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  • tumor-suppressor
  • Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). (wikipedia.org)
  • cancer
  • How and why some cells become post-mitotic in some species has been the subject of much research and speculation, but (as noted above) it is sometimes suggested that cellular senescence evolved as a way to prevent the onset and spread of cancer. (wikipedia.org)
  • The phenomenon of senescence in old tissue appears to be an adaptation of an embryonic development process , now turned to cancer suppression. (fightaging.org)
  • 3 Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. (pubmedcentralcanada.ca)
  • Concomitant inactivation of p53 (also known as Trp53 in mice, and TP53 in humans) and Pten abrogates this senescence response, in turn promoting invasive and lethal prostate cancer 2 . (pubmedcentralcanada.ca)
  • Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. (aacrjournals.org)
  • This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence. (wikipedia.org)
  • proteins
  • Cellular senescence, the process by which biological cells stop dividing in response to stress or damage to their DNA, was shown to trigger the secretion of proteins that cause inflammation in neighboring cells and tissue. (eurekalert.org)
  • Although the specific biological functions of most miRNAs remain largely unknown, they are believed to constitute a large gene regulatory network that can modulate the expression of up to 30% of total cellular proteins. (pubmedcentralcanada.ca)
  • proliferation
  • And still others are investigating how senescence limits stem cell proliferation. (afar.org)
  • Merck Millipore has developed multiple technologies for biomolecular detection and cellular analysis that offer significant advantages over [3H] thymidine incorporation for quantifying cell proliferation with speed, precision, and accuracy. (merckmillipore.com)
  • Diseases
  • Senotherapeutics is an early-stage basic research field for development of possible therapeutic agents and strategies to specifically target cellular senescence, an altered cell state associated with ageing and age-related diseases. (wikipedia.org)
  • Species
  • There are several types of damage to DNA due to endogenous cellular processes: oxidation of bases [e.g. 8-oxo-7,8-dihydroguanine (8-oxoG)] and generation of DNA strand interruptions from reactive oxygen species, alkylation of bases (usually methylation), such as formation of 7-methylguanosine, 1-methyladenine, 6-O-Methylguanine hydrolysis of bases, such as deamination, depurination, and depyrimidination. (wikipedia.org)
  • In the broader sense, ageing can refer to single cells within an organism which have ceased dividing (cellular senescence) or to the population of a species (population ageing). (wikipedia.org)
  • tissue
  • miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells. (wikipedia.org)
  • responses
  • Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. (wikipedia.org)
  • Molecular and Cel
  • Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1," Molecular and Cellular Biology , vol. 25, no. 10, pp. 4046-4061, 2005. (hindawi.com)
  • findings
  • Consistent with our findings in mice, the risk of chemotherapy-induced fatigue was significantly greater in humans with increased expression of a senescence marker in T cells prior to chemotherapy. (aacrjournals.org)
  • humans
  • Unfortunately, as lifespan increases (as it has done in humans), the benefits of senescence can be overshadowed by its consequences. (afar.org)