Hodgkin disease (lymphoma) is a cancer of the lymph system that is characterized by the presence of large, abnormal Reed-Sternberg cells in a background of lymphocytes, macrophages, fibroblasts, and granulocytes. (medscape.com)
Classical Hodgkin lymphoma (HL) accounts for approximately 95% of all HL cases, with the other 5% being nodular lymphocyte-predominant HL (NLP-HL). (medscape.com)
Classical lymphoma is further divided into nodular sclerosis, lymphocyte-rich, mixed cellularity, and lymphocyte-depleted. (medscape.com)
Hodgkin lymphoma has an incidence of about 3 new cases per 100,000 individuals per year, making it one of the most common lymphomas. (medscape.com)
CT, MRI, PET/CT, and PET/MRI play a major role in the diagnosis, staging, and response to therapy of Hodgkin lymphoma. (medscape.com)
Prognostic value of chest x-ray- and CT-defined large mediastinal adenopathy in high-risk pediatric Hodgkin lymphoma: A report from the Children's Oncology Group Study AHOD0831. (ucdenver.edu)
Therapy Selection for Hodgkin Lymphoma in Sickle Cell Disease: balancing risks and benefits. (ucdenver.edu)
For therapeutic purposes, nodular lymphocyte-predominant HL is managed in the same way as indolent non-Hodgkin lymphoma (see Follicular Lymphoma [non-Hodgkin Lymphoma] ). (medscape.com)
Data are included from 3 organizations, including the German Study Hodgkin Lymphoma Study Group (GSHG), European Organization for Research and Treatment of Cancer (EORTC), and the National Cancer Institute of Canada (NCIC). (medscape.com)
While the SSA might be justified in projecting an excellent recovery from the treatment of Hodgkin's lymphoma, especially for the early stages of the disease, some individuals experience persistent long-term fatigue despite complete objective remission and when present this fatigue should be considered in assessing residual functional capacity. (disabilityattorneychicago.com)
This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. (enquirebio.com)
Follicular dendritic cell tumors, Hodgkin lymphoma-classic subtype (highly sensitive), interdigitating dendritic cell tumors, Langerhan cell histiocytosis, and urothelial carcinoma (noninvasive papillary or invasive) also express Fascin-1. (enquirebio.com)
A few cases of classical Hodgkin's lymphoma were also found to be associated with immune deficiency (including HIV infection) or a history of autoimmune disease and cancer that arise due to the transformation of low-grade B-cell lymphoma (mostly chronic lymphocytic leukaemia). (zenonco.io)
The first peak in the incidence pattern of classical Hodgkin's lymphoma appears at about 20-30 years of age, while the second peak of the disease is more associated with the Epstein-Barr virus, which has a lower curable rate than that observed in the first peak. (zenonco.io)
Nodular sclerosis classical Hodgkin lymphoma is the most prevalent histological subtype (70% of cases) of classical Hodgkin's lymphoma. (zenonco.io)
Mixed cellularity classical Hodgkin lymphoma accounts for 15-30% of all cases. (zenonco.io)
Nodular lymphocyte predominant Hodgkin lymphoma: a Lymphoma Study Association retrospective study. (zenonco.io)
Classical Hodgkin lymphoma is derived by malignant transformation of a mature B cell at the germinal center stage of differentiation and is characterized pathologically by multinucleated Hodgkin and Reed-Sternberg cells embedded in a mixed infiltrate of nonneoplastic cells. (mhmedical.com)
Multiple signaling pathways and transcription factors are deregulated in Hodgkin lymphoma, and genetic lesions involving the JAK-STAT and nuclear factor- κ B pathways are commonly identified. (mhmedical.com)
Epstein-Barr virus is an important environmental factor in the pathogenesis of Hodgkin lymphoma and also leads to activation of the nuclear factor- κ B pathway. (mhmedical.com)
Morphologic and immunophenotypic features distinguish the four subtypes of classical Hodgkin lymphoma (accounting for 95 percent of cases) from nodular lymphocyte predominance Hodgkin lymphoma (accounting for 5 percent of cases). (mhmedical.com)
Hodgkin lymphoma spreads in a predictable, contiguous manner and is classified into four stages, I to IV. (mhmedical.com)
Classical Hodgkin lymphoma is treated with the intent to cure the disease in all stages, and long-term survival exceeds 85 percent. (mhmedical.com)
Concerns regarding late treatment effects guide therapy and followup decisions in Hodgkin lymphoma, which disproportionately affects adolescents and young adults. (mhmedical.com)
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. (ox.ac.uk)
Several susceptibility loci for classical Hodgkin lymphoma have been reported. (ox.ac.uk)
We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). (ox.ac.uk)
Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). (ox.ac.uk)
Hodgkin lymphoma (HL) is a malignancy of lymphoid cells that was first described by Thomas Hodgkin in 1832. (wits.ac.za)
Hodgkin lymphoma is less common than Non-Hodgkin Lymphoma (NHL) and accounts for approximately 10-20 % of all the lymphomas encountered. (wits.ac.za)
Hodgkin lymphoma is characterized by the orderly spread of disease from one lymph node group to another (contiguous spread and centripetal distribution) and by the development of systemic symptoms, particularly with advanced stage disease. (wits.ac.za)
The specific initial treatment of Hodgkin lymphoma involves combination chemotherapy and where necessary involved field radiotherapy. (wits.ac.za)
The last decade has witnessed the emergence of Hodgkin lymphoma occurring with increasing frequency in association with the Human Immunodeficiency virus (HIV) infection. (wits.ac.za)
HIV associated Hodgkin lymphoma is generally more aggressive, presents with advanced stage disease, frequent 'B' symptoms, less favorable histology, more frequent bone marrow involvement and overall a poorer prognosis compared to Hodgkin lymphoma in HIV seronegative individuals. (wits.ac.za)
This study was aimed at exploring and defining the changing pattern of Hodgkin lymphoma at Chris Hani Baragwanath Academic Hospital (CHBAH) from January 2005 to December 2012. (wits.ac.za)
Patients and Methods This was a retrospective review of all adult patients with Hodgkin lymphoma seen at the Clinical Hematology Unit, Department of Medicine from January 2005 to December 2012 at CHBAH. (wits.ac.za)
Understanding the differences between these two types of lymphoma can help patients and their families make informed decisions about treatment options and managing their disease. (self-instruct.com)
2. Subtypes: Hodgkin lymphoma has four subtypes based on the microscopic appearance of the RS cells and the surrounding immune cells. (self-instruct.com)
Non-Hodgkin lymphoma has more than 20 subtypes based on the morphology, immunophenotype, genetic abnormalities, and clinical features of the disease. (self-instruct.com)
3. Age Distribution: Hodgkin lymphoma can occur at any age but is more common in young adults and older adults over 55 years old. (self-instruct.com)
Hodgkin lymphoma is distinguished from all other types of lymphoma because of the presence of a special kind of cancer cell called a Reed-Sternberg cell. (cfcancerinst.com)
The five different types of Hodgkin lymphoma are distinguished from each other by the appearance of the lymphoma cells under the microscope. (cfcancerinst.com)
People with a weakened immune system (immunosuppressed) due to an inherited immune deficiency disease, HIV infection, or drugs taken to prevent rejection of a transplanted organ, all have an increased chance of developing lymphoma. (cfcancerinst.com)
Infection with Epstein-Barr virus (EBV), the virus that causes glandular fever, may put some people at a higher risk of developing of Hodgkin lymphoma. (cfcancerinst.com)
In most cases, people who are diagnosed with Hodgkin lymphoma have no family history of the disease. (cfcancerinst.com)
There have been some cases, however, where a brother or sister also develops Hodgkin lymphoma, suggesting a rare family genetic link to the disease. (cfcancerinst.com)
Some people do not have any symptoms when they are first diagnosed with Hodgkin lymphoma. (cfcancerinst.com)
The most common symptom of Hodgkin lymphoma is a firm, usually painless swelling of a lymph node (swollen glands), usually in the neck, under the arms or in the groin. (cfcancerinst.com)
It is important to remember that most people who go to their doctor with enlarged lymph nodes do not have Hodgkin lymphoma. (cfcancerinst.com)
A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32. (medscape.com)
Several chemotherapeutic agents in various combinations are used to treat Hodgkin lymphoma. (medscape.com)
Although the intended target is the malignant cells of Hodgkin lymphoma, the effects of chemotherapy on normal cells of the body are considerable and account for the adverse effects observed with these agents. (medscape.com)
Because most patients with Hodgkin lymphoma are long-term survivors, one of the goals of current therapy is to decrease the long-term adverse effects while maintaining excellent cure rates. (medscape.com)
Recent reports have shown an increased incidence of Hodgkin lymphoma (HL) in patients treated with antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. (amjcaserep.com)
This report is of a case of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) with a good outcome in a 58-year-old Nigerian HIV-positive man who was being treated with ART. (amjcaserep.com)
Hodgkin lymphoma (HL) is the most common acquired immune deficiency syndrome (AIDS)-defining malignancy in human immunodeficiency virus (HIV)-infected patients, usually presenting at an advanced stage and in unusual locations in individuals with HIV/AIDS [1]. (amjcaserep.com)
A literature review showed that the risk of developing Hodgkin lymphoma (HL) is about 10 times higher in HIV-positive patients compared to HIV-negative patients [2]. (amjcaserep.com)
The incidence of Hodgkin's Lymphoma has increased in patients with HIV following use of ART, with the most common histological type being mixed cellularity lymphoma [4]. (amjcaserep.com)
The clinical use of PET and PET/CT aids physicians and patients in developing lymphoma prognoses, specifically for Hodgkin disease and aggressive types of non-Hodgkin lymphoma. (snmjournals.org)
PET and PET/CT are used to initially stage lymphoma, restage disease, and check for remission or recurrence of malignant tissue after treatment. (snmjournals.org)
they include bone marrow, gastrointestinal tract, and other sites that are unusual in non-HIV-associated non-Hodgkin lymphoma, such as the central nervous system and body cavities (eg, pleural, pericardial, peritoneal). (msdmanuals.com)
Diagnosis of non-Hodgkin lymphoma is by biopsy with histopathologic and immunochemical analysis of tumor cells. (msdmanuals.com)
Classical Hodgkin lymphoma (CHL) is a B-cell lymphoma characterized histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells. (globalgenes.org)
Hodgkin lymphoma (HL) is classified into 2 largely distinct subgroups, namely nodular lymphocyte predominant HL (NLPHL) and classic HL (CHL). (duke.edu)
Aberrant NFAT signaling is causally involved in the development of chronic lymphocytic leukemia, non-Hodgkin lymphoma, pancreatic cancer, and several other malignancies. (biomedcentral.com)
Hodgkin lymphoma (HL) is a cancer of the lymph system and is diagnosed by the identification of a characteristic cell under the microscope (the Reed- Sternberg cell). (radiationoncologyassociates.co)
Hodgkin lymphoma most commonly affects lymph nodes in the neck or in the area between the lungs and behind the breastbone but may involve any part of the lymph system and even spread to other organs such as the lungs, liver, bone and bone marrow. (radiationoncologyassociates.co)
Doctors determine the type of Hodgkin lymphoma by performing a biopsy to see how the cells look under a microscope and whether the cells contain certain bio-markers. (radiationoncologyassociates.co)
Nodular lymphocyte-predominant Hodgkin lymphoma represents ~5% of all Hodgkin lymphomas and it often develops in the lymph nodes in the neck, groin, or armpit in younger patients. (radiationoncologyassociates.co)
It is more similar to B cell non-Hodgkin lymphoma and has characteristic "popcorn cells" or "LP cells" that have a marker called CD20 on their surface. (radiationoncologyassociates.co)
Despite significant improvements in the treatment of Hodgkin's lymphoma over the past 2 decades, physicians continue to face dilemmas in therapy for the disease, and many cured patients live with complications of treatment. (cancernetwork.com)
This review considers the treatment of Hodgkin's lymphoma in younger patients, addressing such issues as which patients with early-stage disease may require radiotherapy, what prognostic factors provide information that can affect treatment choices in patients with advanced disease, and what we have learned about treatment complications in this setting. (cancernetwork.com)
Hodgkin's lymphoma (HL) is a rare, curable malignancy, and investigators have made remarkable improvements in treatment of the disease over the past 20 years. (cancernetwork.com)
The data on GDA-201, our NK cell therapy candidate in Phase 1/2 development for non-Hodgkin lymphoma, provide further characterization of its phenotype and functionality, and demonstrate its activity in triggering an adaptive immune response. (oilnow.gy)
These data elaborate on previous results that show the safety and preliminary evidence of activity of GDA-201 in patients with relapsed refractory non-Hodgkin lymphoma. (oilnow.gy)
Standard management of pediatric Non-Hodgkin's Lymphoma (NHL) patients have included an initial assessment of the disease at presentation to establish it's extent. (authorea.com)
The presence of T-cell rosettes around CD20+, BCL6+ LP cells is a useful diagnostic feature of NLPHL and helps distinguish it from progressively transformed germinal centers, mixed cellularity Hodgkin lymphoma, and T cell/histiocyte-rich B cell lymphoma. (webpathology.com)
Subtypes3
In Hodgkin's disease four different subtypes are lymphocyte predominance, mixed cellularity, nodular sclerosing, and lymphocyte depletion. (disabilityattorneychicago.com)
NHL can be further classified into more than 20 subtypes based on the morphology, immunophenotype, genetic abnormalities, and clinical features of the disease. (self-instruct.com)
HD can be categorized into 4 different histologic subtypes: nodular sclerosis (most common), lymphocyte predominance, mixed cellularity, and lymphocyte depletion ( 4 ). (snmjournals.org)
In the nineteenth and twentieth centuries, the affliction was called simply Hodgkin's Disease, as it was discovered by Thomas Hodgkin in 1832. (newworldencyclopedia.org)
Williams Hematology Malignant Lymphoid Diseases Press OW, Lichtman MA, Leonard JP. (mhmedical.com)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)
Lymphomas2
a rare sub-type with the most favorable outcome of all the Hodgkin lymphomas. (cfcancerinst.com)
Lymphomas are part of the broad group of diseases called hematological neoplasms. (newworldencyclopedia.org)
Depletion1
Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. (enquirebio.com)
Predominance1
Myeloma is a disease of middle and old age (50-70 years), male predominance. (emedicodiary.com)
Chemotherapy7
In Stage IV disease chemotherapy can produce a remission of disease in 70 - 80% of cases with at least half of these remaining without disease for as long as 10 years. (disabilityattorneychicago.com)
In this review, we discuss the presentation of cutaneous angiosarcoma, the importance of early diagnosis, and the treatment options available for metastatic disease that has failed first-line chemotherapy. (bvsalud.org)
Doxorubicin-containing chemotherapy plays a major role in treatment of all stages of the disease, whereas radiotherapy is used selectively because of concerns for late toxicities. (mhmedical.com)
Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. (medscape.com)
Multiagent chemotherapy + immunotherapy should be reserved for patients who are having advanced stages of disease and having symptoms/ difficulties related to it. (lymphomaindia.com)
Patients who had Hodgkin's disease are at risk for developing secondary cancers (e.g. leukemia ) in the future, first due to abnormalities in cell production and second, as compounding effect attributed to chemotherapy and radiation. (nursestudy.net)
For advanced disease, prognostic factors may provide information for those wishing to use treatment other than the ABVD regimen (Table 1) or other standard chemotherapy regimens. (cancernetwork.com)
Subtype2
2. Mixed cellularity HL (MCHL): This subtype accounts for 20-25% of cases. (self-instruct.com)
The treatment of HL depends on the subtype, stage, and grade of the disease. (self-instruct.com)
Hodgkin and Reed-Sternberg cells contain monoclonal immunoglobulin gene rearrangements but have lost most of the B-cell-specific expression program. (mhmedical.com)
The inflammatory microenvironment promotes survival and allows escape of Hodgkin and Reed-Sternberg cells from immune attack. (mhmedical.com)
In some cases, the infection leads to the development of Reed-Sternberg cells, which are cancer cells distinct to Hodgkin's disease. (nursestudy.net)
Neoplasm1
PCNSL is now known to be a form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type. (medscape.com)
Refractory1
Allogeneic stem cell transplantation should be considered for refractory disease or for very early relapsing disease. (lymphomaindia.com)
Lesions1
Due to the high cellularity, lesions are often hyperdense on CT and hypointense on T2-weighted MRI images with a variable amount of peritumoral edema. (radiologycases.my)
Bone7
FDG/PET and MRI can identify involvement of bone marrow, and imaging can confirm poor prognostic indicators such as large mediastinal adenopathy, stage IV disease, systemic symptoms, and pleural effusion and pericardial effusion. (medscape.com)
Herein, we write a case of a patient with no known liver disease, presenting with a pathological fracture of the proximal humerus bone secondary to a massive solitary metastasis from HCC. (bvsalud.org)
It is more frequent among older patients with associated infra diaphragmatic lymph nodes, Epstein-Barr virus, or bone marrow disease. (zenonco.io)
This classification system also uses lymph node biopsy, bone marrow evaluation, and tumor size to determine the stage of disease and proper response criteria. (snmjournals.org)
However, progression of the disease with involvement of skeletal bone and brain was registered after 4 months. (cttjournal.com)
The bone marrowbiopsy showed 100% cellularity with diffuse infiltration by mononucleated cells and some multinucleated forms [Figure 2] . (jahjournal.org)
Diagnosis5
Hodgkin's disease is staged in degrees of severity at the time of diagnosis, allowing determination of prognosis and planning of proper modes of treatment. (disabilityattorneychicago.com)
this disease tends to be more widespread at diagnosis. (cfcancerinst.com)
More often, people with FL have no obvious symptoms of the disease at diagnosis. (lymphomaindia.com)
Because the affected areas of the CNS differ from patient to patient, clinical signs and symptoms of the disease are variable, and diagnosis requires a high level of suspicion. (medscape.com)
Hodgkin's disease has become more manageable because of the advances in the diagnosis and treatment of this condition. (nursestudy.net)
Incidence1
Median age at disease presentation is 65 years, with a trend toward an increase of incidence in the oldest population. (radiologycases.my)
Tumor3
The International Classification of Diseases for Oncology (ICD-O) is a domain-specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. (wikipedia.org)
The dense cellularity of the tumor accounts for its isodense or hyperdense appearance on nonenhanced CT scan and hypointense appearance on long TR-weighted MRI imaging. (medscape.com)
Blood Tests - include CBC, Erythrocyte sedimentation rate, Lactate dehydrogenase, Serum creatinine, Alkaline phosphatase, HIV test (including screening for Hepatitits B and C), and serum levels of cytokines (interleukin [IL]-6, IL-10 and soluble CD25 (IL-2 receptor) to assess for tumor burden and disease progression. (nursestudy.net)
Morphology1
The cellularity of the aspirate and morphology of erythroid and myeloid precursors were normal, the number of megakaryocytes was increased. (juniperpublishers.com)
Disorders characterized by abnormal proliferation of immunoglobulin-producing cells and abnormal proliferation of immunoglobulin monoclonal (M protein)represent part of the spectrum of disease due to the neoplastic behavior of the B lymphocyte series. (emedicodiary.com)
Histologic1
Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE. (lookformedical.com)
Patients19
The primary goal of TKI therapy in patients with chronic phase-CML is to prevent disease progression to accelerated phase-CML or blast phase-CML. (bvsalud.org)
It is most common among younger patients with mediastinal involvement and occasionally bulky disease. (zenonco.io)
Cure is a realistic goal in more than 90% of patients with early stage disease. (wits.ac.za)
Other objectives were to review: (i) the impact of HIV on the clinical pattern of disease and (ii) the different treatment options and the outcome of the patients. (wits.ac.za)
The microtome was cleaned lymph node biopsy specimens from healthy patients or carefully, and the blade was replaced for sectioning of each patients with infl ammatory disease, 27 lymph nodes from tissue. (cdc.gov)
This is especially true for younger patients who are diagnosed with early-stage disease. (cfcancerinst.com)
In patients with relapsing or unresponsive disease, hematopoietic stem-cell transplantation significantly prolongs disease-free survival. (medscape.com)
The first line treatment can cure up to 90% of patients in early stage of disease and upto 40% of patients in advanced stages of disease. (lymphomaindia.com)
Radiation can provide a cure in some patients with limited disease. (lymphomaindia.com)
however, the disease does return in most patients. (lymphomaindia.com)
Weakened immune system - Patients with HIV infection, have autoimmune disease, or those on immunosuppressive drugs are considered at risk for developing Hodgkin's Disease. (nursestudy.net)
This is an observational registry database for adult patients diagnosed with degenerative spine disorders, which aims to add information to the understanding of the disease management of this spine diseases. (umn.edu)
Data from this registry may be used to generate descriptive statistics on demographics, and clinical characteristics, including co-morbidities, treatment patterns and adverse outcomes (resulting from treatment or disease), as well as patients' quality of life measurements. (umn.edu)
Newer therapeutic options are still needed for the disease, to minimize complications and to improve the treatment of patients in relapse. (cancernetwork.com)
Still, physicians face dilemmas in therapy for the disease, and many cured patients live with complications of treatment. (cancernetwork.com)
Relapse therapy can cure approximately 50% of patients, depending on patient- and disease-related features, and failure of initial therapy, once considered an ominous sign, may not be such a poor feature any longer. (cancernetwork.com)
In this review, we consider the treatment of HL in younger patients, first evaluating recent clinical trials for early-stage disease, with a special focus on which patients may still need radiotherapy (RT). (cancernetwork.com)
ABVD and RT- Lymphocyte-predominant HL is often a disease of younger patients and differs from classic variants of the disease in important ways. (cancernetwork.com)
Of the 10 response evaluable patients, one had partial response (Ewing sarcoma), seven had stable disease, and two had progressive disease. (authorea.com)
Lymphatic2
Ironically, the lymphatic system is fundamentally important for combating cancer cells-as well as foreign bodies, such as viruses and bacteria , and combating heart disease and arthritis as well. (newworldencyclopedia.org)
These cells crowd the lymphatic system rapidly, thereby causing the manifestations of the disease. (nursestudy.net)
It can be caused by systemic diseases, pregnancy in some women, either directly or as a result of heart failure , or local conditions such as varicose veins , thrombophlebitis , insect bites , and dermatitis . (wikidoc.org)
Mediastinal adenopathy is the most common presentation, and direct extension of the disease can be detected on chest radiographs. (medscape.com)
Fine-needle aspiration cytology (FNAC) was first introduced by Martin and Ellis 4 and has been used as an easy and safe procedure for diagnosing primary and metastatic mediastinal diseases. (allenpress.com)
Antiretroviral therapy1
Highly active antiretroviral therapy (HAART) improves survival in HIV-associated Hodgkin's disease: results of a multicenter study. (medscape.com)
Classification2
Systems used to stage the disease include the Ann Arbor Classification system and the International Working Group response criteria, among others. (snmjournals.org)
List of the cancer sites available in the CI5plus database and their corresponding International Classification of Disease (ICD, 10th revision) codes. (who.int)
Lymph node1
The Cotswolds modification maintains the original 4-stage clinical and pathologic staging framework of the Ann Arbor staging system but also adds information regarding the prognostic significance of bulky disease (denoted by an X designation) and regions of lymph node involvement (denoted by an E designation). (medscape.com)
Cancer1
The information in this article contains billing, coding or other guidelines that complement the Local Coverage Determination (LCD) for MolDX: Minimal Residual Disease Testing for Cancer L38814. (codemap.com)
Neck1
Common signs of disease include enlargement of the lymph nodes in the neck, underarm, stomach, or groin. (lymphomaindia.com)