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  • proteins
  • This review summarizes and updates our knowledge of the nature and functions of ceruloplasmin and the other known and emerging copper-containing molecules (principally proteins) in this fluid, to better understand how they contribute to copper homeostasis and consider their potential significance to health and disease. (rsc.org)
  • Moreover, the relations of the two microorganisms with some Acute Phase Proteins (APPs) inflammatory marker such as Serum Amyloid A (SAA) and Ceruloplasmin (Cp) in serum and milk were inspected. (omicsonline.org)
  • deficiency
  • Excessive therapeutic zinc may lead to block of intestinal absorption of copper and a copper deficiency syndrome characterized by hypochromic microcytic anemia with leukopenia/neutropenia and zero level of ceruloplasmin. (labcorp.com)
  • Falsely low ceruloplasmin levels may be observed in any protein deficiency state, including nephrotic syndrome, malabsorption, protein-losing enteropathy, and malnutrition. (medscape.com)
  • Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. (bio-rad-antibodies.com)
  • expression
  • Ceruloplasmin gene expression was also detected in a human breast adenocarcinoma cell line and in biopsy tissue from women with invasive ductal carcinoma. (biochemj.org)
  • We found expression of ceruloplasmin to be the most enriched in obesity-associated cancer cells. (rice.edu)
  • In summary, we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers. (rice.edu)
  • antioxidant
  • Therefore, the antioxidant effects of ceruloplasmin could have important implications for various neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease in which iron deposition is known to occur. (jneurosci.org)
  • Ceruloplasmin (Cp) is a copper-containing multifunctional oxidase of plasma, an antioxidant, an acute-phase protein and a free radical scavenger. (rsc.org)
  • ferroxidase activity
  • From the functional point of view, ceruloplasmin oxidation caused a decrease in ferroxidase activity, which in turn promotes intracellular iron retention in neuronal cell lines as well as in primary neurons, which are more sensitive to iron accumulation. (jneurosci.org)
  • HEPH
  • We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and highly expressed in intestine. (uniprot.org)
  • decrease
  • Injection of a 2.0 mg Cd ²⁺ /kg B.W. (I.P. as CdC1 ₂ in .05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine oxidase activity within one hour of injection. (oregonstate.edu)
  • novel
  • We demonstrate that ceruloplasmin is a novel adipokine, which is produced and secreted at increased rates in obesity. (rice.edu)