Diazinon caused an inhibition of carboxylesterase (CES) and acetylcholinesterase (AChE) activity in zebrafish larvae, diuron inhibited AChE activity in in vitro testing, and both pesticides significantly affected gene expression and activities of some of the cytochrome P450 (CYP) family enzymes. (springeropen.com)
However, no thorough assessment of their potential to inhibit the major hepatic hydrolase, carboxylesterase 1 (CES1), exists. (inra.fr)
In vitro studies suggest CBD may inhibit a number of drug-metabolizing enzymes, including carboxylesterase 1 (CES1). (inra.fr)
Protein1
This review will be useful in understanding the molecular basis and structural protein of bacterial CEs that are significant for the advancement of enzymology field in industries. (afpm.org.my)
Hydrolysis3
Carboxylesterase 1 is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds (1, 2). (rndsystems.com)
Highly specific hydrolysis of α-1,3-linked L-arabinofuranose residues from doubly substituted D-xylosyl or L-arabinosyl residues of arabinoxylans and branched arabinans, respectively. (megazyme.com)
A range of α-L-arabinofuranosyl-(1-4)-β-D-xylo-oligosaccharides (AXOS) were produced by hydrolysis of wheat flour arabinoxylan (WAX) and acid debranched arabinoxylan (ADWAX), in the presence and absence of an AXH-d3 α-L-arabinofuranosidase, by several GH10 and GH11 β-xylanases. (megazyme.com)
Carboxylesterases2
Carboxylesterases (CEs) are members of prominent esterase, and as their name imply, they catalyze the cleavage of ester linkages. (afpm.org.my)
Carboxylesterases (CEs) are hydrolytic enzymes involved in anticancer drug metabolism. (magnusgroup.org)
Le génome de C. phytofermentans code pour 171 enzymes qui dégradent les polysaccharides (CAZymes), soulignant l'ensemble complexe d'enzymes nécessaires pour transformer la biomasse en sucres. (cea.fr)
Gene2
Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. (wikipedia.org)
This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. (cancerindex.org)
Molecular1
The structure of YahD was determined by molecular replacement using B. cereus carboxylesterase atomic coordinates as a search model as described in Materials and methods. (dna-metabolism.com)
Member of a large1
Carboxylesterase 2 is a member of a large multigene family. (wikipedia.org)
Human1
Carboxylesterase modification (With lithium) As therapeutic enzyme for human Brain diseases. (magnusgroup.org)
Potential1
In addition, the potential biotechnological applications of bacterial CEs are also encompassed. (afpm.org.my)
Range1
The refinement statistics of the final model against all data in the resolution range of 40.00-1.88 are shown in Table 1. (dna-metabolism.com)
Significant1
The results showed a significant increase of GSH after 1 h exposure of zebrafish larvae to both diazinon and diuron. (springeropen.com)
Year2
Optical coherence tomography-guided percutaneous coronary intervention recipients were assessed for underlying ACS causes and followed up for major adverse cardiac events (cardiovascular death, myocardial infarction, heart failure, or ischemia-driven revascularization) at 1 year. (bvsalud.org)
The mortality and heart failure hospitalization rates at 1 year were 12.3% and 15.0%, respectively. (bvsalud.org)
Applications1
Notre objectif est de comprendre la biologie de ces bactéries et de traduire cette connaissance en applications dans la médecine, la gestion environnementale, et les énergies renouvelables. (cea.fr)
Responsible for the hydrolysis1
Carboxylesterase 1 is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds (1, 2). (rndsystems.com)
Intestine1
Many cytochrome P450 family members such as Cyp1a, Cyp2b10, Cyp2c, and most Cyp3a members, as well as carboxylesterase (Ces) 2a were expressed lower in the intestine of GF than CV mice. (nih.gov)
Liver2
In addition, sofosbuvir, like dabigatran etexilate ( Pradaxa , Boehringer Ingelheim), is a prodrug that requires conversion by liveresterases (such as carboxylesterase 1 [CES-1]) to its active metabolite, GS-331007. (medscape.com)
We hypothesized that genetic variation in CES genes expressed in the liver could affect INH-induced hepatotoxicity. (nih.gov)
Member1
Carboxylesterase 2 is a member of a large multigene family. (wikipedia.org)
Products1
Severe acute exacerbations of hepatitis B (HBV) have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine and/or tenofovir disoproxil fumarate (TDF), and may occur with discontinuation of SYMTUZA. (nih.gov)
Effects1
Szafran, Brittany Nichole, "The role of the endocannabinoid system in immune homeostasis with an emphasis on the immune effects of carboxylesterase inhibition by chlorpyrifos in murine lung tissue" (2021). (msstate.edu)
Human Immun1
Although combination antiretroviral therapy (cART) has improved the health of millions of those living with HIV-1 (Human Immunodeficiency Virus, Type 1), the penetration into the central nervous system (CNS) of many such therapies is limited, thereby resulting in residual neurocognitive impairment commonly referred to as NeuroHIV. (inra.fr)
Patients1
As reported by heart wire , the US FDA recently announced a change in labeling for the hepatitis-C antivirals ledipasvir/sofosbuvir ( Harvoni , Gilead Sciences) and sofosbuvir ( Sovaldi , Gilead Sciences) after their manufacturers reported bradycardia, pacemaker intervention, and even death in patients who took the medications along with amiodarone [ 1 ] . (medscape.com)
Higher2
The combined results were shown as relative risks (RRs) with 95% confidence intervals (CI) for per 1 standard deviation (SD) higher value of Lp-PLA2 and the highest versus lowest Lp-PLA2 category. (inra.fr)
In contrast, GF mice had higher intestinal expression of some phase I oxidases (alcohol dehydrogenase 1, aldehyde dehydrogenase a1l1 and 4a1, as well as flavin monooxygenase 5) and phase II conjugation enzymes (UDP-glucuronosyltransferase 1a1, and sulfotransferase 1c2, 1d1, and 2b1). (nih.gov)
Previous1
Our previous study has demonstrated that both HIV-1 Tat as well as opiates such as morphine, can directly induce synaptic alterations via independent pathways. (inra.fr)
Role1
Overall, Ces enzymes appear to play a role in immune homeostasis either through a protective mechanism or a negative feedback mechanism to control inflammation. (msstate.edu)