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  • stroke
  • Tsivgoulis G, Katsanos AH, Alexandrov AV (2014) Reperfusion therapies of acute ischemic stroke: potentials and failures. (springer.com)
  • Gomis M, Dávalos A (2014) Recanalization and reperfusion therapies of acute ischemic stroke: what have we learned, what are the major research questions, and where are we headed? (springer.com)
  • Ischemic stroke results from the occlusion of brain blood vessels, while the middle cerebral artery is mostly involved in ischemic stroke. (plos.org)
  • In the past several decades, pathophysiological process of cerebral ischemia injury was well advanced, however, only intravenous recombinant tissue plasminogen activator (tPA) therapy has been approved so far by the United States Food and Drug Administration for acute ischemic stroke. (plos.org)
  • Ischemia/reperfusion (I/R) caused by ischemic stroke treatments leads to brain injury, and autophagy plays a role in the pathology. (mdpi.com)
  • This study is designed to examine the safety and proof of concept of therapeutic hypothermia prior to conventional revascularization in subjects experiencing acute ischemic stroke by comparing the results to subjects who remain at normal body temperature (normothermic) and proceed directly to reperfusion via conventional reperfusion intervention. (clinicaltrials.gov)
  • Pharmacological targeting of NOD2-mediated inflammatory response at multiple levels may help design a new approach to develop therapeutic strategies for prevention of deterioration of cerebral function and for the treatment of stroke. (ijbs.com)
  • oxidative stress
  • Salvianolic acid B exerts strong resistance to oxidative stress and inflammatory reaction, and improves energy metabolism against cerebral ischemia-reperfusion injuries. (eurekalert.org)
  • We conclude here that pretreating animals with p-coumaric acid can prevent IR-induced brain oxidative stress, infarction size and neuronal vulnerability to death in cerebral IR injuries. (springermedizin.de)
  • The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. (msk.ru)
  • It was found that administration of dihydroquercetin caused a corrective effect to impairments of the respiratory function of mitochondria, indicators of carbohydrate metabolism and parameters of oxidative stress induced by ischemia-reperfusion. (msk.ru)
  • sham group
  • Western blotting analysis showed that the protein aggregates in the ischemia group was 32.12±4.87, 41.86±4.71 and 34.51±5.18 times higher than that in the sham group at reperfusion 12h, 24h and 48h, respectively. (medsci.org)
  • attenuate
  • In the present study, we tested the hypothesis that naringin, a natural antioxidant, could inhibit ONOO − -mediated mitophagy activation and attenuate cerebral I/R injury. (springer.com)
  • pathways
  • The lectin pathway is one of the three activation pathways of the complement activation cascade that can recognise and respond to structures on oxygen deprived cells and contribute to ischaemia and reperfusion injury (IRI). (bl.uk)
  • penumbra
  • In cats given saline cerebral blood flow (CBF) fell and then rose slightly on the marginal gyrus (infarct penumbra). (bmj.com)
  • Pial surface potassium activity remained elevated in the penumbra following reperfusion in glucose infused cats, but returned to normal in saline infused cats. (bmj.com)