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  • PLK4
  • We have previously shown that overexpression of Plk4 in human cells causes the recruitment of electron-dense material onto the proximal walls of parental centrioles (Habedanck et al. (wordpress.com)
  • Here, we have used a cell line allowing the temporally controlled expression of Plk4 to study the formation of centrioles in human cells. (wordpress.com)
  • We show that Plk4 triggers the simultaneous formation of multiple procentrioles around each pre-existing centriole. (wordpress.com)
  • cartwheel
  • Moreover, we demonstrate that recombinant Bld12p self-assembles into structures akin to the central hub of the cartwheel, which serves as a scaffold for centriole formation. (ox.ac.uk)
  • amplification
  • These multiple centrioles form during S phase and persist as flower-like structures throughout G2 and M phase before they disperse in response to disengagement during mitotic exit, giving rise to a typical centriole amplification phenotype. (wordpress.com)
  • formation
  • The mechanisms directing centriole formation are incompletely understood and represent a fundamental open question in biology. (ox.ac.uk)