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  • centriole
  • In vertebrate cells, the centrosome consists of a centriole pair associated with an amorphous matrix. (biologists.org)
  • Plays an important role in cell division and centrosome function by participating in centriole duplication. (abcam.com)
  • The mother centriole has distal and sub-distal appendages that the daughter centriole lacks and functions mainly in the anchoring of new microtubules. (dovepress.com)
  • spindles
  • The spindles assembled without centrosomes are anastral, and it is likely that their microtubules are nucleated at or near the chromosomes. (rupress.org)
  • These spindles assemble from microtubules nucleated near the chromatin, which are sorted into arrays. (rupress.org)
  • In a step requiring dynein, the minus ends of the microtubule arrays are bundled into focused poles, resulting in the formation of bipolar spindles with the plus end of the microtubules radiating toward the chromosomes. (rupress.org)
  • asters
  • Localized within the center of microtubule asters. (abcam.com)
  • Aliquots of centrosome fractions were reconstituted with tubulin media to assemble asters. (nih.gov)
  • B) Asters were composed of microtubules (green) stained by β-tubulin antibody TU27, which project from discrete central foci (red) stained by γ-tubulin antibody EAD24. (nih.gov)
  • cell
  • The decrease in total or in centrosomal AKAP350 led to decreased formation of the nucleus-centrosome-Golgi axis and defective cell migration. (biologists.org)
  • Once neuronal cell bodies have reached their final position, the centrosome seems to be crucial for organizing the cytoskeleton for axonal elongation and particle transport. (humpath.com)
  • One approach is to analyze specialized cell types that lack centrosomes. (rupress.org)
  • While the centrosome is necessary for cell cycle progression and neurogenesis, neuronal differentiation requires sophisticated architectural changes that may be incompatible with a large microtubule network emanating from a focal point. (uni-muenchen.de)
  • nucleus
  • An early event in this phenomenon is the generation of a nucleus-centrosome-Golgi back to front axis. (biologists.org)
  • This suggests that the centrosome must maintain a proper association with the nucleus for migration and normal replication to occur. (rupress.org)