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Cysteine DioxygenaseCysteineSulfur CompoundsTaurineDioxygenasesSulfatesCarboxy-LyasesGlutathioneEnergy MetabolismCysteine EndopeptidasesCysteine ProteasesLipid MetabolismMolecular Sequence DataAmino Acid SequenceGlucoseMetabolismCysteine Proteinase InhibitorsCysteine SynthaseOxidation-ReductionGlycolysisMetabolic Networks and PathwaysKineticsLiverDisulfidesMutationModels, BiologicalSulfhydryl CompoundsMitochondriaBase SequenceEscherichia coliChromatography, High Pressure LiquidAdenosine TriphosphateCellsCitric Acid CycleCell LineSignal TransductionCystineOxygen ConsumptionRecombinant ProteinsMutagenesis, Site-DirectedCells, CulturedBinding SitesLactic AcidSequence Homology, Amino AcidMagnetic Resonance SpectroscopyBiotransformationMass SpectrometryCarbon IsotopesCathepsinsBiological TransportOxidative StressOxygenMetabolomeProtein BindingFatty AcidsTime FactorsModels, MolecularMetabolomicsBacterial ProteinsPyruvic AcidCarbonMicrosomes, LiverCloning, MolecularRNA, MessengerGene Expression ProfilingCytochrome P-450 Enzyme SystemProtein Structure, TertiaryNADHydrogen-Ion ConcentrationCystatinsSubstrate SpecificitySulfurLactatesGene Expression RegulationInsulinDose-Response Relationship, DrugCathepsin LPapainHomeostasisSulfhydryl ReagentsPentose Phosphate PathwayMethionineCathepsin BCarbon-Sulfur LyasesBiochemical ProcessesIronSaccharomyces cerevisiaeAmino AcidsMetabolism, Inborn ErrorsProteinsProtein ConformationProteomeOxidative PhosphorylationSirtuinsCell MembranePhenotypeCarrier ProteinsGene Expression Regulation, BacterialCell Line, TumorGas Chromatography-Mass Spectrometry

ResiduesReversibleBiological systemsEnzymesImportantPlayersRole

Residues5

• In this study, we present a highly efficient method for proteomic profiling of cysteine residues in complex proteomes and in living cells. (unige.ch)
• Xiao and intestinal alterations indicative of mucosal dysbiosis (Grasberger IFN\ and IFN\ (Fink (Fink model of lung epithelial injury in mice (Gorissen redox\dependent regulation of cell signalling pathways, by reversible oxidation of functional cysteine residues. (ees2010prague.org)
• The sulfhydration of cysteine residues in proteins is an important mechanism involved in diverse biological processes. (pharmaceuticalintelligence.com)
• Reactive cysteine residues in proteins have high nucleophilicity and low pKa values and serve as a major target for oxidative modifications, which can vary depending on the subcellular environment, including the type and intensity of intracellular or environmental cues. (pharmaceuticalintelligence.com)
• The biological significance of the Cys150 modification by H2S is not well-studied, but H2S could serve as a biological switch for protein function acting via oxidative modification of specific cysteine residues in response to redox homeostasis (Paul and Snyder, 2012). (pharmaceuticalintelligence.com)

Reversible1

• The reversible nature of this modification provides a mechanism to fine tune biological processes in different cellular redox states. (pharmaceuticalintelligence.com)

Biological systems1

• We have developed a proteomics approach to quantitatively profile the changes of sulfhydrated cysteines in biological systems. (pharmaceuticalintelligence.com)

Enzymes2

• In pancreatic β cells exposed to endoplasmic reticulum (ER) stress, elevated H2S promotes the sulfhydration of enzymes in energy metabolism and stimulates glycolytic flux. (pharmaceuticalintelligence.com)
• We propose that transcriptional and translational reprogramming by the Integrated Stress Response (ISR) in pancreatic β cells is coupled to metabolic alternations triggered by sulfhydration of key enzymes in intermediary metabolism. (pharmaceuticalintelligence.com)

Important2

• 2016). The identity of the DUOX1 cysteines targeted by these electrophiles is yet to be established, but these studies offer the exciting prospect that selective targeting of specific functionally important cysteines within DUOX1 may lead to inhibition of DUOX1, and could be exploited for the development of DUOX\selective inhibitors to treat allergic disorders such as asthma, allergic rhinitis, atopic dermatitis and conjunctivitis. (ees2010prague.org)
• Coenzyme A (CoA) is an important cellular metabolite that is critical for metabolic processes and the regulation of gene expression. (mdpi.com)

Players1

• Our results demonstrate that curcumin covalently modifies several key players of cellular signaling and metabolism, most notably the enzyme casein kinase I gamma. (unige.ch)

Role1

• This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)