Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. (wikipedia.org)
Plasma triglyceride-rich lipoproteins (TRLs), including chylomicrons and very low-density lipoprotein (VLDL), were collected via ultracentrifugation to evaluate their cytotoxic effects on primary pancreatic acinar cells (PACs). (omicsdi.org)
Since the discovery of cholesteryl ester transfer protein (CETP) and its identification as a modulator of HDL-C levels (mediates the exchange of lipids between lipoproteins), there has been much speculation about its role in CAD [ 17 ]. (biomedcentral.com)
Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. (biomedcentral.com)
Circulating triglyceride-rich lipoproteins from hypertriglyceridemic subjects mediated endothelial inflammation and drive monocyte infiltration into the wall of arterial [ 9 ]. (biomedcentral.com)
Cholesteryl2
Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride. (wikipedia.org)
According to this definition, MetS is diagnosed when there are present at least three of the following five MetS features: abdominal obesity, elevated blood pressure, dyslipidemia (elevated triglycerides and low levels of high-density lipoprotein cholesterol), and hyperglycemia. (biomedcentral.com)
Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
Nephrotic syndrome results in increased concentrations of total serum cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and a variable concentration of serum high-density lipoprotein cholesterol (HDL-C) ( 2 ). (biochemia-medica.com)
16q211
The CETP gene is located on chromosome 16 (16q21). (wikipedia.org)
Inhibitors3
The crystal structure of CETP has been obtained with bound CETP inhibitors. (wikipedia.org)
Two CETP inhibitors were previously under development. (wikipedia.org)
Roche (with their partners at Japan Tobacco) and Merck are known to be in the clinic with CETP inhibitors of their own. (chemistryworld.com)
Torcetrapib1
For one thing, it's not clear whether torcetrapib failed because of its CETP activity, or just because it there was something odd about torcetrapib itself. (chemistryworld.com)
Lipid3
The crystal structure of CETP is that of dimer of two TUbular LIPid (TULIP) binding domains. (wikipedia.org)
However, this has not resolved the doubt over whether CETP function as a lipid tube or shuttle. (wikipedia.org)
Results A total of 15 eligible studies were selected according to the inclusion and exclusion criteria, and the data on blood lipid level were collected from 1 435 healthy elderly people and 2 162 elderly people with AD. (zgggws.com)
I405V2
In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity and to metabolic response to nutritional intervention. (wikipedia.org)
The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported healthy (Controls)] was analyzed for the frequency of TaqIB and I405V polymorphisms in the gene coding CETP. (biomedcentral.com)
Coronary heart d1
The D442G mutation, which lowers CETP levels and increases HDL levels also increases coronary heart disease. (wikipedia.org)
Variants1
Widely studied CETP variants is a silent base change called the Thermobius aquaticus IB (TaqIB) affecting the 277th nucleotide in the first intron of the CETP gene [ 18 ]. (biomedcentral.com)
Gene1
Thus the studies evaluating the influence of CETP gene polymorphisms in humans are essential. (biomedcentral.com)
Fatty2
Less CETP activity essentially means more HDL, which helps to reduce the build up of fatty atherosclerotic plaques that block blood vessels. (chemistryworld.com)
A fat tolerance test evidenced delayed plasma triglyceride clearance and greater transient availability of non-esterified fatty acids (NEFA) during the post-prandial state in the apoCIII mice plasma. (biomedcentral.com)
Metabolic syndrome1
As HDL can alleviate atherosclerosis and other cardiovascular diseases, and certain disease states such as the metabolic syndrome feature low HDL, pharmacological inhibition of CETP is being studied as a method of improving HDL levels. (wikipedia.org)
Plasma3
Plasma and CSF samples were collected at several time points before and after treatment. (cdc.gov)
Severe pancreatic injury with large areas of pancreatic necrosis in the entire lobule was induced in Gpihbp1-/- mice when plasma triglyceride levels were greater than 2000 mg/dL. (omicsdi.org)
The cultures of affected tissues forming two continuous total CETP fees( buy there is no theory of everything a and email) indicate not Optionally moved before any plasma imaging can personalize Provided about the network of these personal biofuels to be medicinal rotation. (green-frontier.de)
Levels2
However, ApoC3-tg mice with the same triglyceride levels did not develop large areas of pancreatic necrosis, even upon the administration of poloxamer 407 to further increase triglyceride levels. (omicsdi.org)
In normolipidemic subjects, the absence of the TaqIB restriction site (B2 allele) is associated with decreased CETP activity and, in turn, increased HDL-C levels [ 19 ] resembling a mild form of CETP deficiency. (biomedcentral.com)
PCSK91
We collected single nucleotide polymorphisms (SNPs) of PCSK9 from published genome-wide association studies statistics and conducted drug target MR analysis to detect the causal relationship between PCSK9 inhibitor and the risk of autoimmune diseases. (biomedcentral.com)
Samples were collected1
Blood samples were collected and biochemical analyses were performed. (biomedcentral.com)
Activity1
Elaidic acid, a major component of trans fat, increases CETP activity. (wikipedia.org)
Time1
The data collected for all patients during hospitalization at the BTC were as follows: existence of chronic illness, requirement for mechanical ventilation, Simplified Acute Physiology Score 3 (SAPS 3) and Sequential Organ Failure Assessment (SOFA) on the first day of hospitalization in an intensive care bed in the burn treatment unit (BTU), health-related infection, feeding route, length of hospital stay, and time spent in the BTU. (bvsalud.org)
Data1
Data was collected through a detailed questionnaire and physical examination. (biomedcentral.com)
Studies1
Studies with animal models have been limited, because many species do not express a functional CETP protein and are not reliable to provide strong evidence for CETP's role in disease. (biomedcentral.com)
Patients1
There is no significant difference in CETP allele frequency or genotype distribution among LMCAD and MPCAD patients although there is statistical difference between LMCAD and Controls (p = 0.001). (biomedcentral.com)
High-density lip2
We report GWAS results for nine quantitative metabolic traits (triglycerides, high-density lipoprotein, low-density lipoprotein, glucose, insulin, C-reactive protein, body mass index, and systolic and diastolic blood pressure) in the Northern Finland Birth Cohort 1966 (NFBC1966), drawn from the most genetically isolated Finnish regions. (nature.com)
Nephrotic syndrome results in increased concentrations of total serum cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and a variable concentration of serum high-density lipoprotein cholesterol (HDL-C) ( 2 ). (biochemia-medica.com)
Lipoprotein particles1
This score, derived from nuclear magnetic resonance (NMR) measurements, captures the accumulation of triglyceride-rich, very low-density lipoprotein particles (VLDL-P), and the consequent increase in small LDL particles (LDL-P) and reduction in large HDL particles (HDL-P) [ 10 ]. (biomedcentral.com)
Particles2
Due to the elevation of triglyceride concentration, both VLDLs and chylomicron particles remain in circulation for longer periods. (medscape.com)
Increased activity of CETP under these conditions drives the production of small, dense atherogenic triglyceride-rich LDL particles. (medscape.com)
Polymorphism2
In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity and to metabolic response to nutritional intervention. (wikipedia.org)
Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in altering on CVD risk factors among type 2 diabetes mellitus (T2DM). (nih.gov)
Differential methylation is found within genes associated with obesity, epigenetic regulation and development, such as CETP , FOXP2 , HDAC4 , DNMT3B , KCNQ1 and HOX clusters. (biomedcentral.com)
Cardiovascular1
As HDL can alleviate atherosclerosis and other cardiovascular diseases, and certain disease states such as the metabolic syndrome feature low HDL, pharmacological inhibition of CETP is being studied as a method of improving HDL levels. (wikipedia.org)
Development1
Two CETP inhibitors were previously under development. (wikipedia.org)