Loading...
  • tumors
  • Although centrosome defects have been recognized in tumors for a long time," Pellman said, "it has been a tough problem to rigorously study. (redorbit.com)
  • Centrosome amplification is found in human tumors but not in normal cells, so it is an appealing feature to explore for diagnosis, prognosis, and therapy,' explains Carla Lopes, from the Instituto Português de Oncologia and Instituto Gulbenkian de Ciência in Portugal. (news-medical.net)
  • Given the widespread occurrence of p53 mutations and centrosome amplification in human tumors, our findings on the timing and ordering of these events in Barrett's esophagus tumorigenesis are likely applicable to other cancers as well,' Lopes says. (news-medical.net)
  • Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community. (worldcat.org)
  • The Role of the Centrosome in the Development of Malignant Tumors, W.L. Lingle and J.L. Salisbury . (elsevier.com)
  • spindles
  • Cells with multipolar spindles are characterized by more than two centrosomes, usually four, and sometimes have a second metaphase plate. (wikipedia.org)
  • Cancer is defined by uncontrolled cell growth and malignant cells can undergo cell division with multipolar spindles because they can group multiple centrosomes into two spindles. (wikipedia.org)
  • regulation
  • She is a cell biologist with research focused on cytoskeletal regulation in various cell systems and on cytoskeletal dysfunctions of the centrosome-microtubule complex that play a role in disease such as cancer and in disorders such as infertility and other reproductive disorders. (ebooks.com)
  • Her studies also included collaborations with NASA scientists and experiments aboard the Space Shuttle Endeavour to examine the effects of spaceflight on centrosome-cytoskeletal regulation during development. (ebooks.com)
  • Organelles
  • Cells begin to accumulate centrosomes-;organelles that play a vital role during cell division-;before they transform into cancer cells, according to a new study of patients with Barrett's esophagus condition, which is associated with esophageal cancer. (news-medical.net)
  • However, most of these conditions have not only separated these two organelles, but also caused extensive fragmentation of the Golgi, making it difficult to dissect the specific contribution of Golgi-centrosome proximity. (bioportfolio.com)
  • When cells are ready to divide, because cell size is big enough or because they receive the appropriate stimulus, they activate the mechanism to enter into the cell cycle, and they duplicate most organelles during S (synthesis) phase, including their centrosome. (wikipedia.org)
  • Plk4
  • The researchers found that if they depleted the tumor suppressor p53, cells that chronically lacked Plk4 could divide without centrosomes. (rupress.org)
  • cytoplasm
  • These were originally thought to be scattered only around the centrosomes, but further studies proved that PCM1 was also found throughout the cytoplasm. (wikipedia.org)
  • role
  • books.google.ca - Centrosomes play an integral role in the growth of cells and the ultimate development of many animals, and sometimes plants. (google.ca)
  • In addition to the normal growth of cells, centrosomes can also play a key role in the spread of cancer and are of increased interest to both the genetics and oncology communities. (google.ca)
  • It's not yet clear whether the role of the centrosome in polarity determination is microtubule dependent or independent. (wikipedia.org)
  • occurs
  • Second Polar Body (Discarded afterward) + Ovum Oocyte meiosis, important to all animal life cycles yet unlike all other instances of animal cell division, occurs completely without the aid of spindle-coordinating centrosomes. (wikipedia.org)