Central to tumor cells displaying tumor. Medical search. Frequent questions

The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)
With the exception of Myc (which was only present in a subset of benign, borderline, and malignant tumors), Oct4, Nanog, Sox2, and Klf4 were detectable at variable levels across both normal and diseased tissues. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)
Ostensibly control of the tumor microenvironment and the consequent modified manifestation of relevant proteins may allow suppression of aggressive tumor growth and the metastatic potential characteristic of high-grade malignant tumors. (mdm2-inhibitors.com)
Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)

As such, under the older guidelines, one tumor entity could develop into another tumor entity with a different grade over the course of disease progression. (medscape.com)
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. (nature.com)
We hypothesized that the acquisition of cancer stem cells (CSC), a subpopulation that drive tumor initiation and progression, may contribute to CNT carcinogenesis. (cdc.gov)
The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)
HCC represents a hyper vascularized tumor and its progression is closely related to angiogenesis. (cancer-research-network.com)
The transcription factor HIF-1α also plays a central role in HCC progression and angiogenesis. (cancer-research-network.com)
Moreover, it effectively diminishes both HIF-1α and STAT3 activation in HCC cells, which represent important mediators of HCC progression. (cancer-research-network.com)
Although for years most studies have focused on tumor cells, allowing the discovery of numerous key (epi)-genetic aberrations and oncogenic pathways, it is now widely accepted that ecosystem integration is also critical for the understanding of cancer progression. (haematologica.org)
Our findings support an active role of the PDGF signalling pathway in tumour progression. (lu.se)
Modulation of mitochondrial function thus represents a primary target to rewire metabolism and counteract tumour progression and chemotherapy resistance. (europa.eu)
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. (utsouthwestern.edu)
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. (harvard.edu)
While acidosis hypoxia and IFP frequently have been examined individually we hypothesize that these microenvironmental factors exert additive effects on tumor cell biology and may lead to more aggressive or unexpectedly variable behavior during tumor progression and metastasis. (mdm2-inhibitors.com)

Genetically, MRTs typically demonstrate abnormalities in the SMARCB1 gene located on chromosome 22, which influences the SWI/SNF chromatin remodeling complex that is involved in regulating cell cycle, growth, and differentiation (2). (goldenhelix.com)
A) Tumor cells at the invasive front express nuclear -catenin (inset, black arrows) and display a mesenchymal differentiation. (ourownfuture.org)
These cells are characterized by epithelial differentiation. (ourownfuture.org)
Their neuropathological spectrum is divided into well-differentiated "pineocytoma" (World Health Organization [WHO] grade I), pineal parenchymal tumors of intermediate differentiation and papillary tumor of pineal region (WHO grades II and III), and poorly differentiated "pinealoblastoma" (WHO grade IV). (thieme-connect.com)
Cyclin-dependent kinase 5 (CDK5) phosphorylated DRP1 to improve its activity in BTICs whereas Ca2+-calmodulin-dependent proteins kinase 2 (CAMK2) inhibited DRP1 in non-BTICs recommending tumor cell differentiation induces a regulatory change in mitochondrial morphology. (biopaqc.com)
Regular neural progenitor cells (NPCs) are functionally described by self-renewal and differentiation into relevant lineages7. (biopaqc.com)
BTICs talk about these features but are recognized by their regularity proliferation aberrant appearance of differentiation markers chromosomal abnormalities and tumor development. (biopaqc.com)
As mitochondria represent the central metabolic organelle mitochondria offer a potential link between cellular rate of metabolism and differentiation state. (biopaqc.com)
Nowadays, the molecular functions of this protein have been involved in a variety of cellular functions, such as enhancing proliferation and blocking cell differentiation, enhanced lymphocyte adhesion, and cell morphogenesis. (bvsalud.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
Analysis into cancer development and metastasis provides implicated versican as getting a central function powered by inflammatory stimuli. (healthyconnectionsinc.com)
Versican continues to be suggested to donate to HA fragment activation of macrophages, and improved cancer tumor metastasis through induction from the hyaluronidases (83, 84). (healthyconnectionsinc.com)
The molecular basis of tumor metastasis and current approaches to decode targeted migration-promoting events in pediatric neuroblastoma. (harvard.edu)
Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)

Given the important role of both cytokine-mediated inflammatory microenvironment and cytolytic NK cell activities in immune-oncology therapies, our findings present a compelling argument for further clinical investigation. (frontiersin.org)
Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
Our research will open up new strategies to control Wnt signalling by altering its transport route in the tumour microenvironment. (exeter.ac.uk)
Aggressive B-cell malignancies, such as mantle cell lymphoma (MCL), are microenvironment-dependent tumors and a better understanding of the dialogs occurring in lymphoma-protective ecosystems will provide new perspectives to increase treatment efficiency. (haematologica.org)
This integrated analysis led to the discovery of microenvironment-dependent and tumor-specific secretion of interleukin-32 beta (IL32β), whose expression was confirmed in situ within MCL lymph nodes by multiplex immunohistochemistry. (haematologica.org)
Finally, we demonstrated the efficacy of selective NIK/alternative-NFkB inhibition to counteract microenvironment-dependent induction of IL32β and BAFF-dependent survival of MCL cells. (haematologica.org)
Evidence demonstrating that the tumor ecosystem plays a central role in tumoral expansion and treatment resistance has continued to accumulate since the emergence of the tumor microenvironment concept more than a century ago. (haematologica.org)
Cancer cells display an altered metabolism as a result of genetic mutations, changes in the tumour microenvironment, and interactions with other cell types. (europa.eu)
Background/Purpose: The effects of chemical and physical interactions in the microenvironment of solid tumors have GSK461364 not been fully elucidated. (mdm2-inhibitors.com)

Among immune cells, Foxp3 + regulatory T cells (Treg cells) are potent inhibitors of cancer immunity, and their presence within solid tumors is generally associated with a poor prognosis. (mdpi.com)
although they've shown promise for blood cancers, such as leukemias, their performance for solid tumors has been disappointing. (erwotex.net)

Therefore, the TNM (Tumor size, Nodal involvement, Metastases) system used for most non-CNS tumors is not commonly employed in the evaluation of CNS neoplasms. (medscape.com)
Because neoplasms in the CNS have widely varying features, clinical courses, and prognoses, a robust and reliable grading system is essential for the proper evaluation of CNS tumors. (medscape.com)
Pineal region tumors constitute a rare group of neoplasms. (thieme-connect.com)
Perivascular epithelioid cell tumors (PEComas) are a rare group of mesenchymal neoplasms characterized by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells [ 1 ], which can occur in any part of the body. (biomedcentral.com)
central nervous system neoplasms. (hopkinsmedicine.org)
therefore, few institutions have extensive experience with Hürthle cell neoplasms. (medscape.com)
Some investigators believe that this condition is distinct from other follicular cell neoplasms. (medscape.com)

1% proliferation index in tumor cells. (thieme-connect.com)
Inhibitory AhR-ER crosstalk was investigated in Ishikawa cells using E2-induced cell proliferation and transcriptional activation assays in cells transfected with E2-responsive constructs containing promoter inserts from the progesterone receptor and vitellogenin A2 genes. (tamu.edu)
Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
Studies from a number of laboratories in the past decade have revealed that the central pathways deregulated in cancer often serve to coordinately regulate both classic oncogenic signaling pathways controlling cell proliferation and cell survival with pathways controlling cell metabolism. (aacrjournals.org)
Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
Activation of EGFR regulates essential cellular processes including cell migration, proliferation, and apoptosis ( 1 ). (biorxiv.org)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)

Human immunodeficiency virus (HIV)-associated primary central nervous system lymphoma (PCNSL) is a diffuse, large-cell non-Hodgkin lymphoma of B-cell origin that usually occurs in the brain (rarely in the spinal cord). (medscape.com)
HIV-associated primary central nervous system lymphoma (PCNSL) is typically of B-cell origin. (medscape.com)
Primary central nervous system lymphoma (PCNSL) is the second-most common mass lesion (after toxoplasmosis) in patients with acquired immunodeficiency syndrome (AIDS), occurring in up to 5% of these patients. (medscape.com)
Treatment of primary central nervous system lymphoma. (medscape.com)
While many tumors are classified using both a grading and staging system, staging -which is determined by a tumor's size and spread-is not often used in the context of central nervous system (CNS) tumors. (medscape.com)
2004). Role of Microglia in Central Nervous System Infections. (igem.org)
When MRTs are present in the brain, they are called atypical teratoid/rhabdoid tumors (AT/RT), which accounts for 1-2% of central nervous system tumors in children (2). (goldenhelix.com)
In the AMP guidelines interface the patient and sample information was entered and Central Nervous System/Brain was selected for the Tissue with Rhabdoid Meningioma (RHM) selected as the Tumor Type, Figure 2. (goldenhelix.com)
Looking at the SMARCB1 Alteration and Frequency Outcomes in COSMIC, Figure 4, it is evident that alterations in this gene primarily occur in the central nervous system (CNS)/Brain but also in many other anatomical sites. (goldenhelix.com)
migration and proper central nervous system development. (tam-receptor.com)
Emerging evidence has demonstrated that these factors are expressed in tissues outside of the nervous system and represent a widespread signal transduction system that is involved in the regulation of motility and adhesion in different cell types. (tam-receptor.com)
High primary tumour PDGFRα was associated with increased risk of central nervous system (CNS) recurrence. (lu.se)
Glioblastoma (GBM) - the most common primary central nervous system malignancy in adults and a cancer that Jiang frequently treats in clinic-often displays substantially elevated amounts of CD47 on its tumor cell surfaces, with higher amounts generally suggesting worse outcomes for patients. (erwotex.net)
RGNTs were first described as a distinct entity in 2002 and added to the WHO classification of tumors of the central nervous system in 2007 as a Grade I tumor alongside the papillary glioneuronal tumor. (surgicalneurologyint.com)
This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. (harvard.edu)
Medulloblastoma is the most common malignant central nervous system (CNS) tumor of childhood, with an annual incidence of about 0.5-0.8/100,000 in children younger than 19 years. (medscape.com)
This database includes in situ and nonmalignant central nervous system (CNS) cases. (cdc.gov)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotube s. (cdc.gov)
Methods: Non-tumorigenic human lung epithelial cells were chronically exposed to well-dispersed SWCNT for a period of 6 months at the physiologically relevant concentration of 0.02 mu g/cm(2) surface area dose. (cdc.gov)
Results: We demonstrated for the first time the existence of CSC-like cells in all clones of chronic SWCNT-exposed lung epithelial cells. (cdc.gov)
The radiological impressions included benign stromal tumor, benign epithelial tumor, and borderline epithelial tumor. (iiarjournals.org)
Just like migrating cells separately, each epithelial cell stretches actin-rich protrusions at its industry leading that form fresh adhesions towards the extracellular matrix (ECM). (brain-tumor-cancer-information.com)
Unlike migrating cells individually, nevertheless, migrating epithelial cells must organize these behaviors using their neighbours. (brain-tumor-cancer-information.com)
Many epithelial cells industry leading protrusions extend under the trailing sides from the cells forward, just like overlapping shingles on the roof (Numbers 1A and 1B). (brain-tumor-cancer-information.com)
Throughout their migration (arrow), the follicular epithelial cells crawl along the cellar membrane, which continues to be fixed. (brain-tumor-cancer-information.com)
One way that leading and trailing edge dynamics could possibly be coordinated between migrating epithelial cells is certainly by using a planar signaling program. (brain-tumor-cancer-information.com)
Desmoglein 1 is present in CNS neurons (and in all epithelial cells), and an immunologic cross-reaction between epithelial and CNS isoforms has been suggested. (msdmanuals.com)

Inhibitors of mitochondrial fission [e.g. mitochondrial division inhibitor-1 (Mdivi-1)] may ameliorate neurodegenerative diseases and reduce the cardiotoxicity of chemotherapy36 37 Here we interrogated the role of mitochondrial form and functional SGX-523 control within the cellular hierarchy of the most common primary intrinsic brain tumor glioblastoma using validated and well characterized. (biopaqc.com)
However, these types of inhibitors are not specific for tumors over healthy tissue and therefore cause undesirable side effects. (biorxiv.org)

In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. (oncotarget.com)
Although most mutations in SMARCB1 primarily occur de novo, familial cases have been reported and if inherited leads to a condition called rhabdoid tumor predisposition syndrome (RTPS). (goldenhelix.com)
Metabolic adjustments aren't merely a consequence of oncogenesis as mutations in essential enzymes are principal tumor initiating lesions13. (biopaqc.com)
This clonal expansion and subsequent growth of the tumors appears to be caused by mutations in oncogenes and tumor suppressor genes, and the whole process is accelerated by defects in genes required for maintaining genetic instability. (hopkinsmedicine.org)
Mutations in four or five such genes are required for a malignant tumor to form, while fewer mutations suffice for benign tumorigenesis. (hopkinsmedicine.org)
As the mutations accumulate, the tumors become progressively more dangerous. (hopkinsmedicine.org)
References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development. (nature.com)
IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. (cdc.gov)

BMC Cell Biol. (nature.com)
Nat Cell Biol. (umassmed.edu)
Trends Cell Biol. (nature.com)
J Cell Biol (1995) 129 (6): 1473-1489. (rupress.org)

Pathologists and clinicians should be aware of this rare entity to prevent misdiagnosis of MACF as fibrosarcoma or adult granulosa cell tumor and resultant overtreatment. (iiarjournals.org)

it is, however, not as great as with papillary tumors. (medscape.com)

Therefore mitochondria fission may be related to stem cell biology beneficial for malignancy and harmful in normal mind. (biopaqc.com)
MITIG capitalizes on the recent reported ability of gliomas to import exogenous mitochondria, either isolated or transferred from surrounding neural cells in the brain, to foster tumour development and malignancy in vivo. (europa.eu)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasizing. (medscape.com)
A 1988 study found that a Hürthle tumor that is 4 cm or larger has an 80% chance of histologic evidence of malignancy. (medscape.com)

Traditionally, a WHO CNS grade was an overarching predictor of cellular behavior that could be applied across multiple tumor entities. (medscape.com)
Due to this change, tumor grades more accurately reflect the cellular behavior and subsequent clinical course of each neoplasm. (medscape.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
These tumors are characterized by an unusual combination of mixed cellular elements similar to but not typical of teratomas and can originate at any anatomic location. (goldenhelix.com)
Mitotically-active cellular fibroma (MACF) is a rare form of ovarian fibromatous tumor. (iiarjournals.org)
Our 10-year review of cellular fibromatous tumors of the ovary diagnosed at a single institution revealed four cases of cellular fibroma (CF) and three cases of MACF. (iiarjournals.org)
MACF is a newly-recognized subtype of ovarian cellular fibromatous tumor. (iiarjournals.org)
Cellular fibroma (CF) of the ovary is an uncommon fibromatous tumor characterized by increased cellularity compared to fibroma of the conventional type. (iiarjournals.org)
In 2006, Irving and colleagues ( 4 ) first defined this kind of ovarian tumor as mitotically active cellular fibroma (MACF). (iiarjournals.org)
Mitochondria are highly dynamic organelles that synergize with the central cellular state22. (biopaqc.com)
To meet specific cellular demands of different cell types over time cellular biogenesis is definitely mediated through the dynamic mitochondrial fusion and fission. (biopaqc.com)
Paralleling the emergence of targeted therapeutics in cancer treatment, a variety of experimental approaches has led to the conclusion that tumors bearing some specific genetic alterations may lead them to be uniquely sensitive to agents deregulating their cellular metabolism. (aacrjournals.org)
Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
Campisi, J. Cellular senescence as a tumor-suppressor mechanism. (nature.com)
Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)

Leydig cell tumors comprise 1-3% of testicular tumors. (pathologyoutlines.com)
SUMMARY ANSWER: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs). (tamu.edu)
We further investigated the molecular features of testicular tumors and determined the expression of beta-catenin (CTNNB1) known to be involved in testicular GrCT development. (tamu.edu)

Almost 100% of affected patients have evidence of EBV in the lymphomatous lesions and the CSF, where it is accompanied by impaired specific T-cell responses against EBV antigens. (medscape.com)
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. (nature.com)
In contrast, knockdown of BRD4 but not of BRD2 impairs NK cell cytolytic responses, suggesting BRD4 as critical regulator of NK cell mediated tumor cell elimination. (frontiersin.org)
Natural killer cells are cytolytic lymphocytes belonging to the innate immune system and are involved in anti-viral and anti-tumor responses ( 1 ) and are recognized as major players in immune-mediated anti-tumor therapies ( 2 ). (frontiersin.org)
Moreover, NK cells are poised to release cytokines such as IFN- γ , TNF-α and growth factors that can initiate inflammatory responses mediated by both the innate and the adaptive arm of the immune system. (frontiersin.org)
It is now well established that human tumors express unique antigens, however tumor immune evasion mechanisms often prevent effective naturally occurring anti-tumor immune responses. (biomedcentral.com)
While BTICs stay controversial because of unresolved problems over cell-of-origin and purification BTICs possess generated substantial curiosity because of their resistance to typical therapies evasion of anti-tumor immune system responses advertising of tumor angiogenesis and invasion into regular tissue8-11. (biopaqc.com)
Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
Methods CT26 models were treated with anti-PD-1 on days 3, 6 and 9 following subcutaneous tumor implantation generating variable responses during early tumor development. (bmj.com)
Adoptive transfer of Tet lo showed more effective tumor control than Tet hi , and curative responses were achieved when Tet lo was combined with two doses of anti-PD-1. (bmj.com)
Conclusions Targeting subdominant T cell responses with lower avidity against pMHC affinity neoepitopes showed potential for improving PD-1 immunotherapy. (bmj.com)
The drug activates stress responses in cancer cells that make the immune system more likely to eliminate them. (erwotex.net)
Our lab is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. (hopkinsmedicine.org)
Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. (nature.com)
In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)

In the final stage, we will then hopefully be able to modify the system accordingly, to serve medical purposes: identification and elimination of CD133+ cells and hence contributing towards preventing the fatal consequences of Glioblastoma multiforme. (igem.org)
2009). Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In Vitro. (igem.org)
2009). Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. (igem.org)
Funded by the Marie Skłodowska-Curie Actions programme, the MITIG project aims to understand how this process affects metabolism and tumour development of glioblastoma multiforme (GBM), a common and aggressive brain tumour in adults. (europa.eu)
A combination of immunotherapy agents that encourages some immune cells to eat cancer cells and alert others to attack tumors put mice with a deadly type of brain cancer called glioblastoma into long-term remission, a new study led by UT Southwestern scientists suggests. (erwotex.net)

Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF -V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. (oncotarget.com)
in OS specifically higher levels of hypoxia inducible factor 1-alpha (HIF-1α) are associated with high-grade lesions and enhanced tumor cell growth (6). (mdm2-inhibitors.com)
To evaluate the efficacy and safety of EqualSpheres microspheres loaded with vinorelbine in the treatment of patients with non-small cell lung cancer and obstructive lesions who have failed standard treatments. (who.int)

We initiated a study to evaluate the antitumor efficacy of T cells engineered with an affinity-enhanced TCR specific for the NY-ESO-1 and LAGE-1 cancer testis antigens (NY-ESO c259 -T) in multiple myeloma (MM) patients with antigen-positive tumors in the setting of an autologous stem cell transplant (NCT01352286). (biomedcentral.com)
Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)

[ 2 ] Grade was applied across tumor types, regardless of differences in the clinical course and molecular behavior of different anaplastic tumor entities. (medscape.com)
[ 3 ] Consequently, grading each tumor requires an integrated analysis of histologic features and molecular signatures specific to that tumor type. (medscape.com)
Because the identification of key histopathologic features is highly sensitive to sampling, the new guidelines recommend using molecular signatures-which tend to be more diffuse and thus less sensitive to sampling-as a component in grading certain tumors and as a potential marker of clinical course and prognosis. (medscape.com)
Recent studies suggest that the molecular machinery of nutrient sensation instructs the behavior of stem cells particularly embryonic and hematopoietic stem cells21. (biopaqc.com)
To identify novel molecular regulations, we performed a transcriptomic analysis based on the comparison of circulating MCL cells (n=77) versus MCL lymph nodes (n=107) together with RNA sequencing of malignant (n=8) versus normal B-cell (n=6) samples. (haematologica.org)
Our results suggest that this dramatic reduction of cell density is analogous to a localized reduction of particle density in colloidal glass, or analogous to a localized increase in temperature in molecular glass, creating a 'melted' region of the wounded cell layer. (ibecbarcelona.eu)
This will help cytopathologists to recognize this rare tumor that occurred in the cervix, and the combination of predictive morphology evaluation, immunophenotype, and molecular testing can achieve the definitive diagnosis of PEComa. (biomedcentral.com)
Reuben J. Shaw, Howard Hughes Medical Institute, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037. (aacrjournals.org)

To create an in-vivo-like environment, the cells will be grown in 3D collagen media. (igem.org)
Here, we present an integrated workflow for quantitative in vivo cell-cycle profiling. (nature.com)
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo . (nature.com)
CSC-like cells were isolated using fluorescence-activated cell sorting and were assessed for aggressive behaviors, including acquired apoptosis resistance and increased cell migration and invasion in vitro, and tumor-initiating capability in vivo. (cdc.gov)
These CSC-like cells, in contrary to their non-CSC counterpart, possessed all biological features of lung CSC that are central to irreversible malignant transformation, self-renewal, aggressive cancer behaviors, and in vivo tumorigenesis. (cdc.gov)
ENMD-1198 treatment protects the bone against tumor-induced osteolysis in vivo. (cancer-research-network.com)
Using ex vivo models of primary MCL cells (n=23), we demonstrated that, through the secretion of IL32β, the tumor was able to polarize monocytes into specific MCL-associated macrophages, which in turn favor tumor survival. (haematologica.org)
MITIG will target both paths for mitochondrial importation to remodel organelle content and address i) how incorporation of exogenous mitochondria impacts respiratory metabolism in GBM cells and iii) the relevance of this metabolic rewiring for tumour development in vivo. (europa.eu)

Because of the influence on different cell cycle processes, SMARCB1 is understood to be a tumor suppressor gene. (goldenhelix.com)
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)

The main differentiating histological feature in a TC is the evidence of trichilemmal keratinization, where the tumor exhibits an absence of granular layer between the stratum spinosum and stratum corneum. (jcadonline.com)
The cell block section showed single or clusters of medium-sized epithelioid cells in a background of fibrinoid fluid, with abundant clear or granular eosinophilic cytoplasm. (biomedcentral.com)
Tumor vessels were thickly hyalinized and contained eosinophilic granular bodies and Rosenthal fibers. (surgicalneurologyint.com)
The cells are polyhedral and have abundant granular cytoplasm with well-defined cell borders. (medscape.com)

3 While the clinical differential diagnosis commonly includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and keratoacanthoma, the histopathological differential also includes trichilemmoma, trichoepithelioma, clear cell SCC, clear cell porocarcinoma, and clear cell hidradenocarcinoma. (jcadonline.com)
Therefore, in order to better understand the correlates of response, resistance, and relapse, we initiated a deep characterization of the engineered T cell and tumor phenotype in clinical study participants, and we report the initial findings from these studies here. (biomedcentral.com)
IFN-γ and Granzyme B). NY-ESO c259 -T cells were detected by pentamer staining and their phenotype was correlated with clinical response. (biomedcentral.com)
Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors . (hopkinsmedicine.org)
[ 1 ] These tumors display considerable clinical and biologic heterogeneity, and they have been further defined molecularly and histologically. (medscape.com)

Within an display screen for carcinoma-derived elements with the capacity of activating macrophages, versican was defined as a potent enhancer of metastatic development through TLR2 and co-receptors, TLR6 and Compact disc14 (80). (healthyconnectionsinc.com)
Using a novel cell tradition system in which cells can be cultivated under elevated hydrostatic pressure Ccna2 we investigated the complex relationships of local pH pO2 and hydrostatic pressure separately and in combination to identify the element(s) that experienced probably the most profound effect on the growth of human OS cell lines and their manifestation of the proteins that contribute to metastatic potential. (mdm2-inhibitors.com)
0%. With regards on the number of metastatic tumors, the RFS with the patients was appreciably associated with the number of metastatic nodules within the liver. (rafinhibitors.com)
The outcomes showed that sufferers with a solitary metastatic tumor had a better survival curve, and also the 5 yr RFS rate was 28. (rafinhibitors.com)

For a growing number of tumors the BRAF V600E mutation carries therapeutic relevance. (oncotarget.com)
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
We also highlight the therapeutic approaches aiming at targeting these regulators to enhance anti-tumor immunity. (mdpi.com)
CD34 expression of these stem cells has been exploited for therapeutic purposes in various hematological disorders. (bvsalud.org)
Therapeutic anti-tumor antibodies, for example, require the pro-inflammatory properties of the IgG Fc to eliminate tumor cells, while the anti-inflammatory activity of intravenous IgG requires specific Fc glycans for activity. (sdsc.edu)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune surveillance and elimination of transformed or virally infected cells. (frontiersin.org)
Through the use of this technique, Bartholome confirmed the current presence of the mGR on CCRF-CEM cells and proven how the mGR can be physiologically within monocytes and B-cells from healthful donors, while circulating T-lymphocytes had been consistently adverse (22). (fabretp.org)
The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrate the cutaneous allergic reaction. (cdc.gov)

Microscopically, there are sheets, nests, ribbons or cords of large, round or polygonal cells with defined cell borders, eosinophilic cytoplasm and round central nuclei. (pathologyoutlines.com)
It combines image analysis and machine learning methods for automated 3D segmentation and cell-cycle state identification of individual cell-nuclei with widely varying morphologies embedded in complex tumor environments. (nature.com)
Figure 2: Automatic segmentation of cell nuclei. (nature.com)
Microscopically, some loosely cohesive epithelioid cells were uniform with abundant clear cytoplasm, showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
The epithelioid cells were uniform and approximately the same size as the parabasal cells (Fig. 1 A&B), showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
A few spindled nuclei and melanin pigments were also identified (Fig. 2 A). IHC demonstrated that the epithelioid cells were positive for HMB45 andTFE3 (Fig. 2 B&C), focally positive for Melan-A, while negative for S-100, SOX-10, AE1/AE3, EMA, Desmin, SMA, H-caldesmon. (biomedcentral.com)
Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. (harvard.edu)
The nuclei are enlarged and have a central prominent macronucleolus. (medscape.com)
Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)

The histopathological diagnosis of ovarian fibromatous tumor is usually unequivocal due to their distinct spindle-cell morphology and fascicular growth pattern. (iiarjournals.org)
The cytopathological features were well correlated with cell block and histopathological findings. (biomedcentral.com)

This entity was first identified and documented by Headington 9 in 1976, who described an epidermal-based tumor composed of atypical clear cells derived from adnexal keratinocytes. (jcadonline.com)
A stereotactic needle biopsy was performed and using microscopy it was diagnosed as atypical teratoid/rhabdoid tumors (AT/RT). (goldenhelix.com)
Microscopically, we observed some loosely cohesive atypical cells arranged in single or clusters and sheets, which exhibited epithelioid morphology with abundant clear cytoplasm. (biomedcentral.com)
Distinct round nucleoli were visible in some cells (Fig. 1 C), notably with numerous melanin pigments in the cytoplasm (Fig. 1 D). The primary diagnosis was atypical cells which were suspected to be melanoma. (biomedcentral.com)

Many carcinomas display perineural invasion (PNI) a tropism of tumor cells for surrounding nerve bundles. (tam-receptor.com)
Basal and squamous cell carcinomas of the skin are not reported, except when these occur on the skin of the genital organs. (cdc.gov)
[ 4 ] in a series of 23 patients, the mean tumor size was significantly greater for carcinomas than adenomas (3.1 cm vs 1.9 cm). (medscape.com)

The unique presentation of this patient and his subsequent hospital course may be useful in guiding future discussions around the management of this rare tumor. (surgicalneurologyint.com)

Trichilemmal carcinoma (TC) is a rare cutaneous tumor thought to be derived from the follicular outer root sheath (ORS). (jcadonline.com)
Trichilemmal carcinoma shows many histologic features reminiscent of follicular ORS-notably, its glycogen-rich clear cells, trichilemmal keratinization, and similar immunostaining profile. (jcadonline.com)
Open up in another window Shape 1 The developmental framework for the migration from the follicular epithelium(A and B) Illustrations displaying a migrating epithelium from basal (A) and part (B) sights. (brain-tumor-cancer-information.com)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Controversy exists about the origin of Hürthle cells, which generally are thought to derive from the follicular epithelium. (medscape.com)
On balance, Hürthle cell tumors may be considered to be more likely to metastasize than follicular tumors. (medscape.com)

In addition, development of this opportunistic neoplasm is associated with CD4 + lymphocyte counts below 100 cells/µL. (medscape.com)
A large spectrum of neoplasm can arise in the vicinity of pineal gland including the tumor, metastasizing to the pineal region. (thieme-connect.com)
We have shown that each colon neoplasm arises from a clonal expansion of one transformed cell. (hopkinsmedicine.org)
A Hürthle cell neoplasm is defined generally as an encapsulated thyroid lesion comprising at least 75% Hürthle cells. (medscape.com)

Using a chemo-genetic approach, we identify BET bromodomain containing proteins BRD2 and BRD4 as central regulators of NK cell functions, including direct cytokine secretion, NK cell contact-dependent inflammatory cytokine secretion from monocytes as well as NK cell cytolytic functions. (frontiersin.org)
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. (harvard.edu)

Since then, the guidelines have been revised and fine-tuned as scientific understanding of CNS tumors improved, culminating in the fifth edition, published in 2021. (medscape.com)
[ 2 ] Prior to 2021, an "anaplastic" tumor was categorized as Grade III regardless of whether the tumor was an anaplastic astrocytoma, anaplastic oligodendroglioma, or anaplastic ependymoma. (medscape.com)
Published in 2021, the fifth edition of the WHO Classification of Tumors of the CNS is the most recent version of the international standard for classifying brain and spinal cord tumors. (medscape.com)
Table 2 delineates the possible grades for each specific tumor type described in the 2021 WHO Classification of CNS Tumors. (medscape.com)

It also effectively inhibits the growth of hepatocellular carcinoma through direct effects on the tumor cells, and also through inhibition of angiogenesis. (cancer-research-network.com)
Versican, in either unchanged or fragmented forms filled with the G3 domains, can boost tumor cell migration, development, and angiogenesis (80C82). (healthyconnectionsinc.com)
The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. (hopkinsmedicine.org)

Herein we show that nerve cell lines migrate toward PC3 cells and exhibit extended nerve processes in a Sema4D/plexin-B1-dependent manner a response also blocked by Rho/ROK inhibition. (tam-receptor.com)
These data uncovered the IL32β/BAFF axis as a previously undescribed pathway involved in lymphoma-associated macrophage polarization and tumor survival, which could be counteracted through selective NIK inhibition. (haematologica.org)
Acantholysis (loss of intercellular adhesion with consequent epidermal blister formation) results from either direct inhibition of desmoglein function by autoantibody binding or from autoantibody-induced cell signaling that results in down-regulation of cell-cell adhesion. (msdmanuals.com)

Tumor Chart - Summary table of the seven questions to ask, differential diagnosis and important information about each tumor. (orthopaedicsone.com)
The final pathological diagnosis was PEComa identified by the liquid-based cytology, cell block, cervical biopsy, IHC and FISH result. (biomedcentral.com)
The cytologic characteristics of the tumor can provide sufficient clues for PEComa diagnosis, which includes loosely cohesive, epithelioid morphology with abundant clear or eosinophilic cytoplasm, low-grade nuclear atypia, cytoplasmic melanin pigments. (biomedcentral.com)
Finally, a tentative diagnosis of PEComa was made by combining cell block and IHC, and with the statement that the final diagnosis will require more representative material. (biomedcentral.com)
Objectives: To evaluate the role of cancer stem cell biomarkers in diagnosis and prognosis of OSCC patients. (bvsalud.org)
The COVID-19 pandemic disrupted health services, leading to delays and reductions in cancer screening, diagnosis, and reporting of data to some central cancer registries, which may have contributed to an observed decline in incidence for most cancer sites in 2020. (cdc.gov)

In this review, we summarize the current knowledge on the different intracellular pathways involved in the programming of Treg cell homeostasis and functions in cancer. (mdpi.com)
Following activation, NK cells mediate killing of target cells through two major pathways that require direct contact between NK cells and their target cells ( 6 ). (frontiersin.org)
While all tumor cells display dysregulation of metabolic pathways the differential growth patterns of BTICs suggest that these tumor subpopulations have metabolic features that distinguish them from your tumor bulk17-20. (biopaqc.com)
Transcriptomics analyses showed pathways related to TCR signaling, cytotoxicity and oxidative phosphorylation were significantly enriched in Tet lo found in both regressing and progressing tumors compared with Tet hi , whereas genes related to DNA damage, apoptosis and autophagy were downregulated. (bmj.com)
Two powerful tumour suppressor pathways, controlled by the p53 and retinoblastoma (pRB) proteins, are important for establishing and maintaining the senescence growth arrest. (nature.com)
PCR arrays looking into target genes from the main signaling pathways indicated how the mGR will not exert its results through the transcriptional activity of the most common kinases in these leukemic cells, but RhoA signaling surfaced from our pathway evaluation. (fabretp.org)
Central hearing loss results from damage to the auditory nerve itself, or the brain pathways that lead to the nerve. (medlineplus.gov)

Conclusions: Our findings provide new and compelling evidence for the acquisition of CSC-like cells induced by chronic SWCNT exposure, which are likely to be a major driving force for SWCNT tumorigenesis. (cdc.gov)
Our findings may help understanding the dynamics of tumour cells and the physical mechanisms they use to break away and metastasize. (ibecbarcelona.eu)

This expansion gives rise to a small benign colon tumor (called a polyp or adenoma). (hopkinsmedicine.org)

Cancer outcomes are often indexed to the quality of the immune response to the tumor. (mdpi.com)
To better understand the immune profile of the T cell product and its fate post infusion, baseline and post infusion PBMCs were analyzed by flow cytometry evaluating memory and exhaustion markers (e.g. (biomedcentral.com)
Metabolically active cells, neutrophils, and macrophages from the immune system produce high levels of ROS. (hindawi.com)
Some pharmaceuticals in development aim to boost the innate immune system's action against cancer by blocking CD47, a protein that many cancer cells display on their surfaces that functions as a "don't eat me" signal. (erwotex.net)
Seeking to boost survival for GBM patients, Jiang and his colleagues searched for ways to encourage innate immune cells to eat GBM cells, which not only destroys these cells directly but also helps train the adaptive immune system to continue the attack. (erwotex.net)
The researchers first tested how well CD47 monoclonal antibodies-proteins that stick to and mask CD47-work on GBM cells grown with innate immune cells called phagocytes in petri dishes. (erwotex.net)
Further experiments showed that once phagocytes had eaten their cancerous prey, they used components from these tumor cells to prime the immune system's T cells-the primary adaptive immune cells that fight cancers-to kill more GBM cells. (erwotex.net)
However, in time, the tumor cells developed a different way to evade the immune system by boosting their production of a protein called PD-L1, which shields them from T cell attack. (erwotex.net)
Recent studies have indicated that the Fc effector domain also displays considerable heterogeneity, accounting for its complex effector functions of inflammation, modulation, and immune suppression. (sdsc.edu)

To date, it has been difficult to overcome primary brain cancer resulting from GBM, primarily because the cancer-initiating cells are suspected to be highly resistant to current cancer therapies. (igem.org)
Thus, understanding how Treg cell identity is controlled, is of utmost importance for the development of novel anti-cancer therapies. (mdpi.com)
Both tumors are difficult to treat, and new therapies are urgently needed for these cancers. (hopkinsmedicine.org)
The laboratory focuses on developing new therapies for brain and skull base tumors , and has established the first primary skull base chordoma xenograft mouse model. (hopkinsmedicine.org)

During the preparation of this manuscript, the relationship of hTERT and -catenin was also exhibited in embryonic and adult stem cells as well as in colorectal cancer cell lines.29 Results hTERT and -catenin are coexpressed at the invasive front of human colorectal cancers Many CRCs are characterized by an invasive front with tumor cells displaying -catenin. (ourownfuture.org)
Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)
Due to the conserved nature of vertebrate cell behaviour, our results will be relevant to Wnt signalling during human embryonic development and could suggest novel vulnerabilities to Wnt-dependent diseases - a prerequisite for the development of novel therapeutics. (exeter.ac.uk)
During the interphase of early embryonic cell cycles, the OHO31 protein is present in the cytoplasm and massively accumulates in the nucleus at the onset of mitosis in late interphase and prophase. (rupress.org)

It is an orally active, microtubule disrupting agent that leads to the arrest of cell division and apoptosis in tumor cells. (cancer-research-network.com)

2009). Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins. (igem.org)
To better understand the mechanisms through which tumor cells evade T cell-mediated destruction, we evaluated the surface expression of over 330 proteins on myeloma cells from bone marrow samples using a flow cytometry-based array. (biomedcentral.com)
We also demonstrate that nerves are attracted to tumors through this same system of proteins suggesting that both plexin-B1 and semaphorin 4D are important in the promotion of PNI. (tam-receptor.com)
Treatment of Ishikawa cells with the AhR agonist [3H]2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) gave a radiolabeled nuclear complex that sedimented at 6.0 S in sucrose density gradients, and Western blot analysis confirmed that Ishikawa cells expressed human AhR and AhR nuclear translocator (Arnt) proteins. (tamu.edu)
Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. (exeter.ac.uk)
Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
In these operational systems, specific models of transmembrane proteins localize to opposing sides from the same cell and mediate intercellular conversation by getting together with each other across cell-cell limitations. (brain-tumor-cancer-information.com)
Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer? (mdpi.com)
Our outcomes indicate nevertheless that Cav-1 isn't essential for membrane localization from the GR since CCRF-CEM and Jurkat cells possess an operating mGR, but didn't communicate this caveolar proteins. (fabretp.org)
The lifestyle of such a receptor was also reported inside a mouse pituitary cell range (22), suggesting a second gene can be mixed up in manifestation of the GC-binding proteins at least in the central anxious system. (fabretp.org)
Nevertheless, in rats a GR immunoreactive proteins was detected for the plasma membrane of liver organ cells (10), of hippocampal and hypothalamic neurons (11), and of glial and neuronal cells Pyrantel pamoate in the lateral amygdala. (fabretp.org)
The gene encodes a phosphoprotein of 522 amino acids made of three domains: a central hydrophobic domain of eight repeats of 42-44 amino acids each, displaying similarity to the arm motif found in junctional and nucleopore complex proteins, and flanked by two hydrophilic NH2- and COOH-terminal domains. (rupress.org)

1,2 These tumors predominantly occur in elderly patients on sun-exposed areas, specifically on the head and neck, with the face being the most common location. (jcadonline.com)
RGNTs typically occur in young adults between the ages of 25 and 33 and display a preference for the posterior fossa. (surgicalneurologyint.com)
However, there is certainly raising proof GCs results on a lot of organs and cells, which are 3rd party of transcriptional adjustments and occur quickly, within a few minutes or mere seconds of contact with GCs (2C4). (fabretp.org)
It may occur when the tiny hair cells (nerve endings) that move sound through the ear are damaged. (medlineplus.gov)

Emerging models of PNI strongly suggest that interactions between tumor cells and nerves induce tumor cell migration and stimulate nerve growth or axonogenesis. (tam-receptor.com)
In addition, it significantly inhibits both EGF- and HGF-mediated cancer cell migration and invasiveness. (cancer-research-network.com)
Axelrod and Matis, 2013), whereas the cell migration equipment reaches the basal surface AR-C69931 tyrosianse inhibitor area. (brain-tumor-cancer-information.com)
So far, much of the research into how this migration takes place has been done on individual cells. (ibecbarcelona.eu)
By looking at a collection of migrating cells - in this case, in cells from the surface of the kidney - the scientists discovered that their movement as a group - migration slowing as cell density rises, and the fastest cells moving in large groups whose scale grows with increasing cell density - is similar to a process called glass transition. (ibecbarcelona.eu)
A glass-like behaviour of confluent cells has direct implications on collective migration and its purposes," explains Xavier, whose research at IBEC is funded by the prestigious Catalan Institution for Research and Advanced Studies (ICREA). (ibecbarcelona.eu)
Glass-like dynamics of collective cell migration. (ibecbarcelona.eu)
Our data indicated that PET1 inhibits EGFR-mediated cell migration. (biorxiv.org)

Versican is definitely a big CS-rich proteoglycan indicated at high amounts by proliferating cells and mesenchymal cells and it is deposited in to the ECM during cells remodeling and advancement. (healthyconnectionsinc.com)

In the general population, PCNSL accounts for roughly 4% of primary brain tumors and 1% of all non-Hodgkin lymphoma. (medscape.com)
This is because the brain lacks lymphatics, and thus CNS tumors rarely spread beyond the CNS. (medscape.com)
Magnetic resonance imaging was requested, which identified a small tumor in the brain. (goldenhelix.com)
Medulloblastomas are the most common malignant brain tumor for children and glioblastomas are the most common malignant brain tumor for adults. (hopkinsmedicine.org)
[ 4 ] Adult cases are unusual, accounting for less than 1% of brain tumors. (medscape.com)

Tumour cells displayed high expression of PDGFRα in 20%, and PDGF-CC in 21% of primary tumours, which correlated with the triple-negative subtype (TNBC). (lu.se)

We applied our workflow to quantify cell-cycle effects of three antimitotic cancer drugs over 8 d in HT-1080 fibrosarcoma xenografts in living mice using a data set of 38,000 cells and compared the induced phenotypes. (nature.com)
We observed neurite GSK369796 outgrowth in a co-culture of PC3 cells with wild-type DRG but not from DRG harvested from plexin-B1 knockout mice or in which Sema4D was silenced in the PC3 cells. (tam-receptor.com)
ENMD-1198 -based combination treatments reduce tumor burden but do not eradicate the tumor in mice. (cancer-research-network.com)
PHENOTYPE: Homozygous null mice and MEFs display increased tumor incidence and inducibility, premature death, increased chromosomal instability, and cell cycle abnormalities. (utsouthwestern.edu)

Methods: Protein expression of tumour and/or stromal cell PDGFRα, PDGFRβ and PDGF-CC was evaluated in primary tumours (N = 489), synchronous lymph node metastases (N = 135) and asynchronous recurrences (N = 39) using immunohistochemistry in a prospectively maintained cohort of primary breast cancer patients included during 1999-2003. (lu.se)
Tumour cell PDGFRα was significantly up-regulated in lymph node metastases and asynchronous recurrences. (lu.se)

STUDY QUESTION: What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis? (tamu.edu)

Primary neuronal tumor that intrinsically arise from the pineal gland are referred to as pineal parenchymal tumors (PPTs). (thieme-connect.com)
Immunohistochemical examination revealed neuronal tumor immunophenotype with diffuse positivity for non-specific enolase, synaptophysin, and focal positivity for S-100. (thieme-connect.com)
Mind tumor initiating cells (BTICs) coopt the neuronal high affinity GLUT3 blood sugar transporter to withstand metabolic tension. (biopaqc.com)

2007). Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy. (igem.org)
This would create a maze and challenge the microglia to seek out the cancer cells. (igem.org)
Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional (3D) biological processes such as tissue development and cancer. (nature.com)
Non-small cell lung cancer cells served as a positive control. (cdc.gov)
Malignant Rhabdoid tumors (MRT) are among the most aggressive and lethal forms of infant and child cancer (1). (goldenhelix.com)
PNI promotes cancer cell survival and severely limits the ability NOS2A to establish local control of disease. (tam-receptor.com)
The prostate cancer cell lines PC3 and Du-145 migrate toward nerve cell lines expressing Sema4D a response abrogated when plexin-B1 or Sema4D is usually knocked down through RNA interference (RNAi) or when signaling of RhoA and its downstream effector Rho kinase (ROK) is usually inhibited. (tam-receptor.com)
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. (tamu.edu)
Ishikawa endometrial cancer cells express the estrogen receptor (ER), and this study investigates aryl hydrocarbon receptor (AhR) expression and inhibitory AhR-ER crosstalk in this cell line. (tamu.edu)
Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. (hindawi.com)
In cancer cells, ROS production is mainly due to overexpression of the NADPH oxidase [ 3 ]. (hindawi.com)
While a balance between enhanced ROS production and detoxification can be maintained, cancer cells will proliferate and survive. (hindawi.com)
Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
We further use gastric cancer cells to investigate how cytonemes mobilize Wnts in tumour tissue. (exeter.ac.uk)
Moreover, ENMD-1198 markedly reduces the activation of STAT3, an important transcription factor for regulating VEGF-A in cancer cells. (cancer-research-network.com)
for example, tumours in many forms of cancer display a higher cell density than the surrounding tissues. (ibecbarcelona.eu)
Emerging evidence indicates that cancer cells incorporate mitochondrial genes or whole mitochondria to maintain their bioenergetic state. (europa.eu)
Although this agent did boost the phagocytes' consumption of the cancer cells, "the activity wasn't too striking," Jiang says. (erwotex.net)
Next, he and his colleagues tested increasing the cancer cells' "eat me" signal by administering a drug called temozolomide (TMZ), a decade-old pharmaceutical that's a mainstay for most GBM treatment protocols. (erwotex.net)
Although this drug also increased phagocyte consumption of the cancer cells, these results were also lackluster, says Jiang, also a member of UT Southwestern's Harold C. Simmons Comprehensive Cancer Center. (erwotex.net)
The alterations we find are then studied in-depth to determine how they contribute to the development of cancer, whether it is promoting tumor growth, enhancing the ability for the cancer to invade into normal tissue, or preventing the various fail-safe mechanisms programmed into our cells. (hopkinsmedicine.org)
Furthermore, CD34 expression may also be found on a variety of cancer stem cells. (bvsalud.org)
In this paper, we aimed to carry out a systematic analysis of the structure, functions, and relationship with cancer stem cells of CD34 based on the literature overview. (bvsalud.org)
Twenty-two reports were sought for retrieval, however, we could not find the full text of 3 studies and12 studies were excluded because the biomarkers were not associated with cancer stem cells. (bvsalud.org)
The aim of this study was to investigate the prognostic effect of CD34 + CD38- leukemia cells in this childhood cancer. (bvsalud.org)
Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)

Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)

CDC and NCI will include the 2020 incidence rates in statistical reports and displayed graphics but will not include them in Joinpoint models. (cdc.gov)

Use of HAART leads to an increase in CD4 + T cells and increases survival to more than 18 months. (medscape.com)
The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
We highlighted that while IL32β-stimulated macrophages secreted several protumoral factors, they supported tumor survival through a soluble dialog, mostly driven by BAFF. (haematologica.org)

The third pattern (nearly half of all biopsy samples) was characterized by well-delineated sheets and bundles of spindle cells, which coalesced to form nodules. (cdc.gov)
We report a case of cervix PEComa in a 55-year-old postmenopausal woman, initially identified by the liquid-based cytology test and subsequently confirmed by cell block, cervical biopsy, IHC and FISH result. (biomedcentral.com)

As opposed to many other known alternative treatments, it has not escaped our attention that tat-GFP labeled cells show normal morphology (Maddika 2005), a property especially appreciated and crucial for any conclusions to be made in the course of our research. (igem.org)

As an example, consider the classification of anaplastic tumors as elaborated in the WHO guidelines and Louis et al. (medscape.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)

The 2014 WHO Classification of Tumours of Female Reproductive Organs recognized a separate entity of CF that displays particularly high mitotic activity but no diffuse moderate-to-severe cytological atypia as MACF. (iiarjournals.org)

CD133+ cells have shown resistance to hypoxia, irradiation, and some forms of chemotherapy. (igem.org)
These cells also develop specific strategies to increase ROS resistance and to express the enzymatic activities necessary for ROS detoxification. (hindawi.com)
Further insights on the roles of CD8 + specificities and TCR avidity of naturally arising tumor-specific T cells, where both high and low avidity T cells recognizing the same peptide-major histocompatibility complex (pMHC) coexist in the same tumor, are crucial for understanding T cell exhaustion and resistance to PD-1 immunotherapy. (bmj.com)

Grossly, the tumor is usually a solid, well circumscribed nodule 5 cm or less, with a distinct golden-brown homogenous cut surface. (pathologyoutlines.com)

Lamellarin D, for example, displays strong cytotoxic activity against tumor cell lines, and is a potent topoisomerase I inhibitor. (wikipedia.org)
Lamellarin r 20-Sulfate, an Inhibitor of HIV-1 Integrase Active against HIV Virus in Cell Culture" (PDF). (wikipedia.org)
This is supported by pharmacological targeting where the first-generation pan-BET bromodomain inhibitor JQ1(+) displays anti-inflammatory effects and inhibit tumor cell eradication, while the novel bivalent BET bromodomain inhibitor AZD5153, which shows differential activity towards BET family members, does not. (frontiersin.org)
Each cell also produces these adhesions at its back to permit the trailing advantage to retract and cell AR-C69931 tyrosianse inhibitor body to progress. (brain-tumor-cancer-information.com)

Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)

Visit and use our newly updated chapter - Soft Tissue Tumors-Part 1 (link is also in the center section of our Home Page). (pathologyoutlines.com)
It then discusses all known fibroblastic / myofibroblastic, fibrohistiocytic and lipomatous tumors, include WHO and non-WHO entities (the remaining soft tissue tumors are discussed in the Soft Tissue Tumors-Part 2 chapter). (pathologyoutlines.com)
Figure 4: COSMIC displaying the tissue locations and occurrence of mutation alterations in the SMARCB1 gene. (goldenhelix.com)
An essential component for these developmental processes but also for tissue regeneration and stem cell regulation is the communication of cells by chemical signalling. (exeter.ac.uk)
In healing, for example, in which large groups of cells are removed from a cohesive tissue, the cell density is reduced to nothing at the edge of the wound and cells rapidly migrate inward to fill it. (ibecbarcelona.eu)
Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. (medscape.com)
The epidermal growth factor receptor (EGFR) is a HER-family receptor tyrosine kinase (RTK) that is involved in cell signaling in healthy tissue. (biorxiv.org)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

Chordoma research is led by a comprehensive team including Gary Gallia, M.D., director of the N ... eurosurgery Skull Base Tumor Center. (hopkinsmedicine.org)

Histologically, MACF displayed frequent mitotic figures, as well as increased cellularity and mild cytological atypia. (iiarjournals.org)
The 2003 WHO Classification designated ovarian fibromatous tumor with markedly increased cellularity, increased mitotic activity (≥4 per 10 HPFs), and diffuse moderate-to-severe cytological atypia as fibrosarcoma ( 2 ). (iiarjournals.org)
Since tumors with increased mitotic activity but no diffuse moderate-to-severe cytological atypia have not been categorized ( 7 ), this kind of tumor has been diagnosed mostly as fibrosarcoma. (iiarjournals.org)
Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)

The results revealed the upregulation of several immunosuppressive markers, including PDL-1, on myeloma cells associated with poor prognosis and trafficking, as well as immunosuppression following T cell infusion. (biomedcentral.com)

Background CD8 + T cells are a highly diverse population of cells with distinct phenotypic functions that can influence immunotherapy outcomes. (bmj.com)

Like most cancers glioblastomas display derangement of rate of metabolism to promote a shift towards glycolysis known as the Warburg effect16. (biopaqc.com)
Grasping for aspartate in tumour metabolism. (umassmed.edu)

Cell Stem Cell, 4, 472-476. (igem.org)
These cells also displayed aberrant stem cell markers, notably Nanog, SOX-2, SOX-17 and E-cadherin. (cdc.gov)
Furthermore, we identified specific stem cell surface markers CD24(low) and CD133(high) that are associated with SWCNT-induced CSC formation and tumorigenesis. (cdc.gov)
The CD34 protein was identified almost four decades ago as a biomarker for hematopoietic stem cell progenitors. (bvsalud.org)
Although a complete understanding of this transmembrane protein, including its developmental origins, its stem cell connections, and other functions, is yet to be achieved. (bvsalud.org)
CONCLUSIONS: Various stem cell biomarkers have been found to have diagnostic and prognostic role in oral squamous cell carcinoma such as Cyclin D1, VEGF-A, GD15, and CD44. (bvsalud.org)
Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect. (ouhsc.edu)

8%. As the amount of tumor nodules greater, the actuarial RFS showed a significant reduce. (rafinhibitors.com)

Both ovarian CF and MACF are essentially tumors of fibroblastic origin. (iiarjournals.org)

Anatomy22

Organisms11

Diseases86

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes48

Disciplines and Occupations1

Information Science4

Health Care8

Malignant tumors6

Progression13

Differentiation12

Metastasis6

Microenvironment9

Solid tumors2

Neoplasms7

Proliferation7

Nervous18

Epithelial10

Inhibitors2

Mutations8

Biol4

Granulosa cell1

Papillary1

Malignancy4

Cellular16

Testicular tumors3

Responses16

Glioblastoma5

Lesions3

Antigens2

Molecular8

Vivo8

Suppressor gene3

Granular4

Clinical5

Metastatic4

Therapeutic6

Lymphocytes3

Nuclei9

Histopathological2

Atypical4

Carcinomas3

Rare tumor1

Follicular6

Neoplasm4

Genetic2

20214

Angiogenesis3

Inhibition3

Diagnosis6

Pathways7

Findings2

Adenoma1

Immune9

Therapies4

Embryonic4

Apoptosis1

Proteins14

Occur4

Migration8

Mesenchymal1

Brain5

Subtype1

Mice4

Metastases2

Stromal1

Neuronal3

Cancer26

Histologic1

Incidence1

Survival3

Biopsy2

Morphology1

Anaplastic3

Tumours1

Resistance3

Grossly1

Inhibitor4

Vitro2

Tissue8

Cutaneous1

Chordoma1

Mitotic4

Prognosis1

Outcomes1

Metabolism2

Stem Cell7

Nodules1