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  • tumor
  • Their studies have uncovered the importance of the tumor microenvironment in the inhibition of CAR T cell functions, revealed a critical role for the programmed death-1 (PD-1) pathway in CAR T cell exhaustion within the tumor microenvironment, and demonstrated improved antitumor effects with a CAR T cell-intrinsic PD-1 blockade strategy using a dominant negative form of PD-1. (jci.org)
  • Therefore, this way of action of the c-Myc/Miz1 complex points to a tumor protective mechansim that facilitates the eliminiation of cells harboring an oncogenic mutation. (uni-marburg.de)
  • Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment. (novusbio.com)
  • Mdm2 overexpression, in cooperation with oncogenic Ras, promotes transformation of primary rodent fibroblasts, and mdm2 expression led to tumor formation in nude mice. (wikipedia.org)
  • Decreased TGF-beta signalling has been suggested to cause loss of p27 expression in this tumor type. (wikipedia.org)
  • Merkel
  • The use of advanced high-throughput sequencing and improved rolling circle amplification techniques have identified the novel human polyomaviruses KI, WU, Merkel cell polyomavirus, HPyV6, HPyV7, trichodysplasia spinulosa-associated polyomavirus, and HPyV9. (hindawi.com)
  • Lymphotropic polyomavirus (LPV) and the recent described human PyV KI, WU, Merkel cell polyomavirus (MCPyV), trichodysplasia spinulosa-associated PyV (TSPyV), HPyV6, HPyV7, and HPyV9 all lack an open reading frame (ORF) corresponding to VP4, while BKV and JCV contain a putative VP4 ORF but the expression has not yet been confirmed (Table 1 ). (hindawi.com)
  • In other polyomaviruses, such as Merkel cell polyomavirus, which causes Merkel cell carcinoma in humans, STag appears to be important for replication and to be an oncoprotein in its own right. (wikipedia.org)
  • These are believed to bind zinc in the SV40 STag and confer improved protein stability, but in Merkel cell polyomavirus STag, they have been reported to bind iron-sulfur clusters. (wikipedia.org)
  • In Merkel cell polyomavirus, it appears to play a significant role in oncogenesis, a function performed primarily by LTag in other polyomaviruses. (wikipedia.org)
  • Tumors
  • Unfortunately, application of CAR T cell-mediated therapy for solid tumors has so far been disappointing, and the reasons for this poor response in solid tumors remain unknown. (jci.org)
  • somatic
  • B-cells within the germinal center proliferate and undergo immunoglobulin somatic hypermutation (SHM) of IgV region genes to revise their antigen receptors. (wikipedia.org)
  • checkpoint
  • demonstrate that CAR T cells with intrinsic checkpoint blockade mediated by expression of a dominant negative PD-1 receptor improve effector function and overall survival. (jci.org)
  • phenotypic
  • At the biochemical level, these activities are regulated by the ability of PAK1 to phosphorylate its effector interacting substrates, which in-turn set-up a cascade of biochemical events cumulating into a cellular phenotypic response. (wikipedia.org)
  • vivo
  • Here, we highlight the diversity of animal models and their unique advantages, discuss the use of animal models to profile lncRNA expression, evaluate experimental strategies to manipulate lncRNA function in vivo, and review the phenotypes attributable to lncRNAs. (jci.org)
  • A number of studies in vivo have shown that BTG2 expression is associated with the neurogenic asymmetric division in neural progenitor cells. (wikipedia.org)
  • Precursor
  • BTG1 is also necessary to limit the proliferative expansion of cerebellar precursor cells, as without BTG1 the adult cerebellum is larger and unable to coordinate motor activity. (wikipedia.org)
  • mutations
  • But under certain conditions, cell replication can occur before the DNA damage is repaired, resulting in the formation of mutations. (biomedcentral.com)
  • If the surrounding cells have experienced DNA damage, the result could be mutations, which may lead to cancer. (biomedcentral.com)
  • decreases
  • Knocking down WDR5 in MCF7 dramatically decreases cell viability, but does not alter tumour cell response to doxorubicin. (sigmaaldrich.com)
  • Also, DEPDC1B expression decreases in environments of beta-catenin depletion in multiple myeloma cell lines No interactions of DEPDC1B within any other protein product characterized by experimentation have been verified. (wikipedia.org)
  • polyomaviruses
  • The LT-ag of different polyomaviruses can transform cells from different species and induce tumours in animal models and is therefore implicated in the tumourigenic properties of polyomaviruses (see further). (hindawi.com)
  • In some polyomaviruses - such as the well-studied SV40, which natively infects monkeys - STag is unable to induce neoplastic transformation in the host cell on its own, but its presence may increase the transforming efficiency of LTag. (wikipedia.org)
  • Some, but not all, polyomaviruses are oncoviruses capable of inducing neoplastic transformation in some cells. (wikipedia.org)
  • fibers
  • What sets crocidolite apart from most other carcinogens is the persistent nature of the inhaled fibers, allowing for continued damage to surviving cells throughout the lifetime of the individual. (biomedcentral.com)
  • stem
  • DLBCL patients are at higher risk when they relapse early after R-CHOP chemotherapy and have a poor response to second-line rituximab-containing treatments even when these regimens involve high-dose therapy and autologous stem cell transplant. (wikipedia.org)
  • cancer
  • WDR5 Expression Is Prognostic of Breast Cancer Outcome. (sigmaaldrich.com)
  • The cover image is a false-colored electron micrograph of CAR T cells (blue) attacking and killing cancer cells (magenta). (jci.org)
  • PAK1 knockdown in prostate cancer cells is associated with reduced motility, reduced MMP9 secretion and increased TGFβ expression, which in these cases, is growth inhibitory. (wikipedia.org)
  • However, it is being studied for treatment of small-cell lung cancer, glioblastoma, and chronic myeloid leukemia, either alone or in conjunction with more typical cancer management treatments. (wikipedia.org)
  • activation
  • MDM2 is also required for organ development and tissue homeostasis because unopposed p53 activation leads to p53-overactivation-dependent cell death, referred to as podoptosis. (wikipedia.org)
  • Activation of the nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is found only in ABC DLBCLs and not GCB DLBCLs. (wikipedia.org)
  • P27 can also be regulated by changing its subcellular location Both mechanisms act to reduce levels of p27, allowing for the activation of Cdk1 and Cdk2, and for the cell to begin progressing through the cell cycle. (wikipedia.org)
  • human
  • Our results demonstrate that p38 maintains E-cadherin expression by suppressing TAK1-NF-κB signaling, thus impeding the induction of EMT in human primary mesothelial cells. (biologists.org)
  • In this issue of the JCI , Cherkassky and colleagues report on their use of a murine model of human pleural mesothelioma to explore potential factors that limit CAR T cell efficacy. (jci.org)
  • Expression profiles indicate that DEPDC1B is highly expressed ubiquitously throughout human tissue. (wikipedia.org)