Cerebral amyloid angiopathy in alzheimer s. Medical search. Frequent questions

Deposited amyloid protein in these patients is identical to the amyloid protein seen in sporadic cases, and the likely genetic defect is in the amyloid protein precursor protein ( APP ) gene on chromosome 21. (medscape.com)
Mutations in the amyloid precursor protein (APP), Presenilin (PS) 1 and PS2 genes can result in increased rates of cleavage of the APP into Aβ. (wikipedia.org)
APP encodes amyloid precursor protein, a transmembrane protein which is cleaved to form amyloidogenic Aβ peptides. (alzforum.org)
The APP gene provides instructions for making a protein called amyloid precursor protein. (medlineplus.gov)
In the brain, the amyloid precursor protein plays a role in the development and maintenance of nerve cells (neurons). (medlineplus.gov)
There was no family history of AD, CJD, or any other neurological disease, and genetic analysis showed no disease specific mutations of the prion protein, presenilin 1 and 2, or amyloid precursor protein genes. (bmj.com)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
BACKGROUND AND PURPOSE -: We and others have shown that soluble amyloid β-peptide (Aβ) and cerebral amyloid angiopathy (CAA) cause significant cerebrovascular dysfunction in mutant amyloid precursor protein (APP) mice, and that these deficits are greater in aged APP mice having CAA compared with young APP mice lacking CAA. (wustl.edu)

Since CAA can be caused by the same amyloid protein that is associated with Alzheimer's dementia, brain bleeds are more common in people who have a diagnosis of Alzheimer's disease. (wikipedia.org)
World alzheimer report 2015 - the global impact of dementia: an analysis of prevalence, incidence, cost and trends. (intramed.net)
Wimo A, Prince M. The world Alzheimer report 2010 'The Global Impact of Dementia. (intramed.net)
Vascular dementia is the second most common form of dementia after Alzheimer Disease (AD). (medscape.com)
Comorbid cerebral amyloid angiopathy in dementia and prodromal stages-Prevalence and effects on cognition. (nih.gov)
Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook Dementia Study. (nature.com)
People with hereditary cerebral amyloid angiopathy often have progressive loss of intellectual function (dementia), stroke, and other neurological problems starting in mid-adulthood. (medlineplus.gov)
People with the Flemish and Italian types of hereditary cerebral amyloid angiopathy are prone to recurrent strokes and dementia. (medlineplus.gov)
The first sign of the Icelandic type of hereditary cerebral amyloid angiopathy is typically a stroke followed by dementia. (medlineplus.gov)
Strokes are rare in people with the Arctic type of hereditary cerebral amyloid angiopathy, in which the first sign is usually memory loss that then progresses to severe dementia. (medlineplus.gov)
Two types of hereditary cerebral amyloid angiopathy, known as familial British dementia and familial Danish dementia, are characterized by dementia and movement problems. (medlineplus.gov)
In a clinical setting, differences between the cognitive disturbances in vascular dementia and Alzheimer disease are of limited value in distinguishing the 2 conditions. (medscape.com)
Vascular dementia may have less significant memory dysfunction than Alzheimer disease. (medscape.com)
The diagnosis of vascular dementia is usually made on the basis of clinical, neuroimaging, or neuropathologic evidence of cerebral ischemia in the presence of progressive cognitive decline. (medscape.com)
Management of vascular disease and dementia in a young patient with suspected uncommon causes of stroke (eg, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL] or angiitis) involves ruling out these conditions with the appropriate testing procedures (ie, skin biopsy, cerebral angiography). (medscape.com)
One plausible cause of dementia with AF is the presence of cerebral infarctions 8 and the other mechanism may be the existence of CMBs which have been suggested to be associated with cognitive dysfunction 9 . (researchsquare.com)
Alzheimer disease (AD) is the most common progressive degenerative form of dementia, strongly associated with advancing age. (medscape.com)
1 As one feature of cerebral small vessel disease (CSVD), CMBs were found to have a close association with ischemic or hemorrhagic stroke, dementia, or even mortality. (dovepress.com)
Vascular cognitive impairment and dementia is acute or chronic cognitive deterioration due to diffuse or focal cerebral infarction that is most often related to cerebrovascular disease. (msdmanuals.com)

Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in cerebral vascular smooth muscle cells (VSMCs) generates an Aβ non-clearing VSMC phenotype through transactivation of sterol regulatory element binding protein-2, which downregulates low density lipoprotein receptor-related protein-1, a key Aβ clearance receptor. (nature.com)
Haass, C. & Selkoe, D. J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. (nature.com)
Hereditary cerebral amyloid angiopathy is a condition characterized by an abnormal buildup of protein clumps called amyloid deposits in the blood vessels in the brain, causing vascular disease (angiopathy). (medlineplus.gov)
CAA was a cerebrovascular disease characterized by the deposition of β-amyloid protein in the media and adventitia of small and medium-sized vessels in the cerebral cortex, cortex, and pia mater. (ijpsonline.com)
FDA also wants input on the drug's use in patients taking blood thinners, and in those with a condition called cerebral amyloid angiopathy, in which the protein amyloid - which Leqembi targets - builds up in artery walls and can cause bleeding in the brain. (newsmax.com)
Newswise - As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. (newswise.com)
Memory tests showed mild to a strong improvement in memory function, increased expression levels of postsynaptic density protein 95 (PSD95), and low-density lipoprotein receptor-related protein 1 (LRP1), which are involved in synaptic plasticity and amyloid-beta (Aβ) elimination, respectively. (biomedcentral.com)

The vascular amyloid pathology characteristic of CAA can be classified as either Type 1 or Type 2, the latter type being the more common. (wikipedia.org)
Type 1 CAA pathology entails detectable amyloid deposits within cortical capillaries as well as within the leptomeningeal and cortical arteries and arterioles. (wikipedia.org)
In type 2 CAA pathology, amyloid deposits are present in leptomeningeal and cortical arteries and arterioles, but not in capillaries. (wikipedia.org)
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. (intramed.net)
Jellinger, K. A. Alzheimer disease and cerebrovascular pathology: an update. (nature.com)
Objective memory impairment in people with probable cerebral amyloid angiopathy was related to tau pathology. (medpagetoday.com)
For years, AD has been studied from the perspective of neurons, amyloid plaques, and tau pathology. (wustl.edu)
Several lines of evidence indicate that cerebral amyloid angiopathy (CAA) acts as a significant contributor to the AD pathology [ 13 , 14 ]. (biomedcentral.com)
Amyloid pathology and cognitive function were also examined. (bvsalud.org)

The disease was clinically characterized by multiple and complex intracerebral hemorrhages, so it was also known as cerebral amyloid angiopathy hemorrhage (CAAH) [ 2 , 3 ]. (ijpsonline.com)
When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise the risk of strokes. (newswise.com)

Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid in the media and adventitia of small and mid-sized arteries (and, less frequently, veins) of the cerebral cortex and the leptomeninges. (medscape.com)
In all cases, it is defined by the deposition of amyloid beta (Aβ) in the leptomeningeal and cerebral vessel walls. (wikipedia.org)
Amyloid β-peptide (Aβ) deposition in cerebral vessels contributes to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). (nature.com)
Cerebral amyloid angiopathy (CAA) was a group of diseases characterized by the deposition of the insoluble fibrin (glycoprotein) in brain tissue. (ijpsonline.com)
Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event in Alzheimer disease (AD), factors associated with increased deposition are of great interest. (escholarship.org)

Objective: To investigate the association between the extent of cerebral amyloid angiopathy (CAA) and Apolipoprotein E (Apo E) e4 allele in Alzheimer's disease (AD). (confex.com)
Mutations in APP are associated with familial forms of early onset Alzheimer's disease as well as with Cerebral Amyloid Angiopathy (CAA). (alzforum.org)
CAA-ri has gained additional interest for its notable similarities to amyloid-related imaging abnormalities, a complication of immunotherapy treatments in Alzheimer's disease patients. (iospress.com)
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. (intramed.net)
Current findings on the coincidence of cerebral amyloid angiopathy and Alzheimer's disease]. (nih.gov)
Recent research also suggested that anti-amyloid therapies for Alzheimer's disease accelerated brain atrophy , a point raised at the advisory committee meeting by panelist Tanya Simuni, MD, of Northwestern University in Chicago. (medpagetoday.com)
We previously reported that pathologic measures of arteriosclerosis (AS), cerebral infarction, and Alzheimer's disease (AD) are independently correlated with cortical gray matter (CGM) atrophy measured by in vivo magnetic resonance imaging (MRI). (escholarship.org)
BACKGROUND: The majority of patients with Alzheimer's disease (AD) exhibit amyloid-β (Aβ) deposits at the brain vasculature, a process referred to as cerebral amyloid angiopathy (CAA). (amsterdamumc.org)
Cerebral β-amyloid angiopathy is common in elderly individuals, especially those affected with Alzheimer's disease. (mahidol.ac.th)
Our autopsy study showed direct association between severe cerebral β-amyloid angiopathy and microinfarct burden in Alzheimer's disease brains. (mahidol.ac.th)
The team's NIH-funded research focuses on myeloid cells including microglia and macrophages and lymphatics in Alzheimer's disease (AD) and Cerebral amyloid angiopathy (CAA). (wustl.edu)
It is amazing privilege to work with these outstanding scientists and tackle the neuroimmune aspects of Alzheimer's disease and of cerebral amyloid angiopathy," Dr. Kipnis said. (wustl.edu)
Several antibodies that target amyloid plaques have been studied as experimental treatments for Alzheimer's disease. (newswise.com)
The findings, published Feb. 17 in Science Translational Medicine, suggest a potentially safer approach to removing harmful amyloid plaques as a way of treating Alzheimer's disease and cerebral amyloid angiopathy. (newswise.com)
Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer's disease but also observed in the general population . (bvsalud.org)
An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). (bvsalud.org)

We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. (iospress.com)
Intracerebral hemorrhage under platelet inhibition and oral anticoagulation in patients with cerebral amyloid angiopathy]. (nih.gov)

This may be observed in cases of anterior cerebral artery infarct, parietal lobe infarcts, thalamic infarction, and singular gyrus infarction. (medscape.com)
The individual approach combines a vascular risk factor modification and various therapies addressing the specific subtypes of stroke (eg, antiplatelet drugs to prevent cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants to prevent cardiac emboli). (medscape.com)
The effect of AS on cognition appears to occur through cerebral infarction and CGM atrophy (β = -0.13, s.e. = 0.04). (escholarship.org)
MRI was performed at 3Tesla and cardiovascular risk factors (eg, age, smoking history, and hypertension), cerebral small vessel disease (CSVD) markers (eg, white matter hyperintensities, lacunar infarction, and enlarged perivascular space) and genetic information (eg, APOE, CR1) were recorded. (dovepress.com)
Amyloid β-peptide in young APP mice also increases infarction after focal cerebral ischemia, but the impact of CAA on ischemic brain injury is unknown. (wustl.edu)
METHODS -: To determine this, we assessed cerebrovascular reactivity, cerebral blood flow (CBF), and extent of infarction and neurological deficits after transient middle cerebral artery occlusion in aged APP mice having extensive CAA versus young APP mice lacking CAA (and aged-matched littermate controls). (wustl.edu)
CONCLUSIONS -: These data indicate CAA induces a more severe form of cerebrovascular dysfunction than amyloid β-peptide alone, leading to intra- and postischemic CBF deficits that ultimately exacerbate cerebral infarction. (wustl.edu)
Ischemic Stroke Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). (msdmanuals.com)

In a 6-0 vote, the agency's Peripheral and Central Nervous System Drugs Advisory Committee fully backed the evidence supporting the anti-amyloid monoclonal antibody. (medpagetoday.com)
But all of the anti-amyloid antibodies that have successfully reduced amyloid plaques in Alzheimer's clinical trials also can cause a worrisome side effect: an increased risk of brain swelling and bleeds. (newswise.com)
In clinical trials for anti-amyloid antibodies, roughly 20% of participants develop ARIA, although not all have symptoms. (newswise.com)
Anti-amyloid antibodies work by alerting the immune system to the presence of unwanted material - amyloid plaques - and directing the cleanup crew - inflammatory cells known as microglia - to clear out such debris. (newswise.com)
The researchers compared the number of brain bleeds in mice treated for eight weeks with either HAE-4 or aducanumab, an anti-amyloid antibody that is in phase 3 clinical trials for Alzheimer's. (newswise.com)

CAA has been recognized as one of the morphologic hallmarks of Alzheimer disease (AD), but it is also often found in the brains of elderly patients who are neurologically healthy. (medscape.com)
Impaired elimination and accumulation of soluble and insoluble β-amyloid peptide may underlie the pathogenesis of CAA and explain the link between CAA and Alzheimer disease (AD). (medscape.com)
The amyloid material is only found in the brain and as such the disease is not related to other forms of amyloidosis. (wikipedia.org)
Cerebral amyloid angiopathy- related inflammation (CAA-ri) is an aggressive disease subtype of CAA with characteristic clinical and radiological findings. (iospress.com)
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. (intramed.net)
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. (intramed.net)
Amyloid-dependent and amyloid-independent stages of Alzheimer disease. (intramed.net)
Coincidence of normal pressure hydrocephalus and Alzheimer`s disease: therapeutic implications and open questions]. (nih.gov)
High antioxidant intake significantly reduced the incidence of Alzheimer 's disease (RR = 0.85, 95% CI 0.79-0.92 I 2 = 45.5%), and we additionally carried out subgroup analyses by nutrient type, diet or supplement, region, and study quality score. (iospress.com)
In contrast, a cognitively impaired patient with vascular risks factors but no history of cerebrovascular disease is most likely to have Alzheimer disease. (medscape.com)
Elevated cerebral Aβ level was associated with cholesterol fractions in a pattern analogous to that found in coronary artery disease. (escholarship.org)
With the rising aging population, cerebral amyloid angiopathy is increasing, but effective disease-modifying interventions are nonexistent. (uri.edu)
Although Alzheimer disease (AD) is more frequent in individuals with Down syndrome (DS), the main contributing factor is unknown. (medscape.com)
Many studies suggested that deep CMBs may relate to hypertensive small vessel disease (HTN-SVD) and strictly lobar CMBs for cerebral amyloid angiopathy (CAA), 1 but the risk factors of CMBs are not entirely clear. (dovepress.com)
Down syndrome, Alzheimer disease, and cerebral amyloid angiopathy: the complex triangle of brain amyloidosis. (bvsalud.org)
Alzheimer Disease Alzheimer disease causes progressive cognitive deterioration and is characterized by beta-amyloid deposits and neurofibrillary tangles in the cerebral cortex and subcortical gray matter. (msdmanuals.com)
The reason why Alzheimer disease (AD) is more frequent in individuals with Down syndrome (DS) is not known. (medscape.com)

The antibody targets a minor component of amyloid plaques known as apolipoprotein E (APOE). (newswise.com)

Cerebral amyloid angiopathy can be presented with lobar intracerebral hemorrhage or microbleeds in the brain. (wikipedia.org)
The prevalence of cerebral microbleeds (CMBs) is significantly higher in patients with atrial fibrillation (AF) than in those without AF. (researchsquare.com)
Cerebral microbleeds (CMBs) are small perivascular accumulations of hemosiderin-containing macrophages as a result of extravasation of erythrocytes from cerebral small vessels on histopathological examinations. (researchsquare.com)
Cerebral microbleeds (CMBs) are frequently found in the healthy elderly. (dovepress.com)
The prevalence of cerebral microbleeds is similar to other countries. (dovepress.com)
Cerebral microbleeds (CMBs) are 2-10mm, rounded or circular, well-defined hypointense lesions on gradient-echo T2*-weighted images (GRE T2*WI) or susceptibility-weighted images (SWI) of magnetic resonance imaging (MRI). (dovepress.com)

Cerebral amyloid angiopathy (CAA) is a form of angiopathy in which amyloid beta peptide deposits in the walls of small to medium blood vessels of the central nervous system and meninges. (wikipedia.org)
Plaque-type and vascular amyloid was immunohistochemically identified as deposits of beta-A4 peptide. (bmj.com)
I also accomplished in optimizing a protocol of immunogold silver staining for β-amyloid on semi-thin resin-embedded brain tissue sections and demonstrated a spatial association of β-amyloid deposits in capillary walls and perivascular neuropil, supporting a hypothesis of deficiencies in perivascular drainage in mediating cerebral β-amyloidosis. (mahidol.ac.th)
Coarse granular deposits of PrP in cerebral cortex, basal ganglia, and thalamus. (cdc.gov)

Adverse events included amyloid-related imaging abnormalities (ARIA) with edema or effusions (ARIA-E), which occurred in 13% of people who received lecanemab. (medpagetoday.com)
The side effect, called ARIA, for amyloid-related imaging abnormalities, is visible on brain scans. (newswise.com)
Apart from the infusion-related reactions with lecanemab, it is also associated with amyloid-related imaging abnormalities (ARIA), which are uniquely seen in monoclonal antibodies for AD as it is also seen in solanezumab and aducanumab. (springeropen.com)

Amyloid fibrils may deposit in cerebral vessels, as in β-amyloid CAA, or form senile plaques in brain parenchyma. (medscape.com)
Surprisingly, we found Alzheimer-type senile plaques and cerebral amyloid angiopathy in widespread areas of the brain. (bmj.com)

The Boston Cerebral Amyloid Angiopathy Group has elaborated guidelines for the diagnosis of cerebral amyloid angiopathy (CAA) associated with intracranial hemorrhage (ICH). (medscape.com)
Hereditary cerebral hemorrhage with amyloidosis-Dutch type is an autosomal-dominant disorder with complete penetrance. (medscape.com)
Hereditary cerebral hemorrhage with amyloidosis-Icelandic type is also autosomal dominant. (medscape.com)
To investigate the diagnostic value of the magnetic susceptibility-weighted imaging and routine magnetic resonance imaging in cerebral amyloid angiopathy hemorrhage. (ijpsonline.com)
A total of 64 patients with suspected cerebral amyloid angiopathy hemorrhage diagnosed in our hospital from January 2018 to January 2019 were included in the study. (ijpsonline.com)
The consistency of the two detection methods in the diagnosis of cerebral amyloid angiopathy hemorrhage and the difference in image quality were analyzed. (ijpsonline.com)
Magnetic susceptibility-weighted imaging has obvious advantages in detecting the micro cerebral hemorrhage, and it can show the characteristics of the cerebral amyloid angiopathy multiple hemorrhages, and its diagnostic value was better than that of routine routine magnetic resonance imaging. (ijpsonline.com)

CMBs are classified into two types according to their location (deep and lobar CMBs), and histopathological analysis reveals mainly two types of vascular pathological changes, hypertensive vasculopathy and cerebral amyloid angiopathy (CAA), respectively. (researchsquare.com)

The dynamic between accumulation and clearance of amyloid may be related to impaired drainage from perivascular basement membranes. (medscape.com)
The overarching consortium aims are to establish a data-driven, integrated multi-scale understanding of perivascular brain clearance in health and cerebral amyloid angiopathy, translate experimental findings from rodent models to the human brain, and identify relevant driving forces to be tested in future clinical trials to enhance brain clearance. (uri.edu)
CAA is mainly caused by an impaired Aβ clearance from the cerebral vasculature along perivascular lymphatic drainage pathways. (biomedcentral.com)

Variants (also called mutations) in the APP gene are the most common cause of hereditary cerebral amyloid angiopathy. (medlineplus.gov)

PrP microplaques, synaptic and granular accumulations of PrP restricted to cerebral cortex, basal ganglia, and thalamus. (cdc.gov)

Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. (bvsalud.org)

Common areas of the brain associated with cognitive decline are the white matter of the cerebral hemispheres and the deep gray nuclei, especially the striatum and the thalamus. (medscape.com)

Holtzman and first author Monica Xiong, a graduate student, suspected that an antibody that targets only a minor part of the amyloid plaque might elicit a more restrained response that clears the plaques from both brain tissue and blood vessels without causing ARIA. (newswise.com)

However, some evidence suggests that the amyloid is produced in the smooth muscle cells of the tunica media as a response to damage to the vessel wall (perhaps by arteriosclerosis or hypertension). (medscape.com)

Review: sporadic cerebral amyloid angiopathy. (intramed.net)

The prevalence of hereditary cerebral amyloid angiopathy is unknown. (medlineplus.gov)

Figure 7: Hypoxia increases MYOCD and SRF expression in human cerebral VSMC and pial vessels in APPsw ± mice. (nature.com)
If the clinician has reason to suspect an angiitis affecting cerebral vessels, then an erythrocyte sedimentation rate (ESR) and specific panels may be ordered. (medscape.com)
Now, researchers at Washington University School of Medicine in St. Louis have identified an antibody that, in mice, removes amyloid plaques from brain tissue and blood vessels without increasing risk of brain bleeds. (newswise.com)
We've taken a different approach by targeting APOE, and it seems to be effective at removing amyloid from both the brain tissue and the blood vessels, while avoiding this potentially dangerous side effect. (newswise.com)
To determine whether HAE-4 also removes amyloid from brain blood vessels, the researchers used mice genetically modified with human genes for amyloid and APOE4, a form of APOE associated with a high risk of developing Alzheimer's and cerebral amyloid angiopathy. (newswise.com)
Such mice develop abundant amyloid plaques in brain tissue and brain blood vessels by the time they are about six months old. (newswise.com)
Experiments showed that eight weeks of treating mice with HAE-4 reduced amyloid plaques in brain tissue and brain blood vessels. (newswise.com)
Amyloid plaques in brain blood vessels are dangerous because they can lead to blockages or ruptures that cause strokes. (newswise.com)
The mice had a baseline level of tiny brain bleeds because of their genetic predisposition for amyloid buildup in blood vessels. (newswise.com)

Giant cell arteritis in association with cerebral amyloid angiopathy: immunohistochemical and molecular studies. (mahidol.ac.th)

[ 1 ] It is a component of any disorder in which amyloid is deposited in the brain, and it is not associated with systemic amyloidosis. (medscape.com)
Familial amyloidosis-Finnish type is associated with gelsolin amyloid (AGel). (wikipedia.org)
Associations between serum cholesterol levels and cerebral amyloidosis. (escholarship.org)
Cerebral Aβ was quantified using a Global PIB Index, which averages PIB retention in cortical areas prone to amyloidosis. (escholarship.org)

There are many different types of hereditary cerebral amyloid angiopathy. (medlineplus.gov)
The various types of hereditary cerebral amyloid angiopathy are named after the regions where they were first diagnosed. (medlineplus.gov)
The Dutch type of hereditary cerebral amyloid angiopathy is the most common form. (medlineplus.gov)

apolipoprotein E (APOE) ε2 and ε4 are associated with increased risk of getting cerebral amyloid antipathy. (wikipedia.org)

However, there are types involving other amyloid peptides: the "Icelandic type" is associated with Cystatin C amyloid (ACys). (wikipedia.org)

APOE4 homozygotes, people with underlying cerebral amyloid angiopathy (CAA), and people who require concomitant treatment with anticoagulant agents. (medpagetoday.com)

RESULTS -: We found that aged APP mice have more severe cerebrovascular dysfunction that is CAA dependent, have greater CBF compromise during and immediately after middle cerebral artery occlusion, and develop larger infarctions after middle cerebral artery occlusion. (wustl.edu)
Neurovascular function was tested in anesthetized mice equipped with a cranial window in which cerebral blood flow was monitored by laser-Doppler flowmetry . (bvsalud.org)

Selkoe, D. J. Clearing the brain's amyloid cobwebs. (nature.com)
KINGSTON, R.I. - June 27, 2023 - William Van Nostrand, co-executive director of the George & Anne Ryan Institute for Neuroscience at the University of Rhode Island, is part of a team awarded a five-year, $8 million grant from the prestigious Leducq Foundation that will establish a transatlantic consortium on the study of the brain's waste-clearing system as a contributor to cerebral amyloid angiopathy. (uri.edu)

The term congophilic is sometimes used because the presence of the abnormal aggregations of amyloid can be demonstrated by microscopic examination of brain tissue after staining with Congo red. (wikipedia.org)
Fortunately, they had one such antibody on hand: an antibody called HAE-4 that targets a specific form of human APOE that is found sparsely in amyloid plaques and triggers the removal of plaques from brain tissue. (newswise.com)

Alzheimer's researchers have been searching for decades for therapies that reduce amyloid in the brain, and now that we have some promising candidates, we find that there's this complication," said senior author David Holtzman, MD , the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology . (newswise.com)

Anatomy8

Organisms1

Diseases15

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Psychiatry and Psychology5

Phenomena and Processes4

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care1

Precursor8

Dementia19

Protein7

Pathology9

Known as cerebral amyloid an2

Deposition5

Alzheimer's Disease16

Patients with cerebral2

Infarction8

Anti-amyloid5

Disease17

Component of amyloid plaques1

Microbleeds6

Deposits4

Abnormalities3

Senile plaques2

Hemorrhage7

Lobar1

Perivascular3

Mutations1

Cortex1

Macrophages1

Cognitive decline1

ARIA1

Vessel1

Sporadic1

Prevalence1

Vessels9

Immunohistochemical1

Amyloidosis4

Hereditary3

Apolipoprotein1

Peptides1

APOE41

Mice2

Brain's2

Brain tissue2

Therapies1