• With the formation of neural rosettes, neural tube development and neural differentiation can be modeled using human pluripotent stem cells (hPSCs) in vitro . (creative-biolabs.com)
  • Fig.2 Involvement of active BMP signaling in differentiation and formation of neural rosettes. (creative-biolabs.com)
  • The hPSCs-based neural rosettes have been widely used as models for the research of neural tube development as well as neural differentiation in vitro . (creative-biolabs.com)
  • Differentiation of neural rosettes from human pluripotent stem cells in vitro is sequentially regulated on a molecular level and accomplished by the mechanism reminiscent of secondary neurulation. (creative-biolabs.com)
  • Such embryos have significantly reduced rosette numbers, altered epithelial packing, and show abnormalities in AVE migration. (ox.ac.uk)
  • When the cellular elements predominate, the result is an epithelial cell-rich or myoepithelial cell-rich (ie, cellular) pleomorphic adenoma. (medscape.com)
  • Plants lacking PRF1 or PRF2 had defects in rosette leaf morphology and inflorescence stature, while those lacking PRF3 led to plants with slightly elongated petioles. (biomedcentral.com)
  • Using a GFP-tagged bri1-120 construct, we detected the bri1-120 protein in the plasma membrane, and showed that the phenotypic defects in the rosette leaves of bri1-301 , a kinase-inactive weak allele of BRI1 , can be restored by the overexpression of the bri1-120 proteins in bri1-301 . (biomedcentral.com)
  • TGFß-treated cells exhibit ring-like structures (podosome rosettes, right panel), where vinculin surrounds F-actin cores (tbottom panel: higher magnification of the boxed areasl). (u-bordeaux.fr)
  • Investigating the cellular architecture of the developing cortex, we observed a loss of the radial orientation of radial glial cells, likely due to the disruption of the apical band of adherens junctions, which is the first effect observed after loss of the protein, and the consequent formation of rosette like structures in the brain parenchyma. (uni-muenchen.de)
  • Neural rosettes refer to radially organized cellular structures. (creative-biolabs.com)
  • GBMs have a high rate of cellular proliferation and a marked propensity to invade remote brain structures. (123dok.net)
  • The rosette formation is a histopathological hallmark for multiple tumors, such as a primitive neuroectodermal tumor, human medulloblastoma, glioblastoma, and neuroblastoma. (creative-biolabs.com)
  • Pleomorphic adenomas with an approximately equal proportion of cellular and stromal elements are referred to as classic or mixed-type tumors. (medscape.com)
  • However, a number of common side effects quickly became known, including burns, skin disease and the formation of tumors, but society failed to take these warnings seriously and by 1922, over 100 radiologists and many others working in the medical industry had died from cancer caused by x-rays. (endalldisease.com)
  • In comparison, the exact function of the leucine rich-repeats (LRR) region located before the 70-amino acid island domain in the extracellular cellular portion of BRI1 has not yet been described, due to a lack of specific mutant alleles. (biomedcentral.com)
  • Our results indicated that the extracellular LRR regions before the 70-amino acid island domain of BRI1 are important for the appropriate cellular functioning of BRI1. (biomedcentral.com)
  • Two well-defined pathological hallmarks of AD have been described: the formation of extracellular amyloid plaques and the development of intracellular neurofibrillary tangles (NFTs) formed by aggregated hyperphosphorylated TAU protein [ 4 ]. (biomedcentral.com)
  • Lepidocollema is characterised by the formation of large, flat rosettes on a thick layer of rhizohyphae, the presence of a cellular thalline cortex, apothecia with a thalline margin, asci with a wide apical ring-structure, and thin-walled ascospores. (wikipedia.org)
  • Using primary hepatocytes and 3D organoids, we demonstrate that excessive canalicular pressure causes the loss of apical bulkheads and formation of rosettes. (lisym.org)
  • Molecular and Cellular Neuroscience. (lu.se)
  • Brain development is a complex process achieved in a remarkably controlled spatial and temporal manner through coordinated cellular and molecular events. (ehu.eus)
  • A better understanding of the mechanisms underlying the initiation and progression of GBMs at the molecular and cellular levels will open up new opportunities to develop therapeutic strategies. (123dok.net)
  • The neural markers expressed in neural rosettes include SOX2, PAX6, and SOX1. (creative-biolabs.com)
  • And inhibition of BMP signaling would result in the expression of these markers and the rosette morphology. (creative-biolabs.com)
  • Endothelial podosome rosettes in cultured endothelial cells. (u-bordeaux.fr)
  • Multi-cellular rosettes in the mouse visceral endoderm facilitate the ordered migration of anterior visceral endoderm cells. (ox.ac.uk)
  • Little is known about the cellular rearrangements that accommodate and influence the sustained directional movement of subsets of cells (such as the AVE) within epithelia like the VE. (ox.ac.uk)
  • Using both wild-type embryos as well as mutants in which AVE migration is abnormal or arrested, we show that AVE migration is specifically linked to changes in cell packing in the VE and an increase in multi-cellular rosette arrangements (five or more cells meeting at a point). (ox.ac.uk)
  • Examination of these cells showed that over 90% were E-rosette positive and that all were karyotypically normal and negative for terminal transferase, EBV, and surface immunoglobulins (Morgan et al. (science-connections.com)
  • On microscopic examination, the smears were cellular and showed many loose cohesive clusters and dispersed tumor cells in a background of abundant reactive lymphoid cells and hemorrhage [Figure 1a and b ]. (cytojournal.com)
  • Hodgkin tumor cells extensively interact with rosetting CD4 + T cells by immunological synapse formation involving HLA class II and CD58. (ashpublications.org)
  • We established a novel rosetting model by coculturing HLA-II-matched peripheral blood mononuclear cells with HL cell lines and showed IS formation with activation of rosetting T cells. (ashpublications.org)
  • In conclusion, T-cell rosetting in HL is established by formation of the IS, and activation of rosetting T cells critically depends on the interaction of both TCR-HLA-II and CD2-CD58. (ashpublications.org)
  • cells infected with herpes simplex virus type 1 (hsv-1) form rosettes with c3b-coated erythrocytes, whereas cells infected with herpes simplex virus type 2 (hsv-2) or other herpes viruses do not. (liverpool.ac.uk)
  • Micha's interest lies in discovering mechanisms that regulate the formation of the embryonic tissues using iPS cells, in order to create novel models for human disease and drug development with emphasis on neurodegeneration. (universiteitleiden.nl)
  • We are presently exploring the contribution of these molecules to podosome formation and functioning. (u-bordeaux.fr)
  • 3,4 Previous studies have described the involvement of several adhesion molecules in HL rosette formation. (ashpublications.org)
  • During embryonic development, there are a series of morphogenetic events that lead to the formation of the neural tube. (creative-biolabs.com)
  • However, extensive research has shown that they also play a complex role in the formation of F-actin (filamentous actin) through the replenishment of the ATP-actin monomer pool via catalyzing the exchange of ADP for ATP on Actin [ 12 ]. (biomedcentral.com)
  • Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. (elifesciences.org)
  • We detect alterations of protein properties in numerous cellular pathways and components including ribosome biogenesis and demonstrate that modulation of ribosome maturation through SBDS protein can be helpful for manipulating cell stemness in vitro. (nature.com)
  • However, the cellular and physical processes present during folding have not been defined. (elifesciences.org)
  • PPIs are fundamental to all cellular processes and machinery and instrumental in investigating uncharacterized proteins and inferring biological pathways. (uibk.ac.at)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • evidence that neomycin inhibits binding of herpes simplex virus type 1 to the cellular receptor. (liverpool.ac.uk)
  • The strength of the interaction is thought to be a determining factor for the longevity of a specific pMHCI as well as for the propensity of pMHCI formation. (molcells.org)
  • Gene expression is tightly regulated with many genes exhibiting cell-specific silencing when their protein product would disrupt normal cellular function. (exeter.ac.uk)
  • All of these functions are of importance during the formation of the cerebral neocortex, which consists of the generation of its different cell types, their migration to their destination and their maturation to a functional network. (uni-muenchen.de)
  • Fig.1 Cell morphological changes during rosette formation. (creative-biolabs.com)
  • Calcium signaling mediates five types of cell morphological changes to form neural rosettes. (creative-biolabs.com)
  • To probe the role of rosettes during AVE migration, we develop a mathematical model of cell movement in the VE. (ox.ac.uk)
  • Hence, in our initial attempts to develop cell lines from patients with T -cell neoplasias, we chose clinical subpopulations which represent a more mature form of disease, namely, the cutaneous T -cell lymphomas and leukemias and E-rosette positive T -cell ALL (Gupta and Good 1980). (science-connections.com)
  • They therefore represent a more realistic cellular environment for modeling the cell biology and pathology of the nervous system. (ehu.eus)
  • Their loss under these conditions leads to abnormally dilated canaliculi, resembling liver cell rosettes described in other hepatic diseases. (lisym.org)
  • Intriguingly, the level of CD58 expression correlated with the extent of rosette formation, and CD58 knockout or CD2 blockade reduced both rosette formation and T-cell activation. (ashpublications.org)
  • Taken together, our model and experimental observations suggest that rosettes in the VE epithelium do not form passively in response to AVE migration. (ox.ac.uk)
  • This PPI database facilitates the investigation of CLas cellular biochemistry and physiology, functions of uncharacterized proteins, and pathogenicity mechanisms of the pathogen. (uibk.ac.at)
  • Simulations suggest that while rosettes are not essential for AVE migration, they are crucial for the orderliness of this migration observed in embryos. (ox.ac.uk)
  • Recent research has shown that the dismantlement of neural rosettes promotes neurogenesis and astrogenesis prematurely, which means that the complete rosette structure is essential for orderly neurodevelopment. (creative-biolabs.com)
  • At cellular level, the telencephalon is populated by a large diversity of neurons, including glutamatergic projection neurons, GABA (γ-aminobutyric acid)-ergic interneurons and projection neurons, as well as cholinergic interneurons and projection neurons. (intechopen.com)
  • We find that folding occurs without an obvious cellular pre-pattern, that the outer layer expansion is uniform and fluid-like, and that the cerebellum is under radial and circumferential constraints. (elifesciences.org)
  • Our results show that the formation of multi-cellular rosettes in the mouse VE is dependent on normal PCP signalling. (ox.ac.uk)
  • In addition, neural rosettes can differentiate into distinct region-specific neurons and glia. (creative-biolabs.com)
  • We show that accumulation of RNA induces formation of transcription pockets which displace transcriptionally inactive chromatin. (nature.com)