alone, more than 1 million have died from COVID-19, a painful consequence of how ill-prepared the nation was (and, in many ways, still is) for an infectious disease outbreak. (grist.org)
  • It presents informations and research about infectious disease. (bvs.br)
Cardiac4
  • Later cardiac disease is sometimes accompanied by apical aneurysm and thrombus formation. (cdc.gov)
  • Yet very little is being done to improve access to diagnosis and treatment for both those who already have the disease and those who suffer the serious cardiac manifestations associated with it. (acc.org)
  • Up to 30% of people who contract Chagas go on to suffer from cardiac manifestations and up to 10% suffer from digestive, neurological or mixed alterations. (acc.org)
  • There are very specific cardiac abnormalities associated with Chagas. (medscape.com)
300,0002
  • The often-cited statistic of approximately 300,000 cases in the United States is likely to be a marked underestimation of the true burden of disease. (bu.edu)
  • An estimated 300,000 people are living with Chagas disease in the U.S., but fewer than 1% have been diagnosed. (mainstreetdailynews.com)
Blood Donors3
  • Since 2007, all potential blood donors in the U.S. are screened for exposure to the Chagas parasite. (medscape.com)
  • In a study of Texas blood donors between 2008 and 2012, about one in 6,500 tested positive for the Chagas parasite, reported Melissa N. Garcia, epidemiologist at Baylor College of Medicine in Houston. (medscape.com)
  • The Baylor team followed 17 Houston-area blood donors infected with the Chagas parasite and found that seven (41%) had undiagnosed electrocardiographic abnormalities consistent with Chagas cardiomyopathy. (medscape.com)
Parasitic3
  • Chagas Disease is a parasitic disease caused by coming in contact with the feces of an infected triatomine bug. (novusbio.com)
  • Dr. Pierre Plourde, Medical Officer of Health and Medical Director of Travel Health and Tropical Medicine Services with the Winnipeg Regional Health Authority (WRHA), was the study's corresponding author and worked in partnership with parasitic diseases laboratory specialists Dr. Kamran Kadkhoda, Clinical Microbiologist from Cadham Provincial Laboratory in Winnipeg, and Dr. Ndao, head of the National Reference Centre for Parasitology (NRCP) at the RI-MUHC. (medindia.net)
  • Is the Subject Area "Parasitic diseases" applicable to this article? (plos.org)
Symptomatic2
  • About one third of infected people who are not treated will develop chronic or symptomatic Chagas disease. (mountsinai.org)
  • Symptomatic disease occurs when dead or dying larvae cause a reaction in the body. (cdc.gov)
Roadmap3
  • The World Heart Federation and Inter-American Society of Cardiology Roadmap on Chagas disease is an essential guiding document for anyone involved in the planning, development and implementation of interventions to eliminate the disease. (world-heart-federation.org)
  • This Roadmap is a timely and necessary intervention, providing concrete solutions to counter barriers to the diagnosis, treatment and management of this deadly disease. (acc.org)
  • In order to be implemented successfully, the Chagas roadmap requires committed global action," said Luis Echeverría, head of Department at the Cardiovascular Foundation of Colombia and chair of the Chagas Roadmap Writing Group. (acc.org)
Occurs3
  • The most common long-term manifestation is heart disease, which occurs in 14-45% of people with chronic Chagas disease. (wikipedia.org)
  • Chagas disease occurs in three stages. (msdmanuals.com)
  • The transmission of Chagas disease occurs through the bite of a triatomine bug, also known as the kissing bug, which is found in Texas and other southern states. (michelleatyourservice.com)
20161
  • Created in 2016, the Brazilial Social Forum Against Infectious and Neglected Diseases is an initiative that brings together social representative movements in Brazil that have for decades been defending fundamental rights and building public policies for neglected infectious diseases, all over the country. (fiocruz.br)
Left untreated2
  • If left untreated, Chagas can cause irreversible damage to the heart and other vital organs. (world-heart-federation.org)
  • According to the Mayo Clinic, if Chagas disease is left untreated, it can cause serious heart and digestive problems. (aol.com)
Infections3
  • Up to 45% of people with chronic infections develop heart disease 10-30 years after the initial illness, which can lead to heart failure. (wikipedia.org)
  • Most chronic infections are asymptomatic, which is referred to as indeterminate chronic Chagas disease. (wikipedia.org)
  • It is not a reportable disease to Florida's Department of Health, meaning that the state is not monitoring its occurrence, and researchers are unable to track infections via routine blood and organ donor screening. (mainstreetdailynews.com)
20181
  • 2018 'Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model' Preprints. (preprints.org)
Gastrointestinal1
  • About one-third will develop chronic Chagas, which can attack the heart, brain and gastrointestinal and peripheral systems with fatal results. (mainstreetdailynews.com)
Flow Cytometry1
  • We have 5636 products for the study of Chagas Disease that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits. (novusbio.com)
Illness2
  • Chagas disease is an illness caused by tiny parasites and spread by insects. (mountsinai.org)
  • Courtesy UF Kissing bugs, seen above, are the primary spreader of chagas, a little-known illness caused by a microscopic parasite. (mainstreetdailynews.com)
Healthcare Providers1
  • Many healthcare providers aren't even aware Chagas is in Florida, and testing can be limited, Beatty said. (mainstreetdailynews.com)
Chronic disease1
  • Chronic disease may ultimately be amenable to approaches that characterize the human immune response to Chagas disease, as recently reported by GenomeWeb. (genomeweb.com)
Insect3
  • To avoid Chagas disease, travelers should follow insect bite precautions (see Sec. 4, Ch. 6, Mosquitoes, Ticks & Other Arthropods ) and food and water precautions (see Sec. 2, Ch. 8, Food & Water Precautions ). (cdc.gov)
  • Insect control with insecticides and houses that are less likely to have high insect populations will help control the spread of the disease. (mountsinai.org)
  • Chagas was intrigued by an insect that fed on the blood of the inhabitants of the city. (tghn.org)
Transmission12
  • The disease may also be spread through blood transfusion, organ transplantation, consuming food or drink contaminated with the parasites, and vertical transmission (from a mother to her baby). (wikipedia.org)
  • Although kissing bugs are present in the US, Chagas disease transmission here is very rare. (poison.org)
  • The disease can spread via transmission from mother to child during pregnancy and from infected blood transfusions or organ transplantation. (medindia.net)
  • Chagas disease is a real public health problem due to the transmission from mother to child (baby) up to at least three generations," says co-author Dr. Momar Ndao, a scientist from the Infectious Diseases and Immunity in Global Health Program at the Research Institute of the McGill University Health Centre (RI-MUHC), and an associate professor in the Department of Medicine at McGill University. (medindia.net)
  • The overall risk of mother to fetus transmission of Chagas disease is only about 6 per cent but when the mother has a high number of parasites in her blood during pregnancy the risk of transmission has been described as high as 30 per cent," explains Dr. Plourde. (medindia.net)
  • Few studies have been done to determine the rate of congenital transmission of Chagas. (bu.edu)
  • Historically, disease control has been based on indoor residual spraying and the improvement of housing conditions in rural areas, but the absence of reliable surveillance has resulted in continued transmission. (biomedcentral.com)
  • Together with the low reports of R. prolixus (assumed to be the most common Chagas disease vector in Venezuela ), this has scientists taking a closer look at the role each vector might be playing in the transmission of Chagas disease in Venezuela. (biomedcentral.com)
  • Blood transfusion has been and continues to be a possible source of disease transmission. (medscape.com)
  • Despite the potential for disease transmission through transfused blood, the safety of the blood supply in the United States continues to improve and, in fact, is the greatest that it has ever been. (medscape.com)
  • Webinar for communicators and journalists on how to interrupt mother-to-child transmission of this neglected tropical disease. (coalicionchagas.org)
  • However, there are other routes of transmission such as food-borne, congenital, and blood transfusions, which have enabled the disease to spread to other continents. (meridianbioscience.com)
Vector borne3
  • A tropical blood parasite, which causes harmful vector borne diseases can cause harm to Canadians. (medindia.net)
  • Some of these risks come from diseases that many of us are already familiar with: Lyme disease, for example, which is carried by ticks, or West Nile virus, proliferated by mosquitoes - both vector-borne diseases spread by blood-sucking arachnids and insects. (grist.org)
  • With global temperatures rising, well-known vector-borne illnesses are becoming more common , and other, lesser-known diseases are spreading into new areas. (grist.org)