Cellular oxidative stress. Medical search. Frequent questions

Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. (wikipedia.org)
Production of reactive oxygen species is a particularly destructive aspect of oxidative stress. (wikipedia.org)
Bacteria are the most diverse organism, inhabiting all environments and evolving enzymes to mitigate cellular damage from potentially hazardous reactive oxygen species (ROS). (bodyecology.com)
Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). (edu.au)
Reactive oxygen species -induced oxidative stress in the colon is involved in inflammatory bowel diseases and suggested to be associated with colorectal cancer risk . (bvsalud.org)
Oxidative stress in the cardiovascular system, including brain microvessels and/or parenchymal cells results in an accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) compounds thus promoting leukocyte adhesion and increasing endothelial permeability. (nih.gov)
The mechanisms of PM-related health effects are still incompletely understood, but a hypothesis under investigation is that many of the adverse health effects may derive from oxidative stress, initiated by the formation of reactive oxygen species (ROS) within affected cells. (cdc.gov)
The prolonged oxidative stress and the resultant hypoperfusion in the brain tissues stimulate the expression of nitric oxide synthase (NOS) enzymes, which further drives the formation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). (benthamscience.com)
A short-term gill explant (GE) culture was used as a model in a series of experiments aiming to demonstrate how photoperiod during culture, levels of environmental reactive oxygen species (ROS), time of oxidative stress induction, and the daily light-dark cycle affect the expression of molecular clocks and antioxidant genes in the gills. (nofima.no)
Oxidative stress occurs when the generation of reactive oxygen species (ROS) in a system exceeds the system's ability to neutralize and eliminate them. (nih.gov)
Oxidant damage to cellular DNA, proteins (including the epigenome), and lipids can occur when reactive oxygen species escape cell antioxidant and repair mechanisms. (who.int)

Normal cellular function continuously produces free radicals. (bodyecology.com)
Antioxidants can help deter oxidative stress, which simultaneously prevents free radicals. (bodyecology.com)
Over time, the brain becomes more vulnerable to damage caused by free radicals, unstable molecules that can disrupt cellular processes. (healthnews.com)
Multivitamins typically contain antioxidants like vitamins C and E, which help neutralize harmful free radicals and reduce oxidative stress. (healthnews.com)
For years researchers have known that free radicals can cause cell degeneration, especially in the brain, and oxidative stress has been implicated in a growing list of human diseases, such as Alzheimer's disease, Parkinson's disease and cancer. (nih.gov)
The process of oxidative phosphorylation cannot be completed, and the mitochondria, instead of making water and adenosine triphosphate (ATP), make destructive oxygen free radicals. (medscape.com)
It also eliminates free radicals from the body, which helps to prevent future damage from oxidative stress. (signalscv.com)
Because of this characteristic, this substance helps to improve cellular health while also flushing out free radicals produced by oxidative stress from the body's tissues. (signalscv.com)

The differentially expressed oxidative stress genes (DEOSGs) were analyzed by intersection of DEGs and oxidative stress-related genes. (nature.com)

HO-1 and their products exert beneficial effects through the protection against oxidative injury, regulation of apoptosis, modulation of inflammation as well as contribution to angiogenesis. (springer.com)
This age-related inflammation, also referred to as inflammaging, increases the risk for tissue damage and genetic aberrations that cause cellular transformation and cancer development ( 8 , 9 ). (frontiersin.org)
In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
One of the primary contributors to age-related cognitive decline is believed to be oxidative stress and inflammation. (healthnews.com)
This oxidative stress can lead to inflammation and the accumulation of harmful substances, contributing to cognitive decline. (healthnews.com)
It is also well-known that chronic inflammation results in an excessive burden of oxidative stress and therefore cellular dysfunction. (iasp-pain.org)
Genotoxicity was assessed by the ability of the CNT/F to induce inflammation, oxidative stress, micronuclei formation, and DNA double-strand breakage. (cdc.gov)
Ferritin is an acute-phase reactant that coordinates cellular defense against oxidative stress and inflammation along with transferrin and its receptor. (medscape.com)

While the adverse effects from PM have historically been associated with the airborne concentration of PM and more recently fine-particle PM, we considered it relevant to develop an assay to quantitatively measure the ability of PM to catalyze ROS generation as the initial step in the induction of oxidative stress. (cdc.gov)
Redox activity was highest in the ultrafine fraction, in agreement with results indicating ultrafine s were the most potent toward inducing that heme oxygenase expression and depleting intracellular glutathione, which has relevance to induction of oxidative stress. (cdc.gov)
Induction of oxidative stress either at ZT2 (2 h after lights on) or at ZT14 (2 h after lights off) revealed striking differences that highlighted the temporal sensitivity of the oxidative defence repertoire. (nofima.no)
Per1 was significantly modulated following time-dependent induction of oxidative stress amongst the clock genes. (nofima.no)

Senescence is a stress-response cellular state characterised by proliferative arrest but active metabolism ( 7 ). (frontiersin.org)
Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. (wikipedia.org)
Like all organisms, pathogenic microbes produce ROS as byproducts of aerobic metabolism, but the burden of ROS is magnified when these microbes confront the oxidative burst of the host. (bodyecology.com)
Aβ-mediated oxidative stress results in mitochondrial dysfunction, impairment of glucose metabolism, loss of proteostasis and synaptic plasticity, altered signal transduction, neuroinflammation, and progressive loss of neurons 9 . (nature.com)
Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
For this purpose, two different drugs were used: (1) Sodium thiosulfate (STS), a CN antidote commonly used in humans in case of CN poisoning and (2) 4-methylpyrazole (4MP) which blocks ACN metabolism through the oxidative pathway, preventing CN formation. (cdc.gov)
Oxygen-containing charged particles are common byproducts of cellular metabolism. (mda.org)

encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione. (wikipedia.org)
At higher concentrations, ROS induces cell injury and death, which occurs during the aging process, where accelerated generation of ROS and a gradual decline in cellular antioxidant defense mechanisms, especially in the mitochondria. (nih.gov)
Though the exact mechanism is not known, the therapeutic effect of edaravone (Radicava) is thought to be a result of its antioxidant properties, which combat oxidative stress. (mda.org)
Here we report the coordinated modulation of the molecular clocks and antioxidant defence following chemically induced oxidative stress in the gill mucosa of Atlantic salmon (Salmo salar). (nofima.no)
Collectively, the study revealed the coordinated expression of the core elements in the molecular clock and antioxidant systems in the gill mucosa following oxidative stress. (nofima.no)
1,4] Many factors can increase cellular exposure to oxidative insult, and therefore increase cellular consumption of nutrients - such as glutathione - that provide antioxidant activity. (prohealth.com)
Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)

We would like to understand the complex systems that allow cells to balance the essential process of oxidative folding with potentially damaging ROS production. (cornell.edu)

Our study identified 9 key genes associated with oxidative stress and immune reaction in AD pathogenesis. (nature.com)
These novel changes induced by WNV may serve as of 173 cellular genes were identified by ArrayTools to be biomarkers and help explain the neuropathologic features differentially expressed in the WNV-infected A172 cells. (cdc.gov)
Physiologic dsDNA breaks are generated in a variety of normal cellular functions, including the RAG endonuclease-mediated rearrangement of antigen receptor genes during the normal development of lymphocytes. (biomedcentral.com)
Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease. (cdc.gov)

However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis. (wikipedia.org)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
To observe the effect of H2O2 induced oxidative stress on autophagy and apoptosis of human bone marrow mesenchymal stem cells (hBMSCs). (researchsquare.com)
Under oxidative stress conditions, hMSCs can promote protective autophagy and reduce cell apoptosis or the level of apoptosis caused by excessive autophagy. (researchsquare.com)
This experiment intends to activate the oxidative stress response by H2O2, regulate the autophagy level of human bone mesenchymal stem cells (hBMSCs), and observe the effect of autophagy on the proliferation and apoptosis of hMSCs under oxidative stress. (researchsquare.com)

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
Laboratory data showed that S-acetyl glutathione increased intracellular glutathione and had a positive effect on many oxidative stress biomarkers. (prohealth.com)
Therefore I feel comfortable that it supplements the body's additional need for glutathione when it is under stress. (prohealth.com)

Likewise, the talk will illustrate some mechanistic links between autophagy dysfunction and the loss of cellular function leading to cell death or senescence. (dundee.ac.uk)

Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. (bvsalud.org)
Molecular clocks are known to mediate cellular responses during oxidative stress. (nofima.no)
2021. "Stoichiometric Thiol Redox Proteomics for Quantifying Cellular Responses to Perturbations. (pnnl.gov)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis, and is required to initiate stress response processes in plants. (wikipedia.org)
The measurement of ROS-forming ability in relation to sources and other factors will have potential relevance to control of redox-active PM. If oxidative stress represents a relevant mechanism of toxicity from PM, the measurement of redox activity represents a first step in the elucidation of the subsequent downstream processes. (cdc.gov)
Double strand (ds) DNA breaks are a form of DNA damage that can be generated from both genotoxic exposures and physiologic processes, can disrupt cellular functions and can be lethal if not repaired properly. (biomedcentral.com)
Theme 2 - Integration of cellular signalling pathways and processes. (edu.au)
We conclude that simple surrogates of dose can cause processes are expected to significantly affect the cellular dose. (cdc.gov)
We demand to characterize the hazard potential of the considerable develop these ideas by introducing the concept of cellular dose number of nanomaterials that have been or will be produced is in vitro as an important dose metric and by integrating aspects of material science, solution physics, and kinetics to present the 1 factors and processes affecting the cellular dose for particles. (cdc.gov)

Together, the results suggest that smoking traditional and e-cigarettes can increase oxidative stress , or cell death, which has been linked to tissue and DNA damage. (snopes.com)
Tissue hypoxia and oxidative stress account for most of the pernicious effects of CO in the body. (medscape.com)
Complete biotransformation and protection from oxidative stress are important to maintaining cellular integrity and tissue health. (prohealth.com)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)
Camellia sinensis prevents perinatal nicotine-induced neurobehavioral alterations, tissue injury, and oxidative stress in male and female mice newborns. (bvsalud.org)

Some of the less reactive of these species (such as superoxide) can be converted by oxidoreduction reactions with transition metals or other redox cycling compounds (including quinones) into more aggressive radical species that can cause extensive cellular damage. (wikipedia.org)
DNA damage induced by ionizing radiation is similar to oxidative stress, and these lesions have been implicated in aging and cancer. (wikipedia.org)
However, under the severe levels of oxidative stress that cause necrosis, the damage causes ATP depletion, preventing controlled apoptotic death and causing the cell to simply fall apart. (wikipedia.org)
Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer's disease, in particular. (edu.au)
We propose that hypometabolism, coupled with oxidative stressors, is responsible for most Alzheimer disease (AD) and cerebrovascular accidents (CVAs) and appears to be a central initiating factor for vascular abnormalities, mitochondrial damage and an imbalance in the activity of vasoactive substances, such as different isoforms of nitric oxide synthase (NOS), endothelin-1 (ET-1), oxidative stress markers, mtDNA and mitochondrial enzymes in the vascular wall and in brain parenchymal cells. (nih.gov)
They target the factors that damage mitochondria and reverse its effect, thus eliminating the imbalance seen in energy production and restore the normal cellular function, making these antioxidants very powerful alternate strategies for the treatment of cardiovascular cerebrovascular as well as neurodegenerative diseases including AD. (nih.gov)
Intrauterine and Postnatal Exposure to High Levels of Fluoride Is Associated with Motor Impairments, Oxidative Stress, and Morphological Damage in the Cerebellum of Offspring Rats. (fluoridealert.org)
The mechanism by which ACN renders the cochlea more vulnerable to noise damage is still unknown, but we hypothesize that the decrease of GSH and/or the inhibition of SOD reduce the cochlear intrinsic anti-oxidant defenses and ultimately create oxidative stress. (cdc.gov)
Oxidative stress consequent to chronic hypoperfusion induces mitochondrial damage, which is implicated as the primary cause of cerebrovascular accidents (CVA) mediated Alzheimer's disease (AD). (benthamscience.com)
Generally, the body wants to avoid increasing the rate of cleansing to prevent overwhelming its systems and creating any side effects or cellular damage. (florahealth.com)
This plant helps to decrease oxidative stress-induced cellular damage. (signalscv.com)
The results reaffirm the hypercoagulable state in migraine, and would suggest that this state is most likely a result of a systemic inflammatory state which induces oxidative damage to both erythrocytes and fibrin(ogen) in female episodic migraine-with-aura. (iasp-pain.org)

This programme provides students with a research-orientated training in the application of molecular and cell biology to develop an understanding of chemical toxicity at the cellular and molecular level. (birmingham.ac.uk)
One of the most rapidly developing areas of toxicology is the use of molecular, cell biology and omics to identify adverse outcome pathways (AOPs) and to develop a mechanistic understanding of chemical toxicity at the cellular and molecular level. (birmingham.ac.uk)

While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)

In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)

In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
In this review, we summarize the evidence linking cellular senescence to the pathogenesis of CKD and discuss current understanding of the mechanism and regulators controlling senescence. (frontiersin.org)

Several tissues including the heart have been observed to possess the cellular resources to transcribe SOD3 mRNA from SOD DNA (1). (bodyecology.com)
Furthermore, the results reveal that the time of day plays a crucial influence on how defences are mobilised during oxidative stress, adding new insights into the rhythms of oxidative stress response in mucosal tissues in fish. (nofima.no)
Hypoxia occurs from 3 primary mechanisms: CO diminishes the oxygen-carrying capability of hemoglobin, decreases the uptake of bound oxygen into tissues, and impairs the mechanisms of cellular respiration. (medscape.com)
that is, surges of sympathetic activity and oxidative stress on tissues at the cellular level that cause changes in the cardiac substrate, like fibrosis, that then leads to arrhythmia, especially atrial fibrillation," she added. (medscape.com)

Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. (edu.au)
Oxidative stress is a phenomenon that occurs when there is an imbalance between the production of oxygen-containing molecules that carry an electrical charge, which can be toxic, and a biological system's ability to readily detoxify them. (mda.org)

Autophagy is the process of maintaining cell homeostasis under oxidative stress conditions. (researchsquare.com)

H2O2 can induce hMSCs to produce oxidative stress response. (researchsquare.com)

Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Cellular senescence is characterized by an irreversible and permanent cell cycle arrest coupled with altered transcriptome and secretome. (frontiersin.org)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
More recently, cellular senescence has been considered as an additional cause of age-related tumorigenesis. (frontiersin.org)
However, cellular senescence is not exclusive to ageing. (frontiersin.org)
Cellular senescence, which recently has gained broad attention, is thought to be an important player in the onset and development of diabetic nephropathy. (hindawi.com)
Moreover, we highlight the potential therapeutic targets of cellular senescence in diabetic nephropathy and provide important clues for clinical strategies. (hindawi.com)
Recently, the emerging role of cellular senescence in DN has attracted a broad attention. (hindawi.com)
In the present review, we will focus on the role of cellular senescence and its related mechanisms in DN. (hindawi.com)
Furthermore, we will explore the potential therapeutic targets of cellular senescence and provide important clues for clinical strategies in the management of DN. (hindawi.com)
Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)

2021. "Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. (pnnl.gov)
Specifically, research efforts focus on how the cell maintains a redox environment in the endoplasmic reticulum (ER) lumen appropriate for oxidative protein folding. (cornell.edu)

Specifically, what is the significance of antioxidants, and how do they prevent disease and oxidative stress? (bodyecology.com)
This berry high in antioxidants maintains cellular health. (signalscv.com)

Ionizing radiation can cause DSBs, as well as other DNA lesions, and has been shown to disrupt many cellular functions. (biomedcentral.com)

Supporting our body's efforts in cleansing and supporting healthy cellular functioning is one way we can do this and is a great way to revitalize for the year ahead. (florahealth.com)
Essence® support cellular cleansing throughout the body-the liver, intestines, kidneys, lymphatic system, and brain-in a gentle way that supports the body's systems and natural functioning. (florahealth.com)
It also reverses the effects of oxidative stress on the body's cells. (signalscv.com)

Oxidative stress can contribute to chronic conditions like cancer, heart disease, diabetes, Alzheimer's disease, Parkinson's disease, and eye diseases such as cataracts and age-related macular degeneration. (bodyecology.com)
Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. (edu.au)
The resulting chronic injury stimulus results in progressive cellular hypometabolism. (nih.gov)

There are about 24,000 oxidative DNA adducts per cell in young rats and 66,000 adducts per cell in old rats. (wikipedia.org)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)

We study the molecular mechanisms regulating cellular oxidative folding and stress pathways using a combination of molecular, genetic, and biochemical techniques. (cornell.edu)
Molecular and Cellular Neuroscience. (lu.se)

Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. (wikipedia.org)

2021. "Fate, cytotoxicity and cellular metabolomic impact of ingested nanoscale carbon dots using simulated digestion and a triculture small intestinal epithelial model. (pnnl.gov)
2021. "Characterization of cellular oxidative stress response by stoichiometric redox proteomics. (pnnl.gov)

The crucial role of protein folding for cellular function is underscored by the number of diseases associated with the defective maturation of ER-generated polypeptides (e.g. (cornell.edu)
Maintaining a proper redox balance in the ER is key to maintain an environment for protein generation in the ER and to prevent oxidative stress. (cornell.edu)
Ferritin is the cellular storage protein for iron. (medscape.com)

The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state. (wikipedia.org)
In rat urine, about 74,000 oxidative DNA adducts per cell are excreted daily. (wikipedia.org)
There is also a steady state level of oxidative damages in the DNA of a cell. (wikipedia.org)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
Role of oxidative stress-mediated cell death and signaling pathways in experimental fluorosis. (fluoridealert.org)
However, clinical practice and experiments have shown that ischemia, hypoxia, and inflammatory cell infiltration at the injured site will produce a large amount of ROS, forming an oxidative stress microenvironment. (researchsquare.com)
Mitochondria play a pivotal role in cellular bioenergetics and cell-survival. (benthamscience.com)
Martin's research is focused on the nanoparticle-(mammalian)cell interaction, with a view to determining the mechanistic toxicological, immunological and genotoxic effects that nanoparticles, with varying physico-chemical characteristics, may cause at the cellular level by using advanced, next-level in vitro systems combined with state-of-the-art microscopy and bioanalytical approaches. (swansea.ac.uk)
They are all obviously harmful to the plant, but what's also fascinating is that they all induce a complex array of organelle and cellular signalling pathways within the plant cell, with unique and overlapping components that enable plants to respond to these perturbations. (edu.au)
We aim to understand how chloroplasts and mitochondria play dual functions in the plant cell as 1) metabolic hubs for photosynthesis and respiration respectively, and 2) environmental stress sensors for the cell by releasing a variety of distress signals upon perception of unfavourable conditions. (edu.au)

Living organisms are frequently exposed to oxidative stress and toxic insults, like radiation, UV light, air pollution, toxins and others. (springer.com)

Previous in vitro and in vivo studies revealed that oxidative stress caused by the accumulation of Aβ contributed to the initiation of AD 8 . (nature.com)
RÉSUMÉ Pour étudier les effets de la silymarine sur le développement folliculaire, nous avons recruté 40 femmes en bonne santé subissant une fécondation in vitro (FIV) en raison d'une infertilité masculine. (who.int)

The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

Normal cellular defense mechanisms destroy most of these. (wikipedia.org)

Vascular endothelial and neuronal mitochondria are especially vulnerable to oxidative stress due to their role in energy supply and use, which can cause a cascade of debilitating factors such as the production of giant and/or vulnerable young mitochondrion who's DNA has been compromised. (nih.gov)

Oxidative stress is involved in the modulation of gene expression patterns and metabolic activities, characterized by the disruption of redox homeostasis 7 . (nature.com)

This may result in a fierce cycle of oxidative stress and challenges to detoxification. (prohealth.com)

Oxidative medicine and cellular longevity 2020 7 2020 1305413. (cdc.gov)

Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)

p53's ability to inhibit tumors can be considered as a specific outcome of its stress-responsive effects. (nature.com)
Hypoxic stress in patients with CO poisoning is increased because of CO's effects on mitochondrial electron transport and cellular respiration. (medscape.com)
In this study the effects of excessive oxidative stress through the phases of female migraine-with-aura (FMA) were evaluated by examining the health of the systems of haemostasis. (iasp-pain.org)

Nitrogen monoxide and oxidative stress: composition and intensity of cellular oxidative bursts cocktail. (edpsciences.org)
New metrics to evaluate the relationship between particulate matter and health are also being considered, including particle number concentration, particle composition measures, and particle oxidative load. (cdc.gov)

Here, we review the role of ferroptosis in p53-mediated tumor suppression, with a focus on what cellular factors are critical for p53-dependent ferroptosis during tumor suppression and how p53 modulates both the canonical (GPX4-dependent) and the non-canonical (GPX4-independent) ferroptosis pathways. (nature.com)
Research in the Sevier lab focuses on characterization of the signaling pathways that sense and respond to cellular redox imbalances to alleviate oxidative stress. (cornell.edu)

Anatomy2

Organisms2

Diseases3

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology1

Phenomena and Processes7

Information Science1

Reactive oxygen12

Free radicals8

Expressed oxidative stress genes1

Inflammation8

Induction of oxidative stress4

Metabolism8

Antioxidant8

Process of oxidative1

Genes4

Apoptosis5

Glutathione3

Dysfunction1

Responses3

Processes8

Tissue5

Damage12

Toxicity2

Markers1

Induces1

Mechanism2

Tissues4

Imbalance2

Autophagy1

H2O21

Senescence11

Endoplasmic reticulum2

Antioxidants2

Lesions1

Body's3

Chronic3

Rats2

Molecular2

Mechanisms of cellular1

20212

Protein3

Cell10

Toxins1

Vitro2

Cardiac1

Defense mechanisms1

Vascular1

Homeostasis1

Detoxification1

20201

Harmful1

Effects3

Composition2

Pathways2