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  • acid
  • The level and activity of acid ceramidase in Alzheimer disease (AD) brain may play a role in controlling neuronal apoptosis and may mediate signalling pathways involved in the molecular mechanism of AD. (nih.gov)
  • Overexpression and mass spectrometry analysis of mature human acid ceramidase. (nih.gov)
  • NAAA is both a lysosomal and a secreted enzyme, and like acid ceramidase, has been observed to be proteolytically processed during maturation (1). (novusbio.com)
  • molecule
  • Here, we determined crystal structures of ADIPOR2 bound to a FFA molecule and demonstrate that ADIPOR2 possesses an intrinsic basal ceramidase activity enhanced by adiponectin. (pubmedcentralcanada.ca)
  • mice
  • UT Southwestern researchers showed that introducing ceramidase in diabetic mice returned their insulin sensitivity to normal. (wikipedia.org)
  • activity
  • Because we found that ADIPOR1 also possesses an intrinsic ceramidase activity, we suspect that the two distinct structures may represent key steps of the ADIPORs enzymatic activity. (pubmedcentralcanada.ca)
  • The ceramidase activity is low, however, and further studies will be required to fully characterize ADIPORs enzymatic parameters and their substrate specificity. (pubmedcentralcanada.ca)
  • Recently, the pleiotropic actions of adiponectin were linked to the ceramide signaling pathway as ADIPOR1 and ADIPOR2 activation was shown to lower ceramide levels via the activation of a ceramidase activity measured in crude cell lysates 1 . (pubmedcentralcanada.ca)