Central obesity and metabolic syndrome insulin resistance and nafld metabolic syndrome is central obesity. Medical search. Frequent questions

2 NAFLD is associated with obesity and features of metabolic syndrome, including hypertension, dyslipidemia, central adiposity, insulin resistance, or diabetes. (xiahepublishing.com)
Nordihydroguaiaretic acid (NDGA), the main metabolite of Creosote Bush, has been shown to have profound effects on the core components of metabolic syndrome, including lowering of blood glucose, free fatty acids and triglyceride levels, attenuating elevated blood pressure in several rodent models of dyslipidemia, and improving body weight, insulin resistance, diabetes and hypertension. (biomedcentral.com)
In the present study, a high-fructose diet fed rat model of hypertriglyceridemia, dyslipidemia, insulin resistance and hepatic steatosis was employed to investigate the global transcriptional changes in the lipid metabolizing pathways in three insulin sensitive tissues: liver, skeletal muscle and adipose tissue in response to chronic dietary administration of NDGA. (biomedcentral.com)
MetS is characterized by central obesity, dyslipidemia, elevated blood pressure, and elevated plasma glucose (Gonçalves et al. (ugr.es)
Metabolic dyslipidemia could lead to non-alcoholic fatty liver disease, and its secondary consequence is the development of metabolic syndrome and diabetes. (ac.ir)
1. Srikanth S, Deedwania P. Management of dyslipidemia in patients with hypertension, diabetes, and metabolic syndrome. (ac.ir)
6. Gaggini M, Morelli M, Buzzigoli E, DeFronzo RA, Bugianesi E, Gastaldelli A. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. (ac.ir)
Apart from ovulatory and reproductive dysfunctions, PCOS have chronic metabolic consequences: cardiovascular disease (CVD), obesity, dyslipidemia, obstructive sleep apnoea, and non-fatty liver. (ijpsr.com)
Those battling central obesity, T2DM, dyslipidemia and metabolic syndrome are at a heightened risk of NAFLD. (getoberit.com)
Metabolic syndrome (MetS) is defined as a panel of endocrine disorders, including central adiposity, dyslipidemia, hyperglycemia and hypertension ( Kaur, 2014 ). (frontiersin.org)
Metabolic Syndrome Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal fat), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (merckmanuals.com)

Patients with glucocorticoid excess, Cushing's syndrome, develop a characteristic constellation of adverse metabolic features including central obesity, insulin resistance, proximal muscle wasting, hypertension and non-alcoholic fatty liver disease (NAFLD). (uni-luebeck.de)
Moreover, in this common female patient population, there is markedly high prevalence of multiple cardio-metabolic conditions, such as type 2 diabetes, obesity, and hypertension, which may significantly increase the risk for adverse COVID-19-related outcomes. (beds.ac.uk)
As an endocrinologist board-certified in diabetes , lipidology , hypertension and obesity , practicing in Rockville, Montgomery County, Maryland, one of my objectives is to employ a holistic approach in diagnosing and managing metabolic syndrome. (gertitashkomd.com)
Diseases such as obesity, diabetes, and hypertension have been found to be closely associated with the incidence of NAFLD. (wjgnet.com)
Though the diagnostic criteria for MetS has been variably defined in the literature, most definitions now include the presence of at least three of the following: Abdominal obesity, insulin resistance, hypertension, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein levels. (surgicalneurologyint.com)

Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabolic co-morbidities. (biomedcentral.com)
The result of this study suggests that there is an increased prevalence of all the components of MetS and significant changes in biochemical markers in cases of NAFLD. (biomedcentral.com)
The prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing, currently affecting a quarter of people worldwide [ 1 ]. (springer.com)
4. Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. (ac.ir)
For the Asia-Pacific region, in a systematic review it has been noted that 'in most countries nearly 1/5th of the adult population or more were affected by Metabolic Syndrome with a secular increase in prevalence. (lowcarbneurologist.com)
The prevalence and incidence of MAFLD and NAFLD were used to analyze the epidemic characteristics and its overlapping effects. (xiahepublishing.com)
The prevalence rates of MAFLD and NAFLD were 21.03% and 18.83%, respectively. (xiahepublishing.com)
3 The global prevalence of NAFLD was 25.24%, 4 while it was 29.62% in Asia. (xiahepublishing.com)
Evidence suggests that up to 30% of the United States population has NAFLD, 1 while the prevalence of non-alcoholic steatohepatitis (NASH), the more progressive form of NAFLD, ranges from approximately 3% 2 3 in the general population to 25-70% among morbidly obese patients. (bmj.com)
A recent large, multi-centre study of 733 predominantly Caucasian patients with NAFLD from the USA, UK, Australia and Italy showed a mean age of 48 years, with a male prevalence of 53% and a mean homeostasis model assessment (HOMA) score of 5.53. (bmj.com)
Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. (biomedcentral.com)
Considering high prevalence rates of metabolic diseases linked by insulin resistance, we performed a systematic review of existing literature which addressed the role of probiotics in modulating insulin sensitivity in animals and humans. (biomedcentral.com)
The prevalence of NAFLD is rising rapidly because of ongoing epidemics of obesity and type 2 diabetes. (medscape.com)
6, 7] The prevalence in the morbidly obese population has been estimated as 75-92%, and up to 17% of children and adolescents may be affected with NAFLD. (medscape.com)

Polycystic ovary syndrome, or polycystic ovarian syndrome (PCOS), is the most common endocrine disorder in women of reproductive age. (wikipedia.org)
In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. (beds.ac.uk)
Polycystic ovarian syndrome (PCOS) is a reproductive metabolic disorder affecting nearly 20% females, globally. (ijpsr.com)
Polycystic ovarian syndrome, (PCOS) earlier known as the Stein Leventhal syndrome, is a multisystem endocrine disorder with reproductive and metabolic consequences 1 . (ijpsr.com)
In contrast, women with polycystic ovarian syndrome PCOS, which is characterised by androgen excess, have evidence of increased liver fat. (endocrine-abstracts.org)
Polycystic ovary syndrome (PCOS) is an ovarian disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. (nutrikalp.com)
Polycystic ovary syndrome is a clinical syndrome typically characterized by anovulation or oligo-ovulation, signs of androgen excess (eg, hirsutism, acne), and multiple ovarian cysts in the ovaries. (merckmanuals.com)
Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. (merckmanuals.com)
Polycystic ovary syndrome has several significant potential complications. (merckmanuals.com)
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. (medscape.com)
Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis. (medscape.com)
PCOS is a heterogeneous disease characterized by hyperandrogenism, dysfunctional ovulation, and polycystic ovary morphology, accompanied by metabolic abnormalities, such as insulin resistance (IR) and obesity. (biomedcentral.com)

The role of fructose in NAFLD (steatosis) pathogenesis has received a great deal of attention in part because from 1999 to 2004 the consumption of fructose increased by ~32 % [ 36 ]. (biomedcentral.com)
Subsequently he obtained fellowships from the Wellcome Trust and most recently an MRC senior clinical fellowship investigating the pathogenesis of human obesity and insulin resistance. (uni-luebeck.de)
His research investigates the pathogenesis of human obesity, insulin resistance and non-alcoholic fatty liver disease. (uni-luebeck.de)
Hence, further long term, controlled studies are required to understand the exact pathogenesis and metabolic consequences both in obese and non-obese PCOS women. (ijpsr.com)
Though numerous studies are being done in line with the etiology of PCOS, still the mechanism of pathogenesis and its metabolic impact remains variable and inconclusive. (ijpsr.com)
7 With the deepening of people's understanding of the pathogenesis of NAFLD, the current criteria has been challenged. (xiahepublishing.com)
A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. (wjgnet.com)
Appreciating the pathogenesis of HFD-induced metabolic disorders requires a thorough knowledge of adipose tissue physiology and the regulation of adipokines secretion and action including the role of gender in response to these parameters. (biomedcentral.com)
Data show that hepatic mitochondrial dysfunction is crucial to the pathogenesis of NAFLD. (medscape.com)

Dietary administration of NDGA decreased plasma levels of TG, glucose, and insulin, and attenuated hepatic TG accumulation. (biomedcentral.com)
NAFLD is a condition caused by the accumulation of excess fat in liver cells, typically among individuals who do not drink alcohol. (getoberit.com)
NAFLD involves the accumulation of fat in the liver, leading to inflammation and scarring. (gertitashkomd.com)
It is known that diabetes, type II diabetes mellitus (T2DM) in particular, is often associated with hepatic accumulation of triglycerides in both rodents and humans, which might eventually lead to the development of hepatic steatosis or nonalcoholic fatty liver disease (NAFLD) [ 14 - 16 ]. (hindawi.com)
These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. (wjgnet.com)
Obesity is defined as an increase of adipose tissue mass in the body and its accumulation in peripheral organs that leads to metabolic abnormalities such as type 2 diabetes (T2D), insulin resistance and hyperlepidemia [ 1 , 2 ]. (biomedcentral.com)
Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O 2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. (surgicalneurologyint.com)
Fatty replacement occurs when pancreatic cells that secrete enzymes (acinar cells) are replaced by adipocytes, while fatty infiltration refers to the accumulation of adipocytes due to obesity. (fitnesshacks.org)
People with NAFL have an enlarged liver with excess fat accumulation, but this type of NAFLD comes with minimal inflammation or damage to the liver itself. (inbodyusa.com)
In this study, we sought to determine whether GDF15 plasma concentrations are associated with (1) intrahepatic fat content, (2) changes in intrahepatic fat accumulation over time, and (3) the metabolic phenotype related to NAFLD in youth with obesity. (nature.com)
A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)
Non-Alcoholic Fatty Liver Disease (NAFLD) is defined by an excessive accumulation of lipids in hepatocytes which is not related to alcohol consumption. (enterosys.com)

Our data suggest that inhibition of AR in the T2DM db/db mice led to significant activation in hepatic PPAR α and significant reductions in serum triglycerides (TG) and hepatic TG, suggesting that under hyperglycemia, AR/the polyol pathway might be greatly upregulated to contribute significantly to the hepatic regulation of TG metabolism and the development of nonalcoholic steatohepatitis (NASH) or nonalcoholic fatty liver disease (NAFLD). (hindawi.com)
Analogous to other addictive behaviors, neurochemical changes in those with depression and/or T2DM are thought to cause individuals to increase their food intake to obtain the same reward leading to binge eating, weight gain and obesity. (frontiersin.org)
Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)
Increasing dopamine levels/signals are associated with improved insulin sensitivity, while decreasing dopamine and serotonin levels/signals are associated with weight gain and T2DM development. (frontiersin.org)
26 120 180 ] Body mass index (BMI) has been widely used to indicate the level of obesity, though recent studies have found that abdominal or visceral adiposity (vs subcutaneous), as reflected in the waist-to-hip ratio or waist circumference, is a strong criteria for predicting the risk of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). (surgicalneurologyint.com)
180 ] While obesity is a risk factor for MetS, the fact that not all obese patients develop MetS or T2DM[ 25 106 186 196 203 230 266 ] suggests that adiposity may not be etiologic. (surgicalneurologyint.com)

Nonalcoholic fatty liver disease (NAFLD) is fast becoming a disease of first-world countries, where high fat food is rarely a scarcity, and lives continue to become more sedentary. (nursingcenter.com)
Nonalcoholic fatty liver disease (NAFLD) is an umbrella term that comprises a large spectrum of liver injuries, varying in severity but all leading to fibrosis. (xiahepublishing.com)
Women with PCOS have higher risk of multiple diseases including Infertility, type 2 diabetes mellitus (DM-2), cardiovascular risk, metabolic syndrome, obesity, impaired glucose tolerance, depression, obstructive sleep apnea (OSA), endometrial cancer, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). (wikipedia.org)
We evaluated in a large sample of children and adolescents the association of TG/HDL-C ratio with early signs of morphological vascular changes and cardiometabolic risk factors including nonalcoholic fatty liver disease (NAFLD). (uniroma1.it)
Subjects were stratified into tertiles of TG/HDL-C. There was a progressive increase in body mass index (BMI), BMI-SD score (SDS), waist circumference, blood pressure (BP), liver enzymes, glucose, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein (hsCRP), and cIMT values across TG/HDL-C tertiles. (uniroma1.it)
Using in vitro cell systems including primary cultures of adipose, liver and muscle, we have characterized the action of glucocorticoids upon insulin action and lipid metabolism. (uni-luebeck.de)
We have shown in cross-sectional and intervention clinical studies that 5α-reductase activity is dysregulated in metabolic disease including obesity and NAFLD and have postulated that this represents a compensatory mechanism to protect the liver form the adverse effects of cortisol. (uni-luebeck.de)
Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. (biomedcentral.com)
NAFLD progresses as a silent disease which is disclosed only after a routine health check-up following elevated transaminases levels with no any other recognized causes of fatty liver like alcohol, virus, drugs, autoimmunity [ 10 , 11 ]. (biomedcentral.com)
Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet therapeutic needs. (springer.com)
A pharmacological pan-HIF-P4H inhibitor protected WT mice on both diets against obesity, metabolic dysfunction, and liver damage. (springer.com)
Fig. 4: Transfer of steatotic and metabolic phenotypes to mice through FMT of material from patients with liver steatosis grade 3. (nature.com)
Meex, R. C. R. & Watt, M. J. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. (nature.com)
2014). Patients with MetS are also more susceptible to develop type 2 diabetes mellitus (Reaven, 2004), and their hepatic morphology and function can be adversely affected leading to the development of Non Alcoholic Fatty Liver Disease (NAFLD) (Marchesini et al. (ugr.es)
Furthermore, NAFLD pathology is now considered as the liver manifestation of MetS (Angelico et al. (ugr.es)
Type 2 diabetes mellitus contributes heavily towards developing chronic progressive diseases, including but not limited to nonalcoholic fatty liver disease, due to its close association with insulin resistance. (getoberit.com)
Fatigue, discomfort in the upper right abdomen, or even an enlarged liver - these are some signs whispering the possible existence of NAFLD. (getoberit.com)
A liver biopsy, despite being as invasive as a detective digging deep into crime evidence, stands tall as one of the most conclusive methods confirming a diagnosis of NAFLD. (getoberit.com)
Liver diseases, particularly NAFLD , are also more prevalent in individuals with metabolic syndrome. (gertitashkomd.com)
This underscores the multisystem impact of metabolic syndrome, affecting not only the cardiovascular and metabolic systems but also the liver. (gertitashkomd.com)
Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver disease (NAFLD). (wjgnet.com)
Thus, high blood glucose levels persist, and some of them are converted to triglycerides in the liver, which leads to non-alcoholic fatty liver disease (NAFLD), and with excess triglycerides going to the bloodstream elevating the triglyceride levels in the blood. (lowcarbneurologist.com)
Therefore, we aimed to compare the difference in epidemiological and clinical characteristics between MAFLD and non-alcoholic fatty liver disease (NAFLD) among Asian populations. (xiahepublishing.com)
Compared with NAFLD, the newly proposed definition of MAFLD is more practical and accurate, and it can help identify more fatty liver patients with high-risk diseases. (xiahepublishing.com)
1 FLD is currently divided into alcoholic fatty liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) based on the history of alcohol intake. (xiahepublishing.com)
2 As NAFLD is a common cause of chronic liver disease, it has attracted more and more attention. (xiahepublishing.com)
We propose that 5αR may regulate GC exposure and therefore may modulate metabolic phenotype in human liver.Primary human hepato. (endocrine-abstracts.org)
Non-alcoholic fatty liver disease NAFLD has been associated with androgen deficiency, yet in the majority of patients with non-alcoholic steatohepatitis NASH, androgens levels are normal. (endocrine-abstracts.org)
Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with nafld: a randomized clinical trial. (cranberryinstitute.org)
Background We aimed to evaluate the effect of cranberry supplementation on serum liver enzymes, hepatic steatosis, and cardiometabolic risk factors in patients with non-alcoholic fatty liver (NAFLD). (cranberryinstitute.org)
Patients suffering from lipodystrophies experience reduced body fat, severe insulin resistance, hypertriglyceridemia, and hypoleptinemia, and nonalcoholic fatty liver disease. (medscape.com)
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. (wjgnet.com)
An estimated 30% of adults and 10% of children and adolescents in the United States have nonalcoholic fatty liver disease (NAFLD), defined as liver fat content exceeding 5% (Figure 1 )[ 1 - 3 ]. (wjgnet.com)
Non-alcoholic fatty liver disease is associated with obesity, non-insulin dependent diabetes, and hypertriglyceridemia and represents the hepatic manifestation of the metabolic syndrome[ 4 ]. (wjgnet.com)
Clinical predictors of advanced non-alcoholic liver disease (NAFLD) are needed to guide diagnostic evaluation and treatment. (bmj.com)
Non-alcoholic fatty liver disease (NAFLD) is a well-recognised liver disease that is associated with underlying insulin resistance and has been linked with the growing epidemic of obesity and the metabolic syndrome. (bmj.com)
and obesity/metabolic syndrome, which may lead to non-alcoholic fatty liver disease (NAFLD). (medscape.co.uk)
Eighty obese patients with normal liver enzyme levels but presenting with ultrasonographic evidence of NAFLD formed the population of this cross-sectional study. (biomedcentral.com)
Metabolic problems such as obesity, especially central obesity, fatty liver, high cholesterol, and diabetes are some of the risk factors related to non-alcoholic fatty pancreas disease. (fitnesshacks.org)
Obesity is one of the biggest body composition risk factors for developing nonalcoholic fatty liver disease and other liver issues. (inbodyusa.com)
In animal models, it has been noted that it may play a role in the progression of non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease in children. (nature.com)
1] The main lesions described in that study-namely, steatosis, liver cell injury, and the unique zone 3 "chicken wire" fibrosis (see the second image below)-remain central in establishing the diagnosis. (medscape.com)
At present, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the United States and, indeed, worldwide. (medscape.com)
The pathogenetic processes of nonalcoholic fatty liver disease (NAFLD) and its progression are multifactorial and are influenced by both environmental and genetic factors. (medscape.com)
18] NAFLD remains a diagnosis of exclusion, made by eliminating other liver diseases. (medscape.com)
The injury pattern of nonalcoholic steatohepatitis (NASH) in the adult population is central zonal, with steatosis, liver cell injury, and inflammation accentuated in zone 3. (medscape.com)

The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
Obesity is characterized by increased body adiposity and leads to insulin resistance. (medscape.com)
The resemblance between the metabolic abnormalities of these extreme states of adiposity underscores the importance of fat tissue in energy homeostasis. (medscape.com)
A requirement of insulin resistance and abdominal adiposity as part of the diagnostic criteria depends on the group or agency proposing the definition. (surgicalneurologyint.com)

The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. (frontiersin.org)
Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. (frontiersin.org)
Additional genetic subtypes include progeroid syndromes, autoinflammatory disorders, and SHORT syndrome. (medscape.com)
Our data suggest gender specific interactions between the diet's fatty acid source, the adipocyte-secreted proteins and metabolic disorders. (biomedcentral.com)
Thus, HFD-inducing metabolic disorders act via PPARγ to induce different levels of systemic homeostatic remodelling. (biomedcentral.com)
The non-alcoholic fatty pancreas can develop due to an unhealthy diet, lack of physical activity, and other lifestyle factors that contribute to obesity and metabolic disorders. (fitnesshacks.org)
Our innovative methods allow us to tap into new knowledge by exploring new approaches for the treatment of metabolic diseases and disorders. (enterosys.com)
Targeting the Enteric Nervous System to Treat Metabolic Disorders? (enterosys.com)

We have identified a novel mechanism by which glucocorticoids cause insulin resistance in skeletal muscle through serine phosphorylation of insulin receptor substrate 1. (uni-luebeck.de)
Dynamic studies of insulin action, including hyperinsulinaemic euglycemic pincers and intravenous glucose tolerance tests, which are often sampled, show that women with PCOS are more insulin resistant than weight-matched control women, with defects mainly in skeletal muscle. (nutrikalp.com)
The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study. (biomedcentral.com)
An increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters. (biomedcentral.com)
Because skeletal muscle is the major site of insulin-mediated glucose utilization (up to 80% in the postprandial state), losses in skeletal muscle mass may lead to metabolic impairments [ 12 ]. (biomedcentral.com)
Furthermore, to date, no studies have investigated the relationship between changes in skeletal muscle mass over time and metabolic syndrome development. (biomedcentral.com)
Therefore, we investigated whether baseline skeletal muscle mass and its changes over time have independent associations with metabolic syndrome development in a large 7-year longitudinal study. (biomedcentral.com)
While all of these factors can have a major impact on your overall metabolic health Two of these factors, your skeletal muscle mass, and your body fat mass, can have a huge impact on your overall metabolic health. (inbodyusa.com)
Insulin signaling is preserved in skeletal muscle during early diabetic ketoacidosis. (medscape.com)

Nonalcoholic steatohepatitis (NASH) is a deadly subset disease of those diagnosed with NAFLD. (nursingcenter.com)
Background and aims: The triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. (uniroma1.it)
We are living the midst a global epidemic of metabolic disease with rapidly escalating rates of obesity, type 2 diabetes and insulin resistance. (uni-luebeck.de)
Most recently, based upon observations in a patient with Cushing's disease without a clinical phenotype, we have identified a novel role for 11β-HSD1 in controlling the response to exogenous glucocorticoid excess raising the potential for therapeutic inhibition of 11β-HSD1 may not only as a treatment for Cushing's disease, but as an approach to the treatment of iatrogenic glucocorticoid excess to limit adverse metabolic effects. (uni-luebeck.de)
Hence, this study aims to recognize various risk factors including metabolic components and blood parameters to predict the possible incidence of the disease. (biomedcentral.com)
The global outbreak of the new disease (COVID-19) caused by the novel severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) has reached pandemic status in March 2020 [ 1 , 2 ]. (beds.ac.uk)
Metabolic syndrome (MetS) is a cluster of interrelated metabolic conditions which increase the risk of developing cardiovascular disease (Kaur, 2014). (ugr.es)
Central obesity refers to excessive abdominal fat around the stomach area, which increases your chances significantly towards developing this disease. (getoberit.com)
Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of heart disease, NASH, and type 2 diabetes, among others. (gertitashkomd.com)
Additionally, metabolic syndrome raises the risk of kidney disease. (gertitashkomd.com)
Individuals with this syndrome face an increased likelihood of developing chronic kidney disease , emphasizing the pervasive nature of its consequences on various vital organs. (gertitashkomd.com)
To better understand the demographics of NAFLD and risk factors for advanced disease, this study analysed 827 patients with NAFLD at two geographically separate tertiary medical centres. (bmj.com)
Obesity is increasing rapidly on a global scale and is associated with comorbidities that require expensive medical care and limit the life span,[ 4 180 ] including increased risk of all cause and cardiovascular disease mortality. (surgicalneurologyint.com)
Metabolic Syndrome (MS) and obesity, mainly visceral obesity, are associated with increased mortality due to Coronary Artery Disease (CAD). (biomedcentral.com)
Cardiovascular disease, metabolic syndrome and erectile dysfunction. (blogspot.com)
While NAFLD does not always cause symptoms on its own, having it can increase your risk for other serious health issues, such as cardiovascular disease and Type 2 diabetes. (inbodyusa.com)
This condition results in the development of pathological conditions such as type 2 diabetes, obesity, cardiovascular disease, hepatic steatosis and stroke. (enterosys.com)

Women with PCOS show various abnormalities in insulin action. (nutrikalp.com)

A subset of persons with NAFLD progresses to nonalcoholic steatohepatitis (NASH), consisting of hepatic steatosis accompanied by inflammation and fibrosis (Figure 1 )[ 5 ]. (wjgnet.com)

Erratic lifestyle predisposes to insulin resistance, or obesity leads to subsequent hyperinsulinemia and hyperandrogenemia. (ijpsr.com)
Obesity per se is associated with insulin resistance and compensatory hyperinsulinemia. (nutrikalp.com)
Hyperinsulinemia due to insulin resistance may be present and may contribute to increased ovarian production of androgens. (merckmanuals.com)
Type 2 diabetes is a pathological state characterized by hyperglycemia, hyperinsulinemia, glucose intolerance and insulin-resistance. (enterosys.com)

Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). (mdpi.com)
These findings suggest that NDGA ameliorates hypertriglyceridemia and steatosis primarily by inhibiting lipogenesis and enhancing fatty acid catabolism in three major insulin responsive tissues by altering the expression of key enzyme genes and transcription factors involved in de novo lipogenesis and fatty acid oxidation. (biomedcentral.com)
Long-term energy regulation: Hypothalamus senses and integrates energy balance signals including hormones such as insulin, leptin, ghrelin, and nutrients such as fatty acids, amino acids, and glucose. (unboundmedicine.com)
However, the heart of all these problems including the fatty pancreas is insulin resistance ( 2 ). (fitnesshacks.org)
Insulin resistance also leads to peripheral lipolysis (breaking down of fat cells in free fatty acids and glycerol) and the resulting overflow of fatty acids leads to the onset of NAFLD. (fitnesshacks.org)

In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. (frontiersin.org)
After an average 2.28-year follow-up, the incidence densities of MAFLD and NAFLD were 41.58 per 1,000 person-years and 37.69 per 1,000 person-years, respectively. (xiahepublishing.com)
A further longitudinal study is needed to elucidate the casual relationship between low muscle mass and metabolic syndrome incidence across the full age range of the population, beyond the sarcopenia context. (biomedcentral.com)

In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. (frontiersin.org)
Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). (frontiersin.org)
Your health care provider who is familiar with metabolic syndrome will make the diagnosis by obtaining the necessary tests, including blood pressure monitoring, waist circumference monitoring, blood glucose, serum insulin, and lipid profile (triglycerides and HDL). (lowcarbneurologist.com)

Further, according to the NCEP ATP III criteria, 13.6% of NAFLD were present with MetS where risk estimate was significant (OR = 2.15). (biomedcentral.com)
Whereas, other criteria (IDF) for MetS showed higher frequency (30.1%) with higher risk (OR = 29.75) for the presence of MetS in NAFLD patients. (biomedcentral.com)
Indeed NAFLD is mutually and bidirectionally linked with MetS of which it is both the cause and the consequences. (biomedcentral.com)
The term MetS, or originally Syndrome X, was proposed to foster a coherent clinical approach to management and therapeutic intervention. (surgicalneurologyint.com)

we have challenged the dogma that glucocorticoids cause insulin resistance in all tissues and demonstrated insulin sensitization both in vitro and in translational clinical studies selectively in human adipose tissue. (uni-luebeck.de)
He embarked upon a career in Diabetes and Endocrinology and secured an MRC Clinical Training Fellowship in 2000 and obtained his PhD from University of Birmingham studying steroid metabolism and human obesity in 2003. (uni-luebeck.de)
This strong overlap of risk factors for both worse PCOS cardio-metabolic manifestations and severe COVID-19 should be highlighted for the clinical practice, particularly since women with PCOS often receive fragmented care from multiple healthcare services. (beds.ac.uk)
The characteristic clinical features range from hirsutism, androgenic alopecia 2 , acne, insulin resistance 3 , acanthosis nigricansin 4 , to menstrual dysfunction 5 . (ijpsr.com)
However, medical problems associated with the insulin resistance of this syndrome and its corresponding complications may develop over time and themselves present with clinical symptoms. (lowcarbneurologist.com)
First, due to differences in the basic characteristics, living habits and genetic susceptibility of the population, the clinical manifestations, pathological characteristics and clinical outcomes of NAFLD are obviously heterogeneous. (xiahepublishing.com)
8 - 11 Therefore, the original diagnostic criteria may affect the clinical prognosis of NAFLD. (xiahepublishing.com)
Methods In the present parallel-designed randomized controlled clinical trial, 110 patients with NAFLD were enrolled. (cranberryinstitute.org)
Data concerning the clinical characteristics of NAFLD patients have been obtained mainly from several relatively small, single-centre studies with varying results. (bmj.com)
PCOS is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (merckmanuals.com)
To formulate clinical practice guidelines for the assessment, treatment, and prevention of pediatric obesity. (medscape.com)
In addition, the review provides a comprehensive overview of the current progress in the efficacy of insulin sensitization therapy in the management of PCOS, providing the latest evidence for the clinical treatment of women with PCOS and IR. (biomedcentral.com)
Furthermore, we aim to summarize and provide an update on the current research status of insulin sensitization therapy for women with PCOS to provide more effective and reasonable clinical treatment. (biomedcentral.com)
Consistent beneficial results for intestinal barrier function, immune system and metabolism were reported in animals may encourage long-term randomized clinical trials in people with obesity and cardiometabolic risk. (biomedcentral.com)
Promising results of fecal transplantation have also emerged from clinical trials including obese individuals with metabolic disturbances [ 9 ]. (biomedcentral.com)

Those who are insulin resistant have an abundance of adipose tissue in their abdominal area. (nursingcenter.com)
Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)
Adverse effects of high-fat diets (HFD) on metabolic homeostasis are linked to adipose tissue dysfunction. (biomedcentral.com)
The goal of this study was to examine the effect of the HFD nature on adipose tissue activity, metabolic disturbances and glucose homeostasis alterations in male mice compared with female mice. (biomedcentral.com)

It has been over 30 years since Reaven first described metabolic syndrome, which commonly affects overweight individuals ( 1 ). (frontiersin.org)
In the current study, we explored the association of circulating plasma concentrations of GDF15 with NAFLD in youth with overweight/obesity, and whether changes in plasma concentrations in GDF15 parallel the changes in intrahepatic fat content (HFF%) over time. (nature.com)
Plasma GDF15 concentrations were measured by ELISA in 175 youth with overweight/obesity who underwent an oral glucose tolerance test (OGTT) and magnetic resonance imaging (MRI) to assess intrahepatic, visceral, and subcutaneous fat. (nature.com)
These data suggest that plasma GDF15 concentrations change with change in intrahepatic fat content in youth with overweight/obesity and may serve as a biomarker for NAFLD in children. (nature.com)
To achieve our aims, we measured GDF15 in 175 youth with overweight/obesity who underwent an oral glucose tolerance test and an MRI to measure intrahepatic fat content. (nature.com)
Herein, we show that in youth with overweight/obesity, GDF15 plasma concentration is associated with NAFLD and NAFLD-related phenotypes and that changes in plasma GDF15 concentration are driven by changes in intrahepatic fat content. (nature.com)

Both NAFLD and its progression into NASH are seen almost simultaneously, with at least some of the components of metabolic syndrome. (nursingcenter.com)
Perhaps, the strongest risk factors for the development of NASH syndrome are obesity and insulin resistance. (nursingcenter.com)
This group tends to develop the other criteria of metabolic syndrome and run a much greater risk of developing NASH. (nursingcenter.com)
Many individuals remain blissfully unaware they have NAFLD until it evolves into something far more dangerous such as NASH or cirrhosis. (getoberit.com)
The aim of this review is to describe the data linking PPARα and PPARγ to NAFLD/NASH and to discuss the use of PPAR ligands for the treatment of NASH. (wjgnet.com)

Obesity and inflammation: the linking mechanism and the complications. (drced.com)
The second hit may be oxidative or metabolic stress and dysregulated cytokine production resulting from efforts to compensate for altered lipid homeostasis, leading to subsequent inflammation and fibrosis. (medscape.com)
Although the specific pathways leading to inflammation and fibrosis are not clearly pinpointed, evidence supports a role for dysregulated lipid partitioning mediated by insulin resistance and concomitant altered cytokine profiles. (medscape.com)

This interconnection underscores the importance of managing metabolic syndrome to prevent the onset of this chronic metabolic disorder. (gertitashkomd.com)
Lifestyle change is the treatment of choice for all women with PCOS, and insulin sensitization is a promising choice for the chronic treatment of women with PCOS. (biomedcentral.com)

Insulin resistance and elevated blood sugar levels, characteristic components of metabolic syndrome, significantly escalate the risk of progressing to diabetes. (gertitashkomd.com)

Western diet, rich in saturated fat and carbohydrates, especially fructose, is considered to be one of the major causes of the NAFLD epidemic [ 3 ]. (springer.com)

screening for comorbidities of obesity should be applied in a hierarchal, logical manner for early identification before more serious complications result. (medscape.com)
Therefore, recognizing the strong influence of IR on the occurrence and development of PCOS, accurate assessment of insulin sensitivity in the early stages of PCOS, and effective intervention on IR are essential to reduce the risk of long-term complications. (biomedcentral.com)

This underlying insulin resistance is thought to be a central factor in the development of metabolic syndrome. (gertitashkomd.com)

It is considered the hepatic manifestation of metabolic syndrome, strongly linked to obesity and insulin resistance (IR), which further predisposes for diabetes and cardiovascular diseases [ 2 ]. (springer.com)
A significant correlation exists between central obesity, metabolic syndrome - conditions like high blood pressure, abnormal cholesterol levels, etc., that occur together, thereby increasing one's risk of heart diseases and type 2 diabetes mellitus - both closely linked with NAFLD . (getoberit.com)
Disturbance of circadian rhythms underlies various metabolic diseases. (researchgate.net)

Serum insulin, insulin resistance, and homocysteine levels are higher in women with PCOS. (wikipedia.org)
Among women in reproductive age, the obese rural population also found vulnerable to PCOS, indicates the role of lifestyle factors in this syndrome. (ijpsr.com)
Both non-obese and obese PCOS women found vulnerable to the same metabolic consequences. (ijpsr.com)
In that regard, this review tries to summarize the existing mechanistic evidence and metabolic consequences of PCOS and the possible avenues for future research. (ijpsr.com)
Obesity tends to reduce early LH levels and GnRH stimulation levels in women with PCOS although their responses remain elevated when compared to age- and weight-matched control women. (nutrikalp.com)
Since most of the diagnostic criteria support the idea that PCOS is an ovarian disorder, it is the main target that causes the syndrome. (nutrikalp.com)
Ovarian steroidogenesis is disturbed in a syndrome with increased circulating androgen levels that is frequently noted in women with PCOS stigmata. (nutrikalp.com)
PCOS involves various pathophysiological factors, and affected women usually have significant insulin resistance (IR), which is a major cause of PCOS. (biomedcentral.com)
Insulin sensitization drugs are a new treatment modality for PCOS. (biomedcentral.com)
IR is present in all phenotypes, and insulin sensitivity varies according to the PCOS phenotype. (biomedcentral.com)

When the theory of two ovarian salts developed, that is, thecal salt can only produce LH stimulating androgens, while the granulosa salt can only aromatize androgens from salt to estrogen under the influence of FSH, this LH preponderance is considered to be the main etiology of the syndrome. (nutrikalp.com)
This syndrome involves anovulation or ovulatory dysfunction and androgen excess of unclear etiology. (merckmanuals.com)

High risk for NAFLD was associated with existing co-morbid conditions like cardiovascular risk patients (3.18 times) followed by obese patients (1.72 times) and Diabetes Mellitus patients (1.68 times) at a significant level. (biomedcentral.com)
Frequently, my patients inquire about the definition, significance, and available therapeutic options for metabolic syndrome. (gertitashkomd.com)
Among the total patients diagnosed at baseline or follow-up, most patients had both MAFLD and NAFLD, accounting for 78.84% and 82.88%, respectively. (xiahepublishing.com)
Patients with GC excess (Cushing s syndrome) develop central obesity, insulin resistance and hepatic steatosis. (endocrine-abstracts.org)
Conclusion The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD. (cranberryinstitute.org)
insulin resistance was present in 91% and advanced fibrosis in 24% of patients. (bmj.com)
Insulin resistance and its co-morbidities are often present in patients with NAFLD. (bmj.com)
Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)

In comparing the factors that contribute to the buildup of excess calories in obesity, an imbalance of energy homeostasis can be considered as the basis. (wjgnet.com)
The ovary contains numerous small preantral follicles due to continuous processes and increased central stroma due to thecal hyperplasia and excess stroma from irregular gonadotropin exposure. (nutrikalp.com)
Obesity Obesity is excess body weight, defined as a body mass index (BMI) of ≥ 30 kg/m 2 . (merckmanuals.com)
Obesity is defined as an excess of body weight with a body max index higher than 30kg/m2. (enterosys.com)

Increased visceral fat results in reduced levels of adiponectin and increased proinflammatory milieu leading to insulin resistance and endothelial dysfunction. (unboundmedicine.com)
Central obesity is an independent predictor of erectile dysfunction in older men. (blogspot.com)
Wirth A, Manning M, Büttner H. [Metabolic syndrome and erectile dysfunction. (blogspot.com)
PURPOSE: We examined the impact of obesity, physical activity, alcohol use and smoking on the development of erectile dysfunction. (blogspot.com)
Obesity (multivariate relative risk 1.9, 95% CI 1.6-2.2 compared to men of ideal weight in 1986) and smoking (RR 1.5, 95% CI 1.3-1.7) in 1986 were associated with an increased risk of erectile dysfunction, while physical activity (RR 0.7, 95% CI 0.7-0.8 comparing highest to lowest quintile of physical activity) was associated with a decreased risk of erectile dysfunction. (blogspot.com)
We found that obesity and smoking were positively associated , and physical activity was inversely associated with the risk of erectile dysfunction developing. (blogspot.com)
Executive dysfunction in Klinefelter syndrome: associations with brain activation and testicular failure. (medscape.com)

It also has important metabolic consequences, including the risk of diabetes and cardiovascular risk factors, and long-term treatment. (nutrikalp.com)

Adopting a truly translational, bench-to-bedside approach, my work has defined the role of pre-receptor glucocorticoid metabolism within key target tissues upon the development of global metabolic phenotype. (uni-luebeck.de)

Youth with NAFLD had significantly higher plasma concentrations of GDF15 than those without NAFLD, independent of age, sex, ethnicity, BMI z -score (BMIz), and visceral fat ( P = 0.002). (nature.com)

This review discusses the role of adipokines and PPARs with regard to hepatic energy metabolism and progression of NAFLD. (wjgnet.com)

A waist circumference of 40 inches (102 centimeters) or greater in men and 35 inches (88 centimeters) or greater in women is indicative of central obesity. (gertitashkomd.com)

Metabolic syndrome is a combination of conditions that include insulin resistance/Type II diabetes, HTN, hyperlipidemia, and obesity. (nursingcenter.com)
Kahn, S. E., Hull, R. L. & Utzschneider, K. M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. (nature.com)
Type 2 Diabetes Mellitus: A Catalyst for NAFLD? (getoberit.com)
When your body becomes resistant to insulin, it allows glucose build-up within your bloodstream rather than being absorbed into cells, leading eventually to type 2 diabetes mellitus - thus creating a conducive environment for the onset of NAFLD . (getoberit.com)
Moreover, the syndrome is closely linked to the development of type 2 diabetes . (gertitashkomd.com)
Objective Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. (researchgate.net)
[ 2 ] However, it is known that millions of US individuals have obesity and type 2 diabetes mellitus . (medscape.com)
At the beginning of the ontogeny syndrome, as in the ontogeny of type 2 diabetes, it is characterized by increased production of insulin beta salt pancreatic chant to control the level of glucose around. (nutrikalp.com)
Both states are commonly accompanied by the presence of type 2 diabetes, metabolic syndrome, and obesity. (fitnesshacks.org)

Genetic and environmental factors are important for the development of NAFLD. (wjgnet.com)
Insulin resistance may be due to a combination of genetic and lifestyle factors. (lowcarbneurologist.com)
Pediatric obesity has its basis in genetic susceptibilities influenced by a permissive environment starting in utero and extending through childhood and adolescence. (medscape.com)
Genetic screening for rare syndromes is indicated only in the presence of specific historical or physical features. (medscape.com)
Despite a significant increase in research on pediatric obesity since the initial publication of these guidelines 8 years ago, further study is needed of the genetic and biological factors that increase the risk of weight gain and influence the response to therapeutic interventions. (medscape.com)
Genetic and epigenetic changes, hyperandrogenaemia, and obesity aggravate IR. (biomedcentral.com)

New Horizons: Epidemiology of Obesity, Diabetes Mellitus, and Cancer Prognosis. (medscape.com)

Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. (researchgate.net)
Traditionally this has involved studying both central and peripheral molecules involved in hunger and satiety, such as leptin, orexin (also known as hypocretin), insulin, alpha-melanocyte-stimulating hormone (α-MSH), glucagon-like peptide -1 (GLP-1), amylin, glucose-dependent insulinotropic polypeptide (GIP, also known as a gastric inhibitory polypeptide), adiponectin and cholecystokinin (CCK). (frontiersin.org)
Finally, increased insulin levels are associated with peripheral availability of sex steroids through impacting sex-binding hormone circulating globulin (SHBG). (nutrikalp.com)
In view of the current understanding of the potentially deleterious effects of peripheral and hepatic insulin resistance, multiple hits may be possible. (medscape.com)

Metabolic syndrome: This appears as a tendency towards central obesity and other symptoms associated with insulin resistance, including low energy levels and food cravings. (wikipedia.org)
When such symptoms appear on stage, it calls for immediate action - diagnostic tests to confirm if indeed NAFLD is playing behind the scenes. (getoberit.com)
There are usually no immediate physical symptoms in metabolic syndrome. (lowcarbneurologist.com)

Evidence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. (wjgnet.com)
In this article, we reviewed the evidence that eating, especially high-caloric foods, stimulates the limbic system, initiating Reward Deficiency Syndrome. (frontiersin.org)

Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. (frontiersin.org)
Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77-0.84). (frontiersin.org)
In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome. (frontiersin.org)

We report the case of a woman in whom a thickened PS was diagnosed following the onset of central diabetes insipidus revealed by polyuria-polydypsia syndrome of late pregnancy and postpartum. (bvsalud.org)

Insulin resistance is a state wherein certain cells of the body (e.g. the muscle cell) do not efficiently use insulin for glucose uptake. (lowcarbneurologist.com)
Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. (diabetesjournals.org)
In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and postweaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylation relative to controls. (diabetesjournals.org)

Obesity and its association with insulin resistance play a crucial role in pancreatic infiltration with adipocytes (fat cells). (fitnesshacks.org)

The change in triglycerides (TG) and HDL-C (high density lipoprotein cholesterol) was also statistically significant in different grades of NAFLD. (biomedcentral.com)

Growing rates of obesity represent a global lifestyle-related health problem [ 1 ]. (biomedcentral.com)

This increased risk is attributed to factors like high blood pressure , elevated triglyceride levels, and insulin resistance , all of which contribute to the strain on the cardiovascular system. (gertitashkomd.com)

Perhaps most concerning is the overall increase in mortality associated with metabolic syndrome. (gertitashkomd.com)
Obesity is thus a worldwide healthcare problem increasing morbid-mortality [ 2 ]. (biomedcentral.com)

Anatomy16

Organisms7

Diseases57

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Psychiatry and Psychology6

Phenomena and Processes64

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture6

Information Science4

Named Groups4

Health Care34

Geographicals11

Dyslipidemia11

Hypertension5

Prevalence14

Polycystic12

Pathogenesis9

Accumulation12

T2DM7

Liver46

Adiposity4

Disorders8

Skeletal muscle9

Disease17

Abnormalities1

Nonalcoholic steatohepatitis1

Hyperinsulinemia4

Fatty5

Incidence3

Diagnosis4

MetS4

Clinical15

Adipose tissue4

Overweight6

NASH5

Inflammation3

Chronic2

Components of metabolic syndrome1

Epidemic1

Complications2

Development of metabolic syndrome1

Diseases3

PCOS10

ETIOLOGY2

Patients8

Excess4

Dysfunction7

Cardiovascular risk1

Phenotype1

Visceral1

Progression1

Waist circumference1

Type9

Genetic6

Diabetes mellitus1

Peripheral4

Symptoms3

Evidence2

Adiponectin3

Onset1

Glucose uptake3

Association with insulin1

High-density lip1

Rates of obesity1

Triglyceride levels1

Mortality2