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Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsRad52 DNA Repair and Recombination ProteinFungal ProteinsRad51 RecombinaseDNA RepairMolecular Sequence DataDNA Repair EnzymesAmino Acid SequenceDNA-Binding ProteinsMutationRecombination, GeneticDNA DamageBase SequenceSequence Homology, Amino AcidDNA HelicasesGenetic Complementation TestMethyl MethanesulfonateSchizosaccharomycesDNA, FungalGene Expression Regulation, FungalUltraviolet RaysGenes, FungalUbiquitin-Conjugating EnzymesSchizosaccharomyces pombe ProteinsCloning, MolecularAdenosine TriphosphatasesCell Cycle ProteinsEndonucleasesPlasmidsCheckpoint Kinase 2EndodeoxyribonucleasesMutagenesisEpistasis, GeneticLigasesDNARec A RecombinasesDNA, Single-StrandedNuclear ProteinsProtein BindingGamma RaysRNA, FungalDNA Breaks, Double-StrandedChromosomes, FungalSequence AlignmentGene DeletionDose-Response Relationship, RadiationGenome, FungalPhenotypeTranscription FactorsTranscription, GeneticSaccharomycesSuppression, GeneticMeiosisRestriction MappingAdenosine TriphosphateRecombinant Fusion ProteinsProtein Structure, TertiaryConserved SequenceMembrane ProteinsDNA PrimersCDC28 Protein Kinase, S cerevisiaeDNA ReplicationEscherichia coliRNA, MessengerRecombinant ProteinsCarrier ProteinsSequence Homology, Nucleic AcidHaploidyCell CycleAllelesGenes, SuppressorProtein-Serine-Threonine KinasesTransformation, GeneticKineticsBinding SitesTemperatureDiploidyOpen Reading FramesTwo-Hybrid System TechniquesRepressor ProteinsDNA, ComplementaryChromosome MappingMitosisProtein KinasesVacuolesbeta-FructofuranosidaseSaccharomycetalesPhylogenySpecies SpecificityMitochondriaKluyveromycesFermentationSequence Analysis, DNAModels, GeneticModels, BiologicalPheromonesCell NucleusDNA TopoisomerasesSilent Information Regulator Proteins, Saccharomyces cerevisiae
RAD17SaccharomycesHus1Checkpoint controlGenePombeYeastComplexesMiceRepairMitotic recombination in Saccharomyces cerevisiaeRecombinationPutativeMeioticDouble-strandMeiosisProtein
RAD173
  • The S. cerevisiae checkpoint protein Rad17, the orthologue of human Rad1, forms a homocomplex in response to treatment with DNA damaging agents, and the complex is required for yeast survival after exposure to genotoxic agents [ 12 ]. (biomedcentral.com)
  • The purified Rad17 and Rad9-Hus1-Rad1 (9-1-1) complexes can form a stable co-complex in the presence of ATP, using Rad17-Rad9 interactions. (reactome.org)
  • From computer modeling studies, the Rad17 subunit of the complex is also proposed to interact with the C-terminus of Rad1, p36 with the C-terminus of Hus1, and p38 with the C-terminus of Rad9. (reactome.org)
Saccharomyces2
Hus11
  • It is not clear whether Rad1, Rad9 and Hus1 also have distinct functional activities independent of the heterotrimeric form. (biomedcentral.com)
Checkpoint control1
Gene4
  • Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene. (wikipedia.org)
  • To determine whether Rad1 functions to maintain genomic stability and prevent tumor development, we generated Mrad1 mutant mice by gene targeting. (biomedcentral.com)
  • Inactivation of the mouse Huntington's disease gene homolog hdh . (nature.com)
  • Furthermore, dispensable essential and bypass suppressor gene pairs reflected simultaneous changes in the mutational landscape of S. cerevisiae strains. (bvsalud.org)
Pombe1
  • The 9-1-1 complex has also been found to interact with base excision repair factors human DNA polymerase beta, flap endonuclease FEN1, and the S. pombe MutY homolog (SpMYH), indicating that 9-1-1 also plays a direct role in DNA repair. (reactome.org)
Yeast2
  • In yeast the 9-1-1 complex (including RAD1) facilitates meiotic recombination. (wikipedia.org)
  • The Rad1 protein, evolutionarily conserved from yeast to humans, exists in cells as monomer as well as a component in the 9-1-1 protein complex. (biomedcentral.com)
Complexes1
  • Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. (wikipedia.org)
Mice2
  • Testis-specific disruption of RAD1 in mice results in defective double-strand break repair, depletion of germ cells and infertility. (wikipedia.org)
  • These data suggest a possibility that Rad1 in humans and mice might have distinct functions independent of the 9-1-1 heterotrimer. (biomedcentral.com)
Repair1
  • Hu Q, Tang D, Wang H, Shen Y, Chen X, Ji J, Du G, Li Y, Cheng Z. The Exonuclease Homolog OsRAD1 Promotes Accurate Meiotic Double-Strand Break Repair by Suppressing Nonhomologous End Joining. (wikipedia.org)
Mitotic recombination in Saccharomyces cerevisiae1
Recombination2
  • In yeast the 9-1-1 complex (including RAD1) facilitates meiotic recombination. (wikipedia.org)
  • Meiotic crossover (CO) recombination initiates from programmed DNA double-strand breaks (DSBs) around hotspots, and results in reciprocal exchange of chromosome segments between homologous chromosomes (homologs). (chuo-u.ac.jp)
Putative1
  • The isolation of mouse and human putative homologs of rad21 is reported here. (nih.gov)
Meiotic1
  • Hu Q, Tang D, Wang H, Shen Y, Chen X, Ji J, Du G, Li Y, Cheng Z. The Exonuclease Homolog OsRAD1 Promotes Accurate Meiotic Double-Strand Break Repair by Suppressing Nonhomologous End Joining. (wikipedia.org)
Double-strand1
  • Testis-specific disruption of RAD1 in mice results in defective double-strand break repair, depletion of germ cells and infertility. (wikipedia.org)
Meiosis2
  • Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. (wikipedia.org)
  • 11. Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene. (nih.gov)
Protein1
  • Cell cycle checkpoint protein RAD1 is a protein that in humans is encoded by the RAD1 gene. (wikipedia.org)