• Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. (medscape.org)
  • IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk. (medscape.org)
  • Bevacizumab was recently approved for use in advanced cervical cancer and platinum-resistant ovarian cancer. (cancernetwork.com)
  • The overall survival advantage bevacizumab confers in advanced cervical cancer prompted a paradigm shift in the standard of care for this disease. (cancernetwork.com)
  • In August 2014, the US Food and Drug Administration (FDA) approved bevacizumab for the treatment of advanced cervical cancer, the first gynecologic cancer for which an anti-angiogenic agent has demonstrated an advantage in overall survival (OS). (cancernetwork.com)
  • This review evaluated whether giving additional anticancer drugs (ACTs) after standard treatment could help women with locally advanced cervical cancer to live longer compared with standard treatment alone. (cochrane.org)
  • We searched the literature to March 2014 and identified two randomised controlled trials comparing standard treatment versus standard treatment plus ACT in women with locally advanced cervical cancer. (cochrane.org)
  • We found insufficient evidence to support giving additional anticancer drugs to women who have received standard treatment for locally advanced cervical cancer, as currently only limited data are available from two very different trials. (cochrane.org)
  • However, inconsistency in trial design, inclusion criteria for participants, interventions and survival benefit has been noted among trials of ACT after CCRT for locally advanced cervical cancer (LACC). (cochrane.org)
  • To evaluate the effect of adjuvant chemotherapy (ACT) after concurrent chemoradiation (CCRT) on survival of women with locally advanced cervical cancer compared with CCRT alone. (cochrane.org)
  • Concurrent chemo-radiotherapy is the usual treatment for locally advanced cervical cancer. (oncologyradiotherapy.com)
  • A better understanding of locally advanced cervical cancer (LACC) is mandatory for further improving the rates of disease control, since a significant proportion of patients still fail to respond or undergo relapse after concurrent chemoradiation treatment (CRT), and survival for these patients has generally remained poor. (biomedcentral.com)
  • Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: first results of the randomized PORTEC-2 trial. (medscape.org)
  • BACKGROUND: HAPPY (Humanity Assurance Protocol in interventional radiotherapy) reports the necessity for gynecological cancer patients to undergo interventional radiotherapy (IRT, also called brachytherapy). (bvsalud.org)
  • For patients who are medically inoperable or who refuse surgery, pelvic external beam radiation with brachytherapy (generally dosed at 70-80 Gy to total point A dose) is a treatment option. (medscape.com)
  • Brachytherapy as a form of treatment for gynecological tumors has been used for a long time in Brazil (since 1991) and can be considered as a form of radiotherapy treatment. (biomedcentral.com)
  • High Dose Rate (HDR) brachytherapy aims at delivering high dose rates of radiation in restricted volumes of the body, thereby increasing disease control and lower treatment toxicity for adjacent normal tissues. (biomedcentral.com)
  • High Dose Rate brachytherapy (HDR) is a therapeutic modality of radiotherapy in which radioactive sources are used in close contact with the region to be treated. (biomedcentral.com)
  • Over time, brachytherapy has been consolidated and has become a safe technique for patients with cervical tumors and with very satisfactory results of regression and even cure of the tumor [ 1 ]. (biomedcentral.com)
  • In these stages, if the patient has a clinical contraindication or if she does not accept the surgery, the choice becomes exclusive radiotherapy, using teletherapy supplemented by brachytherapy. (biomedcentral.com)
  • Among the treatments for improving survival in women with high-risk and early-stage endometrial cancer are radiation plus chemotherapy, vaginal cuff brachytherapy plus chemotherapy, and adjuvant chemotherapy. (medpagetoday.com)
  • The first study was the Phase III randomized Gynecologic Oncology Group (GOG)-249 trial, which compared vaginal cuff brachytherapy plus chemotherapy with pelvic radiation therapy for endometrial cancer, with a principal focus on recurrence-free survival. (medpagetoday.com)
  • Improving survival in women with high-risk, early-stage (stages I-II) endometrial cancer has been the goal of research exploring various modalities such as radiation plus chemotherapy, vaginal cuff brachytherapy plus chemotherapy, and adjuvant chemotherapy. (medpagetoday.com)
  • The Phase III randomized Gynecologic Oncology Group (GOG)-249 trial, presented at the most recent American Society for Radiation Oncology (ASTRO) annual meeting , compared vaginal cuff brachytherapy plus chemotherapy with pelvic radiation therapy for the treatment of stage I-II high-risk, early-stage endometrial cancer. (medpagetoday.com)
  • Of the 601 patients accrued, 301 were assigned to the pelvic external-beam radiation therapy (PXRT) arm and 300 were assigned to the vaginal cuff brachytherapy and chemotherapy (VCB/C) arm. (medpagetoday.com)
  • It also suggests that the trend in our field of abandoning pelvic radiation in favor of chemotherapy-brachytherapy combinations for high-risk patients is premature and not supported by clinical evidence. (medpagetoday.com)
  • Combination of radiation therapy and chemotherapy in treating solid malignant tumors, systematic radiation therapy of cutaneous lymphoma with electrons, development of new techniques of exterior radiation therapy, brachytherapy, and intraoperative radiotherapy, quality control of radiation therapy. (dramedical.com)
  • Tolerance of the vaginal vault to high-dose rate brachytherapy and concomitant chemo-pelvic irradiation: Long-term perspective. (dramedical.com)
  • Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sexual intercourse. (wikipedia.org)
  • Also, moderate pain during sexual intercourse and vaginal discharge are symptoms of cervical cancer. (wikipedia.org)
  • The overall survival rate was 91% for PXRT versus 88% for VCB/C. While no differences were seen between vaginal or distant failure, pelvic or para-aortic nodal recurrences were more common in the patients receiving VCB/C (25 versus 12). (medpagetoday.com)
  • According to the recommendations by the Society of Gynecologic Oncology (SGO) and the National Comprehensive Cancer Network (NCCN), histories and physical examinations at each visit and annual cervical/vaginal cytologies are recommended during post-treatment surveillance. (koreamed.org)
  • To the best of our knowledge, our case is the sixth case that primary adenosarcomas arising in vaginal endometriosis and it is the first case living without chemo-therapy or radiotherapy. (scirp.org)
  • In March 1998, the patient was found to have multiple polys in the vaginal posterior fornix and a fistula that was at the posterior fornix and extended to the pelvic cavity. (scirp.org)
  • the first symptom of cervical cancer is usually irregular, often postcoital, vaginal bleeding. (msdmanuals.com)
  • Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. (medscape.org)
  • Intensity-modulated radiation therapy after hysterectomy: comparison with conventional treatment and sensitivity of the normal-tissue-sparing effect to margin size. (medscape.org)
  • Images show initial anteroposterior (AP, left) and lateral (right) fields used for postoperative adjuvant pelvic external-beam radiotherapy in a patient with stage IC grade 2 adenocarcinoma of the endometrium who underwent hysterectomy. (medscape.com)
  • Medically operable patients with stage IA2 tumors are treated with radical hysterectomy or radical trachelectomy with pelvic lymph node dissection. (medscape.com)
  • However, if there is lymphovascular invasion, radical hysterectomy and pelvic lymphadenectomy, or sentinel lymph node technique can be indicated. (biomedcentral.com)
  • Feasibility Study of Adjuvant Chemotherapy Using Taxane Plus Carboplatin for High-Risk Patients With Uterine Cervical Non-Squamous Cell Carcinoma After Radical Hysterectomy. (sgsg.biz)
  • She had endometriosis and has undergone supra-cervical hysterectomy. (scirp.org)
  • Marie Plante, MD, of Canada's Université Laval and the CHUQ Hotel Dieu de Québec, discusses phase III results from a study that compared radical hysterectomy and pelvic node dissection vs simple hysterectomy and pelvic node dissection in patients with low-risk early-stage cervical cancer. (ascopost.com)
  • Gynecologic cancers were among the first malignancies treated with ionizing radiation, more than a century ago. (medscape.com)
  • In this article, clinical indications and common techniques for radiation therapy in the management of common gynecologic cancers are described. (medscape.com)
  • Adjuvant systemic therapy and radiotherapy are often given following surgery for many types of cancer, including colon cancer, lung cancer, pancreatic cancer, breast cancer, prostate cancer, and some gynaecological cancers. (wikipedia.org)
  • citation needed] Hyperthermia therapy or heat therapy is also a kind of adjuvant therapy that is sometimes given in combination with radiotherapy or chemotherapy to boost the effects of these conventional treatments in treating advanced cancers. (wikipedia.org)
  • The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers. (medsci.org)
  • An estimated 371 000 new cases of invasive cervical cancer are diagnosed world wide each year, representing nearly 10% of all cancers in women. (cmaj.ca)
  • HPV 16 and 18 strains are responsible for nearly 50% of high grade cervical pre-cancers. (wikipedia.org)
  • HPV vaccines protect against two to seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers. (wikipedia.org)
  • About 70% of cervical cancers and 90% of deaths occur in developing countries. (wikipedia.org)
  • Tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) testing using a validated/US Food and Drug Administration- approved test is recommended for all metastatic cervical cancers (category 2A). (medscape.com)
  • The cause of most cervical cancers is human papillomavirus (HPV) infection. (msdmanuals.com)
  • Other frequently involved regions include 10q, 3p, and 18q, with no significant differences found in the chromosomal regions involved in endometrial from cervical cancers. (medmuv.com)
  • 52 patients were with stage I endometrial cancer, whereas 3/3 patients with cervical cancer had locally advanced stages (IIB-IVA). (bvsalud.org)
  • Can additional chemotherapy after initial treatment for locally advanced stage cervical cancer reduce recurrence and extend life? (cochrane.org)
  • Standard treatment for locally advanced stage cervical cancer (stage IIB to IVA) is 'concurrent chemoradiation' when anticancer drugs are given during the same treatment period as pelvic radiotherapy (radiation therapy to lower abdomen). (cochrane.org)
  • Current standard treatment for patients with cervical cancer who have locally advanced stage disease (International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IVA) is concurrent chemoradiation therapy (CCRT). (cochrane.org)
  • The primary therapy for early stage cervical cancer is surgery and that for locally advanced disease is concurrent chemoradiotherapy. (koreamed.org)
  • Phase II study of combination chemitherapy with docetaxel and carboplatin for locally advanced or recurrent cervical cancer. (sgsg.biz)
  • ASCO 2023 Omitting Radiation in Rectal Cancer: 'Less Is More' Many patients with locally advanced rectal cancer can skip radiotherapy to the pelvic area, and instead be treated with chemotherapy and then surgery, suggest the results from the PROSPECT trial. (medscape.com)
  • The depth of tumoral invasion and the histopathologic grade of the tumor influence the recommendations for adjuvant postoperative therapy. (medscape.com)
  • Tumor diameter, pelvic lymph node metastasis, vascular invasion, deep stromal invasion and close resection margins are most often used to target adjuvant treatment to those patients with highest risk of relapse [ 4 - 7 ]. (medsci.org)
  • Up on first oncologist consultation and/or radiotherapy planning, tumor stage were classified according to the International Federation of Gynecology and Obstetrics (FIGO) staging system [ 11 ]. (biomedcentral.com)
  • We defined the "LVSI index" as "TD×%MMI×tumor grade×cervical stromal involvement. (medsci.org)
  • The major tenets in accurately assessing tumor size in patients with early stage cervical cancer currently include physical examination, imaging studies, and pathologic evaluation. (bmj.com)
  • When considering imaging studies, magnetic resonance imaging (MRI) provides the highest level of accuracy in the assessment of cervical tumor size. (bmj.com)
  • MRI imaging is also significantly more accurate in measuring tumor size, delineating cervical tumor boundaries, and local tumor extension when compared with computed tomography (CT) scan. (bmj.com)
  • When comparing with pelvic ultrasound, the accuracy of both imaging techniques (MRI and pelvic ultrasound) in the assessment of tumor size in small versus large tumors is comparable. (bmj.com)
  • Tumor size has consistently been a key component in the stage of disease in patients diagnosed with cervical cancer. (bmj.com)
  • Cervical cancer is a malignant tumor that develops in the uterine cervix and high risk human papilloma virus causes the disease. (koreamed.org)
  • B.S. Huang, N.M. Tsang, S.M. Lin, D. Y. Lin, J. M. Lien, C. C. Lin, W. T. Chen, W.Y. Chen, J. H. Hong* High-dose hypofractionated X-ray radiotherapy for hepatocellular carcinoma: Tumor responses and toxicities. (cgmh.org.tw)
  • RTOG 0417 was a development II study of 49 patients treated with bevacizumab in combination with concurrent radiotherapy and cisplatin in stage IIBВ-IIIB infirmity or IBВ-IIA disease with biopsy-proven pelvic nodal metastasis and/or tumor size of at least 5 cm [53]. (daubnet.com)
  • ASCO 2023 Oral Drug for Brain Tumor Could Change Treatment Landscape In patients with gliomas bearing IDH1/2 mutations, the brain barrier-crossing oral drug vorasidenib kept tumors at bay, and could be used instead of more toxic chemotherapies and radiation. (medscape.com)
  • Although adjuvant radiotherapy is commonly used to manage advanced or metastatic cervical and endometrial cancer, it is sometimes administered as adjuvant therapy for ovarian cancer. (medscape.com)
  • In Egypt,the highest number in gynecological malignancy is for ovarian cancer, followed by uterine and cervical cancer. (oncologyradiotherapy.com)
  • Postoperative radiotherapy is reserved for cases in which histopathologic analysis of the removed specimen reveals features suggesting a high risk for local recurrence. (medscape.com)
  • The results indicated that the adjuvant therapy given after the initial radical mastectomy "significantly decreased recurrence rate in pre-menopausal women with four or more positive axillary lymph nodes. (wikipedia.org)
  • The reason why performing the SCC-Ag test during post-treatment surveillance is not recommended for asymptomatic patients is that the survival benefit of post-recurrence salvage therapy is still uncertain, except for surgery for central pelvic recurrence after primary radiotherapy [ 8 9 ]. (koreamed.org)
  • Considering that adjuvant radiotherapy after surgical resection was effective to decrease loco-regional recurrence and most treatment failures were distant metastasis, multimodal therapy including surgery, radiotherapy, and chemotherapy might be an optimal treatment for uterine carcinosarcoma patients. (e-roj.org)
  • Histologic results of para-aortic lymphadenectomy in patients treated for stage IB2/II cervical cancer with negative [18F]fluorodeoxyglucose positron emission tomography scans in the para-aortic area. (medscape.com)
  • In the past, a full lymphadenectomy, including the pelvic and para-aortic nodes, was recommended in all patients with EC. (medsci.org)
  • Low-risk corpus cancer: Is lymphadenectomy or radiotherapy necessary? (ntnu.edu.tw)
  • A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer. (medscape.org)
  • Treatment protocols for cervical cancer are provided below, including treatment by stage, chemoradiation therapy, and chemotherapy. (medscape.com)
  • If high-risk features are noted on final pathologic review (ie, lymphovascular invasion, positive margins, or involvement of pelvic nodes), adjuvant concurrent chemoradiation has improved overall survival. (medscape.com)
  • Patients with a CRP-Albumin ratio of more than 0.8 are at significant risk of relapse and death after chemoradiation or radiation. (waocp.com)
  • For a curative radiotherapy or chemoradiation an adequate treatment of the CTV is essential. (biomedcentral.com)
  • A total of 34 patients were treated with definitive chemoradiation, 22 patients were treated with an adjuvant radio(chemo)therapy. (biomedcentral.com)
  • The study of the underpinning mechanisms of chemoradiation response was carried out through in vitro models of cervical cancer. (biomedcentral.com)
  • Most women with early cervical cancer (stages IA-IB1 and IIA1) are cured with surgery or radiotherapy (RT), or both, while exclusive concurrent chemoradiation (CRT) is the preferred modality for the cure of LACC (FIGO stage IB2 through stage IVA) [ 4 , 5 ]. (biomedcentral.com)
  • Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. (medscape.org)
  • Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. (medscape.org)
  • Intensity-modulated radiation therapy use in the U.S., 2004. (medscape.org)
  • A survey of intensity-modulated radiation therapy use in the United States. (medscape.org)
  • Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis. (medscape.org)
  • Intensity-modulated whole pelvic radiation therapy in patients with gynecologic malignancies. (medscape.org)
  • Initial clinical experience with intensity-modulated whole-pelvis radiation therapy in women with gynecologic malignancies. (medscape.org)
  • Radiation therapy is an essential component in Gynecology in the primary nonsurgical management and the adjuvant postoperative treatment of selected malignancies arising in the female reproductive tract. (medscape.com)
  • Radiation therapy may also be used for hormonal ablation. (medscape.com)
  • Adjuvant therapy, also known as adjunct therapy, adjuvant care, or augmentation therapy, is a therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. (wikipedia.org)
  • The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. (wikipedia.org)
  • An example of such adjuvant therapy is the additional treatment usually given after surgery where all detectable disease has been removed, but where there remains a statistical risk of relapse due to the presence of undetected disease. (wikipedia.org)
  • The term "adjuvant therapy," derived from the Latin term adjuvāre, meaning "to help," was first coined by Paul Carbone and his team at the National Cancer Institute in 1963. (wikipedia.org)
  • Despite the initial pushback from the breast cancer surgeons who believed that their radical mastectomies were sufficient in removing all traces of cancer, the success of Bonadonna's and Fisher's trials brought adjuvant therapy to the mainstream in oncology. (wikipedia.org)
  • Since then, the field of adjuvant therapy has greatly expanded to include a wide range of adjuvant therapies to include chemotherapy, immunotherapy, hormone therapy, and radiation. (wikipedia.org)
  • Neoadjuvant therapy, in contrast to adjuvant therapy, is given before the main treatment. (wikipedia.org)
  • For example, radiotherapy or systemic therapy is commonly given as adjuvant treatment after surgery for breast cancer. (wikipedia.org)
  • Oncologists use statistical evidence to assess the risk of disease relapse before deciding on the specific adjuvant therapy. (wikipedia.org)
  • Because the treatment is essentially for a risk, rather than for provable disease, it is accepted that a proportion of patients who receive adjuvant therapy will already have been cured by their primary surgery. (wikipedia.org)
  • Some forms of cancer fail to benefit from adjuvant therapy, however. (wikipedia.org)
  • To our knowledge this is the first reported case of an isolated vesicocutaneous fistula related to previous radiation therapy for recurrent vulvar cancer. (annals.edu.sg)
  • PURPOSE: This retrospective, multicenter study analyzes the efficacy and safety of stereotactic body radiation therapy in a large cohort of patients with oligometastatic/persistent/recurrent uterine cancer. (bvsalud.org)
  • METHODS AND MATERIALS: Clinical and radiation therapy data from several radiation therapy centers treating patients by stereotactic body radiation therapy between March 2006 and October 2021 were collected. (bvsalud.org)
  • Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer and Common Terminology Criteria for Adverse Events scales were used to grade toxicities. (bvsalud.org)
  • Primary endpoints were the rate of complete response to stereotactic body radiation therapy, and the 2-year actuarial local control rate "per-lesion" basis. (bvsalud.org)
  • RESULTS: In the study, 157 patients with oligometastatic/persistent/recurrent uterine cancer bearing 272 lesions treated by stereotactic body radiation therapy at 14 centers were analyzed. (bvsalud.org)
  • 1] Until recently, treatment paradigms in gynecologic oncology have mainly included a combination of radical surgery, cytotoxic chemotherapy (CT), and radiation therapy. (cancernetwork.com)
  • Treatment may consist of some combination of surgery, chemotherapy, and radiation therapy. (wikipedia.org)
  • radiation therapy may also be an option in select cases. (medscape.com)
  • The other study, PORTEC (Post-Operative Radiation Therapy in Endometrial Carcinoma), compared the standard of care with adjuvant chemotherapy during and after radiotherapy for patients with high-risk endometrial cancer. (medpagetoday.com)
  • The age of the patient is also an important factor, especially in stage III disease, when considering different treatment options, but for now pelvic radiation therapy appears to remain the standard of care for high-risk, endometrial cancer patients. (medpagetoday.com)
  • The daily use of image guidance (IGRT) is finding more frequent application in radiation therapy. (biomedcentral.com)
  • Postoperative radiation therapy for rectal cancer. (nih.gov)
  • F.H. Chen, S.Y. Fu, Y.C. Yang, C.C. Wang, C.S. Chiang and J. H. Hong* Combination of vessel-targeting agents and fractionated radiation therapy: the role of the SDF-1/CXCR4 pathway. (cgmh.org.tw)
  • C. C. Wang, C. H. Lai, Y. T. Huang, A. C. Chao, H. H. Chou and J. H. Hong* HPV genotypes predict survival benefits from concurrent chemotherapy and radiation therapy in advanced squamous cell carcinoma of the cervix. (cgmh.org.tw)
  • Aim: The main objective of this study was evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy receiving concurrent chemo radiotherapy for evaluation of the response of treatment,toxicity profile and quality of life of both radiotherapy treatment modalities. (oncologyradiotherapy.com)
  • Intensity Modulated Radiotherapy (IMRT)for Whole Pelvic Radiation Therapy (WPRT) is considered superior to 3D conformal radiotherapy in dose distribution to targets and to spare normal tissue as (BM) supported by many dosimetric studies [ 7 ]. (oncologyradiotherapy.com)
  • Evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy cases receiving concurrent chemo radiotherapy. (oncologyradiotherapy.com)
  • It is also known to frequently occur in postmenopausal women, especially in those who have received pelvic radiation therapy [ 2 , 3 ]. (e-roj.org)
  • But chemo-therapy and radiation therapy were not taken and the patient remained in a good condition throughout the 9-year follow-up period. (scirp.org)
  • RADIOTHERAPY, ALSO KNOWN as radiation therapy, is a treatment where ionizing x-ray and gamma ray radiation are directed at tumors and used to kill cancer cells. (endalldisease.com)
  • Post-Radiation Therapy Imaging Appearances in Cervical Carcinoma. (acr.org)
  • To review the post radiation therapy effects on cervical carcinome. (acr.org)
  • Operational Ontology for Oncology (O3) - A Professional Society Based, Multi-Stakeholder, Consensus Driven Informatics Standard Supporting Clinical and Research use of "Real -World" Data from Patients Treated for Cancer: Operational Ontology for Radiation Oncology. (uc.edu)
  • The study was carried out in adult oncology department of Tikur Anbesa Specialized Hospital (TASH) radiotherapy center, under the Addis Ababa University. (biomedcentral.com)
  • Background: This phase 2 prospective randomized double-arm study carried out at Clinical Oncology Department Tanta University, Radiotherapy Department, NCI, Cairo University and Gharbia cancer society through the period from May 2018 to December 2019 and enrolled 60 patients with cervical carcinoma. (oncologyradiotherapy.com)
  • This study included 40 cervical cancer patients admitted to the Gynecologic Oncology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, between January 2000 and October 2013. (biomedcentral.com)
  • Radiotherapy & Oncology. (acr.org)
  • Our trial clearly demonstrates that adjuvant pelvic radiation should remain the standard of care for high-risk, early-stage endometrial cancer patients," the lead author of the study, Marcus Randall, MD, of the University of Kentucky College of Medicine in Lexington, said in an ASTRO news release. (medpagetoday.com)
  • The most common gynecological malignancy in the United States is endometrial cancer [ 1 ], cervical cancer is the fourth most frequent cancer in women in the world is occurring mostly in developing countries [ 2 ]. (oncologyradiotherapy.com)
  • For further recommendations concerning cervical cancer evaluation and management of abnormal Pap test results, and treatment of cervical intraepithelial neoplasia (CIN), see the American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines. (medscape.com)
  • The precursor to cervical cancer is cervical intraepithelial neoplasia (CIN). (msdmanuals.com)
  • Bleeding after douching or after a pelvic exam is a common symptom of cervical cancer. (wikipedia.org)
  • 0.001), and presence of cervical stromal invasion (P = 0.002) were identified as the risk factors for LVSI. (medsci.org)
  • By using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance. (medsci.org)
  • In our previous study of cervical carcinomas FIGO stage I-IV we found that increase expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis [ 22 ]. (medsci.org)
  • About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. (wikipedia.org)
  • We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). (biomedcentral.com)
  • Diagnosis and treatment of cervical carcinomas. (medscape.com)
  • Nearly 1500 new cases of cervical cancer were estimated to have been diagnosed in Canadian women in 2000, and an estimated 430 women died from the disease in the same year. (cmaj.ca)
  • Posttherapy surveillance of women with cervical cancer: an outcomes analysis. (medscape.com)
  • We identified two RCTs involving 978 women with cervical cancer stage IIB to IVA. (cochrane.org)
  • Infection with HPV is generally believed to be required for cervical cancer to occur. (wikipedia.org)
  • In medical research, the most famous immortalized cell line, known as HeLa, was developed from cervical cancer cells of a woman named Henrietta Lacks. (wikipedia.org)
  • We analyzed data from a total of 56 patients with cervical cancer, FIGO stage IB-IVA, treated with HT at our institute from June 2008 to December 2009. (biomedcentral.com)
  • The objective of a cervical screening programme is to prevent invasive cancer of the cervix by detecting and treating pre-invasive disease of the cervix. (annals.edu.sg)
  • Cervical cancer is a cancer arising from the cervix. (wikipedia.org)
  • Patients with biopsy proven carcinoma cervix treated with Radiotherapy or Chemo-radiation from January 1st, 2016 to September 30th, 2017 were included. (waocp.com)
  • Increased serum SCC-Ag levels are observed in squamous cell carcinoma of the esophagus, lung, head and neck, and cervix, but increased levels may also be found in benign diseases such as skin disorders [ 5 ], pelvic inflammatory disease, cystitis, and renal failure [ 6 7 ]. (koreamed.org)
  • ORGANIZED SCREENING HAS CONTRIBUTED TO A DECLINE in cervical cancer incidence and mortality over the past 50 years. (cmaj.ca)
  • Fig. 1 shows age-standardized incidence and mortality rates for cervical cancer in Canada, the United States and the cancer surveillance regions of the World Health Organization (WHO). (cmaj.ca)
  • Fig. 1: Annual incidence and mortality rates (per 100 000 women) of invasive cervical cancer in Canada, the United States and cancer surveillance regions of theWorld Health Organization. (cmaj.ca)
  • Table 1 shows Canada's incidence and mortality rates for cervical cancer (averages for latest 5-year reporting periods) and estimated numbers of new cases and deaths for 2000. (cmaj.ca)
  • Cervical cancer is the second most commonly diagnosed and the second leading cause of cancer death in the country, with age standardized incidence and mortality rate of 26.4 and 18.4 per 100,000 population each year, respectively (GLOBOCAN 2012) [ 8 ]. (biomedcentral.com)
  • Results: There was statistically significant difference in favor of IMRT bone marrow sparing plans regarding a lower dose to organs at risk, total pelvic bone and bowel. (oncologyradiotherapy.com)
  • In 1976, shortly after Bonadonna's landmark trial, Bernard Fisher at the University of Pittsburgh initiated a similar randomized trial that compared the survival of breast cancer patients treated with radiation after the initial mastectomy to those who only received the surgery. (wikipedia.org)
  • The aim of adjuvant treatment is to improve disease-specific symptoms and overall survival. (wikipedia.org)
  • Human papillomavirus (HPV) infection is now recognized as the main cause of cervical cancer, the role of coexisting factors is better understood, a new cytology reporting terminology has improved diagnosis and management of precursor lesions, and specific treatment protocols have increased survival among patients with early or advanced disease. (cmaj.ca)
  • The results showed an increase in failure-free survival, 75.5% in the chemoradiotherapy arm, compared with 68.6% in the patients treated with radiation only, but the 5-year survival rate did not improve with the addition of adjuvant chemotherapy. (medpagetoday.com)
  • However, there are limited data on cervical cancer treatment patterns and survival in the country. (biomedcentral.com)
  • Herein, we examine treatment patterns and survival of cervical cancer patients treated in Tikur Anbessa Hospital Radiotherapy Center (TAHRC), the only hospital with radiotherapy facility in the country. (biomedcentral.com)
  • As expected, survival was lower in patients with advanced stage at initiation of radiotherapy and in those treated as palliative care. (biomedcentral.com)
  • The survival of cervical cancer patients remains low in Ethiopia because of late presentation and delay in receipt of radiotherapy, leading to stage migration in substantial proportion of the cases. (biomedcentral.com)
  • This study was done to identify the influence of pre-treatment inflammatory biomarkers on survival in patients treated with radical chemo-radiation or radiation. (waocp.com)
  • Hence, we conducted this prospective observational study to identify the effect of pre-treatment inflammatory biomarkers on survival in cervical cancer patients treated by radical radiotherapy or chemo-radiation. (waocp.com)
  • Adjuvant chemotherapy (ACT) can be given in an attempt to improve survival by eradicating residual disease in the pelvis and treating occult disease outside the pelvic radiation field. (cochrane.org)
  • When pelvic lymph nodes are involved, the 5-year survival rate may be as low as 0% [ 6 ]. (biomedcentral.com)
  • If radiotherapy improves survival and quality of life in cancer patients, then we should keep using it. (endalldisease.com)
  • Anti-angiogenic agents are an important adjuvant treatment strategy in gynecologic cancer. (cancernetwork.com)
  • Cervical Cancer Screening and Prevention Cervical cancer is a common gynecologic malignancy and a major cause of cancer deaths in low- and middle-resource countries ( 1, 2). (msdmanuals.com)
  • If known disease is left behind following surgery, then further treatment is not technically adjuvant. (wikipedia.org)
  • Nearly half of patients present with stage I disease and about one third of patients treated with surgery received adjuvant treatment [ 2 ]. (medsci.org)
  • This adjuvant treatment is accompanied by considerable morbidity [ 3 ]. (medsci.org)
  • The past 2 decades have witnessed substantial progress in our understanding of the natural history of cervical cancer and in major treatment advances. (cmaj.ca)
  • The aim of this treatment is to administer high doses of radiation in restricted volumes of the organism, to have greater control of the disease and less toxicity of the treatment to the adjacent normal tissues [ 1 ]. (biomedcentral.com)
  • FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. (uc.edu)
  • Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. (uc.edu)
  • However, the number of cervical patients is continuously increasing from year to year, which makes the waiting time for receipt of radiation treatment to be very long [ 7 , 9 , 10 ]. (biomedcentral.com)
  • Therefore, delays in treatment is another major challenge of cervical cancer care in Ethiopia. (biomedcentral.com)
  • Accurate staging of patients with cervical cancer is crucial for appropriate treatment planning. (bmj.com)
  • During post-treatment surveillance, 53 patients were diagnosed as having recurrent cervical cancer based on biopsy or a radiological test showing progression of a lesion. (koreamed.org)
  • Serum SCC-Ag test was helpful in detecting recurrent cervical squamous cell carcinoma during post-treatment surveillance, and the optimal cutoff value was ≥2 ng/mL. (koreamed.org)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • For more information, see Cervical Cancer Treatment . (cancer.gov)
  • According to TNM staging, the treatment option will vary from surgery to surgery accompanied with radiotherapy and chemotherapy. (nepjol.info)
  • The recommended standardized treatment includes primary surgery for diagnosis, staging and cytoreduction, followed by adjuvant chemotherapy Surgery must be performed by an Oncologist Gynecologist or an Oncologist Surgeon because inadequate surgery performed by another specialist has been reported in 75% of cases. (bvsalud.org)
  • Our results define a predictive gene signature that can help in cervical cancer patient stratification, thus providing a useful tool towards more personalized treatment modalities. (biomedcentral.com)
  • Today, up to 60% of cancer patients receive radiotherapy as a part of their treatment regimens 1 and yet most are never fully aware of the risks involved with exposure to ionizing radiation. (endalldisease.com)
  • Dr. Aaron Clark is a neurosurgeon specializing in minimally invasive outpatient procedures for lumbar and cervical herniated discs and stenosis, as well as minimally invasive lumbar fusion surgery. (ucsf.edu)
  • To evaluate the impact of postoperative radiotherapy (PORT) on patterns of failure and survivals in uterine carcinosarcoma patients treated with radical surgery. (e-roj.org)
  • doses in patients with cervical cancer receiving pelvic and paraaortic irradiation. (medscape.org)
  • Pelvic radiotherapy was delivered in 48 cases, 8 patients were treated with pelvic and extended field radiotherapy because of paraaortic lymph node metastases. (biomedcentral.com)
  • Worldwide, cervical carcinoma is the second most frequent malignancy among women and the death rate is 8 per 100,000 [ 1 ]. (medsci.org)
  • Cervical cancer (see the image below) is the third most common malignancy in women worldwide, and it remains a leading cause of cancer-related death for women in developing countries. (medscape.com)
  • While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer. (wikipedia.org)
  • To review the conceptual, methodological, and technical innovations underpinning strategies for adaptive target volume selection and risk-adapted dose prescription in cervical cancer. (acr.org)
  • As described here, two recent studies have indicated that pelvic radiation following surgery should remain the standard of care for these patients, with some exclusions. (medpagetoday.com)
  • Two recently published studies suggest that pelvic radiation following surgery should remain the standard of care for this patient population, with some exceptions. (medpagetoday.com)
  • Diagnosis is typically by cervical screening followed by a biopsy. (wikipedia.org)
  • One of the major challenge of cervical cancer care is Ethiopia is delay in diagnosis, since most of the patients seek medical care at advanced stage of the disease [ 7 , 9 ]. (biomedcentral.com)
  • Diagnosis is by a cervical Papanicolaou test and biopsy. (msdmanuals.com)
  • Cervical and ovarian carcinogenesis employ different pathways to achieve cellular immortalization, and this has a significant bearing on the evidence supporting the use of anti-angiogenic agents in the two malignancies. (cancernetwork.com)
  • Perineural spread of pelvic malignancies to the lumbosacral plexus and beyond: clinical and imaging patterns. (medscape.com)
  • However, for women with distant metastatic disease at presentation, cure is unlikely, although palliative radiotherapy frequently improves a patient's quality of life when used to relieve symptoms. (medscape.com)
  • This trend, suggestive of a resurgence in cervical cancer, has also been observed in many European countries and could reflect increased cancer detection by the use of new diagnostic techniques, such as human papillomavirus (HPV) testing and cervicography, or it could be the result of a cohort effect. (cmaj.ca)
  • Human papillomavirus ( HPV ) infection must be present for cervical cancer to occur. (medscape.com)
  • Recognition of the etiologic role of human papillomavirus ( HPV ) infection in cervical cancer has led to the recommendation of adding HPV testing to the screening regimen in women 30-65 years of age (see Workup). (medscape.com)