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Saccharomyces cerevisiaeSaccharomyces cerevisiae Proteinscdc25 PhosphatasesCDC2 Protein Kinasecdc42 GTP-Binding Proteincdc42 GTP-Binding Protein, Saccharomyces cerevisiaeFungal ProteinsCell Cycle ProteinsCdc20 Proteinsras-GRF1Molecular Sequence DataProtein-Serine-Threonine KinasesProtein KinasesMutationCDC28 Protein Kinase, S cerevisiaeAmino Acid SequenceGene Expression Regulation, FungalBase SequenceCell CycleGenes, FungalSchizosaccharomycesCloning, MolecularSchizosaccharomyces pombe ProteinsMitosisSequence Homology, Amino AcidPhosphatidylinositol 3-KinasesMAP Kinase Signaling SystemGenetic Complementation TestCDC2-CDC28 KinasesDNA, FungalPlasmidsCalcium-Calmodulin-Dependent Protein KinasesProtein Kinase InhibitorsPhosphorylationsrc-Family Kinasesp21-Activated KinasesCyclin-Dependent KinasesProtein BindingGenes, cdcProtein Kinase CCyclic AMP-Dependent Protein Kinasesp38 Mitogen-Activated Protein KinasesCyclin BProtein-Tyrosine KinasesRNA, FungalRecombinant Fusion ProteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase KinasesMAP Kinase Kinase KinasesSignal TransductionDNA-Binding ProteinsJNK Mitogen-Activated Protein KinasesKineticsProtein Structure, TertiaryMitogen-Activated Protein Kinase 3Chromosomes, FungalUbiquitin-Protein Ligase ComplexesTranscription, GeneticNuclear ProteinsRecombinant ProteinsEnzyme ActivationBinding SitesPhenotypeSubstrate SpecificityCasein Kinase IIGene DeletionTranscription FactorsCreatine KinaseCasein KinasesModels, BiologicalGenome, FungalRNA, MessengerPhosphotransferases (Alcohol Group Acceptor)G2 PhaseeIF-2 KinaseSuppression, GeneticCarrier ProteinsPyruvate KinaseCell DivisionBlotting, WesternRibosomal Protein S6 KinasesCyclinsDNA ReplicationIntracellular Signaling Peptides and ProteinsSequence AlignmentAnaphase-Promoting Complex-CyclosomePhosphoprotein PhosphatasesMAP Kinase Kinase 1MutagenesisMitogen-Activated Protein KinasesCell NucleusSaccharomycesIsoenzymesMAP Kinase Kinase 41-Phosphatidylinositol 4-KinaseSaccharomycetalesReceptor Protein-Tyrosine KinasesCyclin-Dependent Kinase 2TransfectionDNA Primers

Cyclin-dependeFission yeastCyclinsMitoticTyrosine kinaseMitosisProteinPhosphorylationSubstrateInhibitorsRolesActivityAbsenceSaccharomycesBudding yeastCyclin-dependent protein kinaseCDKsGenePombeSubunit1996MammalianComplexes1999EukaryoticCDK2Cdc25ProgressionReplicationRegulationTranscriptionHsp90Cell cyclePhaseFamilyComplexRoleShowsFormPublications

Cyclin-depende2

• Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. (nature.com)
• Brown, N. R., Noble, M. E., Endicott, J. A. & Johnson, L. N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (nature.com)

Fission yeast2

• Stern, B. & Nurse, P. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. (nature.com)
• Fisher, D. L. & Nurse, P. A single fission yeast mitotic cyclin B p34 cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. (nature.com)

Cyclins3

• The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16INK4a. (wikipedia.org)
• It is widely assumed that degradation of mitotic cyclins causes a decrease in mitotic cdc2/CDC28 kinase activity and thereby triggers the metaphase to anaphase transition. (ox.ac.uk)
• Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in the phosphorylation of 150 Cdk1 (Cdc28) substrates. (nature.com)

Mitotic4

• The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
• Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. (ox.ac.uk)
• Two observations made on the budding yeast Saccharomyces cerevisiae are inconsistent with this scenario: (i) anaphase occurs in the presence of high levels of kinase in cdc15 mutants and (ii) overproduction of a B-type mitotic cyclin causes arrest not in metaphase as previously reported but in telophase. (ox.ac.uk)
• Although we did not identify any highly Clb2-specific substrates, we found that Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. (nature.com)

Tyrosine kinase1

• Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. (wikidata.org)

Mitosis1

• Kinase destruction is therefore implicated in the exit from mitosis rather than the entry into anaphase. (ox.ac.uk)

Protein7

• Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. (wikipedia.org)
• The protein encoded by this gene is a member of the Ser/Thr protein kinase family. (wikipedia.org)
• This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (wikipedia.org)
• It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (wikipedia.org)
• Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. (wikipedia.org)
• CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
• The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. (wikidata.org)

Phosphorylation2

• This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (wikipedia.org)
• mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. (wikidata.org)

Substrate1

• Schulman, B. A., Lindstrom, D. L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. (nature.com)

Inhibitors1

• Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. (nature.com)

Roles1

• A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION , and APOPTOSIS . (nih.gov)

Activity1

• The execution of anaphase and the destruction of CDC28 kinase activity therefore appear to take place independently of one another. (ox.ac.uk)

Absence1

• The behaviour of esp1 mutants shows in addition that kinase destruction can occur in the absence of anaphase completion. (ox.ac.uk)

Saccharomyces8

• CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. (nih.gov)
• A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression from the G1 PHASE to the S PHASE in the CELL CYCLE. (ucdenver.edu)
• Identification and characterization of individual cyclin-dependent kinase complexes from Saccharomyces cerevisiae. (ucdenver.edu)
• Saccharomyces cerevisiae is a single-celled eukaryotic microorganism belonging to the kingdom of Fungi. (blogspot.com)
• We have prepared phosphorylated cyclin-dependent protein kinase 2 (CDK2) for crystallization using the CDK-activating kinase 1 (CAK1) from Saccharomyces cerevisiae and have grown crystals using microseeding techniques. (nih.gov)
• Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae. (sdbonline.org)
• The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. (sdbonline.org)
• In budding yeast ( Saccharomyces cerevisiae ), Cdc14 is essential for both and thought to be the major Cdk-counteracting phosphatase. (biologists.com)

Budding yeast2

• It had become clear by then that the clock in cell cycle involved the cyclin-dependent kinases or CDKs, the cdc2 gene of S pombe , the fission yeast and the CDC28 gene in S cerevisiae , the budding yeast. (medscape.com)
• The Cdk-activating kinase (CAK) from budding yeast. (sdbonline.org)

Cyclin-dependent protein kinase2

• From NCBI Gene: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. (nih.gov)
• A cyclin-dependent protein kinase in each yeast cell can replace each other between Cdc28 in S. cerevisiae and Cdc2 in S. pombe . (blogspot.com)

CDKs4

• Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. (elifesciences.org)
• Central components of these networks are the cyclin-dependent kinases (CDKs). (elifesciences.org)
• Of these, five are divergent CDK-related kinases (CRK), i.e. they are clearly related to CDKs but have no clear orthologues in the yeast or human kinomes. (elifesciences.org)
• Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin - dependent kinases (CDKs). (biologists.com)

Gene8

• Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. (wikipedia.org)
• The protein encoded by this gene is a member of the Ser/Thr protein kinase family. (wikipedia.org)
• This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (wikipedia.org)
• This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (wikipedia.org)
• The SGV1 gene encodes an apparent protein kinase homologous to CDC28/cdc2 kinase: SGV1 is 42% identical to CDC28. (elsevierpure.com)
• The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. (nih.gov)
• At non-permissive temperatures, every S. cerevisiae cell that carries a mutation in a specific cdc gene will arrest a bud of the same size. (blogspot.com)
• The cdc28 gene of S. cerevisiae is highly homologous with cdc2 + gene of S. pombe . (blogspot.com)

Pombe2

• Both the proteins of cdc2 and cdc28 are analogous in terms of their function and cdc2 − mutant of S. pombe is complemented to CDC28 of S. cerevisiae . (blogspot.com)
• Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe . (sdbonline.org)

Subunit1

• It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (wikipedia.org)

19961

• The eukaryotic genome S. cerevisiae was sequenced completely for the first time in 1996. (blogspot.com)

Mammalian1

• A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE, S CEREVISIAE and the CDC2 PROTEIN KINASE found in mammalian species. (nih.gov)

Complexes3

• Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. (wikipedia.org)
• Anaphase-promoting-complex (APC) of yeast is considered as one of the significant substrates for Cdc28-Cln2 and Cdc28-Cln1 complexes. (blogspot.com)
• The Cdc28 protein kinase subunits, Cks1 and Cks2, play dual roles in Cdk-substrate specificity and Cdk-independent protein degradation, in concert with the E3 ubiquitin ligase complexes SCFSkp2 and APCCdc20. (figshare.com)

19992

• 1999). Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. (sdbonline.org)
• 1999). Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. (sdbonline.org)

Eukaryotic1

• Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication. (elifesciences.org)

CDK22

• Phosphorylated CDK2 exhibits histone H1 kinase activity corresponding to approximately 0.3% of that observed with the fully activated phosphorylated CDK2-cyclin A complex. (nih.gov)
• 1997). Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/cdc2 but not cyclin A/cdk2. (sdbonline.org)

Cdc252

• Dephosphorylation of Cdc2 by Cdc25 phosphatase(s) at positions T14 and Y15 leads to generation of active MPF heterodimers ( right ). (comprehensivephysiology.com)
• Signals relating to DNA damage and completeness of replication impact on balance of Wee1 (a Cdc2 inhibitory kinase) and Cdc25 activities to delay entry into M phase. (comprehensivephysiology.com)

Progression1

• Progression through the cell cycle critically relies upon post-translational mechanisms including changes in activity of cell cycle kinases and phosphatases, and ubiquitin-mediated degradation of specific components once their function is complete. (elifesciences.org)

Replication2

• Even when the cdc28 cells are arrested in G 1 phase, at non-permissive temperatures they continue to grow in size but do not initiate bud formation, DNA replication, or synthesize, and thereby cannot enter the S phase. (blogspot.com)
• Once the Cdc28-Cln3 has been activated, it phosphorylates and acivates the transcription factors MBF and SBF, which then induce transcription in CLN1 and CLN2 genes and other genes for DNA replication such as genes encoding DNA polymerase, DNA ligase, and enzymes needed for synthesizing deoxyribonucleoside triphosphate. (blogspot.com)

Regulation1

• Furthermore, this work shows how membrane receptor guanylyl cyclases hijack the regulatory mechanisms used for active kinases to facilitate their regulation. (bvsalud.org)

Transcription2

• Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). (nih.gov)
• During the late S phase in S. cerevisiae , transcription of two additional genes Clb3 and Clb4 also occur, forming heterodimeric kinases along with Cdc28. (blogspot.com)

Hsp901

• As a membrane protein and non-kinase client of Hsp90-Cdc37, this work shows the remarkable plasticity of Cdc37 to interact with a broad array of clients with significant sequence variation. (bvsalud.org)

Cell cycle2

• This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. (nih.gov)
• The cdc28 of S. cerevisiae is cell cycle protein kinase that was identified as the first protein kinase. (blogspot.com)

Phase3

• Wu X, An X, Zhang C, Huang M. Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase. (ucdenver.edu)
• The phenotypic behavior of cdc28 mutants that are sensitive to temperature signifies the importance of the Cdc28 function in allowing the cell into S phase. (blogspot.com)
• thus cyclin - dependent kinase (CDK) must actively contribute to stationary phase establishment. (biologists.com)

Family1

• CDK4 is a member of the cyclin-dependent kinase family. (wikipedia.org)

Complex1

• This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). (nih.gov)

Role1

• To investigate the role of the liver kinase (LK) B1 protein, an activator of AMP-activated protein kinase (AMPK), in AMPK signaling suppression when exposed to vesicant, a kind of chemical warfare agent. (bvsalud.org)

Shows1

• This graph shows the total number of publications written about "CDC28 Protein Kinase, S cerevisiae" by people in this website by year, and whether "CDC28 Protein Kinase, S cerevisiae" was a major or minor topic of these publications. (ucdenver.edu)

Form1

• Conversion of Cdc2 from "prestart" form to a "poststart" form ( asterisk ) is inhibited by Rum1. (comprehensivephysiology.com)

Publications1

• Below are the most recent publications written about "CDC28 Protein Kinase, S cerevisiae" by people in Profiles. (ucdenver.edu)