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  • Ataxia
  • Since SK channels are critical regulators of DCN firing rate, SK openers such as the drug riluzole may reduce neuronal hyperexcitability and thereby be useful in the therapy of cerebellar ataxia. (clinicaltrials.gov)
  • On this base the investigators published a pilot study in patients with chronic cerebellar ataxia (Ristori et al. (clinicaltrials.gov)
  • The present protocol is aimed at verifying the safety and efficacy of riluzole administration for a longer period, in a larger sample size of patients, with more stringent diagnostic criteria (hereditary cerebellar ataxia), respect to the above pilot study. (clinicaltrials.gov)
  • Efficacy of Riluzole in Hereditary Cerebellar Ataxia: a Randomized Double-blind Placebo-controlled Trial. (clinicaltrials.gov)
  • excitatory
  • The fate of the ptf1a expressing ventral LRL zone which gives rise to (excitatory cells of) the inferior olive (climbing fiber origin) and (inhibitory cells of ) cochlear nuclei in amniotes, has not been determined in anamniotes. (frontiersin.org)
  • Special for the zebrafish in comparison to amniotes is the predominant origin of anamniote excitatory deep cerebellar nuclei homologs (i.e., eurydendroid cells) from ptf1a expressing VCP cells, the sequential activity of various atoh1 paralogs and the incomplete coverage of the subpial cerebellar plate with proliferative EGL cells. (frontiersin.org)
  • ataxia
  • The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from ataxia clinics and cerebellar laboratories throughout North America, Europe and Asia. (springer.com)
  • Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. (springer.com)
  • To investigate whether Stiff-person syndrome (SPS) and cerebellar ataxia (CA) are associated with distinct GAD65-Ab epitope specificities and neuronal effects. (biomedcentral.com)
  • By contrast, GAD65-Ab from a patient with cerebellar ataxia (Ab CA) markedly decreased the NMDA-mediated turnover of glycerol. (biomedcentral.com)
  • lesions
  • Clark GA, McCormick DA, Lavond DG, Baxter K, Gray W, Thompson RF (1982) Effects of electrolytic lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal respnses. (springer.com)
  • Glickstein M, Hardiman MJ, Yeo CH (1983) The effects of cerebellar lesions on the conditioned nictitating membrane response of the rabbit. (springer.com)
  • pontine
  • We suggest that HVI receives information related to the US via climbing fibres from the olive and CS information via mossy fibres from the pontine nuclei. (springer.com)
  • Neurobiology
  • Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. (springer.com)
  • nonsomatic
  • We suggest that by bridging the motor and nonmotor systems, the cerebellar FN may help to integrate somatic motor and nonsomatic functions and consequently contribute to generate a coordinated response to internal and external environments. (biomedcentral.com)
  • medial
  • As one of the ultimate integration stations and outputs of the spinocerebellum, the FN holds a key position in the axial, proximal and ocular motor control by projecting to the medial descending systems and eye movement related nuclei. (biomedcentral.com)
  • receives
  • The nucleus lateralis receives terminals from the dorsomedial area (mainly from the rostral level of the LRN), the nuclei interpositalis from the dorsolateral area (mainly from the central level) and the nucleus medialis from the intermedioventral area (mainly from the caudal level). (wiley.com)
  • behavioral
  • To develop a comprehensive theory of sensorimotor learning and control, it is crucial to determine the neural basis of coding and plasticity embedded into the cerebellar neural circuit and how they are translated into behavioral outcomes in learning paradigms. (plos.org)