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  • peripheral
  • In the cat , it is observed that A-type horizontal cells have a density of 225 cells/mm 2 near the center of the retina and a density of 120 cells/mm 2 in more peripheral retina. (wikipedia.org)
  • Retinas of newborn, juvenile, and adult Callithrix jacchus and Macaca fascicularis monkeys and control human retinas were studied to determine the localization of angiostatin relative to III β-tubulin, glial fibrillary acidic protein, vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM), and the angiostatin receptor αvβ3-integrin in the foveal, macular, and peripheral retina. (arvojournals.org)
  • the expression of angiostatin in the avascular foveal region and the peripheral retina suggests that angiostatin may play a role in the regulation of retinal vascularization, providing a possible explanation for the development and persistence of an avascular fovea. (arvojournals.org)
  • 4. The device of claim 1 wherein each conductive contact is positioned in the peripheral region of the lens substrate, and is connected to its corresponding recording electrode via an electrically conductive trace that is electrically insulated from the surface of the eye. (google.com)
  • Implant AG
  • An artificial retina developed by Retina Implant AG of Reutlingen, Germany, has restored meaningful vision to most of the nine blind people - eight with retinitis pigmentosa, one with cone-rod dystrophy - enrolled in a clinical trial. (blindness.org)
  • Walter G. Wrobel, chief executive officer of Retina Implant AG, says the company will seek regulatory approval, known as a CE mark, to market the device in Europe. (blindness.org)
  • periphery
  • David Phillips at the University of Glasgow and a few pals say they've found a way to use a single pixel to create images in which the central area is recorded in high resolution while the periphery is recorded in low resolution. (technologyreview.com)
  • The cells that have already started to differentiate are highlighted in purple and are located at the periphery of the retina. (wellcomeimageawards.org)
  • The captivating kaleidoscope effect is created by the elongated cells and the radiating growth of the undifferentiated region closest to the lens towards the differentiated cells on the periphery. (wellcomeimageawards.org)
  • Cone
  • The processing of cone signals in the retina can, however, be heavily disrupted with subsequent loss of both YB and RG chromatic sensitivity. (arvojournals.org)
  • fluid
  • 4 Chronically high blood sugar associated with diabetes can weaken the blood vessels in the eye, leading to fluid leaking into the retina (edema). (biospace.com)
  • cells
  • There is a greater density of horizontal cells towards the central region of the retina. (wikipedia.org)
  • These studies demonstrate contrasting gene-environment phenodeviances and roles of Ranbp2 between dopaminergic and glial cells of the brain and retina upon oxidative stress-elicited signaling and factors triggering a continuum of metabolic and cellular manifestations and proxies linked to oxidative stress, and chorioretinal and neurological disorders such as Parkinson. (springer.com)
  • These cells line the back of the eye in the region known as the retina. (retina-international.org)
  • Rods and cones are photoreceptive cells located in the retina of the eye. (britannica.com)
  • This type is found in the photosensitive cells in your retina. (studymode.com)
  • Two distinct functional types of cells frequently encountered, one ON and one OFF, had non-opponent spectral sensitivity, relatively high response gain, transient light responses, and large receptive fields (RFs) that tiled the region of retina recorded, suggesting that they belonged to the same morphological cell class, most likely parasol. (jneurosci.org)
  • stimulus
  • In fact, despite one region of the stimulus (e.g., the hole in the center of the Asahi shape in Fig. 1 ) appearing brighter than the background, both images have the same luminance in physical terms. (pnas.org)
  • rods
  • In the retina of vertebrates the rods and cones have photopigment-bearing regions (outer segments) composed of a large number of pancakelike disks. (britannica.com)
  • supportive
  • Finally, MPTP-treated wild-type and Ranbp2 +/− mice present distinct metabolic footprints in the brain or selective regions thereof, such as striatum, that are supportive of RanBP2-mediated regulation of interdependent metabolic pathways of lysine, cholesterol, free-fatty acids, or their β-oxidation. (springer.com)
  • blood
  • fluorescein angiogram - an imaging technique involving the use of a coloured dye, which after being injected into the arm travels to the eye where it highlights blood vessels in the retina (only an ophthalmologist will perform this for you). (southerncross.co.nz)
  • responsible for supplying blood to the Retina. (consumersresearchcncl.org)
  • study
  • This study aims to assess the impact of the subretinal implant RETINA IMPLANT Alpha AMS on the patient's daily life, using validated activities of daily living and questionnaires. (clinicaltrials.gov)
  • In addition, the study will provide additional information about the safety and efficacy of the CE-certified RETINA IMPLANT Alpha AMS. (clinicaltrials.gov)
  • The goal of this study is to examine whether these AMD-associated variants alter expression levels of ARMS2 and HTRA1 in human retina samples. (molvis.org)
  • As we continue to study the disease in the brain, the emerging field of ocular AD warrants further investigation of how the retina may faithfully reflect the neurological disease. (springer.com)
  • disease
  • In preclinical testing, the candidates demonstrated reduced leakage into the retina and shorter mean circulation times - suggesting a slowing of the disease progression. (biospace.com)
  • In this experiment, Verseon's compounds demonstrated reduced leakage into the retina and shorter mean circulation times, both of which suggest a slowing of the disease progression. (biospace.com)
  • Stargardt disease is caused by the accumulation of toxic byproducts from vitamin A processing in the retina. (fightingblindness.org)
  • results
  • Collectively, these results indicate that microglia and the immune system are dynamic during a successful regenerative response in the retina. (biomedcentral.com)
  • Interim results of the Alpha IMS clinical trial were released less than a week after Second Sight Medical Products, Inc., of Sylmar, California, received market approval for its artificial retina, the Argus II, from the FDA. (blindness.org)
  • This results in the activation of inflammatory pathways and vasodilation in the retina, leading to edema. (biospace.com)
  • human
  • We did not find association between AMD susceptibility variants at 10q26 and steady-state expression levels of either ARMS2 or HTRA1 in the human retina. (molvis.org)
  • damage
  • We find evidence of early leukocyte infiltration to the retina in response to ouabain injection followed by a period of immune cell proliferation that likely includes both resident microglia and substantial numbers of proliferating, extra-retinally derived macrophages, leading to rapid accumulation upon retinal damage. (biomedcentral.com)
  • Typically, each person with RP only has damage in one pair of genes, and gene therapy to replace defective genes by inserting healthy genes into the retina via harmless viruses is being explored in clinical trials for a small number of RP genes. (retina-international.org)
  • cause
  • By inhibiting plasma kallikrein, Verseon's drug candidates target the direct cause of downstream inflammation caused by this hyperactivity and can potentially lower leakage into the retina. (biospace.com)
  • reflect
  • A computational method for analyzing electrophysiological potentials recorded at five or more locations on the anterior surface of the eye, which reflect the spatial distribution of activity of the retina, is also provided. (google.com)