• Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). (wikipedia.org)
  • Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. (elifesciences.org)
  • Psychosine (Galactosyl-sphingosine) is a lyso-form of galactosyl-ceramide (GalCer), accumulated in the genetic disorder of galactosylceramidase, Krabbe's disease. (sphingolipidclub.com)
  • Human neutral ceramidase (nCDase) is an enzyme that plays a critical role in colon cancer and there are currently no potent or clinically effective inhibitors for nCDase reported to date. (wikipedia.org)
  • Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function. (nih.gov)
  • Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid metabolite that regulates numerous processes important for inflammation and cancer. (sphingolipidclub.com)
  • Human neutral ceramidase (nCDase) is an enzyme that plays a critical role in colon cancer and there are currently no potent or clinically effective inhibitors for nCDase reported to date. (wikipedia.org)
  • 20. Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. (nih.gov)
  • Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al. (utsouthwestern.edu)
  • In turn, decreased activity of sphingosine-1-phosphate lyase 1 (SGPL1) results in the accumulation of sphingosine-1-phosphate (S1P), which contributes to disturbance in all intracellular processes. (scientificarchives.com)