AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Sphingosine N-AcyltransferaseCeramidesSphingolipidsOxidoreductasesIchthyosiform Erythroderma, CongenitalFumonisinsEnzyme AssaysSphingosineSpinocerebellar DegenerationsActivating Transcription Factor 6HEK293 CellsMembrane ProteinsGene Expression Regulation, EnzymologicRNA, Small InterferingCell Line, TumorApoptosisGolgi ApparatusMass SpectrometryHomeostasisCatalysisRNA, MessengerSubstrate SpecificityMice, Knockout
CeramidesTissue
Ceramides2
  • CerS4 synthesizes ceramides containing C18-22 fatty acids in a fumonisin B1-independent manner. (wikipedia.org)
  • Recently, we demonstrated that human breast cancer tissue displays increased activity of CerS2, 4, and 6, together with enhanced generation of their products, ceramides C-16:0, C-24:0, and C-24:1. (fakpathway.com)
Tissue2
  • CerS4 (TRH1) mRNA was found in all tissues and is strongly expressed in skin and muscle In a 2009 study of breast cancer, total ceramide synthase levels were increased in malignant tissue, and CerS4 was one of three ceramide synthases to show an increase in mRNA levels. (wikipedia.org)
  • Upon administration of leptin, a decrease in ceramide levels was observed in rat white adipose tissue, as were expression levels of a number of genes in the sphingolipid metabolic pathway, including CerS2 and CerS4. (wikipedia.org)