Sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside, is a class of sulfolipids, specifically a class of sulfoglycolipids, which are glycolipids that contain a sulfate group. (wikipedia.org)
Sulfatide is synthesized primarily starting in the endoplasmic reticulum and ending in the Golgi apparatus where ceramide is converted to galactocerebroside and later sulfated to make sulfatide. (wikipedia.org)
Originally, in 1933, it was first reported by Blix that sulfatide contained amide bound fatty acid and 4-sphingenine and that the sulfate of sulfatide was thought to be attached to the C6 position of galactose. (wikipedia.org)
Sulfatide degradation occurs in the lysosomes. (wikipedia.org)
Saposin B extracts sulfatide from the membrane, which makes it accessible to arylsulfatase A. Arylsulfatase A can then hydrolyze the sulfate group. (wikipedia.org)
Galactosylceramide can be converted to sulfatide by adding a sulfate group. (medscape.com)
Lysosomal2
As a member of the sulfatase family, arylsulfatase A is encoded by the ARSA gene and required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). (bio-techne.com)
Galactosylceramide degradation is catalyzed by GALC, a lysosomal hydrolase. (medscape.com)
Gangliosides3
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). (affbiotech.cn)
Glycosphingolipids: Structure and importance of gangliosides and cerebrosides. (cutm.ac.in)
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. (lookformedical.com)
Hydrolyze1
Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS). (bio-techne.com)
Arylsulfatase2
Here, arylsulfatase A hydrolyzes the sulfate group. (wikipedia.org)
Degradation of arylsulfatase A in the endoplasmic reticulum. (medlineplus.gov)
Amino1
Primary Structure of proteins, methods of determining N- and C- terminal aminoacids, amino acid composition.Sequencing by Edman's degradation method. (cutm.ac.in)
Protein1
The resulting complex can down-regulate protein production by several mechanisms, including inhibition of mRNA translation into protein and/or by enhancement of RNase H degradation of the mRNA transcripts. (justia.com)