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AntibioticCephradinePenicillinsCephalothinCephaloglycinCefazolinKeflinPenicillinAntibioticsPatientsDrugsActivitySemisynthetic cephalosporinPenicillinsPiperacillin1972AncefAntibacterialKeflex1973TotalCase

Antibiotic3

• In 1964 Lilly introduced the first cephalosporin antibiotic, Keflin (cephalothin), into the United States market. (wikipedia.org)
• 16.Thornhill TS, Levison ME, Johnson WD, Kaye D. In vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin C antibiotic. (webmd.com)
• Cefalexin is a semi synthetic cephalosporin antibiotic for oral administration. (medthority.com)

Cephradine1

• SKC sold only two cephalosporins-Ancef and Anspor (cephradine). (wikipedia.org)

Penicillins6

• Penicillins, cephalosporins, carbapenems and monobactams all inhibit peptidoglycan cross-linking through interaction of the common β-lactam ring with the transpeptidase enzymes. (pharmacy180.com)
• Cephalosporins should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and the cephalosporins. (medthority.com)
• Before instituting therapy with cefalexin, every effort should be made to determine whether the patient has had previous hypersensitivity reactions to the cephalosporins, penicillins or other drugs. (medthority.com)
• There is some clinical and laboratory evidence of partial cross-allergenicity of the penicillins and cephalosporins. (medthority.com)
• Pseudomembranous colitis has been reported with virtually all broad-spectrum antibiotics, including macrolides, semisynthetic penicillins and cephalosporins. (medthority.com)
• Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. (lookformedical.com)

Cephalothin1

• Cephaloridine versus cephalothin: relation of the kidney to blood level differences after parenteral administration. (webmd.com)

Cephaloglycin1

• It subsequently introduced four additional cephalosporin drugs: in 1972 Keflex (cephalexin), in 1967 Loridine (cephaloridine), in 1971 Kafocin (cephaloglycin), and in 1973 Kefzol (cefazolin). (wikipedia.org)

Cefazolin1

• Lilly had patents on all its cephalosporin antibiotics except Kefzol (cefazolin), which this case concerns. (wikipedia.org)

Keflin3

• Lilly dominated the cephalosporin market with its sales of Keflin and Keflex, but its Kefzol and SKC's Ancef were in direct competition with comparable sales. (wikipedia.org)
• Hospitals were free to purchase SmithKline's Ancef with their Keflin and Keflex orders with Lilly, so no tie-in was compelled, but if they did so they risked loss of the 3% rebate on all cephalosporin purchases from Lilly, where 75% of the total was Keflex and Keflin. (wikipedia.org)
• The district court concluded: Lilly, by linking its most powerful cephalosporin products, Keflin and Keflex, to its unpatented product, Kefzol, has unlawfully used its monopoly power to foreclose competition in and to exclude competition from the cephalosporin market. (wikipedia.org)

Penicillin1

• For example, penicillin G (benzylpenicillin), ampicillin and cephaloridine are particularly effective in causing rapid lysis of Gram-negative bacteria such as E. coli. (pharmacy180.com)

Antibiotics2

• Before 1973 Lilly adopted a marketing program known as the Cephalosporin Savings Plan (CSP), designed to make its cephalosporins more competitive with other antibiotics. (wikipedia.org)
• Cefalexin is contraindicated in patients with known allergy to the cephalosporins group of antibiotics or to any of the excipients listed in section 6.1. (medthority.com)

Patients1

• Pharmacokinetics of a new cephalosporin, cephacetrile, in patients with normal and impaired renal function. (webmd.com)

Drugs1

• From 1964 to 1972, Lilly's patents gave it a monopoly over all the cephalosporin drugs then in use. (wikipedia.org)

Activity1

• 7.Kaplan K, Reisberg BE, Weinstein L. Cephaloridine: antimicrobial activity and pharmacologic behavior. (webmd.com)

Semisynthetic cephalosporin1

• A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. (wakehealth.edu)

Penicillins1

• We can draw a sequence of reactions which describes the biosynthesis of all penicillins and cephalosporins, however the total sequence exists in no one microorganism. (nih.gov)

Piperacillin1

• Grandhe and colleagues [ 18 ] patch-tested 30 patients (aged 22 to 69 years) with 18 antibacterial agents: nine cephalosporins, five fluoroquinolones, penicillin G, amoxicillin, piperacillin, and co-trimoxazole. (medscape.com)

19721

• From 1964 to 1972, Lilly's patents gave it a monopoly over all the cephalosporin drugs then in use. (wikipedia.org)

Ancef3

• SKC sold only two cephalosporins-Ancef and Anspor (cephradine). (wikipedia.org)
• Lilly dominated the cephalosporin market with its sales of Keflin and Keflex, but its Kefzol and SKC's Ancef were in direct competition with comparable sales. (wikipedia.org)
• Hospitals were free to purchase SmithKline's Ancef with their Keflin and Keflex orders with Lilly, so no tie-in was compelled, but if they did so they risked loss of the 3% rebate on all cephalosporin purchases from Lilly, where 75% of the total was Keflex and Keflin. (wikipedia.org)

Antibacterial1

• A cephalosporin antibacterial agent that is used in the treatment of infections, including urinary-tract and respiratory-tract infections. (nih.gov)

Keflex1

• The district court concluded: Lilly, by linking its most powerful cephalosporin products, Keflin and Keflex, to its unpatented product, Kefzol, has unlawfully used its monopoly power to foreclose competition in and to exclude competition from the cephalosporin market. (wikipedia.org)

19731

• In 1973, competitors began to introduce new cephalosporins. (wikipedia.org)

Total1

• The CSP provided that a rebate in the form of Lilly merchandise would be paid to hospitals based on the total amount of Lilly cephalosporins that they purchased. (wikipedia.org)

Case1

• one in each case was due to cephalosporins (1 of 3), clindamycin (1 of 3), and espiramycin (1 of 2), and no reactions were seen to quinolones (2) and co-trimoxazole (7). (medscape.com)