AcuteIschemiaPost myocardial infarctionCoronaryElevation myocardialNecrosisMesenchymal stemCardiovascularMolecularDysfunctionSenescenceSTEMIIschemic heart dRedox stateApoptosisHeartComplicationThromboticCardiomyocytesInflammationMiceAnginaMortality2022Therapeutic strategyVentricularMetabolicCells2019Myocardium2020PatientsOccursProteinsGeneticTissueLaboratoryProcessesAtherosclerosisPlasticitySensoryGenomicMetabolismMouseOxygen
Acute18
- The prevention of cardiovascular diseases is a matter of great concern, of which acute myocardial infarction (AMI) remains one of the leading causes of death resulting in high morbidity worldwide. (nih.gov)
- Acute myocardial infarction, reperfusion type. (medscape.com)
- Acute anterior myocardial infarction. (medscape.com)
- Protection by nitrite against the ischemic effects induced by acute myocardial infarction in mice. (cdc.gov)
- Objective: This research was aimed to investigate the correct dose of nitrite that would act as a protection against the ischemic effects induced by acute myocardial infarction (AMI). (cdc.gov)
- A recent study reported an increased risk of acute myocardial infarction (AMI) within 7 days of contracting infection with influenza A and influenza B virus (3). (cdc.gov)
- Why Do Marijuana and Synthetic Cannabimimetics Induce Acute Myocardial Infarction in Healthy Young People? (karger.com)
- KCNJ11 polymorphisms and sudden cardiac death in patients with acute myocardial infarction. (cdc.gov)
- Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). (hindawi.com)
- The epidemiological data reflects the global trend for Europe, where coronary artery disease (CAD) with its complication in the form of acute myocardial infarction (AMI) and, in the longer-term, heart failure, accounts for 20% of all deaths among Europeans [ 2 , 3 ]. (hindawi.com)
- Eleven trials (1474 patients, 35 years or older) comparing add-on therapy of the creatine-based drug on standard treatment to placebo control in patients with heart failure (6 trials in 1226 / 1474 patients ), or acute myocardial infarction (4 trials in 220 / 1474 patients) or 1 in ischemic heart disease (28 / 1474 patients) were identified. (cochrane.org)
- In contrast, the acute myocardial infarction trials studied intravenous creatine phosphate only. (cochrane.org)
- The duration of the study intervention was shorter for the acute patients, from a two hour intravenous infusion of creatine phosphate in acute myocardial infarction ( Ruda 1988 , Samarenko 1987 ), to six months in patients with heart failure on oral phosphocreatinine therapy ( Carmenini 1994 ). (cochrane.org)
- In the acute myocardial infarction patients the follow-up period varied from the acute treatment period ( Ruda 1988 ) to 28 days after start of the symptoms ( Samarenko 1987 ) or end of the hospitalization period ( Zochowski 1994 ). (cochrane.org)
- Introduction: Cardiogenic shock is a frequent complication of acute myocardial infarction. (muni.cz)
- Acute myocardial infarction (AMI) is myocardial necrosis caused by acute and continuous ischemia and hypoxia of coronary arteries, which can be complicated by shock, arrhythmia, or heart failure. (biomedcentral.com)
- A shorter form of this homepage is also published at http://www.infarctcombat.org/heartnews-17.html main page = http://www.infarctcombat.org , the homepage of a clinic in Sao Paulo which had excellent results with ouabain in acute myocardial infarction until ouabain was forbidden because of political, not medical causes. (twoday.net)
- Timely reperfusion therapy can effectively reduce myocardial loss and significantly reduce acute mortality in patients with MI [ 2 ]. (biomedcentral.com)
Ischemia9
- Myocardial infarction (MI) (ie, heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia). (medscape.com)
- Addressing this medical and socioeconomical challenge, a better understanding of the pathophysiology of myocardial ischemia must be achieved. (hindawi.com)
- metabolic acidosis, arrhythmias, myocardial ischemia or infarction, and noncardiogenic pulmonary edema, although any organ system might be involved. (cdc.gov)
- TTS-patients present with chest pain, ST-segment elevation or ischemia signs on ECG and increased troponin, similar to myocardial infarction. (umm.de)
- CMRI applications include assessment of myocardial ischemia and viability, cardiomyopathies, myocarditis, vascular diseases, and congenital heart disease [ 1 ]. (intechopen.com)
- Infarction of the intestine can occur due to mesenteric ischemia. (picmonic.com)
- From the perspective of etiology, AMI is usually due to the rupture or erosion of unstable plaques with high lipid contents and easy breakage after coronary atherosclerosis, resulting in thrombosis and lumen blockage, which lead to certain degrees of ischemia and irreversible myocardial injury [ 3 ]. (biomedcentral.com)
- In a mouse model of myocardial ischemia repefusuin (MI/R) injury, intravenous injection of our formula resulted in the enrichment of RvD1 in the injured area, which in turn promotes clearance of dead cells, production of specialized proresolving mediators (SPMs), and angiogenesis during injury repair, effectively improving cardiac function. (biomedcentral.com)
- Efficient removal of dead cells and timely resolution of inflammation are exactly the keys to the restoration of cardiac function after myocardial ischemia-reperfusion (MI/R) injury [ 6 , 7 , 8 ]. (biomedcentral.com)
Post myocardial infarction3
- Genetic variants in post myocardial infarction patients presenting with electrical storm of unstable ventricular tachycardia. (cdc.gov)
- He was previously a senior investigator at Novartis, where he established and led preclinical efforts in areas including post-myocardial infarction and heart failure, congenital heart disease, and cellular senescence. (regulusrx.com)
- 2020 ) Myeloid interleukin-4 receptor α (IL4Rα) is essential in post-myocardial infarction healing by regulating inflammation and fibrotic remodeling. (academictree.org)
Coronary4
- Patients with underlying ischemic heart disease may develop angina or myocardial infarction because of coronary hypoperfusion. (msdmanuals.com)
- CMRI techniques produce high spatial, contrast, and temporal resolution image data for evaluation of cardiac and great vessel anatomy, coronary artery imaging, regional tissue characterization, vascular blood flow, cardiac chamber filling and contraction, and myocardial perfusion, myocardial viability. (intechopen.com)
- Myocardial infarction (MI), a clinical manifestation of coronary heart disease, is the leading cause of cardiovascular-related deaths [ 1 ]. (biomedcentral.com)
- It is well established that myocardial infarction resulting from the occlusion of a major coronary artery leads to cardiomyocyte necrosis and initiates a wound healing response. (scipedia.com)
Elevation myocardial2
- The aims of this study were to describe the extent and time course of oxidative stress and evaluate the prognostic value of oxidative stress markers in patients who experienced ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock. (muni.cz)
- Here we present a case of non-ST-segment elevation myocardial infarction associated with small vessel or microvascular dysfunction as determined by multimodality imaging in a patient with COVID-19. (fortunepublish.com)
Necrosis1
- This review will summarize the molecular and cellular links between inflammation and thrombosis in the context of myocardial infarction, which support the concept of a thrombo inflammatory state leading to the vessel obstruction and to the subsequent myocardial necrosis. (intechopen.com)
Mesenchymal stem1
- 27. Iron oxide nanoparticle-mediated development of cellular gap junction crosstalk to improve mesenchymal stem cells' therapeutic efficacy for myocardial infarction. (nih.gov)
Cardiovascular5
- Markers of inflammation, such as C-reactive protein (CRP), myeloperoxidase (MPO) and leukocyte levels are strong predictors of cardiovascular death, myocardial infarction, and stroke. (intechopen.com)
- Platelet adhesion and aggregation at sites of vascular injury is essential for hemostasis but is also a central pathomechanism underlying ischemic cardiovascular diseases such as myocardial infarction or stroke. (uni-wuerzburg.de)
- At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. (hindawi.com)
- In this review, we explore the intrinsic and extrinsic causes of cellular senescence and their role in the onset of these cardiovascular pathologies. (hindawi.com)
- This is at least partly due to a progressive impairment of the cellular processes regulating cardiac and vascular homeostasis, finally leading to the development of cardiovascular pathologies. (hindawi.com)
Molecular6
- Journal of Molecular and Cellular Cardiology. (wikipedia.org)
- This FOA issued by the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, encourages applications from institutions or organizations that propose to utilize cellular reprogramming, molecular profiling, and genomics to investigate functional aspects of genetic variation in humans. (nih.gov)
- NHLBI is soliciting a phased technology development and implementation program whose goal is to add a functional dimension to genomic studies by combining cellular reprogramming strategies with molecular profiling or cellular assays, followed by integration of this information with existing genotypic and clinical phenotypic data to assess how naturally occurring human genetic variation influences the activities of biological networks in cell-based models of disease. (nih.gov)
- Journal of molecular and cellular cardiology 2004 Feb 36 (2): 287-93. (cdc.gov)
- J of Molecular & Cellular Cardiology. (wisc.edu)
- Activation of the cellular senescence genetic program prompts a series of molecular changes, mostly affecting cell cycle, extracellular matrix (ECM), secretion of growth factors, and inflammatory mediators. (hindawi.com)
Dysfunction3
- He is the principal investigator for a Phase I-II clinical trial of stem cell therapy for patients with left ventricular dysfunction after myocardial infarction. (wikipedia.org)
- Symptoms and Signs Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. (msdmanuals.com)
- Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction. (nih.gov)
Senescence2
- Nuclear morphology is a deep learning biomarker of cellular senescence. (nih.gov)
- Cellular senescence has been for long time an underestimated biological process, even after its discovery in 1961 by Hayflick and Moorhead [ 2 ]. (hindawi.com)
STEMI1
- Methods: Plasma/serum levels of selected biomarkers of oxidative stress (oxidised guanine species (OGS), malondialdehyde, and glutathione peroxidase 3) and markers, which simultaneously reflect severe cellular damage (ferric ion reducing antioxidant power (FRAP), Cu/Zn-superoxide dismutase (SOD), and glutathione) were measured seven times per week in a prospective cohort of 82 patients with STEMI complicated by cardiogenic shock. (muni.cz)
Ischemic heart d1
- Full reports or abstracts from 1164 papers were reviewed, yielding 11 trials considering treatment with creatine or creatine analogues in 1474 patients with heart failure, ischemic heart disease or myocardial infarction. (cochrane.org)
Redox state2
- Since mitochondria are involved in tumorigenesis through ROS production and modulation of oxidative metabolism, we investigated the biological effects of pomegranate on cellular redox state, proliferation and metabolism in the breast cancer cell line MDA-MB-231 (MDA). (biomedcentral.com)
- Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State. (ox.ac.uk)
Apoptosis1
- Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling. (wisc.edu)
Heart15
- His research interests include delivery of stem cells to the heart for repair of myocardial infarction. (wikipedia.org)
- The Cell-based Therapy Group has formulated an Institute-wide implementation plan integrating basic and translational research programs to support the development of new cellular therapies including these Specialized Centers for Cell-Based Therapy (SCCT) for Heart, Lung, and Blood Diseases. (nih.gov)
- Its effects are caused not only by impaired oxygen delivery but also by disrupting oxygen utilization and respiration at the cellular level, particularly in high-oxygen demand organs (i.e., heart and brain). (cdc.gov)
- Heart failure is considered the end-stage phenotype of a variety of different basal cardiac defects, determined by several possible cellular regulation mechanisms. (benthamscience.com)
- Cellular mechanisms of impaired energetic metabolism, contractile force generation and propagation, ion channel exchanges and mitochondrial functioning are commonly recognized as the principal causes of the development of heart failure. (benthamscience.com)
- Adverse remodeling of the left ventricle (LV) after myocardial infarction (MI) results in abnormal tissue biomechanics and impaired cardiac function, often leading to heart failure. (stanford.edu)
- The effect on death and the size of myocardial infarction and the heart function were unclear. (cochrane.org)
- in adult patients with essential hypertension, heart failure, or myocardial infarction. (cochrane.org)
- The outcomes assessed were death, total myocardial infarction (fatal or non-fatal), hospitalizations for congestive heart failure, change in ejection fraction, and changes in diastolic and systolic blood pressure in mm Hg or as percent change. (cochrane.org)
- After administration in a rat model of myocardial infarction, the HG showed long-term retention in the heart and allowed for a sustained release of EVs for at least 7 days. (unav.edu)
- Infarction in the heart is known as myocardial infarction. (picmonic.com)
- Other projects in the laboratory examine the use of ESCs and their derivatives in cellular therapies for heart disease. (wisc.edu)
- Raval, A., T. Kamp and L. Hogle Cellular Therapies for Heart Disease: Unveiling the Ethical and Public Policy Challenges. (wisc.edu)
- Here, we demonstrate our workflow using four short axis sections of the mouse heart following myocardial infarction. (frontiersin.org)
- Mauro Santibanez-Koref, J. E. Schneider, A. M. Blamire and H. M. Arthur, Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction, IJC Heart & Vasculature (2016). (scipedia.com)
Complication2
- Myocardial injury is increasingly recognized as a complication in patients with COVID-19, but the pathophysiological basis remains uncertain. (fortunepublish.com)
- Myocardial injury is increasingly recognized as a complication of COVID-19, but its pathophysiologic basis remains poorly characterized [1]. (fortunepublish.com)
Thrombotic2
- Prospective epidemiological studies show TMAO to be atherogenic and associated with increased risk for arterial thrombotic events (myocardial infarction and stroke). (nih.gov)
- Myocardial infarction appears when these processes culminate with a thrombotic event. (intechopen.com)
Cardiomyocytes1
- The human cardiomyocytes obtained from hESCs provide a powerful system to create disease models and to evaluate the cellular electrophysiological and functional properties of human cardiomyocytes at different stages of development. (wisc.edu)
Inflammation2
- Both forms of myocardial injury-AMI and CABG procedure-trigger an intense local and systematic inflammatory response in pathogen-free form termed sterile inflammation [ 4 ]. (hindawi.com)
- The resultant combination of cardiomyocyte death, inflammation and fibrosis leads to a situation where non-contractile scar tissue gradually replaces the infarcted myocardial tissue. (scipedia.com)
Mice3
- Infarct size and degree of cell death were reduced in Siah2(-/-) mice subjected to myocardial infarction. (nih.gov)
- Myocardial infarction models in mice and large animals have been developed to pilot cellular therapies first employing mouse ESCs and derivatives. (wisc.edu)
- Mice are frequently used in research to examine outcomes of myocardial infarction (MI) and to investigate therapeutic interventions at an early pre-clinical stage. (scipedia.com)
Angina1
- One of the most necessary things in the contemporary medicine is to call attention to a topic that seems to be unbelievable at first sight: Ouabain (in german: g-Strophanthin), an extraction of an african plant called "strophanthus gratus", which since 1991 is discovered as an endogenous substance - a new hormone, prevents angina pectoris and myocardial infarction by 80 - 100 percent without side effects. (twoday.net)
Mortality2
- In particular, it is not clear whether there is an effect on mortality, progression of myocardial infarction and ejection fraction, while there is some evidence that dysrhythmia and dyspnoea might improve. (cochrane.org)
- 354: 447-55) decease mortality and/or sudden death following myocardial infarction. (nih.gov)
20221
- She started her post-doc career in Prof Joseph Powell's group in 2020, focusing on population-scale stem cell technology to understand how common DNA variation shapes cellular phenotypes before joining UNSW in 2022. (edu.au)
Therapeutic strategy2
- Despite the significant advancement in therapeutic strategy including optimized pharmacotherapy and myocardial revascularization, the prognosis of patients with CVD remains unsatisfactory. (hindawi.com)
- Thus, the combination of HGs and EVs represents a promising therapeutic strategy for myocardial repair. (unav.edu)
Ventricular1
- In this lab, through the combination of these two techniques, cellular models of channelopathy and cardiomyopathy such as short QT syndrome, Brugada syndrome, Takotsubo cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy have been established, which are useful for mechanistic study and drug-testing. (umm.de)
Metabolic1
- With the increase in metabolism-related research, using a new method to explore the metabolic changes in vessels, especially vascular endothelial cells, will reach a new stage for the study of myocardial infarction. (biomedcentral.com)
Cells3
- SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells. (stanford.edu)
- Bone marrow from DsRed-transgenic donors was transplanted into recipients to lineage-trace circulating cells after myocardial infarction (MI). (stanford.edu)
- Ongoing research focuses on identifying optimal cellular populations derived from ESCs for cardiac therapy, determining the best delivery strategies, and overcoming challenges related to immune rejection of allogeneic cells. (wisc.edu)
20191
- 2019 ), but a detailed characterization of cellular zones of injury, repair and/or remodeling is lacking. (frontiersin.org)
Myocardium1
- Bioengineered analog of stromal cell-derived factor 1α preserves the biaxial mechanical properties of native myocardium after infarction. (stanford.edu)
20201
- 2020 ) Cellular reprogramming: Mathematics meets medicine. (academictree.org)
Patients2
- Therefore, we have established cellular models of SQTS including SQTS1 and SQTS5 using hiPSC-CMs from SQTS-patients and are carrying out studies regarding arrhythmogenesis of SQTS and screening effective drugs for treatment of SQTS-patients. (umm.de)
- Risk factors profile of young and older patients with myocardial infarction. (ox.ac.uk)
Occurs1
- These multiple blood supplies will cause red infarction if an infarct occurs. (picmonic.com)
Proteins1
- Cytoskeleton, Inc. has overcome these problems by providing a cell permeable form or C3 Transferase that can efficiently inactivate cellular Rho proteins in as little as 2 h. (cytoskeleton.com)
Genetic1
- Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. (cdc.gov)
Tissue1
- SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to tissue regeneration remain controversial. (stanford.edu)
Laboratory2
- Several years ago, our laboratory established a cryoinjury-induced myocardial infarction model in zebrafish, whereby a freezing-thawing procedure destroys approx. (unifr.ch)
- The cellular electrophysiology laboratory consists of patch-clamp, calcium imaging and single-cell contraction measurement facilities. (umm.de)
Processes1
- Creatine kinase is an enzyme that regenerates cellular ATP, which is used for energy demanding processes. (cochrane.org)
Atherosclerosis1
- Atherosclerosis is the main cause of myocardial infarction. (intechopen.com)
Plasticity1
- Ultimate goal is an improved understanding of the cellular plasticity of mature functional organs in vertebrates. (unifr.ch)
Sensory1
- Cacao regulates cellular immune response , neural signaling , and sensory perception. (llu.edu)
Genomic1
- After finishing her PhD, she was involved in establishing a state-of-the-art single-cell genomic centre, the so-called Garvan Weisman Centre for Cellular Genomic (GWCCG), to provide single-cell multi-omic platforms to all scientists nationally and internationally. (edu.au)
Metabolism2
- The creatine kinase system, the central regulatory system of cellular energy metabolism, provides ATP in situ at ATP-ases involved in ion transport and muscle contraction. (cochrane.org)
- As a graduate student, she discovered the mechanisms by which a persistent oncogenic herpesvirus induces cancer by reprogramming host cellular signaling and metabolism. (unc.edu)
Mouse1
- When you mouse over it, the arrow will indicate one of the largest plaques which has broken open, rupturing the endothelium that normally lines the aorta and exposing the cellular debris and lipid in the core of the plaque. (umassmed.edu)
Oxygen1
- The evidence for several different mechanisms by which n-3 fatty acids may alter arrhythmias was discussed in detail, including potential effects on cardiac sodium channels, calcium channels, the sodium- calcium exchanger, lipid rafts, calcium release from the sarcoplasmic reticulum, kinases including PKA and CaMKII, and myocardial oxygen stress. (nih.gov)