The PKC family of serine-threonine kinases contains thirteen PKC isoforms, and each isoform can be distinguished by differences in primary structure, gene expression, subcellular localization, and modes of activation. (wikipedia.org)
The epsilon isoform of PKC is abundantly expressed in adult cardiomyocytes, being the most highly expressed of all novel isoforms, PKC-δ, -ζ, and -η. (wikipedia.org)
PKCε and other PKC isoforms require phosphorylation at sites Threonine-566, Threonine-710, and Serine-729 for kinase maturation. (wikipedia.org)
Cellular localization of the atypical isoforms of protein kinase C (aPKCζ/PKMζ and aPKCλ/ι) on the neuromuscular synapse. (illumina.com)
The isoform beta 1 has been studied as a possible target for anti-cancer drugs and as an inducer, via diacylglycerol generation, of the translocation of specific protein kinase C (PKC) isozyme to the nucleus. (curehunter.com)
Encodes2
Human PRKCE gene (Ensembl ID: ENSG00000171132) encodes the protein PKCε (Uniprot ID: Q02156), which is 737 amino acids in length with a molecular weight of 83.7 kDa. (wikipedia.org)
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. (jefferson.edu)
Calcium1
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. (wikipedia.org)
Receptors1
Receptors for activated C-kinase (RACK) have been found to anchor active PKC in close proximity to substrates. (wikipedia.org)
Targets1
PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. (wikipedia.org)
Cellular3
This kinase has been shown to be involved in many different cellular functions, such as apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. (wikipedia.org)
Its molecular interactions were determined through KEGG analysis, and real-time PCR-based expression analysis was performed to assess its co-expression with another oncogenic cellular pathway (miR-223, KLF9, and PKCε) proteins in ovarian cancer. (bvsalud.org)
This noble gas induced cardioprotective effect was abolished on a cellular level by blockers of protein kinase C (PKC) and p38 mitogen activated protein kinase (p38 MAPK) [ 3 ]. (biomedcentral.com)
Cardiac2
In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. (wikipedia.org)
We hypothesized that helium induces pre- and postconditioning in CABG-patients, affecting signaling molecules protein kinase C-epsilon (PKC-ε), p38 mitogen activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK-1/2) and heat shock protein 27 (HSP-27) within cardiac tissue, and reducing postoperative troponin levels. (biomedcentral.com)
Gene2
Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. (wikipedia.org)
The protein encoded by this gene is one of the PKC family members. (wikipedia.org)
Complexes1
Protein-protein docking was performed and docked complexes were subjected to molecular dynamics simulation to gauge the variants impact on PKCε's molecular interactions. (bvsalud.org)
Activation2
ROS generated via pharmacologic activation of the mitochondrial potassium-sensitive ATP channel (mitoK(ATP)) and the endogenous G-protein coupled receptor ligand, apelin. (wikipedia.org)
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. (ximbio.com)
Levels1
Helium preconditioning did not significantly alter the primary outcome (molecular levels of kinases PKC-ε and HSP-27, ratio of activated p38 MAPK or ERK ½). (biomedcentral.com)
Beta3
Protein Kinase C beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Protein Kinase C beta" by people in this website by year, and whether "Protein Kinase C beta" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Protein Kinase C beta" by people in Profiles. (jefferson.edu)
Association3
in mice expressing a constitutively-active PKCε, all sarcomeric proteins showed greater association with PKCε, and the cTnT, tropomyosin, desmin and myosin light chain-2 exhibited changes in post-translational modifications. (wikipedia.org)
In the present study, the aim was to find the association of its variants rs1553369874 and rs1345511001 with cervical cancer and to determine the influence of these variants on the protein-protein interactions of PKCε, which can lead towards cancer development and poor survival rates. (bvsalud.org)
Mitogen-Activat1
MAPK phosphatases (MKP) downregulate the activity of mitogen-activated protein kinases (MAPK), such as ERK1/2, and modulate the processes regulated by these kinases. (bvsalud.org)
Serine-threoni1
The PKC family of serine-threonine kinases contains thirteen PKC isoforms, and each isoform can be distinguished by differences in primary structure, gene expression, subcellular localization, and modes of activation. (wikipedia.org)
Isoform3
PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. (wikipedia.org)
The epsilon isoform of PKC is abundantly expressed in adult cardiomyocytes, being the most highly expressed of all novel isoforms, PKC-δ, -ζ, and -η. (wikipedia.org)
In contrast, we found a complete lack of constitutive expression of the epsilon isoform of Protein Kinase C (PKC) in DP thymocytes, although it was present in mature thymocytes and peripheral T cells. (ox.ac.uk)
PRKCE4
Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. (wikipedia.org)
Human PRKCE gene (Ensembl ID: ENSG00000171132) encodes the protein PKCε (Uniprot ID: Q02156), which is 737 amino acids in length with a molecular weight of 83.7 kDa. (wikipedia.org)
For this purpose, the expression of miR-205-5p and protein kinase C ϵ (PRKCE) was quantified in the peripheral blood sample harvested from GBC patients and healthy volunteers. (nih.gov)
After isolating the GBC stem cells, ectopic expression and depletion experiments were conducted to analyze the effect of miR-205-5p and PRKCE on cell proliferation, drug resistance, apoptosis, and colony formation rate as well as the expression of apoptotic factors (Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), and cleaved caspase 3). (nih.gov)
Genes2
In 2004, Dr. Li was selected as co-chair of the Pathways to Discovery program, which supports research to advance our understanding of how the building blocks of the body - genes, proteins, metabolites - function and interact via complex systems to maintain health and respond to disease. (nih.gov)
By characterizing the role of these genes and certain proteins this project aims to deepen the knowledge of the roles of lipids in pathogenesis and hopefully develop ways to combat infection of people with weakened immune systems. (tcu.edu)
Mice2
in mice expressing a constitutively-active PKCε, all sarcomeric proteins showed greater association with PKCε, and the cTnT, tropomyosin, desmin and myosin light chain-2 exhibited changes in post-translational modifications. (wikipedia.org)
Using triple transgenic mice expressing a TCR transgene, dominant negative ras/Mek proteins and a reporter gene construct with AP-1 or NF-kappa B binding sites, we showed a complete lack of transcriptional activity of NF-kappa B but not AP-1 in DP thymocytes, whereas both were transcriptionally active in mature T cells after antigenic stimulation. (ox.ac.uk)
Rats2
After 5-7 days, food intake, body weight, and fat pad weight did not differ between Ad-GPAT1 and Ad-enhanced green fluorescent protein control rats, but the chow-fed Ad-GPAT1 rats developed fatty liver, hyperlipidemia, and insulin resistance. (duke.edu)
Hepatic diacylglycerol and lysophosphatidate were elevated in Ad-GPAT1 rats, suggesting a role for these lipid metabolites in the development of hepatic insulin resistance, and hepatic protein kinase Cepsilon was activated, providing a potential mechanism for insulin resistance. (duke.edu)
Apoptosis2
This kinase has been shown to be involved in many different cellular functions, such as apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. (wikipedia.org)
A pro-apoptotic effect of beta(1)-AR was also blocked by the PKA inhibitor H89, while the protein kinase A (PKA) activators forskolin and dibutyryl-cAMP both induced apoptosis. (nih.gov)
Amino1
Epac1 and 2 are 881 and 993 amino acid homologous proteins with Epac2 having a N-terminal extension. (pancreapedia.org)
Actin6
AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Promoter2
14. Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta. (nih.gov)
The methodology of this project includes the amplifying promoter and end sequences from the unidentified protein to fuse the primer with sgRNA to create a construct ultimately. (tcu.edu)
Role2
In this study, we examined the role of PKCϵ, an oncogenic kinase highly expressed in NSCLC and other cancers, in KRAS-driven tumorigenesis. (nih.gov)
9. RUNX1, but not its familial platelet disorder mutants, synergistically activates PF4 gene expression in combination with ETS family proteins. (nih.gov)
Complex1
Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death. (lu.se)
Family3
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. (wikipedia.org)
PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. (wikipedia.org)
The protein encoded by this gene is one of the PKC family members. (wikipedia.org)
Potential1
The overall problem in this study is the implications these fungal proteins may have and the lack of understanding surrounding their involvement which is essential to research in order to create a pathway leading toward potential drug targets. (tcu.edu)
Activity3
Taken together the results suggest that the lack of PKC epsilon in DP thymocytes could lead to the absence of NF-kappa B activity after antigenic stimulation contributing to negative selection. (ox.ac.uk)
The first study was through data base screening for a molecule with RapGEF activity and homology to cyclic AMP binding proteins (8) and the second by a screen for cyclic AMP binding proteins in brain (23). (pancreapedia.org)
The catalytic region has the CDC25-homology domain, which is responsible for the guanine-nucleotide exchange activity, and the Ras exchange motif (REM), which stabilizes the catalytic helix of CDC25HD, and the Ras-association (RA) domain, which is a protein interaction motif. (pancreapedia.org)
Expression1
The lack of NF-kappa B transactivation and PKC epsilon expression in CD4(+)CD8(+) thymocytes correlates with negative selection. (ox.ac.uk)
Originally2
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS . (nih.gov)
Epac (Exchange protein directly activated by cAMP) is an important effector for cAMP, which was originally thought to act only through protein kinase A (PKA) or cyclic nucleotide binding ion channels. (pancreapedia.org)
Study1
For 1) we specifically study mechanisms of Smac mimetics which are small molecules mimicking the effect of the pro-apoptotic protein Smac. (lu.se)