Cell SurvivalSurvival RateCytophagocytosisApoptosisDisease-Free SurvivalSignal TransductionSurvivalProto-Oncogene Proteins c-aktSurvival AnalysisGraft SurvivalCell Line, TumorProtein-Serine-Threonine KinasesPhosphatidylinositol 3-KinasesCells, CulturedCell DeathCell LinePhosphorylationEnzyme ActivationDNA DamageCell ProliferationRNA, Small InterferingProto-Oncogene ProteinsMitochondriaProto-Oncogene Proteins c-bcl-2Oxidative StressTreatment OutcomeTime FactorsDNA RepairKaplan-Meier EstimateTransfectionMutationStress, PhysiologicalHeLa CellsRetrospective StudiesEnzyme InhibitorsModels, BiologicalGene Expression RegulationMolecular Sequence DataNeoplasm StagingDNA-Binding ProteinsReactive Oxygen SpeciesNuclear ProteinsProportional Hazards ModelsFollow-Up StudiesProtein BindingAntineoplastic Combined Chemotherapy ProtocolsAntineoplastic AgentsCombined Modality TherapyPrognosisAmino Acid SequenceLung NeoplasmsBreast NeoplasmsImmunohistochemistryMice, Inbred C57BLNeoplasm Recurrence, LocalMultivariate AnalysisMice, KnockoutBlotting, WesternAdenocarcinomaTumor Markers, BiologicalGene Expression Regulation, NeoplasticNeoplasm Metastasisbcl-X ProteinNeoplasmsCisplatinDisease Progressionbcl-Associated Death ProteinReverse Transcriptase Polymerase Chain ReactionBrain NeoplasmsRisk FactorsMice, TransgenicCaspase 3Cell DivisionLiver NeoplasmsProspective StudiesCell DifferentiationRNA, MessengerCohort StudiesTumor Cells, CulturedDoxorubicinDose-Response Relationship, DrugChemotherapy, AdjuvantDisease Models, AnimalAutophagyCaspasesTumor Suppressor Protein p53NF-kappa BCarcinoma, Squamous CellUp-RegulationLymphatic MetastasisAge FactorsRNA InterferenceCarcinoma, Non-Small-Cell LungColorectal NeoplasmsApoptosis Regulatory ProteinsMice, Inbred BALB CFluorouracilDrug Resistance, NeoplasmIn Situ Nick-End LabelingGlioblastoma