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  • deep cerebe
  • This template has been validated to guarantee a significant improvement in voxel-to-voxel alignment of the individual fissures and the deep cerebellar nuclei compared to Montreal Neurological Institute (MNI) whole-brain template. (frontiersin.org)
  • Purkinje cells project inhibitory signals to the deep cerebellar nuclei(DCN) which have a critical role in cerebellar function and motor performance. (clinicaltrials.gov)
  • cerebellum
  • Diseases that affect the structure or function of the cerebellum. (dmoztools.net)
  • The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer's disease (AD). (frontiersin.org)
  • These findings support the role of the cerebellum in higher-level functions, and whilst confirming previous data on the involvement of Crus I in AD dementia, provide new evidence of an involvement of the vermis in the early stages of the disease. (frontiersin.org)
  • Due to the fundamental role of the cerebellum in posture and gait control, we examined cerebellar structural and functional connectivity (FC) in patients with PD and FOG. (springer.com)
  • Rare Diseases
  • The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. (nih.gov)
  • skeletal muscle
  • Lysosomal α-glucosidase deficiency (Pompe disease) not only leads to glycogen accumulation in skeletal muscle, but also in the cerebral arteries. (springer.com)
  • patterns
  • We identified several distinct rsFC patterns of the two cognitive-related cerebellar subregions: default-mode network (DMN), frontoparietal network (FPN), visual network (VN) and sensorimotor network (SMN). (frontiersin.org)
  • Collectively, we demonstrated the distinct rsFCs patterns of cerebellar sub-regions with various functional networks, which were differentially impaired in the AD patients. (frontiersin.org)
  • severity
  • Sway speed when standing quietly with eyes open was significantly increased in those with SCA6 and strongly correlated with disease severity scores. (ucl.ac.uk)
  • Increases in SCA6 response magnitudes to moving visual stimuli strongly correlated with disease severity scores. (ucl.ac.uk)
  • superior
  • DTI parameters were obtained on the superior, middle, and inferior cerebellar peduncles. (springer.com)
  • DTI parameters in superior and middle cerebellar peduncles were altered in PD-FOG compared with PD-nFOG and significantly correlated with FOG-Q. There were no differences in cerebellar volumes between PD-FOG and either PD-nFOG or HS. (springer.com)
  • The height of BA bifurcation was assessed semi-quantitatively using the Smoker's criteria and quantitatively by measuring the outlet angle of the superior cerebellar artery (SUCA). (springer.com)
  • closely
  • The disease-specific prion protein distribution profile in slices closely resembles that in vivo , demonstrating granular spot like deposition predominately in the molecular and Purkinje cell layers. (frontiersin.org)
  • objective
  • The aim of this study was to develop an easily applied, objective, and reproducible method for determining average cerebellar tracer uptake so that images can be scaled specifically to cerebellar activity prior to the performance of SPM analysis. (stir.ac.uk)