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  • solid tumors
  • Conclusions The effects of Laromustine on solid tumors and with radiation are complex and are influenced by microenvironmental and proliferative heterogeneity within these malignancies. (cylch.org)
  • The work reported here extends preclinical studies of this novel investigational anticancer agent to explore additional questions related to its potential use in the treatment of solid tumors. (cylch.org)
  • In addition, we compared the effects of Laromustine on proliferating and quiescent cells, because solid tumors generally contain large numbers of non-proliferating clonogenic cells, which are resistant to the many anticancer drugs that target pathways critical to cell proliferation. (cylch.org)
  • herbal
  • Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. (medhelp.org)
  • exposure
  • exposure to ionizing radiation, certain drugs (e.g., alkylating agents used in cancer treatment), and infection with retroviruses retrovirus, type of RNA virus that, unlike other RNA viruses, reproduces by transcribing itself into DNA. (thefreedictionary.com)
  • Some leukemias can be prevented by avoiding exposure to benzene, nicotine, or radiation. (umm.edu)
  • Exposure to anticancer drugs can result in transgenerational genomic instability in mice. (nih.gov)
  • To establish whether exposure to anticancer drugs can result not only in mutation induction in the germ line of treated animals, but also in altered mutation rates in their offspring, we evaluated mutation rates in the offspring of male mice treated with three commonly used chemotherapeutic agents: cyclophosphamide, mitomycin C, and procarbazine. (nih.gov)
  • After paternal exposure to any one of these three drugs, expanded simple tandem repeat mutation frequencies were significantly elevated in the germ line (sperm) and bone marrow of their offspring. (nih.gov)
  • Tobacco and smoking, obesity, alcoholism, too much sun exposure and radiation are among the common risk factors, while genetics also plays a pivotal role with increased risk among siblings and relatives. (lifehack.org)
  • certain
  • It belongs to a class of drugs known as anthracenediones and works by slowing or stopping the growth of certain cells (including cancer cells and cells that affect the body's natural defenses). (medhelp.org)
  • According to a pair of studies featured in the journal Science, the patients who responded best to treatment with a certain class of immunotherapy drugs were those with the more diverse and robust microbiomes. (uexpress.com)
  • Clinical Trial
  • In fact, major findings of aspirin's anticancer effects in humans are also derived from clinical trial data originally compiled for the study of its anti-thrombotic effects [ 3 , 4 ]. (hindawi.com)
  • Fever
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used to treat pain, fever, and inflammation. (hindawi.com)
  • bone marrow
  • There are a number of diseases in which the bone marrow is defective, such as aplastic anemia, some forms of leukemia, and deficiencies in the bone marrow caused by cancer treatments with drugs and irradiation. (google.es)
  • cells
  • A novel anticancer drug 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS106) has been shown to radiosensitize tumor cells and to improve the therapeutic efficiency of X-irradiation. (biomedcentral.com)
  • Chemotherapy is the use of drugs to kill cancer cells. (ucsfhealth.org)
  • Also, studies suggest that CoQ10 analogs ( drugs that are similar to CoQ10) may prevent the growth of cancer cells directly. (cancer.gov)
  • Unlike chemotherapy, which targets all of the fast-dividing cells within the body no matter their origin, or radiation, which kills cancer cells by damaging the DNA in all of the cells in its path whether they are healthy or cancer cells, immunotherapy approaches cancer quite precisely, and at the cellular level. (uexpress.com)
  • leukemia
  • 2008). Phase I/II trials showed that Laromustine had significant activity in the treatment of acute myeloid leukemia (AML) and high risk myelodysplastic disorders, with a therapeutic ratio and toxicity profile suggesting that the drug might have value for the treatment of patients with refractory disease and in the treatment of these diseases in the aged (Giles 2007, Giles et al. (cylch.org)
  • studies
  • Aspirin's affordability and ease of access, together with its relatively reduced side effects with respect to other traditional NSAIDs [ 5 ], have also helped to increase its appeal as a potential chemopreventive agent and target in anticancer studies. (hindawi.com)
  • effects
  • Drug interactions may change how your medications work or increase your risk for serious side effects. (medhelp.org)
  • growth assays showed effects of regimens combining Laromustine and radiation that were compatible with additive or subadditive interactions. (cylch.org)
  • Aspirin
  • In recent years, there has been a growing interest in aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) because of their promising antineoplastic properties. (hindawi.com)
  • dietary
  • Because CoQ10 is sold as a dietary supplement rather than a drug, it is not regulated by the US Food and Drug Administration (see Question 8 ). (cancer.gov)
  • type
  • Type 1: Th e microcapsules are subcutaneously injected in the area surrounding the tumor, followed by delivery of radiations. (omicsonline.org)
  • delivery
  • To receive news and publication updates for Journal of Drug Delivery, enter your email address in the box below. (hindawi.com)
  • potential
  • Thus, phycocyanin has an important development and utilization as a potential drug, and phycocyanin has become a new hot spot in the field of drug research. (jcancer.org)