• It was the first natural product antibiotic known to inhibit lipid synthesis. (wikipedia.org)
  • Furthermore, the study objective was to screen inhibitory molecules that block the function of predicted genes through several biophysical approaches. (bvsalud.org)
  • Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. (wikipedia.org)
  • In sterol synthesis, cerulenin inhibits HMG-CoA synthetase activity. (wikipedia.org)
  • A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. (lookformedical.com)
  • It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. (lookformedical.com)
  • It was also reported that cerulenin specifically inhibited fatty acid biosynthesis in Saccharomyces cerevisiae without having an effect on sterol formation. (wikipedia.org)
  • 93) J. Awaya, T. Kesado, and S. : Preparation of 13C- and 3H-labeled cerulenin and biosynthesis with 13C NMR. (satoshi-omura.info)
  • In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. (wikipedia.org)
  • citation needed] Cerulenin causes a dose-dependent decrease in HER2/neu protein levels in breast cancer cells, from 14% at 1.25 to 78% at 10 milligrams per liter, and targeting of fatty acid synthase by related drugs has been suggested as a possible treatment. (wikipedia.org)
  • Antiproliferative and pro-apoptotic effects have been shown in colon cells as well. (wikipedia.org)