• Acupuncture treatment on the motor area of the scalp for motor dysfunction in children with cerebral palsy: study protocol for a multicenter randomized controlled trial. (rcsi.com)
  • Scalp acupuncture has been widely used as treatment for motor dysfunction in children with cerebral palsy in China. (rcsi.com)
  • Previous studies have failed to provide high-quality evidence to demonstrate the effectiveness of this treatment in children with cerebral palsy. (rcsi.com)
  • The aim of this study is to evaluate the effectiveness of Jiao's scalp acupuncture when combined with routine rehabilitation treatment versus routine rehabilitation treatment alone for motor dysfunction in children with cerebral palsy. (rcsi.com)
  • One hundred cerebral palsy patients with motor dysfunction were enrolled. (rcsi.com)
  • Cerebral palsy patients in the control group will receive conventional rehabilitation treatment, whereas patients in the acupuncture group will receive a combination of scalp acupuncture and conventional rehabilitation treatment. (rcsi.com)
  • The Paediatric Evaluation of Disability Inventory and the Cerebral Palsy Quality of Life Questionnaire for Children will be selected as secondary outcome measures. (rcsi.com)
  • This is the first trial evaluating the efficacy and safety of scalp acupuncture as a treatment for motor dysfunction in children with cerebral palsy. (rcsi.com)
  • The results of this trial are expected to provide relevant evidence demonstrating that scalp acupuncture can be used as an effective rehabilitation treatment method for improving motor dysfunction in children with cerebral palsy. (rcsi.com)
  • This study examined the family emotional climate as assessed by Five Minute Speech Samples and the relation with parenting stress and parenting behaviors among parents of children (6-17 years, 64.7% boys) with autism spectrum disorder, cerebral palsy, Down syndrome, and without any known disability ( n = 447). (springer.com)
  • Treatment of spastic varus/ equinovarus foot with split-tendon transfers in Cerebral Palsy: how does it affect the hindfoot motion? (researchgate.net)
  • Introduction The flexible spastic varus foot in cerebral palsy is commonly corrected by split-tendon transfer of tibialis anterior or tibialis posterior. (researchgate.net)
  • Young patients (6-25 years) with spastic cerebral palsy (GMFCSI-II) were retrospectively included. (researchgate.net)
  • unilateral or bilateral spastic cerebral palsy, spastic paresis) represent two characteristic paralytic disorders of the upper extremity. (researchgate.net)
  • Objective: Aim of the investigation was to assess the contribution of pain to functional, social, and health-related quality of life (Qol) outcomes in adults with cerebral palsy. (researchgate.net)
  • Design: This monocentric, prospective study included long-term data for ambulant adults with cerebral palsy and at level I to III in the Gross Motor Function Classifica. (researchgate.net)
  • Salivary osmolality reflects the hydration status of individuals with cerebral palsy necessary for adequate unstimulated salivary flow rate. (bvsalud.org)
  • Methods: The sample consisted of 99 children with cerebral palsy aged 6 to 13 years old. (bvsalud.org)
  • Conclusions: The effectiveness of oral motor performance plays an important role in the hydration status of children with cerebral palsy and those with worse oral motor performance may be at higher risk of oral diseases. (bvsalud.org)
  • Cerebral palsy describes a group of chronic disorders that involve movement and posture development, often accompanied by epilepsy, secondary musculoskeletal problems and disturbances of sensation, perception, cognition, communication and behavior. (bvsalud.org)
  • Alterations in mastication and swallowing in children with cerebral palsy result in feeding dysfunctions that may lead to reduced dietary intake, prolonged feeding times and poor nutritional status accompanied by compromised physical performance 3-7 . (bvsalud.org)
  • Children with cerebral palsy present low unstimulated salivary flow rate, pH and buffer capacity 8 , and variations in the activity of enzymes and sialic acid concentrations 9 . (bvsalud.org)
  • It has also been reported that children with cerebral palsy present increased salivary osmolality and total protein concentration 10 , together with increased salivary, urine and plasma osmolalities, characterizing an impaired hydration status 11 . (bvsalud.org)
  • Considering that an adequate fluid intake and homeostasis of total body water is essential for human health and survival, the aims of this study were to investigate whether (i) oral motor performance is determinant for hydration status and (ii) the effect of a supplemental oral fluid supply on salivary osmolality in children with cerebral palsy. (bvsalud.org)
  • Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. (nature.com)
  • Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). (nature.com)
  • The incidence and risk factors of postoperative cognitive dysfunction (POCD) during robot-assisted radical cystectomy (RARC) in extreme Trendelenburg positioning and pneumoperitoneum are still controversial. (biomedcentral.com)
  • Preoperative and postoperative arterial blood gas (ABG), S-100β, C-reactive protein (CRP), and cognitive dysfunction scales were tested. (biomedcentral.com)
  • It is used in patients with cognitive dysfunction involving either a general decline of overall brain function or a localized or lateralized deficit. (medscape.com)
  • Therefore, temporospatial analysis of the EEG record is a useful indicator of cortical dysfunction in dementia and correlates with the degree of cognitive impairment. (medscape.com)
  • Encephalopathy encompasses a number of conditions that lead to cognitive dysfunction. (medscape.com)
  • One plausible cause of dementia with AF is the presence of cerebral infarctions 8 and the other mechanism may be the existence of CMBs which have been suggested to be associated with cognitive dysfunction 9 . (researchsquare.com)
  • In a previous study, we have reported alleviation of cognitive dysfunction after performing catheter ablation in patients with AF 13 , and observed de novo appearance of CMBs in correspondence with preexisting embolic microinfarctions. (researchsquare.com)
  • Introduction Sensory dysfunctions and cognitive impairments are related to each other. (researchgate.net)
  • Pulmonary exposure to these nanoparticle s induces local and systemic inflammation, cardiovascular dysfunction, and even cognitive deficits. (cdc.gov)
  • We hypothesized that bradykinin receptor inhibition alleviates the vascular dysfunction in a transgenic arcAβ mouse model of cerebral amyloidosis and that fMRI techniques can be used to monitor the treatment response. (uzh.ch)
  • In summary, bradykinin receptors blockade recovered cerebral vascular dysfunction in a mouse model of cerebral amyloidosis. (uzh.ch)
  • The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion. (bvsalud.org)
  • CAA was a cerebrovascular disease characterized by the deposition of β-amyloid protein in the media and adventitia of small and medium-sized vessels in the cerebral cortex, cortex, and pia mater. (ijpsonline.com)
  • An electroencephalogram showed mild bilateral cerebral dysfunction. (cdc.gov)
  • Cerebral MRI showed bilateral increased signal intensity in peridentatal regions on T2 weighted sequences. (bmj.com)
  • Patients underwent bilateral insonation of middle cerebral arteries with standard 2-Hz probes over the temporal windows with transcranial Doppler. (karger.com)
  • Two patients with Erdheim-Chester disease with progressive cerebellar dysfunction and pyramidal signs are reported on. (bmj.com)
  • 2 Only a few patients with cerebellar dysfunction have been described. (bmj.com)
  • 3 4 We report on two patients with Erdheim-Chester disease with slowly progressive cerebellar dysfunction, associated with pyramidal symptoms. (bmj.com)
  • Cerebellar dysfunction was slowly progressive. (bmj.com)
  • Symptoms are due to direct invasion and replication of the infectious agent in the central nervous system, resulting in objective clinical evidence of cerebral or cerebellar dysfunction. (cdc.gov)
  • The posterior cerebral arteries (PCAs) are paired vessels, usually arising from the top of the basilar artery and curving laterally, posteriorly, and superiorly around the midbrain. (medscape.com)
  • Cerebrovascular disease is a group of conditions characterized by disorders of the cerebral vessels. (edu.au)
  • Amyloid fibrils may deposit in cerebral vessels, as in β-amyloid CAA, or form senile plaques in brain parenchyma. (medscape.com)
  • In the past few decades the immense development of neuroradiological methods enabled better imaging of cerebral blood vessels. (hindawi.com)
  • Cerebral endothelium is a one cell layer on the inner wall of the vessels and as such is a difficult subject to image. (hindawi.com)
  • Cerebral microbleeds (CMBs) are small perivascular accumulations of hemosiderin-containing macrophages as a result of extravasation of erythrocytes from cerebral small vessels on histopathological examinations. (researchsquare.com)
  • The ICP elevation along with pneumoperitoneum further increases in the extreme Trendelenburg positioning, which may rise the risk of brain edema, blood-brain barrier damage, as well as potential brain injury caused by the decrease of cerebral perfusion and insufficient supply of oxygen. (biomedcentral.com)
  • Our purpose was to apply blood-brain barrier permeability imaging in patients with global cerebral edema by using extended CT perfusion. (ajnr.org)
  • In addition, the PCAs, via the posterior communicating arteries (PCOM), may become important sources of collateral circulation for the middle cerebral artery (MCA) territory. (medscape.com)
  • Using pressure myography, we found that spontaneous tone significantly increased and L-NAME-induced vasoconstriction was significantly blunted in middle cerebral arteries (MCAs) harvested from antibiotic-treated rats. (edu.au)
  • Invariably, these cases show severe atheroma of the cerebral arteries. (bmj.com)
  • TCD enables continuous monitoring of mean blood flow velocity through the cerebral arteries and therefore the evaluation of cerebral blood flow [ 2 ]. (hindawi.com)
  • Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction. (nih.gov)
  • In this study, we observed the effects of propofol on multiple aspects of mitochondrial dysfunction by studying the mitochondria isolated from rat brains subjected to focal cerebral ischemia-reperfusion. (nih.gov)
  • Since the equilibrative nucleoside transporter -2 (Ent2) is important in regulating brain adenosine homeostasis , the present study aimed to investigate the role of Ent2 in mice with cerebral ischemia - reperfusion . (bvsalud.org)
  • Cerebral ischemia - reperfusion injury was examined in mice with transient middle cerebral artery occlusion (tMCAO) for 90 minutes, followed by 24-hour reperfusion . (bvsalud.org)
  • Ent2 deletion reduced the infarct volume, brain edema , and neuroinflammation in mice with cerebral ischemia - reperfusion . (bvsalud.org)
  • Ent2 plays a critical role in modulating cerebral collateral circulation and ameliorating pathological events of brain ischemia and reperfusion injury . (bvsalud.org)
  • Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischemia. (lu.se)
  • These results demonstrate that propofol may protect against mitochondrial dysfunction by preventing the ultrastructural change to the mitochondria and the calcium-induced mitochondrial swelling. (nih.gov)
  • Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction. (cam.ac.uk)
  • We identified patients with persistent raised LPR despite adequate cerebral glucose and oxygen provision, which we clinically classified as cerebral 'mitochondrial dysfunction' (MD). In patients with TBI and MD, we administered disodium 2,3-13C2 succinate (12 mmol/L) by retrodialysis into the monitored region of the brain. (cam.ac.uk)
  • Infarct volume, brain edema , neuroinflammation , microvascular structure, regional cerebral blood flow (rCBF), cerebral metabolic rate of oxygen (CMRO2), and the production of reactive oxygen species (ROS) were examined following the reperfusion . (bvsalud.org)
  • Effects of auditory stimulation on regional cerebral blood flow in autistic children. (bvsalud.org)
  • Global cerebral edema occurs after SAH and is associated with BBB disruption. (ajnr.org)
  • Detection of global cerebral edema using current imaging techniques is challenging. (ajnr.org)
  • Patients with SAH underwent CTP in the early phase after aneurysmal rupture (days 0-3) and were classified as having global cerebral edema or nonglobal cerebral edema using established noncontrast CT criteria. (ajnr.org)
  • Extended CTP was used to evaluate blood-brain barrier permeability in patients with SAH with and without global cerebral edema. (ajnr.org)
  • Further study of blood-brain barrier permeability is needed to improve diagnosis and monitoring of global cerebral edema. (ajnr.org)
  • Cerebral edema in intracerebral hemorrhage: pathogenesis, natural history and potential treatments from translation to clinical trials Frontiers in Stroke. (nottingham.ac.uk)
  • Ninety-nine non-institutionalized male and female children (aged 6 to 13 years-old) with a medical diagnosis of spastic cerebral palsy13, who were referred to a specialized rehabilitation center in São Paulo, SP, Brazil, were consecutively included in this study. (bvsalud.org)
  • Therefore, the aim of this study was to determine the effect of gut bacterial disruption on cerebral endothelial function. (edu.au)
  • In this review, the role of cerebrovascular reactivity to L-arginine (CVR-L-Arg) for assessment of cerebral endothelial function is discussed. (hindawi.com)
  • However, it seems to show specific cerebral endothelial function. (hindawi.com)
  • So far CVR-L-Arg has been used to study cerebral endothelial function in many pathological conditions such as stroke, migraine, etc. (hindawi.com)
  • In conclusion CVR-L-Arg is a promising noninvasive research method that could provide means for evaluation of cerebral endothelial function in physiological and pathological conditions. (hindawi.com)
  • Until recently it was impossible to determine specific cerebral endothelial function. (hindawi.com)
  • However, these techniques do not enable any evaluation of cerebral endothelial function. (hindawi.com)
  • In the past few years cerebrovascular reactivity to L-arginine by means of TCD has emerged as a parameter for evaluation of cerebral endothelial function [ 3 - 7 ]. (hindawi.com)
  • Functional magnetic resonance imaging (fMRI) techniques can be used to assess cerebrovascular dysfunction in Alzheimer's disease, an important and early contributor to pathology. (uzh.ch)
  • This study provides clear evidence that acute exposure to MDMA results in cerebrovascular dysfunction. (erowid.org)
  • Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects impaired energy metabolism. (cam.ac.uk)
  • Immunoblotting revealed that the eNOS-P/total eNOS ratio was significantly reduced in cerebral artery lysates from antibiotic-treated rats compared to controls. (edu.au)
  • Title : Thalamocortical Dysfunction and Thalamic Injury after Asphyxial Cardiac Arrest in Developing Rats Personal Author(s) : Shoykhet, Michael;Simons, Daniel J.;Alexander, Henry;Hosler, Christina;Kochanek, Patrick M.;Clark, Robert S. B. (cdc.gov)
  • to determine the effect, if any, acute exposure to MDMA has on the cerebral circulation, independently of alterations in cerebral metabolic demand. (erowid.org)
  • Here, we examine the cerebral spinal fluid (CSF)-derived peptidomic fraction as a reflection of neuropathological alterations induced by pulmonary carbon nanomaterial exposure. (cdc.gov)
  • Thus, pericyte degeneration as seen in neurological disorders such as Alzheimer's disease may contribute to neurovascular dysfunction and neurodegeneration associated with human disease. (nature.com)
  • His research aims to develop clinical biomarkers and novel therapeutics for (physio)pathological conditions associated with neurodegeneration and/or endothelial dysfunction, notably stroke, hypertension, diabetes and ageing. (nottingham.ac.uk)
  • The mechanism for coma or impaired consciousness involves dysfunction of both cerebral hemispheres or of the reticular activating system (also known as the ascending arousal system). (merckmanuals.com)
  • Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition. (bvsalud.org)
  • Researchers can look at proteins and cells in the spinal fluid to see if there is any neurological dysfunction, including abnormal immune activity or blood-brain-barrier impairment. (eurasiareview.com)
  • In 1994, after three years of progressive neurological dysfunction, diagnosis of Erdheim-Chester disease was made by analysis of biopsies of the femur bones, showing infiltration with foamy histiocytes lacking Birbeck granules and S-100 protein, and with few lymphocytes. (bmj.com)
  • Cerebral microdialysis was performed to obtain semi real time measurements of cerebral metabolic status. (lu.se)
  • Cerebral injury remains a significant complication of cardiac operations. (elsevierpure.com)
  • We determined the incidence of cerebral dysfunction in a population of elderly patients undergoing open chamber cardiac operations (group 1) as compared with a younger population (group 2) and an age-matched group of elderly patients undergoing major noncardiac operations (group 3). (elsevierpure.com)
  • Elderly patients having open chamber cardiac operations exhibit significantly more cerebral dysfunction in the early postoperative period than those undergoing major noncardiac operations and younger patients after open chamber procedures. (elsevierpure.com)
  • This study is the first time researchers have tested a large cohort of people living with Long COVID for spinal fluid markers of brain inflammation and blood-brain-barrier dysfunction. (eurasiareview.com)
  • There was no abnormality on brain CT but cerebral MRI showed abnormal increased signal intensity on T2 weighted sequences in the sphenoidal region and in both dentate nuclei. (bmj.com)
  • Vocal cord dysfunction (VCD) is the sudden, abnormal narrowing closure of the vocal cords during inhalation causing obstruction of the airflow, and is characterized by a noise that can mimic the sound of wheezing. (news-medical.net)
  • A new study found that neuroinflammation and blood-brain-barrier dysfunction are not likely drivers of the symptoms, giving researchers more clues in their quest to uncover what actually may be the culprit. (eurasiareview.com)
  • The researchers did not find any significant differences between the experimental and control groups, suggesting that neuroinflammation and blood-brain-barrier dysfunction are unlikely to be the causes of neuropsychiatric symptoms associated with Long COVID. (eurasiareview.com)
  • Carbon nanotube exposure triggers a cerebral peptidomic response: barrier compromise, neuroinflammation and a hyperexcited state. (cdc.gov)
  • Several pathological features of T2DM and AD may contribute to the development of hippocampal IR, including increases in oxidative stress and in the amount of pro-inflammatory cytokines and amyloid-β peptides, as well as hypothalamic-pituitary-adrenal axis dysfunction. (nature.com)
  • Posterior cerebral artery (PCA) stroke is less common than stroke involving the anterior circulation . (medscape.com)
  • This study highlights the potential of the microbiota as a target to reverse endothelial dysfunction and a preventative approach to reducing risk of stroke and aneurysms. (edu.au)
  • Cerebral vascular protection is critical for stroke treatment . (bvsalud.org)
  • Cerebral endothelium is probably one of the most specific types but until recently it was impossible to determine its function. (hindawi.com)
  • L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. (hindawi.com)
  • Cerebral endothelium is probably one of the most specific types since it is the crucial element of the well-known blood-brain barrier. (hindawi.com)
  • Computed tomography (CT) scan of the brain showing hypodense areas in the right occipital lobe consistent with a recent posterior cerebral artery (PCA) ischemic infarct. (medscape.com)
  • Clinical dementia is a fairly broad-based decline of brain function, and most definitions center on the patient's intellectual decline and memory dysfunction. (medscape.com)
  • Cerebral autoregulation maintains constant blood flow (CBF) through the brain in spite of changing mean arterial pressure [ 8 ]. (hindawi.com)
  • TNF-a evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor Immunobiology. (nottingham.ac.uk)
  • Dev Brain Dysfunction , (7), 119-128. (bvsalud.org)
  • Prolonged time of pneumoperitoneum caused by carbon dioxide retention or even hypercapnia, may also lead to increase of intracranial pressure secondary to cerebral vascular expansion. (biomedcentral.com)
  • In general, patients with PCA distribution strokes exhibit less overall chronic disability than do those with anterior cerebral, middle cerebral, or basilar artery infarctions. (medscape.com)
  • The prevalence of cerebral microbleeds (CMBs) is significantly higher in patients with atrial fibrillation (AF) than in those without AF. (researchsquare.com)
  • Low cerebral blood flow can affect cognition in patients with high-grade asymptomatic internal carotid artery stenosis. (karger.com)
  • Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
  • Similarly, measuring cerebral blood volume changes upon pharmacological stimulation using vessel dilator acetazolamide revealed recovery of regional impairment of cerebral vascular reactivity in arcAβ mice upon noscapine treatment. (uzh.ch)
  • Ischemic strokes occur when blood cannot flow to cerebral structures. (medscape.com)
  • Endothelial dysfunction renders the vasculature at risk of impaired blood flow and increases the potential of developing cerebrovascular disease. (edu.au)
  • The role of pericytes in the regulation of cerebral blood flow (CBF) and neurovascular coupling remains, however, under debate. (nature.com)
  • Transcranial Doppler sonography is used for evaluation of cerebral blood flow changes. (hindawi.com)
  • Ultrasound remains the ultimate method for real time functional cerebral blood flow imaging. (hindawi.com)
  • Autoregulation of cerebral blood flow consists of mechano- and chemoregulation. (hindawi.com)
  • Measurements: Non-invasive optical monitoring was used to measure cerebral blood flow and oxygenation. (lu.se)
  • While not significant there was a trend to an increase in optically measured cerebral blood flow and hemoglobin concentration in the CO group. (lu.se)
  • Our findings suggest that disruption of the gut microbiota leads to cerebral endothelial dysfunction through reduction of eNOS activity. (edu.au)
  • Although the bones of the scull remain an obstacle for ultrasound waves and therefore ultrasound may not seem to be the optimal technique for cerebral vessel imaging, transcranial ultrasound techniques were improved and found their place and indications. (hindawi.com)
  • Fanconi syndrome is due to dysfunction of the renal proximal tubule resulting in the urinary loss of substances normally reabsorbed by the kidney at this site, such as bicarbonate, glucose, amino acids, phosphate, small proteins, and uric acid. (bmj.com)
  • Cerebral endothelial dysfunction is mentioned in the pathophysiology of several neurological diseases. (hindawi.com)
  • Measurements of heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), end-tidal CO 2 (etCO 2 ), and cerebral oxygen were immediately obtained after different time points during the surgery. (biomedcentral.com)
  • The aim of this prospective observational study was to find the incidence rate as well as possible risk factors of POCD in RARC with cerebral oxygen monitoring. (biomedcentral.com)
  • The CO group showed a significantly higher cerebral lactate-to-pyruvate ratio. (lu.se)
  • Treatment with Outgrowth Endothelial Cells Protects Cerebral Barrier against Ischaemic Injury Cytotherapy. (nottingham.ac.uk)