• citation needed] CETP inhibitors inhibit cholesterylester transfer protein (CETP), which normally transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins (VLDL or LDL). (wikipedia.org)
  • Lipid-poor HDL precursors mature by obtaining cholesterol and phospholipids from cell membranes or triglyceride-rich lipoproteins. (jci.org)
  • and APOC3, which slows the clearance of triglyceride-rich lipoproteins and their remnant lipoprotein particles, or RLPs, lipids that have been linked previously to cardiovascular disease. (asbmb.org)
  • Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
  • Moreover, thyroid hormones stimulate the cholesteryl ester transfer protein (CETP), an enzyme which transports cholesteryl esters from HDL2 to the very low density lipoproteins (VLDL) and triglycerides in the opposite direction 9 (figure). (hormones.gr)
  • Main lipid and protein components of high-density lipoproteins. (encyclopedia.pub)
  • Lipoproteins are composed of a neutral lipid (TAG, cholesteryl esters, or both) core surrounded by a shell of amphipathic apolipoproteins, phospholipid, and unesterified cholesterol. (pharmacy180.com)
  • Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. (bvsalud.org)
  • Because CETP helps in the transfer of cholesterol from HDL to other lipoproteins, CETP deficiency affects low-density lipoprotein (LDL) cholesterol levels and slows removal of HDL cholesterol from the blood. (msdmanuals.com)
  • The lipoproteins in CI-943 individual serum were tagged with [3H] lipid as well as the tagged LDL was isolated by thickness gradient ultracentrifugation as defined (65). (phytid.org)
  • Lipoproteins containing apoA-I [highdensity lipoprotein (HDL)] are key mediators in RCT, whereas non-high-density lipoproteins (non-HDL, lipoproteins containing apoB) are involved in the lipid delivery pathway. (anatoljcardiol.com)
  • This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). (biomedcentral.com)
  • Cholesterol travels in the blood in distinct particles containing both lipid and proteins (lipoproteins). (biomedcentral.com)
  • The Residual Risk Reduction Initiative (R 3 i) has previously highlighted atherogenic dyslipidaemia, defined as the imbalance between proatherogenic triglyceride-rich apolipoprotein B-containing-lipoproteins and antiatherogenic apolipoprotein A-I-lipoproteins (as in high-density lipoprotein, HDL), as an important modifiable contributor to lipid-related residual cardiovascular risk, especially in insulin-resistant conditions. (biomedcentral.com)
  • The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). (nih.gov)
  • The drug works by inhibiting cholesteryl ester transfer protein (CETP), which regulates the exchange of cholesterol and triglycerides between plasma lipoproteins. (chemistryworld.com)
  • Since the discovery of cholesteryl ester transfer protein (CETP) and its identification as a modulator of HDL-C levels (mediates the exchange of lipids between lipoproteins), there has been much speculation about its role in CAD [ 17 ]. (biomedcentral.com)
  • More recently, studies in mice with targeted inactivation of ABCA1 ( 11 ) have demonstrated a critical role of ABCA1 in lipid metabolism and confirmed its role in the biogenesis of HDL. (jci.org)
  • The enzyme PCSK9 protein regulates cholesterol metabolism by degrading the low-density lipoprotein receptor. (asbmb.org)
  • Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
  • Thyroid disorders are known to influence lipid metabolism and are common in dyslipidemic patients. (hormones.gr)
  • These changes in the lipid profile are explained by the regulatory effect of thyroid hormones on the activity of some key enzymes of lipoprotein metabolism. (hormones.gr)
  • The alterations in the lipid profile observed in different thyroid abnormalities, the effect of treatment of these disturbances on the restoration of lipid metabolism, as well as the potential clinical implications and therapeutic guidelines are briefly discussed. (hormones.gr)
  • Its actions on lipid metabolism intersect with multiple sleep regulatory mechanisms, but its effects on sleep have never been documented. (nature.com)
  • Sleep is particularly sensitive to shifts in lipid metabolism. (nature.com)
  • Given the long history of the clinical use of nicotinic acid and its complex actions on lipid metabolism, it is remarkable that its effects on sleep has never been documented. (nature.com)
  • Considering the reciprocal relationship between sleep and lipid metabolism, the complex actions of nicotinic acid on lipid metabolism and the existence of other multiple regulatory nodes where nicotinic acid may potentially modulate sleep, we investigated the effects of systemic administration of nicotinic acid on sleep. (nature.com)
  • Lipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. (bvsalud.org)
  • Candidate gene polymorphisms related to lipid metabolism in Asian Indians living in Durban, South Africa. (ox.ac.uk)
  • The same researchers published a paper last year in the journal Nutrition ​ ​ that indicated that baru nut consumption may help improve levels of HDL cholesterol and reduce waist sizes in overweight and obese women, and lead to significant reductions in cholesteryl ester transfer protein expression (CETP), a marker of lipid metabolism. (nutraingredients-latam.com)
  • Familiar combined hyperlipidemia (FCH) is the familiar occurrence of this disorder, probably caused by polymorphisms in molecules and enzymes that participate in lipoprotein metabolism, such as ApoCII and ApoCIII and CETP (cholesterylester transferring protein). (the-medical-dictionary.com)
  • Thus, from the HDL subclasses distribution point, when assessing the coronary heart disease(CHD) risk not only rely on the TC levels, but also the concentrations of TG, HDL-C and LDL-C must considered in case the potential risk for desirable TC subjects with other plasma lipids metabolism disorders. (biomedcentral.com)
  • In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)
  • Favourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. (biochemia-medica.com)
  • The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis. (biomedcentral.com)
  • CETP inhibitors do not reduce rates of mortality, heart attack, or stroke in patients already taking a statin. (wikipedia.org)
  • We've had our ups and downs with CETP inhibitors. (medscape.com)
  • Cholesteryl ester transfer protein (CETP) inhibitors are specific drugs designed to increase HDLC and HDL functions. (bvsalud.org)
  • Posthoc analyses of large clinical trials with CETP inhibitors have demonstrated their potential anti-diabetic properties. (bvsalud.org)
  • These include the next generation peroxisome proliferator-activated receptorα agonists, cholesteryl ester transfer protein inhibitors and monoclonal antibody therapy targeting proprotein convertase subtilisin/kexin type 9. (biomedcentral.com)
  • The launch of antidyslipidemic agents from two novel drug classes - proprotein convertase subtilisin/kexin type 9 (PCSK9) and cholesterylester transfer protein (CETP) inhibitors - will be the primary drivers of market growth during this period, and will offset the strong generalisation that has and will continue to impact this market to 2022, says the study, from Decision Resources. (pharmatimes.com)
  • Yet we see continued physician optimism for CETP inhibitors, which also primarily target HDL-C. While this enthusiasm is driven by their additional LDL-C-lowering ability, the pendulum appears to be swinging back to LDL-C as the most robust modifiable dyslipidemia target, according to experts we interviewed," says Dr Narang. (pharmatimes.com)
  • CETP Inhibitors (cholesteryl ester transfer protein inhibitors) are still under development. (wikidoc.org)
  • Roche (with their partners at Japan Tobacco) and Merck are known to be in the clinic with CETP inhibitors of their own. (chemistryworld.com)
  • A CETP inhibitor is a member of a class of drugs that inhibit cholesterylester transfer protein (CETP). (wikipedia.org)
  • JTT-705: is there still future for a CETP inhibitor after torcetrapib? (wikipedia.org)
  • Anacetrapib, a New CETP Inhibitor: The New Tool for the Management of Dyslipidemias? (wikipedia.org)
  • This is a cholesteryl ester transfer protein (CETP) inhibitor, and I'd like to get your take on that as well. (medscape.com)
  • Cholesteryl ester transfer protein (CETP) inhibitor. (adipogen.com)
  • The adverse effects of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib on cardiovascular outcome, which were observed despite a substantial increase in HDL levels, have suggested that a better understanding of the vascular effects of HDL from patients with CAD is urgently required. (health.am)
  • With the trial meeting its primary and secondary endpoints, results provide evidence use of the once-daily, oral, low-dose cholesteryl ester transfer protein (CETP) inhibitor from NewAmsterdam Pharma Company, in combination with ezetimibe, was associated with statistically significant and clinically meaningful reductions in LDL-C and apolipoprotein B (ApoB). (consultantlive.com)
  • 0.001) without an effect on biomarkers for oxidative stress (autoantibodies to epitopes of oxidized LDL, F2-isoprostanes, 8-hydroxy-2'deoxyguanosine), inflammation (C-reactive protein), or levels of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide. (the-medical-dictionary.com)
  • We look forward to sharing topline data from BROADWAY and BROOKLYN in the second half of 2024, as we work to establish obicetrapib as a next-generation CETP inhibitor for some of the world's most prevalent and debilitating diseases. (pawtuckettimes.com)
  • NewAmsterdam is developing obicetrapib, an oral, low-dose and once-daily cholesteryl ester transfer protein ("CETP") inhibitor, as the preferred LDL-C lowering therapy to be used as an adjunct to maximally tolerated statin therapy for high-risk cardiovascular disease patients. (pawtuckettimes.com)
  • Compared to traditional lipid-lowering drugs such as statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, HMGCRi), PCSK9i can regulate the immune function by suppressing dendritic cell (DC)-mediated T cell activation [ 13 ]. (biomedcentral.com)
  • The hamsters were fed diets rich in either fish oil or a MIX oil to investigate whether fish oil has beneficial effects in lowering plasma lipid and lipoprotein levels. (mun.ca)
  • Four hundred and eighty-six subjects, aged 33 to 78 years (56.1 ± 8.4), were recruited to participate in a study examining plasma lipid and apolipoprotein concentrations. (biomedcentral.com)
  • were recruited to participate in a study examining plasma lipid and apo concentrations at West China Medical Center, Sichuan University. (biomedcentral.com)
  • This CETP inhibition, which exchanges a triglyceride molecule for a cholesteryl ester molecule between HDL-C-containing and apolipoprotein B (ApoB)-containing particles, also this particular therapeutic has been shown in prior studies to decrease ApoB significantly and, actually, to even decrease Lp(a), which is interesting. (medscape.com)
  • Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones: H. Tomoda, et al. (adipogen.com)
  • The therapeutic approaches include CETP inhibition, peroxisome proliferator-activated receptor (PPAR) agonists, synthetic farnesoid X receptor agonists, and gene therapy. (anatoljcardiol.com)
  • Genetic and pharmacological studies support the hypothesis that CETP inhibition reduces cardiovascular risk by lowering LDL, which, by extension, may also lower VCID. (biomedcentral.com)
  • They are intended to reduce the risk of atherosclerosis (a cardiovascular disease) by improving blood lipid levels. (wikipedia.org)
  • Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by endothelial dysfunction, vascular inflammation, and the buildup of lipids, cholesterol, calcium, and cellular debris within the intima of the vessel wall. (medscape.com)
  • The basic purpose of the management of HA and related lipid abnormalities is to reduce the risk of atherosclerosis, which is the main mechanism of increased morbidity and mortality. (medscape.com)
  • They are intended to reduce the risk of atherosclerosis (a cardiovascular disease) by improving blood lipid levels.At least three medications within this class have failed to result in benefits however. (vondellhenderson.com)
  • Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)
  • Once advanced atherosclerotic plaques are established, the process by which they undergo a reduction in one or more standard parameters (size, lipid content, foam cell content, and macrophage inflammation) is termed atherosclerosis regression. (skanestugan.se)
  • HDL heterogeneity is the result of the activity of several factors that assemble and remodel HDL particles in plasma: ATP-binding cassette transporter A1 (ABCA1), lecithin cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP), hepatic lipase (HL), phospholipid transfer protein (PLTP), endothelial lipase (EL), and scavenger receptor class B type I (SR-BI). (anatoljcardiol.com)
  • Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation. (nih.gov)
  • PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
  • LBP belongs to a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). (assaygenie.com)
  • LBP catalyzes the transfer of LPS monomers from LPS aggregates to HDL particles, to phospholipid bilayers, and to a binding site on soluble CD14 (sCD14). (assaygenie.com)
  • High-density lipoprotein cholesterol (HDL-C), which consists mostly of cholesterol, phospholipid, and protein, is produced and secreted by the liver and intestine. (medscape.com)
  • The impairment of these pathways is partly dependent on cellular ATP-binding cassette transporter (ABC) A1-mediated efflux to lipid-poor apolipoprotein (apo) A-I in the extracellular space. (bvsalud.org)
  • These transporters promote unidirectional cholesterol efflux to lipid-poor apolipoprotein A-I (apoA-I), apoE, or HDL particles, respectively, and are under the transcriptional control of liver X receptors (LXRs), master intracellular sensors that are activated in response to cholesterol biosynthetic intermediates and oxysterols ( 11 , 12 ). (diabetesjournals.org)
  • The relationship between TaqIB gene polymorphism and the LMCAD was independent of lipid profile, with the exception of apolipoprotein A. (biomedcentral.com)
  • Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. (icr.ac.uk)
  • The plasma cholesteryl ester transfer protein (CETP) activity in fish oil fed hamsters was lower compared to the MIX diet fed hamsters, thus this increase in LDL-cholesterol concentration and decrease in HDL-cholesterol concentration in fish oil fed hamsters are not a result of increased CETP activity. (mun.ca)
  • In cooperation with bactericidal permeability-increasing protein (BPI), LBP binds LPS and interacts with the CD14 receptor, most likely playing a role in regulating LPS-dependent monocyte responses. (assaygenie.com)
  • The LDL:HDL ratio in humans is set mainly by CETP activity, which exchanges cholesteryl esters for triglycerides across lipoprotein fractions to raise LDL and lower HDL as CETP activity increases. (biomedcentral.com)
  • Association between the PLTP rs4810479 SNP and Serum Lipid Traits in the Chinese Maonan and Han Populations. (nih.gov)
  • These lipid disorders may occur in primary (inherited) [ 5 - 7 ] or secondary form [ 8 ]. (hindawi.com)
  • Overview of Cholesterol and Lipid Disorders The body needs fats (lipids) for growth and energy. (msdmanuals.com)
  • Finally, we discuss recent publications revealing the association of CETP single nucleotide polymorphisms (SNPs) with the risk of cardiovascular and metabolic diseases, lifestyle factors, diet and therapeutic interventions. (bvsalud.org)
  • and 3) describing the functions of cholesteryl ester transfer protein (CETP) in regulating the LDL:HDL ratio in humans, including therapeutic strategies targeting CETP. (biomedcentral.com)
  • Cholesterol ester transfer protein (CETP) Taq1B polymorphism influences the effect of a standardized cardiac rehabilitation program on lipid risk markers. (cdc.gov)
  • Overt and subclinical hypothyroidism have an adverse effect on the serum lipid profile that may predispose to the development of atherosclerotic disease. (hormones.gr)
  • Cholesteryl ester transfer protein (CETP) deficiency is a rare autosomal recessive disorder caused by a mutation of the CETP gene. (msdmanuals.com)
  • In normolipidemic subjects, the absence of the TaqIB restriction site (B2 allele) is associated with decreased CETP activity and, in turn, increased HDL-C levels [ 19 ] resembling a mild form of CETP deficiency. (biomedcentral.com)
  • Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highly regulated in macrophages and mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for HDL formation. (jci.org)
  • Indeed, the capacity of HDL to mediate cholesterol efflux from lipid-laden macrophages has been observed to be impaired after substantial oxidative modification of HDL by myeloperoxidase or malondialdehyde, a lipid peroxidation product, as observed in atherosclerotic plaques. (health.am)
  • While LXR-deficient mice are leaner than littermate controls and are protected against diet-induced obesity, the mechanisms that control fat loss in these mice are still a matter of debate and could involve either reduced lipogenesis, enhanced lipid oxidation and lipolysis, or reduced cholesterol efflux pathways ( 14 ). (diabetesjournals.org)
  • Considering the potential detrimental role of LDL in AD and the importance of HDL's beneficial effects on endothelial cells, high CETP activity may lead to compromised BBB integrity, increased CAA deposits and greater neuroinflammation. (biomedcentral.com)
  • The ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing BI 6727 molecular weight protein (ASPP) family of proteins regulates apoptosis through interaction with p53 and its family members. (coxsignal.com)
  • Determining how lipid pathways and cardiovascular disease are linked is a complex and rapidly evolving quest. (asbmb.org)
  • These findings suggest that PCSK9i may be involved in the pathogenesis of autoimmune diseases through pathways other than lipid-lowering. (biomedcentral.com)
  • In addition, in our previous study, we observed reduction of abdominal adiposity after intervention with baru almond [Nutrition, 2018, 55-56, 154-160], which may have contributed to the increase of GPx activity, since the reduction of body fat seems to reduce the downregulation in gene and protein expression from antioxidant enzymes such as GPx. (nutraingredients-latam.com)
  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
  • The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP. (biomedcentral.com)
  • Thus the studies evaluating the influence of CETP gene polymorphisms in humans are essential. (biomedcentral.com)
  • The CETP gene is located on chromosome 16q21. (biomedcentral.com)
  • Widely studied CETP variants is a silent base change called the Thermobius aquaticus IB (TaqIB) affecting the 277th nucleotide in the first intron of the CETP gene [ 18 ]. (biomedcentral.com)
  • Despite cholesterol being delivered as cholesteryl ester in adipocytes, approximately 95% of cholesterol paradoxically exists as free cholesterol (FC) ( 7 ) and resides in the plasma membrane or the cytosolic interface of lipid droplets where it is readily available for mobilization ( 8 ). (diabetesjournals.org)
  • Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 National Heart, Lung, and Blood Institute Workshop. (skanestugan.se)
  • probably because the disease also causes other changes in lipid levels and other abnormalities in the way the body breaks down food. (msdmanuals.com)
  • The R 3 i believes that monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk. (biomedcentral.com)
  • The hepatic microsomal triglyceride transfer protein (MTTP) activity was not significantly altered by fish oil, suggesting that increased levels of plasma VLDL is not due to increased production in the liver. (mun.ca)
  • 2 "The data presented today are highly encouraging, showing that the combination of obicetrapib and ezetimibe delivers robust impacts on multiple atherogenic lipid parameters. (consultantlive.com)
  • For one thing, it's not clear whether torcetrapib failed because of its CETP activity, or just because it there was something odd about torcetrapib itself. (chemistryworld.com)
  • Data from the phase 2 ROSE2 study presented at the National Lipid Association (NLA) Scientific Sessions 2023 is highlighting the potential of obicetrapib plus ezetimibe as an adjunct to statin therapy for improving management of dyslipidemia . (consultantlive.com)
  • At the National Lipid Association ("NLA") Scientific Sessions in June 2023, NewAmsterdam presented full data from the Phase 2 ROSE2 trial evaluating obicetrapib in combination with ezetimibe as an adjunct to high intensity statin therapy. (pawtuckettimes.com)
  • CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk of cardiovascular and metabolic diseases. (bvsalud.org)
  • Furthermore, we focus on recent experiments on animal CETP-expressing models, deciphering the regulation and functions of CETP in various genetic backgrounds and interaction with different external factors. (bvsalud.org)
  • Genetic restoration of CETP expression in mice to generate a more human-like lipid profile may increase the relevance of murine models for VCID studies. (biomedcentral.com)
  • However, when the researchers injected purified LPS into mice to simulate infection, the mice that were genetically altered to express CETP cleared endotoxins at a slower rate than mice who expressed no CETP. (asbmb.org)
  • Study of effect modifiers of genetically predicted CETP reduction. (pharmacogenomics.ca)
  • Protein-containing fractions had been pooled and focused 10-flip (30 kDa MWCO concentrators, Sartorius). (phytid.org)
  • Fractions containing CETP were concentrated and pooled 10-flip and CI-943 stored in 4C. (phytid.org)
  • Thompson A, Angelantonio ED, Sarwar N, Erqou S, Saleheen D, Dullaart RPF, Ye Z , Danesh J. (2008) Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels and coronary risk. (cam.ac.uk)
  • In vitro fluorogenic assays of CETP-mediated TG and CE transfer For perseverance of in vitro CETP transfer activity, a continuing fluorogenic assay defined previously (64) was utilized. (phytid.org)
  • Low CETP activity is associated with better cardiovascular health, due to decreased LDL and increased HDL, which may also improve brain health. (biomedcentral.com)
  • Less CETP activity essentially means more HDL, which helps to reduce the build up of fatty atherosclerotic plaques that block blood vessels. (chemistryworld.com)
  • Increases in HDL-C levels may also be attributable to decreasing plasma cholesteryl ester transfer protein (CETP) activity by statins. (medscape.com)
  • Four immunological assays detected essentially no FXIII protein, FXIII-A antigen, and A2B2 antigen, but normal FXIII-B antigen. (coxsignal.com)
  • And then we have high-sensitivity C-reactive protein, or CRP, which is a general measure of inflammation in the body. (nourishedbyscience.com)
  • Lipopolysaccharide binding protein (aka LBP) is a plasma protein which facilitates the diffusion of bacterial LPS (endotoxin). (assaygenie.com)
  • Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
  • I'm very happy to be here today to discuss clinical research in lipid-lowering therapies and lipoprotein-lowering therapies with my colleagues, Drs Budoff and Shubrook. (medscape.com)
  • This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. (hindawi.com)
  • The failure of non-statin drugs to demonstrate a cardiovascular outcomes benefit above that of statin therapy in clinical trials has further cemented the first-line status of the statin class, and eroded physician willingness to address residual risk by normalising non-LDL [low-density lipoprotein] lipids," comments Decision Resources analyst Pam Narang. (pharmatimes.com)
  • JPEG 196 kb) 441_2012_1490_MOESM4_ESM.jpg (195K) GUID:?851FD4CF-998A-45EE-BC20-96F98A53E982 Abstract Despite being initially recognized in mice, little is known about the sites of production of users of the BPI fold (BPIF) containing (PLUNC) family of putative innate defence proteins in this species. (revoluciondelosgladiolos.org)
  • Studies with animal models have been limited, because many species do not express a functional CETP protein and are not reliable to provide strong evidence for CETP's role in disease. (biomedcentral.com)
  • Both studies met their primary endpoints, achieving statistically significant and clinically meaningful reductions in LDL-C, as well as improvements in additional lipid and lipoprotein parameters that we believe are predictive of cardiovascular disease risk. (pawtuckettimes.com)
  • Kanter and Bornfeldt recently published fluorescence microscopy images of atherosclerotic lesions in a mouse with induced Type 1 diabetes in the Journal of Lipid Research . (asbmb.org)
  • The CETP-expressing mice also had worse sepsis outcomes. (asbmb.org)
  • Unlike humans, wild-type mice do not express catalytically active CETP and have HDL as their major lipoprotein fraction. (biomedcentral.com)
  • In 2013, the American Heart Association reported that proportions of American adults aged 20 or above had abnormal blood lipid serum profile (details are shown in Table 1 ) [ 4 ]. (hindawi.com)
  • If a high HDL level is found in a person who is not taking lipid-lowering drugs, doctors look for the cause of the elevation. (msdmanuals.com)
  • They are called lipid-lowering drugs (LLD) or agents. (wikidoc.org)
  • Consequently, dyslipidemia may be implicated in the pathogenesis and progression of autoimmune diseases, but the effects of various lipid-lowering drugs on autoimmune diseases warrant further investigation. (biomedcentral.com)
  • Compounds had been preincubated with CETP and HDL donor contaminants for either 1 or 24 h before addition of VLDL/LDL acceptor contaminants. (phytid.org)
  • Built for binding lipids, most of the compounds that can alter its function have to be large and greasy themselves, and that never helps a drug's chances. (chemistryworld.com)
  • 2001), and subsequently made the key observation that PLUNC belongs to a group of proteins that make up the largest ERK5-IN-1 branch of a lipid transfer protein family. (revoluciondelosgladiolos.org)
  • 2004). Structural similarity across the PLUNC/BPI family suggested that these proteins would function by binding lipid molecules (Beamer et al. (revoluciondelosgladiolos.org)
  • 2002). PLUNC proteins are encoded by genes in a single locus on human chromosome 20q11, and conserved loci are found in all mammals. (revoluciondelosgladiolos.org)
  • PLUNC proteins encoded by these genes were originally grouped into short (SPLUNC1 etc.) and long (LPLUNC1 etc.) proteins on the basis of structural homology to the domains of BPI, with SPLUNCs having structural similarity to the N-terminal domain name of BPI, and LPLUNCs having structural similarity to both domains (Bingle and Craven. (revoluciondelosgladiolos.org)
  • Hyperthyroidism may be the underlying cause for acquired hypocholesterolemia or unexpected improvement of the lipid profile of a previously hyperlipidemic patient. (hormones.gr)
  • Most individuals are diagnosed with hypoalphalipoproteinemia (HA) based on the results of a routine lipid profile measurement. (medscape.com)
  • Hui (2019) looked at an association between breastfeeding in the first three months of life with lipid profile and adiposity at around 17.5 years in a population in Hong Kong. (breastfeedingnetwork.org.uk)
  • Aloïs Dusuel and colleagues at the University of Burgundy recently published findings in the Journal of Lipid Research that a protein tightly related to key players of the RLT pathway, cholesteryl ester transfer protein, or CETP, does not contribute to the binding and transfer of LPS in plasma. (asbmb.org)