Loading...
  • Thus
  • Thus, the focus of this Commentary will be on identifying and describing the fundamental features of 3D cell culture systems that influence cell structure, adhesion, mechanotransduction and signaling in response to soluble factors, which - in turn - regulate overall cellular function in ways that depart dramatically from traditional 2D culture formats. (biologists.org)
  • We thus assessed the effect of androgens and the bone microenvironment on the nuclear translocation of ErbB-3 by using xenograft tumor models generated from bone-derived prostate cancer cell lines, MDA PCa 2b, and PC-3. (aacrjournals.org)
  • influences
  • The variability of the cellular environment along an individual cochlea arising from patch-like generation of flat epithelium, and the possible variability between individuals resulting from genetic influences on the rate at which remodelling occurs may pose challenges to devising the appropriate regenerative therapy for a deaf patient. (biomedsearch.com)
  • Research in the past decade has increased our understanding of how the breast microenvironment influences tumor development. (aacrjournals.org)
  • cells
  • These therapeutic mAbs neutralize pathogenic cytokines (e.g., anti-TNF mAbs for rheumatoid arthritis), inhibit cellular proliferation (e.g., herceptin for Her-2 + breast cancers), induce agonistic or inhibitory receptor activities to regulate cellular functions (e.g., anti-CD3 mAb for transplantation rejection), and eliminate malignant and pathogenic cells by targeting cell surface Ags ( 1 , 2 , 3 ). (jimmunol.org)
  • In this study, we demonstrate a greater complexity involving the circulatory dynamics of B cells and survival factors from the microenvironment as critical regulators that determine the mechanistic basis for immunodepletion through complement or the reticuloendothelial system (RES) 3 . (jimmunol.org)
  • Accordingly, sCD30 level could be applied to detection of microenvironment formation for tumor stem cells and their monitoring in ATL. (omicsonline.org)
  • these non-transformed cells forming the microenvironment in which tumour cell growth is contained and supported. (biomedcentral.com)
  • Using what is observed about how cells respond to their microenvironment, Liu is working to develop materials and scaffolds that have a controlled host response after implantation into the body. (uci.edu)
  • cell
  • The Sensing Cell Culture Flask (SCCF) is a cell culture monitoring system accessing the cellular microenvironment in 2D cell culture using electrochemical microsensors. (mdpi.com)
  • Kieninger J, Tamari Y, Enderle B, Jobst G, Sandvik JA, Pettersen EO, Urban GA. Sensor Access to the Cellular Microenvironment Using the Sensing Cell Culture Flask. (mdpi.com)
  • The tumor microenvironment is composed of a variety of different cell types that work in concert to support or limit the growing tumor. (frontiersin.org)
  • Defining the cellular environment in the organ of Corti following extensive hair cell loss: a basis for future sensory cell replacement in the Cochlea. (biomedsearch.com)
  • critical
  • We also assess another critical component of the microenvironment, the "irritability" or inflammability of nanoparticles toward human lung macrophages using rocket immuno-electrophoresis, a powerful and quantitative immuno-analytical technique consists of a two-dimensional immunoelectrophoresis with a combination of conventional electrophoretic separation and electro-immunodiffusion. (aacrjournals.org)
  • cancers
  • Biopsies taken from individual tumours exhibit extensive differences in their cellular composition due to the inherent heterogeneity of cancers and vagaries of sample collection. (biomedcentral.com)
  • response
  • Liu seeks to create biomaterial surfaces that mitigate the foreign body response by utilizing materials with mechanical and biochemical properties that mimic the native cellular microenvironment. (uci.edu)