Cellular membranes models biological. Medical search. Frequent questions

According to the Fluid Mosaic Model, in contrast to other models, the cell membrane is composed of a single lipid bilayer which is associated with two groups of proteins. (wikipedia.org)
Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
Cellular iron levels and iron associated proteins are differentially expressed in many cancers, and recently, it was reported that high expression levels of iron importer and low levels of iron exporter were associated with a poor prognosis in breast cancer patients. (american.edu)
Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
In order to function, the cellular generators depend on the support of numerous highly specialized membrane proteins in the inner mitochondrial membrane. (sciencedaily.com)
In investigating the insertion of a family of membrane proteins which is of great pharmacological interest, the so-called ABC transporters, the research team made the surprising discovery that some segments of the transporters are evidently initially skipped by the insertion machinery and transported completely over the membrane. (sciencedaily.com)
Thus, the scientists were able to demonstrate for the first time that at least two different protein translocases cooperate closely to insert proteins with complex structures into the inner mitochondrial membrane. (sciencedaily.com)
These proteins - which drive various membrane remodeling events such as fission reactions that release intralumenal vesicles into endosomes and viruses from the cell surface -are one of Phylllis Hanson's many research interests. (asbmb.org)
My long-term overall interest is in the cell biology of molecular machines, with a particular interest in understanding how proteins regulate the structure and organization of membranes, both inside and outside the cell. (asbmb.org)
Specifically, we use recombinantly expressed proteins and purified native protein complexes in combination with a wide variety of model membrane systems, including planar lipid bilayers (single channel electrophysiology), giant unilamellar vesicles, lipid nanodiscs and supported bilayers. (db-engine.de)
To create particular shaped cells and cell organelles, membranes must undergo deformations which are determined by the structure and elasticity of the membrane and this process is most probable driven by proteins, lipids and/or interplay of both. (db-engine.de)
Unlike membrane remodeling in classical curvature-dependent processes like clathrin-mediated endocytosis, cristae junctions are most likely shaped by integral membrane proteins. (db-engine.de)
In structure-based drug design, he explained, proteins are designed three-dimensionally, atom by atom, using computer models of the molecules and then deploying different screening techniques to target the receptor of interest. (fapesp.br)
The fluid-mosaic model of Singer and Nicolson in 1972 proposed the plasma membrane as a two-dimensional fluid composed of lipids and proteins. (bvsalud.org)
Specifically, for membrane proteins, it provides a key analytical dimension to determine the identity of bound lipids and to decipher their effects on the observed structural assembly. (bvsalud.org)
We recently developed an approach to study membrane proteins directly from intact and tunable lipid membranes where both the biophysical properties of the membrane and its lipid compositions can be customized. (bvsalud.org)
Extending this, we use our liposome-nMS platform to decipher the lipid specificity of membrane proteins through their multiorganelle trafficking pathways. (bvsalud.org)
Considering that the cellular trafficking pathway of most eukaryotic integral membrane proteins involves residence in multiple organellar membranes, this study highlights how the lipid-specificity of the same integral membrane protein may change depending on the membrane context. (bvsalud.org)
Further, leveraging the capability of the platform to study membrane proteins from liposomes with curated biophysical properties, we show how we can disentangle chemical versus biophysical properties, of individual lipids in regulating membrane protein assembly. (bvsalud.org)
Membranes host numerous proteins and are responsible for the exchange of molecules and ions, cell signaling, and cell compartmentation. (utc.fr)
We propose that the perturbation of the membrane by misfolded proteins involves long term occupation of the membrane by these proteins, rather than transient perforation events. (diamond.ac.uk)
My initial research started with the understanding of membrane curvature in monoolein-water system using polymer as a proxy for proteins. (ncbs.res.in)
This proposal tests the paradigm-shifting hypothesis that mitochondrial-derived proteins (MPDs) play a previously unappreciated role in the regulation of cellular and organismal function, and that disregulation of MDPs is important in disease development. (nih.gov)
Dr. Chul Ki Kim from KIST further added that "researches for applying the technology to various research fields such as diseases known to be caused by mutated proteins attached to cellular membranes like Alzheimer's disease, Parkinson's' disease, and diabetes, and technology to rapidly and precisely detect an extremely small number of infectious viruses such as COVID-19 and influenza are being conducted in parallel. (eurekalert.org)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
The adhesins appear to be outer membrane proteins that allow the rickettsia to be phagocytosed into the host cell. (medscape.com)
While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

To demonstrate this, we used VAMP2 and reconstituted it in the endoplasmic reticulum (ER), Golgi, synaptic vesicle (SV), and plasma membrane (PM) mimicking liposomes. (bvsalud.org)
Indeed, the plasma membrane delimits the intracellular compartment from the extracellular environment and intracellular membranes. (utc.fr)

They form the intricately shaped compartments of life and are involved in cell recognition, cell communication, and numerous other biological processes. (mpg.de)
In particular, iron has the capability to donate and accept electrons, which is an extremely useful property for many biological processes. (american.edu)
To avoid iron toxicity, yet to deliver adequate amounts of iron for biological processes, life on Earth has evolved to have sophisticated machinery that regulates iron at both the systemic and the cellular levels. (american.edu)
We're looking at their role in an increasingly huge range of cell biological processes, and we're particularly excited right now about a recent discovery that the ESCRT machinery responds to and facilitates the repair of super-small-scale damage in membranes that can be caused by any number of insults from the environment. (asbmb.org)
The Meinecke lab focuses on the in vitro reconstitution of processes at and across cellular membranes. (db-engine.de)
A program that focuses on the application of physics principles to the scientific study of the mechanisms of biological processes and assemblies at all levels of complexity. (myfuture.com)
Dec. 13, 2021 Fluorescence light microscopy has the unique ability to observe cellular processes over a scale that bridges four orders of magnitude. (sciencedaily.com)
In the area of atmospheric chemistry, the chemical transformation of the atmosphere is being modelled both experimentally and theoretically to understand how these processes are currently affecting and driving climate change. (mcgill.ca)
This review surveys various models of membrane organization, culminating in a new model that incorporates nonequilibrium processes and forces exerted by interactions with extramembrane elements such as the actin cytoskeleton. (bvsalud.org)
BuBuilding simplified in vitro models of complex biological systems is a proven method to study cellular processes quantitatively. (ucmerced.edu)
Giant liposomes - through the entrapment of appropriate enzymes, ribosomes, DNA, and cytoskeletal components - can recapitulate complex cellular processes in a simplified geometry. (ucmerced.edu)
It will also provide an introduction into how understanding basic cellular processes can be used to understand the mechanisms by which antibiotics specifically inhibit certain bacteria and permit the identification of new targets for the development of novel antibiotics. (ncl.ac.uk)
The objective being to give an overview of the methods used in the discovery of molecular mechanisms used by model bacteria and the application of this in understanding the basic processes involved in bacterial growth and development in terms of regulation and biological function. (ncl.ac.uk)

In vitro Studies of Protein Transfer Across Human Fetal Membranes. (researchgate.net)
Maternal sera were dialyzed in vitro across individual or combined fetal membranes to elucidate the functions of the membranes in protein transport. (researchgate.net)
Non-cellular assessment of nanoparticle durability, protein interactions, complement activation, and pro-oxidant activity is also considered. (cdc.gov)
Applicants to this FOA should propose work to solve a substantial biological problem for which the determination of many protein structures is necessary. (nih.gov)
After two decades researching protein-protein and protein-membrane interactions involved in membrane trafficking at WUSTL, Hanson recently moved her lab to the University of Michigan Medical School's department of biochemistry - which she now chairs . (asbmb.org)
These include SNAREs, which mediate vesicle function, and NSF, a AAA+ ATPase that maintains protein dynamics of the SNAREs, and thus membrane trafficking. (asbmb.org)
They are thought to be important for cellular physiology as they help to maintain specific protein composition of inner membrane sub-domains. (db-engine.de)
Includes instruction in research methods and equipment operation and applications to subjects such as bioenergetics, biophysical theory and modeling, electrophysics, membrane biology, channels, receptors and transporters, contractility and muscle function, protein shaping and folding, molecular and supramolecular structures and assemblies, and computational science. (myfuture.com)
By directly studying VAMP2 from these customized liposomes, we show how the same transmembrane protein can bind to different sets of lipids in different organellar-mimicking membranes. (bvsalud.org)
In degenerative diseases associated with protein misfolding and aggregation, protein molecules or their aggregates are believed to permeate these barriers and threaten membrane integrity. (diamond.ac.uk)
We used neutron reflectivity to study the interaction of insulin, a model amyloidogenic protein, with a DSPC floating lipid bilayer. (diamond.ac.uk)
Structural changes consistent with protein partitioning to the membrane interior and adsorption to a gel phase model lipid bilayer were observed under conditions where the native fold of the protein is significantly destabilised. (diamond.ac.uk)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)

Two concepts have been proposed for the cytoplasmic distribution process of hydrophobic or amphipathic molecules, (i) slowing of diffusion due to instantaneous binding to immobile cellular structures and (ii) slow binding after instantaneous distribution throughout the cytosol. (nih.gov)
Unlike man-made computer components that are meticulously ordered on a chip, the molecules that make up biological 'computers' are diffuse within the cell. (sciencedaily.com)
Combining artificial intelligence with an increasingly important approach known as "structured-based drug design", the computational platform developed by Naiad is able to screen billions of molecules in search of those with therapeutic potential, precisely selecting several hundred for cellular testing in the laboratory. (fapesp.br)
The carefully controlled permeability of cellular membranes to biological molecules is key to life. (diamond.ac.uk)
The study also led us to understand the library of structures formed during the membrane interactions with the polymeric molecules. (ncbs.res.in)
Here, I design active molecules and active polymers using squirmer model system. (ncbs.res.in)
The claim is that such structures would display minimal life-like behavior (reproductive and potentially evolutive) if the intravesicle ribozymes catalyze their own replication and the production of membrane molecules at the expenses of certain precursors available in the environment. (frontiersin.org)
With this new technology known as "Membrane coated-FET (lipid-FET)," molecules suspended in highly ionic concentrated solution, to a level of human blood, can be detected with higher sensitivity compared to that of the existing sensor, and dilution of the solution up to 100,000-fold is not required. (eurekalert.org)

A whole variety of model membrane systems have been developed in the last few decades. (utc.fr)

Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. (nature.com)
This has been made possible by visualizing membrane heterogeneities and their dynamics and appreciating the asymmetrical arrangement of lipids in living cell membranes. (bvsalud.org)
Nicolson found that at the cellular and molecular levels the actual replacement of damaged cellular lipids with undamaged lipids helped to maintain proper structure and function of cellular structures, mainly cell membrane and organelle membranes (especially those of mitochondria), and this is important for maintaining stable cellular functions. (betterhealthguy.com)
Our lab is currently investigating mechanisms for building the cell membrane by fabricating bioinspired giant liposomes from purified lipids. (ucmerced.edu)

Many cellular organelles are membrane-bound structures with complex membrane composition and shape. (jussieu.fr)
When iron metabolism ceases to function properly, the resulting iron excess or deficit can lead to serious faults in other cellular structures and regulatory systems. (american.edu)
The shapes of these structures are formed by physical forces that operate on membranes. (db-engine.de)

The generators in the cellular power plants are biological membranes located inside the mitochondria. (sciencedaily.com)
The scientists were thus able to use mitochondria from baker's yeast as a model system for their study, which has now been published in the journal Current Biology . (sciencedaily.com)
One of the most peculiar membrane shapes is observed in mitochondria. (db-engine.de)

After matching the models for the relative dispersion the remaining differences in relative skewness are predicted, discussing the relative roles of membrane permeability, cellular binding and cytoplasmic transport. (nih.gov)
II Factors Affecting Membrane Permeability. (orellfuessli.ch)
8 Virally Mediated Changes in Cellular Permeability. (orellfuessli.ch)

Our lab takes an interdisciplinary approach to this topic, employing cutting-edge biochemical, biophysical and cell biological techniques. (db-engine.de)
A simple biophysical model they developed indicates that in picking out the target molecule from a crowd of look-alikes, the recognizer has an advantage if it's slightly off-target. (sciencedaily.com)
The research interests of the members of the Chemical Physics Thematic Research Group are diverse, with groups focusing on high-end laser and NMR spectroscopies, kinetics and modelling of atmospheric chemical reactions, experimental and theoretical biophysical chemistry, polymers at interfaces, and statistical and quantum mechanics. (mcgill.ca)
Fifty years hence, advances in biophysical and biochemical tools, particularly optical imaging techniques, have allowed for a better understanding of the physical nature, organization, and composition of cell membranes. (bvsalud.org)

A central topic of the conference is the interplay of curvature and composition that governs membrane shapes. (mpg.de)
The Max Planck Society recognizes his outstanding doctoral thesis on the curvature elasticity of fluid membranes. (mpg.de)
Cristae junctions are rather uniform with inner diameters between 15 - 35 nm and hence display high degrees of membrane curvature. (db-engine.de)

Even minute errors in the composition of the inner mitochondrial membrane can lead to severe metabolic derangements, which can have an especially negative impact on the energy-hungry muscle and nerve cells. (sciencedaily.com)
The impact of Cu 2+ (as CuSO 4 ) and the two engineered CuO NPs on the cell respiration and mitochondrial function is different as studied with oxygen consumption rate, ETC mutants, and mitochondrial membrane depolarization measurements. (marquette.edu)

We leveraged Caenorhabditis elegans ' touch receptor neurons as a simple model amenable to in vivo whole-cell patch-clamp recording and an integrated experimental-computational approach to dissect the mechanisms underlying the spatial and temporal dynamics we observed. (nih.gov)
Understanding how cristae junctions are formed and maintained or in other words, unraveling the molecular mechanisms of membrane remodeling at cristae junctions, is therefore of utmost importance. (db-engine.de)
Nanomaterials are used in many commercial products and new applications in biomedicine, yet their fate, potential toxicity, and mechanisms of internalization in biological cells have not been well defined. (marquette.edu)
Despite these advances, mechanisms underlying the local spatiotemporal organization of membrane components remain unclear. (bvsalud.org)
Biological membranes and their related molecular mechanisms are essential for all living organisms. (utc.fr)
My doctoral work aimed to unravel the mechanisms behind different pluripotency states in mouse, dog and human and their evolutionary significance using induced pluripotent stem cells (iPSCs) as models. (ncbs.res.in)
In recent years there have been significant advances in our understanding of the cellular and molecular mechanisms through which allergic sensitization to chemicals is induced and regulated. (cdc.gov)

Therefore, an important question of current cell biology in conjunction with physics and mathematics is to elucidate the functional cause for these different membrane morphologies as well as how they are formed. (db-engine.de)
This module provides an up to date understanding of how fundamental research in bacterial cell biology helps to elucidate central biological questions such as the control and regulation of cell division and of gene expression in bacteria. (ncl.ac.uk)

This simple mechanism is coined 'conformational proofreading' and may explain the observed deformations in many biological recognition systems. (sciencedaily.com)

In clarifying this coupled mechanism of membrane insertion, project head Dr. Martin van der Laan and his team have solved a hotly debated scientific problem and made a major contribution to our understanding of the composition and functioning of cellular power plants. (sciencedaily.com)

These computational organ and cell models can be used to study the impact of pharmaceutical drugs, test hypotheses, assess risk and for closed-loop validation of medical devices. (auckland.ac.nz)
Thus, bio-inspired computing is a multi-disciplinary field devoted to studying complex problems using computational methods modeled after design principles encountered in nature. (wikicfp.com)

N. Patil, S. Bonneau, F. Joubert, AF Bitbol, H. Berthoumieux* , Mitochondrial cristae modeled as an out-of-equilibrium membrane driven by a proton field , Phys. (jussieu.fr)
Major structure giving elements of the inner membrane are the so-called cristae junctions. (db-engine.de)
This short, tubular membrane segments connect the flat inner boundary membrane with the morphological dynamic cristae membranes. (db-engine.de)

The physicist published the first complete description of the bending energy of membranes and was a leading pioneer in the field of membrane physics. (mpg.de)
With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)

At the " Biomembrane Days", experts from all over the world inform about recent advances in understanding the morphology and molecular organizat ion of biomimetic and biological membranes. (mpg.de)
The elaboration of membrane based biomimetic systems allows us to reconstitute and investigate, in controlled conditions, biological events occurring at the membrane interface. (utc.fr)

With S.J. Singer, Nicolson published a paper titled "The fluid mosaic model of the structure of cell membranes" in 1972, which is now regarded as a classic paper in cell biology. (wikipedia.org)
With over 600 scientific papers, the majority of Nicolson's research is in cancer biology and cellular properties related to aging. (wikipedia.org)
It was the first model in cell biology to be based on thermodynamics properties. (wikipedia.org)
This FOA encourages applications to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. (nih.gov)
Biology has served as inspiration for Computer Science in recent years, given that biological systems tend to be adaptive, reactive, and distributed. (wikicfp.com)
A general program of biology at the introductory, basic level or a program in biology or the biological sciences that is undifferentiated as to title or content. (myfuture.com)
Includes instruction in general biology and programs covering a variety of biological specializations. (myfuture.com)

To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
Biological membranes also play a major role in metabolism regulation and cellular physiology (e.g., mitochondrial membranes). (utc.fr)

The proposed model provides a comprehensive understanding of membrane organization, taking into account the dynamic nature of the cell membrane and its interactions with its immediate environment. (bvsalud.org)
anical interactions at the cellular level. (lu.se)

1 Reconstituted Membrane Systems. (orellfuessli.ch)
We model these coupled systems using reaction-diffusion equations and generalized Helfrich models. (jussieu.fr)
Many years ago, I read a review article about membrane fusion, which I was working on at the time, with a title that raised the ever-present question of mimicry and mechanism in model systems. (asbmb.org)
An integrated, combined program that focuses on the scientific study of cells, cellular systems, and the molecular basis of cell structure and function. (myfuture.com)
Among the themes that unite the research being performed in this group is the attempt to learn new chemistry and physics from biological systems. (mcgill.ca)
My postdoctoral research at Prof. Raghu Padinjat`s lab in NCBS involves the use of brain organoids and iPS model systems in understanding the signalling alterations involved in neuropsychiatric disorders. (ncbs.res.in)
They will take this work one step further and create new model systems to determine the 3-D relationships and functions of different epithelial cell types as the basal cells detect and respond to various drugs, hormones, chemicals and pathogens that appear in the cavity of the organ. (nih.gov)
A very large radiation dose received in a short enough period of time to preclude significant repair can cause cellular walls to collapse and disrupt organ systems, producing deterministic effects such as acute radiation syndrome, cataracts, and teratogenesis (mental retardation, IQ reduction, microencephaly, stunted growth). (cdc.gov)

Objectives: To investigate the potential role of a commercially available preparation of micronized Amniotic Membrane Allograft (AMA) (Amniofix, MiMedx, USA) in the biological augmentation of an in vitro model of rotator cuff repair with respect to cellular pro- liferation, collagen content and mechanical properties of the bone- tendon interface. (researchgate.net)
Methods: The in vitro model consisted of artificial bone-tendon constructs (BTC). (researchgate.net)
Evaluation of the efficacy of proposed agents in an in vitro model is convenient and allows assessment of the mechanical properties of the bone-tendon interface as well as the effect on fibroblast proliferation and collagen content of the tissue. (researchgate.net)
The three key elements of the toxicity screening strategy are: Physicochemical Characteristics, In Vitro Assays (cellular and non-cellular), and In Vivo Assays. (cdc.gov)
In vitro techniques allow specific biological and mechanistic pathways to be isolated and tested under controlled conditions, in ways that are not feasible in in vivo tests. (cdc.gov)
However, in the mid- to late 1990s, a number of laboratories interested in cold transduction began to use primary cultures of either dorsal root (DRG) or trigeminal (TG) ganglia neurons as in vitro models of sensory afferents. (nih.gov)
Soft tissue engineering for both clinical use and as novel 3D in vitro models for improved laboratory studies. (sheffield.ac.uk)

Given their apparent simplicity ("simple bags of hemoglobin") these cells have been the subject of many studies on cellular physiology. (frontiersin.org)

We demonstrate easy encapsulation of macromolecules and production of liposomes with membranes of complex compositions. (ucmerced.edu)

The relative dispersion of cellular residence times is introduced as a model-independent measure of cytoplasmic equilibration kinetics, which indicates whether diffusion through the cytoplasm is rate limiting. (nih.gov)

Choline is an essential nutrient that the human body needs in vast quantities for cell membrane synthesis, epigenetic modification, and neurotransmission. (bvsalud.org)

We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)

Wolfgang Helfrich made numerous theoretical and experimental contributions to membrane physics, in particular on vesicle shapes, membrane shape fluctuations, and the effect of electric fields on vesicles. (mpg.de)
The Resonant models are validated with experimental data and with other published models. (auckland.ac.nz)
Single cell experiments [ 11 ] could provide iterative validation of models with experimental results. (lu.se)

A molecular-level picture of polymer dynamics and structure at surfaces and interfaces is being developed through theoretical modelling, high-field solids NMR spectroscopy, electron microscopy, and other surface characterization methods. (mcgill.ca)

13 Regulation of Erythropoiesis and Possible Implications of the Cell Membrane. (orellfuessli.ch)
not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)

Evaluation was done at term (30 days' gestation) assessing fetal survival, fetal membrane integrity and histology of the membranes. (researchgate.net)

These organelles are surrounded by two membranes and especially the convoluted inner membrane displays a complex ultra-structure. (db-engine.de)

Pere Roca-Cusachs obtained his PhD in cellular biophysics in 2007 from the Medical School at the University of Barcelona. (ibecbarcelona.eu)

We are interested in recruiting highly motivated and creative Postdocs and PhD students to study the fascinating molecular organization of cellular membranes. (db-engine.de)

Selected by the Virtual Journal of Biological Physics Research, Sep. (jussieu.fr)
Selected by the Virtual Journal of Biological Physics Research, Feb. 15, Vol. 17(4), 2009. (jussieu.fr)
Selected by the Virtual Journal of Biological Physics Research, Nov. 15, Vol. 14(10), 2007. (jussieu.fr)
These attempts share a common anti-vitalistic viewpoint: synthesizing (cellular) life from scratch should be possible, and it would demonstrate that the biological phenomenology follows a "continuity principle" with respect to physics and chemistry. (frontiersin.org)

The possible neurodegenerative effect of CuO NPs was evaluated with C. elegans as a genetic model. (marquette.edu)

Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
Led by Chifman, our research team worked to better understand and develop the oncogenic pathway portion of the established pathway model. (american.edu)
The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
namely, defects in the oncogenic pathway are noted to induce modifications in cellular iron homeostasis. (american.edu)
In the schema of our project, our team sought two central goals: to increase the biological accuracy of the model through the addition of cellular species and intra-pathway connections to the oncogenic pathway, and to conduct new simulations using the updated oncogenic pathway. (american.edu)

Resonant model-A new paradigm for modeling an action potential of biological cells. (auckland.ac.nz)
In addition, red blood cells have served as a paradigm for membrane transport models and they are considered as drug carriers. (frontiersin.org)

Membranes play a cent ral role for the structure and function of all cells. (mpg.de)
The Resonant model is used to simulate entrainment between competing sinoatrial node cells. (auckland.ac.nz)
More recently the accessibility and purification of hematopoietic progenitor cells has enabled studies on erythroid maturation and the hematopoietic system, which in turn has driven research into novel biological concepts and methods. (frontiersin.org)
The cell membrane, the boundary that separates living cells from their environment, has been the subject of study for over a century. (bvsalud.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

The new model accurately reproduces non-linear potential morphologies for a variety of cell types. (auckland.ac.nz)
Biological membranes exhibit function-related shapes, leading to a plethora of complex and beautiful cell and cell organellar morphologies. (db-engine.de)

Criteria for model discrimination are developed using the first three central moments (mean, variance, and skewness) of the cellular residence time and organ transit time distribution, respectively. (nih.gov)
It is shown under which conditions the models are indistinguishable on the basis of venous organ outflow concentration-time curves. (nih.gov)
Organ level simulation of bioelectric behavior in the body benefits from flexible and efficient models of cellular membrane potential. (auckland.ac.nz)

5 Some Problems Concerning the Role of Water and Protons in the Function of Biological Membranes. (orellfuessli.ch)
H Berthoumieux ,Gaussian field model for polar fluids as a function of density and polarization: toward a model for water, J. Chem. (jussieu.fr)
He currently coordinates an EU-funded Future and Emerging Technologies (FET) project dedicated to understanding the mechanical control of biological function. (ibecbarcelona.eu)
It is expected that these awards will lead to new collaborations between researchers emphasizing biological function and researchers emphasizing biological structure. (nih.gov)
Following the reaction of biological membranes to external stimuli reveals fundamental insights into cellular function. (bvsalud.org)
Such behaviour suggests that azobenzene glycolipids can act as a bidirectional switch in DPPC monolayers providing a tool to investigate membrane structure-function relationships in depth. (bvsalud.org)
Langer and Vacanti 19 defined tissue engineering as an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function. (bvsalud.org)

These radicals react with intra- and inter-cellular machinery, often generating undesired biochemical effects. (american.edu)
it has really helped piece together the biochemical and cellular puzzles that we're interested in. (asbmb.org)

The Korean team of researchers successfully developed a proprietary biosensor technology with significantly enhanced molecular sensitivity using the artificial lipid membrane that mimics cellular membrane. (eurekalert.org)

Among the biological agents re- because species specificity limits the causes lymphoproliferative diseas- viewed in Volume 100B of the IARC feasibility of this approach for most of es in New World monkeys and in Monographs (IARC, 2012) are sever- these viruses. (who.int)

During 1970-1971 he worked as senior research associate in the Armand Hammer Cancer Centre of the Cancer Council Laboratory at the Salk Institute for Biological Studies, La Jolla. (wikipedia.org)
While working as research associate at the Salk Institute for Biological Studies, Nicolson collaborated with S.J. Singer at the University of California, San Diego. (wikipedia.org)
Thus, Julia Chifman's research aims to understand the cause of iron dysregulation in breast cancer through the study of certain cellular signaling pathways that affect iron homeostasis. (american.edu)
The ecology of environmental antibiotic resistance has recently become an important area of research as antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are recognized as emerging biological contaminants. (marquette.edu)
Therefore, the research team proposed the use of the model membrane to overcome this obstacle. (eurekalert.org)
Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)

If differences in outflow curve shapes (their relative skewness) cannot be detected, independent information on binding and/or diffusion kinetics is necessary to avoid model misspecification. (nih.gov)

Garth L. Nicolson (born October 1, 1943) is an American biochemist who made a landmark scientific model for cell membrane, known as the Fluid Mosaic Model. (wikipedia.org)

Special attention has been focused on PUFA, specifically LA and ALA, given their functions of maintaining cell membranes under normal conditions, as well as their brain functions and the transmission of nerve impulses 2 , 4 . (nature.com)
Specifically, the method is used to model human and rabbit sinoatrial node, human ventricular myocyte and squid giant axon electrophysiology. (auckland.ac.nz)

Hanson joined the ranks of associate editors at the Journal of Biological Chemistry in November 2017. (asbmb.org)

There is a strong likelihood that biological activity of nanoparticle s will depend on physicochemical parameters not routinely considered in toxicity screening studies. (cdc.gov)

They made a seminal model for the structure of cell membranes, which they named the Fluid Mosaic Model, and published in a 12-page paper in the February 18, 1972, issue of Science. (wikipedia.org)

I Structural and Functional Relationships in Cell Membranes. (orellfuessli.ch)

She returned to Yale for a postdoctoral fellowship in membrane trafficking before joining Washington University in St. Louis as an assistant professor in 1997. (asbmb.org)

Scientists have developed a model showing that even though it appears counterintuitive, the observation that some molecular keys are not always an exact fit for their molecular locks actually helps them in discerning the right target. (sciencedaily.com)
Weizmann Institute scientists have developed a model showing that even though it appears counterintuitive, the observation that some molecular keys are not always an exact fit for their molecular locks actually helps them in discerning the right target. (sciencedaily.com)
Dec. 17, 2020 Scientists have developed a procedure that combines various resolution levels in a computer simulation of a biological virus. (sciencedaily.com)
May 8, 2020 Scientists have developed a method that combines different resolution levels in a computer simulation of biological membranes. (sciencedaily.com)

One of the fundamental principles underlying the quantum mechanical model of the atom is the wave-particle duality of electrons. (massimopigliucci.blog)
The purpose of this article is to review the biological principles of tissue engineering and the hurdles that must be overcome to develop regenerative endodontic procedures. (bvsalud.org)

Dynamic changes in biological conditions are modeled with changing model coefficients and this approach enables ionic channel alterations to be captured. (auckland.ac.nz)
After repeated tests for applying the cellular membrane to the surface of the FET-based molecular detection chip, it was confirmed that molecule detection is available without additional pretreatment, even in a high-concentration ionic solution. (eurekalert.org)

2 Molecular Aspects of Membrane Fusion. (orellfuessli.ch)
As cell membranes are both dynamic and compositionally complex, replicating these aspects in a model membrane are essential. (lu.se)

Anatomy50

Organisms12

Diseases1

Chemicals and Drugs87

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes68

Disciplines and Occupations3

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Proteins29

Plasma membrane2

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Variety of model membrane systems1

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Mitochondrial membrane2

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20171

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